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NTIS 바로가기Journal of Korean Medicine Rehabilitation : JKMR = 한방재활의학과학회지, v.29 no.4, 2019년, pp.15 - 27
김민지 (동국대학교 한의과대학 한방재활의학과교실) , 최유라 (동국대학교 한의과대학 한방재활의학과교실) , 신나래 (동국대학교 한의과대학 한방재활의학과교실) , 이명종 (동국대학교 한의과대학 한방재활의학과교실) , 김호준 (동국대학교 한의과대학 한방재활의학과교실)
Objectives This study was performed to evaluate anti-obesity effects of Crataegus pinnatifida (CP) on high-fat-diet induced obese mice. Methods The experimental animals were divided into four groups: normal diet (NOR) group, high fat diet (HFD) group, HFD+Xenical (XEN) group, and HFD+CP (CP) group. ...
핵심어 | 질문 | 논문에서 추출한 답변 |
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비만 인구는 1975년에 비해 얼마나 증가하였는가 | 비만 인구는 전 세계적으로 급속하게 증가하고 있다. 1975년 이래 비만 인구는 거의 3배가 되었으며 2016년에는 성인의 39%가 과체중이고 13%가 비만이다1). 국내 비만 유병률도 2009년 29. | |
국내에서 장시간 사용이 허용된 비만 치료제들의 부작용은 무엇인가 | 국내에서 장시간 사용이 허용된 비만 치료제는 총 4가지가 있는데, lorcaserin, orlistat, bupropion/naltrexone 병합제, liraglutide이다6). Locaserin과 bupropion/naltrexone 병합제는 식욕을 억제하지만 오심, 변비, 두통을 일으키며, orlistat는 지방흡수를 저해하지만 지방변, 팽만감 같은 장관 내 부작용이 있다. 또한 liraglutide는 혈당, 식욕에 영향을 주어 비만을 개선하지만, 저혈당뿐 아니라 오심, 설사같은 소화기계 부작용이 흔히 발생한다7). 이와 같은 약물의 부작용 때문에 이를 대체할 수 있는 비만치료에 대한 관심이 높아지고 있다. | |
산사란 무엇인가 | 산사(Crataegus pinnatifida, CP)는 장미과(Rosaceae) 산사나무(Crataegus pinnatifida Bunge)의 잘 익은 열매로8), 실험적 연구에서 고혈압, 당뇨를 포함한 대사질환 개선9), 기억력 개선10), 알레르기성 접촉피부염11) 및 호흡기질환12) 완화, 백내장 예방13) 등 다양한 효능이 보고되었다. 대사와 관련되어서는 이상지질혈증과 비만에 효과가 있다고 밝혀졌는데, 3T3-L1 세포의 분화와 중성지방의 축적을 억제하였고, 비만 쥐에서는 신체 및 지방 조직의 무게를 감소시키고 혈청과 간조직의 지질 수치를 낮추었다14). |
World Health Organization. Obesity and overweight. WHO Fact sheet. 2015. [cited 2019 Sep 13]; Available from: URL: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight.
S eo MH, K im YH, H an K , Jung JH, P ark YG, L ee SS, Kwon HS, Lee WY, Yoo SJ. Prevalence of obesity and incidence of obesity-related comorbidities in Koreans based on National Health Insurance Service Health Checkup Data 2006-2015. J Obes Metab Syndr. 2018;27(1):46-52.
Everett E, Tamimi H, Greer B, Swisher E, Paley P, Mandel L, Goff B. The effect of body mass index on clinical/pathologic features, surgical morbidity, and outcome in patients with endometrial cancer. Gynecol Oncol. 2003;90(1):150-7.
von Gruenigen VE, Courneya KS, Gibbons HE, Kavanagh MB, Waggoner SE, Lerner E. Feasibility and effectiveness of a lifestyle intervention program in obese endometrial cancer patients: a randomized trial. Gynecol Oncol. 2008;109(1):19-26.
Seo MH, Lee WY, Kim SS, Kang JH, Kang JH, Kim KK, Kim BY, Kim YH, Kim WJ, Kim EM, Kim HS , Shin YA, Shin HJ, Lee KR, Lee KY, Lee SY, Lee SK, Lee JH, Lee CB, Chung S, Cho YH, Choi KM, Han JS , Yoo S J. 2018 Korean Society for the Study of Obesity Guideline for the Management of Obesity in Korea. J Obes Metab Syndr. 2019;28(1):40-5.
Kim MK, Kim CS. Recent advances in anti-obesity agents. Korean J Med. 2018;93(6):501-8.
Srivastava G, Apovian CM. Current pharmacotherapy for obesity. Nat Rev Endocrinol. 2018;14(1):12-24.
Korea Pharmaceutical Information Center. Information of herbal medicines [cited 2019 Sep 14]. Available from: URL: https://www.health.kr/researchInfo/herbalMedicine1_detail.asp?idx537.
Dehghani S, Mehri S, Hosseinzadeh H. The effects of Crataegus pinnatifida (Chinese hawthorn) on metabolic syndrome: A review. Iran J Basic Med Sci. 2019;22(5):460-8.
Lee J, Cho E, Kwon H, Jeon J, Jung CJ, Moon M, Jeon M, Lee YC, Kim DH, Jung JW. The fruit of Crataegus pinnatifida ameliorates memory deficits in ${\beta}$ -amyloid protein-induced Alzheimer's disease mouse model. J Ethnopharmacol. 2019;243:112107.
Shin IS, Lee MY, Lim HS, Ha H, Seo CS, Kim JC, Shin HK. An extract of crataegus pinnatifida fruit attenuates airway inflammation by modulation of matrix metalloproteinase-9 in ovalbumin induced asthma. PLoS One. 2012;7(9):e45734.
