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NTIS 바로가기생명과학회지 = Journal of life science, v.30 no.2, 2020년, pp.211 - 220
The activity of CAR can be regulated not only by ligand binding but also by phosphorylation of regulatory factors involved in extracellular signaling pathways, cross-talk interactions with transcription factors, and the recruitment, degradation, and expression of coactivators and corepressors. This ...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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pregnane x receptor는 주로 체내 어디에서 발현되는가? | PXR은 주로 간과 장관에서 발현되며, 외인성 물질의 감지를 통한 해독 대사뿐만 아니라 담즙산과 콜레스테롤 대사, 포도당과 지방의 에너지 대사 및 스테로이드와 호르몬 등을 포함한 내인성 물질의 항상성 조절 그리고 세포 증식, 염증과 면역반응에도 중요한 기능을 하는 것으로 보고되어 왔다[53]. PXR은 다른 NR과 구조적으로 유사하지만, 비교적 크고 유연한 LBD를 함유하여 다양한 리간드와 결합할 수 있는 특징이 있어 광범위한 xenobiotics의 조절에 토대가 된다[51]. | |
48 family의 핵 수용체 유전자에 함유된 6부위 기능적 domain은? | 이 핵 수용체들은 리간드에 의해 활성화되는 전사 조절 인자로서 대사 항상성을 포함한 다양한 생물학적 기능에 중요한 역할을 한다. 인간에게는 48 family의 핵 수용체 유전자가 존재하며, 전형적으로 대부분 variable N-terminal regulatory domain (A/B), 보존적 DNA-binding domain (DBD, C), variable hinge region (D), 보존적 ligand-binding domain (LBD, E) 및 variable C-terminal domain (AF-2, F) 등의 6 부위 기능 적 domain을 함유한다[62]. NR은 리간드와 결합하거나 화학적 신호에 의해 자극될 경우, 구조적 변화를 통해 활성화되며, 주로 homodimer 또는 retinoid x receptor (RXR)와 heterodimer를 형성하여 핵으로 이동한 다음 다양한 coactivator 또는 corepressor 들을 동원하여 표적 유전자의 promoter에 위치한 특이적 cis-acting response element에 결합하여 유전자 전사를 조절한다[4]. | |
CYP450s, transferases 및 transporters는 어떤 역할을 하는가? | 간은 이러한 기능을 수행하기 위하여 외인성 물질 대사 효소인 cytochrome P450s (CYP450s) 및 특이적 transferases와 같은 효소와 대사물질의 체외 배출을 위한 다양한 transporters를 유도할 수 있는 기전을 보유하고 있다[34]. 따라서, CYP450s, transferases 및 transporters는 다양한 세포작용에 관여하는 화합물들의 항상성을 유지하고 외인성 화합물들의 제거에 중요한 역할을 한다. |
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