[논문]국화류 추출물 및 분획물의 생리활성 비교연구

강정란; 유은미; 한갑훈

doi:10.22156/cs4smb.2019.9.9.245

초록
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본 연구는 우리나라 전역에 자생하는 국화류3종 학슬, 희렴, 한련초를 대상으로 MeOH 80% 추출물 및 헥산, 클로로포름, 에틸아세테이트, 부탄올 및 물분획을 이용한 항균활성, 항산화 및 tyrosinase 저해활성효과에 대한 연구를 통해 기능성 화장품소재로서의 이용가능성을 확인하고자 하였다. 연구결과 항균활성의 경우 MeOH 80% 추출물에서는 한련초와 용매분획 중에서는 학슬의 헥산분획, 희렴의 클로로포름분획, 에틸아세테이트 분획, 한련초의 클로로포름분획을 중심으로 항균력을 나타내었다. 항산화 활성의 경우 3종 모두 용매분획 중 에틸아세테이트, 부탄올 분획에서 90%이상의 효과를 나타내었다. Tyrosinase 저해활성의 경우 희렴과 학슬의 에틸아세테이트 분획물에서 우수한 활성을 나타내었다. 이상의 국화류3종 MeOH 80%추출물 및 분획물에서 항산화 및 미백작용이 우수하므로 기능성화장품소재 개발 활용이 가능할 것으로 생각된다.

Abstract ▼ AI-Helper

This study was conducted to investigate the anti-oxidative, anti-oxidative and tyrosinase inhibitory effects of MeOH 80% extract and hexane, chloroform, ethyl acetate, butanol and aqueous fraction on three kinds of compositae plants in Korea. In the antimicrobial effect, the extract and chloroform f...

This study was conducted to investigate the anti-oxidative, anti-oxidative and tyrosinase inhibitory effects of MeOH 80% extract and hexane, chloroform, ethyl acetate, butanol and aqueous fraction on three kinds of compositae plants in Korea. In the antimicrobial effect, the extract and chloroform fraction of Eclipta prostrata and hexane fraction of Carpesium abrotanoides L. and chloroform fraction of Siegesbeckia glabrescens exhibited significant inhibition. The antioxidant activity of ethyl acetate and butanol fractions was more than 90% in all three plants. In case of tyrosinase activity, showed a potent inhibition ethlyacetate fraction of Siegesbeckia glabrescens and Carpesium abrotanoides L, which were higher than control group. In MeOH 80% extracts, there was not found to have antimicrobial, anti-oxidant and tyrosinase inhibitory activity, however there was ethylacetate fraction of Siegesbeckia glabrescens to show effectss commonly in the three assay system.

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표/그림 (3)

표 Table 1. Antimicrobial effect of each plants extracts on various microbial strains
$Fig. 1. DPPH radical-scavenging activities of each plants. methanol 80% extract (MC), n-hexane fraction (HE), chloroform fraction (CH), ethylacetate fraction (EA), n-butylalcohol fraction (BU) and aqueous fraction (AQ). A : Carpesium abrotanoides L.; B : Siegesbeckia glabrescens; C : Eclipta prostrata$ 그림 Fig. 1. DPPH radical-scavenging activities of each plants. methanol 80% extract (MC), n-hexane fraction (HE), chloroform fraction (CH), ethylacetate fraction (EA), n-butylalcohol fraction (BU) and aqueous fraction (AQ). A : Carpesium abrotanoides L.; B : Siegesbeckia glabrescens; C : Eclipta prostrata
$Fig. 2. Effect of fraction tyrosinase inhibition activity from each plants.methanol 80% extract (MC), n-hexane fraction (HE), chloroform fraction (CH), ethylacetate fraction (EA), n-butylalcohol fraction (BU) and aqueous fraction (AQ). A : Carpesium abrotanoides L.; B : Siegesbeckia glabrescens; C : Eclipta prostrata$ 그림 Fig. 2. Effect of fraction tyrosinase inhibition activity from each plants.methanol 80% extract (MC), n-hexane fraction (HE), chloroform fraction (CH), ethylacetate fraction (EA), n-butylalcohol fraction (BU) and aqueous fraction (AQ). A : Carpesium abrotanoides L.; B : Siegesbeckia glabrescens; C : Eclipta prostrata

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문제 정의

This study was conducted to investigate the antimicrobial activity, antioxidant activity and tyrosinase inhibitory activity of 80% MeOH extracts and extracts of Carpesium abrotanoides L., Siegesbeckia glabrescens and Eclipta prostrata which are native to Korea, using hexane, chloroform, ethyl acetate, butanol and water fraction The purpose of this study was to investigate the possibility of using as a raw material for functional cosmetics related to anti - aging and whitening. The results of the study are as follows.

제안 방법

In this study, three kinds of chrysanthemum plants were selected from 80% extracts of MeOH and extracts from three kinds of chrysanthemums, which were naturally grown in Korea. In this study, hexane, chloroform, ethyl acetate, Butanol and water fraction were investigated for the antimicrobial activity, antioxidant activity and tyrosinase inhibitory activity.

대상 데이터

The materials used in the experiment were three kinds of Compositae plants which were planted in the ground part of Carlsium abrotanoides L., the whole plant of Siegesbeckia glabrescens and Eclipta prostrata, After thoroughly drying in a drier, 100 g of the plant was ground and pulverized and stored at 4 ℃ at low temperature.
The strains used in the experiment were A. niger, one of the major sources of cosmetics, ATCC 8642, a standard strain. Nutrient medium was used for A.

성능/효과

aeruginosa, only the chloroform fraction showed antibacterial activity. As a result of observing the growth inhibition rings caused by the extracts and solvent fractions of methanol of the three kinds of the above three kinds of Compositae plan the clear zone of the growth inhibition was maintained for the E. coli and P. aeruginosa strains continuously And it was confirmed that it could be used as an antimicrobial active material having a sterilizing effect as well as a growth inhibiting effect.
All three water fractions showed lower activity than vitamin C, the control sample. In this experiment, it is highly possible that the flavonoid components contained in the plant tops and the upper parts of the used plants were significantly extracted from the polar solvent, which showed higher activity than the vitamin C in the ethyl acetate and butanol fractions. These antioxidant enzymes are likely to be able to remove free radicals from the body, so they can be developed as natural products for functional foods and functional cosmetics.
Compositae plants, which live in all parts of Korea and can be edible, have been used for a long time due to their advantages in large quantities and the pharmacological effects of antipyretic, detoxification, analgesic, headache, diuretic, infectious infection, cholanitis, antifungal activity, antioxidant activity, anti-inflammatory activity, and sedation in oriental medicine[13,14]. In this study, three kinds of chrysanthemum plants were selected from 80% extracts of MeOH and extracts from three kinds of chrysanthemums, which were naturally grown in Korea. In this study, hexane, chloroform, ethyl acetate, Butanol and water fraction were investigated for the antimicrobial activity, antioxidant activity and tyrosinase inhibitory activity.

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국화류 추출물 및 분획물의 생리활성 비교연구
Comparison of Biological Activities on Extracts and Fractions in Compositae Plants 원문보기

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국화류 추출물 및 분획물의 생리활성 비교연구 Comparison of Biological Activities on Extracts and Fractions in Compositae Plants 원문보기

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국화류 추출물 및 분획물의 생리활성 비교연구
Comparison of Biological Activities on Extracts and Fractions in Compositae Plants 원문보기

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