Wang T, Zhang P, Zhao C, Zhang Y, Liu H, Hu L, Gao X, Zhang D. Prevention effect in selenite-induced cataract in vivo and antioxidative effects in vitro of Crataegus pinnatifida leaves. Biol Trace Elem Res. 2011;142(1):106-16.
Lee JJ, Lee HJ, Oh SW. Antiobesity effects of Sansa (Crataegi fructus) on 3T3-L1 cells and on high-fathigh-cholesterol diet-induced obese rats. J Med Food. 2017;20(1):19-29.
Khan MJ, Gerasimidis K, Edwards CA, Shaikh MG. Role of gut microbiota in the aetiology of obesity: proposed mechanisms and review of the literature. J Obes. 2016; 2016:7353642.
Ansari A, Bose S, Yadav MK, Wang JH, Song YK, Ko SG, Kim H. CST, an herbal formula, exerts anti-obesity effects through brain-gut-adipose tissue axis modulation in high-fat diet fed mice. Molecules. 2016;21(11):E1522.
Zhang S, Zhang C, Li M, Chen X, Ding K. Structural elucidation of a glucan from Crataegus pinnatifida and its bioactivity on intestinal bacteria strains. Int J Biol Macromol. 2019;128:435-43.
Clark JD, Gebhart GF, Gonder JC, Keeling ME, Kohn DF. The 1996 guide for the care and use of laboratory animals. ILAR Journal. 1997;38(1):41-48.
Caporaso JG, Kuczynski J, Stombaugh J, Bittinger K, Bushman FD, Costello EK, Fierer N, Pena AG, Goodrich JK, Gordon JI, Huttley GA, Kelley ST, Knights D, Koenig JE, Ley RE, Lozupone CA, McDonald D, Muegge BD, Pirrung M, Reeder J, Sevinsky JR, Turnbaugh PJ, Walters WA, Widmann J, Yatsunenko T, Zaneveld J, and Knight B. QIIME allows analysis of high-throughput community sequencing data. Nature Methods. 2010;7(5):335-336.
Korean Society for the Study of Obesity. Causes of Obesity. [cited 2019 Sep 13]; Available from: URL: http://general.kosso.or.kr/html/?pmodeobesityCause.
Aierken A, Buchholz T, Chen C, Zhang X, Melzig MF. Hypoglycemic effect of hawthorn in type II diabetes mellitus rat model. J Sci Food Agric. 2017;97(13):4557-61.
Kuo DH, Yeh CH, Shieh PC, Cheng KC, Chen FA, Cheng JT. Effect of Shan zha, a Chinese herbal product, on obesity and dyslipidemia in hamsters receiving high-fat diet. J Ethnopharmacol. 2009;124(3):544-50.
Eckburg PB, Bik EM, Bernstein CN, Purdom E, Dethlefsen L, Sargent M, Gill SR, Nelson KE, Relman DA. Diversity of the human intestinal microbial flora. Science. 2005;308(5728):1635-8.
Castaner O, Goday A, Park YM, Lee SH, Magkos F, Shiow STE, Schroder H. The gut microbiome profile in obesity: a systematic review. Int J Endocrinol. 2018;2018:4095789.
Le Chatelier E, Nielsen T, Qin J, Prifti E, Hildebrand F, Falony G, Almeida M, Arumugam M, Batto JM, Kennedy S, Leonard P, Li J, Burgdorf K, Grarup N, Jorgensen T, Brandslund I, Nielsen HB, Juncker AS, Bertalan M, Levenez F, Pons N, Rasmussen S, Sunagawa S, Tap J, Tims S, Zoetendal EG, Brunak S, Clement K, Dore J, Kleerebezem M, Kristiansen K, Renault P, Sicheritz-Ponten T, de Vos WM, Zucker JD, Raes J, Hansen T; MetaHIT consortium, Bork P, Wang J, Ehrlich SD, Pedersen O. Richness of human gut microbiome correlates with metabolic markers. Nature. 2013;500(7464):541-6.
Paek JK, Lee SY. Can gut microbiota modulation be used as a practical treatment for obesity? J Obes Metab Syndr. 2018;27(2):75-7.
Yumuk V, Tsigos C, Fried M, Schindler K, Busetto L, Micic D, Toplak H. European guidelines for obesity management in adults. Obes Facts. 2015;8(6):402-24.
Korean Society of Lipid an Artherosclerosis. 2018 Korean Guidelines for the Management of Dyslipidemia 4th ed. 2018. [cited 2019 Sep 13]; Available from: URL: http://www.lipid.or.kr/bbs/?codecare.
Korean Society of Lipid an Artherosclerosis. Dyslipidemia. [cited 2019 Sep 13]; Available from: URL: http://www.lipid.or.kr/faq/index2.php#none.
Gholam PM, Flancbaum L, Machan JT, Charney DA, Kotler DP. Nonalcoholic fatty liver disease in severely obese subjects. Am J Gastroenterol. 2007;102(2):399-408.
Moseti D, Regassa A, Kim WK. Molecular regulation of adipogenesis and potential anti-adipogenic bioactive molecules. Int J Mol Sci. 2016;17(1):E124.
Vargas-Castillo A, Fuentes-Romero R, Rodriguez-Lopez LA, Torres N, Tovar AR. Understanding the biology of thermogenic fat: is browning a new approach to the treatment of obesity? Arch Med Res. 2017;48(5):401-13.
Altshuler-Keylin S, Kajimura S. Mitochondrial homeostasis in adipose tissue remodeling. Sci Signal. 2017;10(468):eaai9248.
Patterson E, Ryan PM, Cryan JF, Dinan TG, Ross RP, Fitzgerald GF, Stanton C. Gut microbiota, obesity and diabetes. Postgrad Med J. 2016;92(1087):286-300.
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