최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기Biomolecules & therapeutics, v.28 no.1, 2020년, pp.74 - 82
Park, Hye Jin (Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University) , Kwon, Huiyoung (Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University) , Lee, Ji Hye (Division of Endocrinology, School of Medicine, Kyungpook National University) , Cho, Eunbi (Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University) , Lee, Young Choon (Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University) , Moon, Minho (Department of Biochemistry, College of Medicine, Konyang University) , Jun, Mira (Institute of Convergence Bio-Health, Dong-A University) , Kim, Dong Hyun (Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University) , Jung, Ji Wook (Department of Herbal Medicinal Pharmacology, College of Herbal Bio-industry, Daegu Haany University)
Alzheimer's disease (AD) is a progressive and most frequently diagnosed neurodegenerative disorder. However, there is still no drug preventing the progress of this disorder. β-Amyrin, an ingredient of the surface wax of tomato fruit and dandelion coffee, is previously reported to ameliorate m...
* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.
Amani M Shokouhi G Salari AA 2019 Minocycline prevents the development of depression-like behavior and hippocampal inflammation in a rat model of Alzheimer’s disease Psychopharmacology (Berl.) 236 1281 1292 10.1007/s00213-018-5137-8 30515523
Arbel-Ornath M Hudry E Boivin JR Hashimoto T Takeda S Kuchibhotla KV Hou S Lattarulo CR Belcher AM Shakerdge N Trujillo PB Muzikansky A Betensky RA Hyman BT Bacskai BJ 2017 Soluble oligomeric amyloid-beta induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain Mol. Neurodegener 12 27 10.1186/s13024-017-0169-9 28327181
Beurel E Grieco SF Jope RS 2015 Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases Pharmacol. Ther 148 114 131 10.1016/j.pharmthera.2014.11.016 25435019
Birnbaum JH Bali J Rajendran L Nitsch RM Tackenberg C 2015 Calcium flux-independent NMDA receptor activity is required for Abeta oligomer-induced synaptic loss Cell Death Dis 6 e1791 10.1038/cddis.2015.160 26086964
Chen TJ Wang DC Chen SS 2009 Amyloid-beta interrupts the PI3K-Akt-mTOR signaling pathway that could be involved in brain-derived neurotrophic factor-induced Arc expression in rat cortical neurons J. Neurosci. Res 87 2297 2307 10.1002/jnr.22057 19301428
Chicca A Marazzi J Gertsch J 2012 The antinociceptive triterpene beta-amyrin inhibits 2-arachidonoylglycerol (2-AG) hydrolysis without directly targeting cannabinoid receptors Br. J. Pharmacol 167 1596 1608 10.1111/j.1476-5381.2012.02059.x 22646533
da Silva KA Paszcuk AF Passos GF Silva ES Bento AF Meotti FC Calixto JB 2011 Activation of cannabinoid receptors by the pentacyclic triterpene alpha,beta-amyrin inhibits inflammatory and neuropathic persistent pain in mice Pain 152 1872 1887 10.1016/j.pain.2011.04.005 21620566
Dubois B Feldman HH Jacova C Dekosky ST Barberger-Gateau P Cummings J Delacourte A Galasko D Gauthier S Jicha G Meguro K O’Brien J Pasquier F Robert P Rossor M Salloway S Stern Y Visser PJ Scheltens P 2007 Research criteria for the diagnosis of Alzheimer’s disease: revising the NINCDS-ADRDA criteria Lancet Neurol 6 734 746 10.1016/S1474-4422(07)70178-3 17616482
Ferretti MT Allard S Partridge V Ducatenzeiler A Cuello AC 2012 Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer’s disease-like amyloid pathology J. Neuroinflammation 9 62 10.1186/1742-2094-9-62 22472085
Fu AK Hung KW Huang H Gu S Shen Y Cheng EY Ip FC Huang X Fu WY Ip NY 2014 Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer’s disease Proc. Natl. Acad. Sci. U.S.A 111 9959 9964 10.1073/pnas.1405803111 24958880
Gregoire CA Bonenfant D Le Nguyen A Aumont A Fernandes KJ 2014 Untangling the influences of voluntary running, environmental complexity, social housing and stress on adult hippocampal neurogenesis PLoS ONE 9 e86237 10.1371/journal.pone.0086237 24465980
Hardy J Selkoe DJ 2002 The amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics Science 297 353 356 10.1126/science.1072994 12130773
Haughey NJ Nath A Chan SL Borchard AC Rao MS Mattson MP 2002 Disruption of neurogenesis by amyloid beta-peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer’s disease J. Neurochem 83 1509 1524 10.1046/j.1471-4159.2002.01267.x 12472904
Ishii M Nakahara T Ikeuchi S Nishimura M 2015 beta-Amyrin induces angiogenesis in vascular endothelial cells through the Akt/endothelial nitric oxide synthase signaling pathway Biochem. Biophys. Res. Commun 467 676 682 10.1016/j.bbrc.2015.10.085 26498523
Jeon SJ Park HJ Gao Q Lee HE Park SJ Hong E Jang DS Shin CY Cheong JH Ryu JH 2015 Positive effects of beta-amyrin on pentobarbital-induced sleep in mice via GABAergic neurotransmitter system Behav. Brain Res 291 232 236 10.1016/j.bbr.2015.05.005 26026786
Jiang Y Liu Y Zhu C Ma X Ma L Zhou L Huang Q Cen L Pi R Chen X 2015 Minocycline enhances hippocampal memory, neuroplasticity and synapse-associated proteins in aged C57 BL/6 mice Neurobiol. Learn. Mem 121 20 29 10.1016/j.nlm.2015.03.003 25838119
Jo J Whitcomb DJ Olsen KM Kerrigan TL Lo SC Bru-Mercier G Dickinson B Scullion S Sheng M Collingridge G Cho K 2011 Abeta(1?42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3beta Nat. Neurosci 14 545 547 10.1038/nn.2785 21441921
Kim HY Lee DK Chung BR Kim HV Kim Y 2016 Intracerebroventricular injection of amyloid-beta peptides in normal mice to acutely induce alzheimer-like cognitive deficits J. Vis. Exp 109 e53308
Kitagishi Y Nakanishi A Ogura Y Matsuda S 2014 Dietary regulation of PI3K/AKT/GSK-3beta pathway in Alzheimer’s disease Alzheimers Res. Ther 6 35 10.1186/alzrt265 25031641
Krishnan K Mathew LE Vijayalakshmi NR Helen A 2014 Anti-inflammatory potential of beta-amyrin, a triterpenoid isolated from Costus igneus Inflammopharmacology 22 373 385 10.1007/s10787-014-0218-8 25300965
Ma J Gao Y Jiang L Chao FL Huang W Zhou CN Tang W Zhang L Huang CX Zhang Y Luo YM Xiao Q Yu HR Jiang R Tang Y 2017 Fluoxetine attenuates the impairment of spatial learning ability and prevents neuron loss in middle-aged APPswe/PSEN1dE9 double transgenic Alzheimer’s disease mice Oncotarget 8 27676 27692 28430602
Maurya R Srivastava A Shah P Siddiqi MI Rajendran SM Puri A Yadav PP 2012 beta-Amyrin acetate and beta-amyrin palmitate as antidyslipidemic agents from Wrightia tomen-tosa leaves Phytomedicine 19 682 685 10.1016/j.phymed.2012.03.013 22541636
Mu Y Gage FH 2011 Adult hippocampal neurogenesis and its role in Alzheimer’s disease Mol. Neurodegener 6 85 10.1186/1750-1326-6-85 22192775
Nabavi S Fox R Proulx CD Lin JY Tsien RY Malinow R 2014 Engineering a memory with LTD and LTP Nature 511 348 352 10.1038/nature13294 24896183
Nair AB Jacob S 2016 A simple practice guide for dose conversion between animals and human J. Basic Clin. Pharm 7 27 31 10.4103/0976-0105.177703 27057123
Nair SA Sabulal B Radhika J Arunkumar R Subramoniam A 2014 Promising anti-diabetes mellitus activity in rats of beta-amyrin palmitate isolated from Hemidesmus indicus roots Eur. J. Pharmacol 734 77 82 10.1016/j.ejphar.2014.03.050 24726843
Noble W Garwood C Stephenson J Kinsey AM Hanger DP Anderton BH 2009 Minocycline reduces the development of abnormal tau species in models of Alzheimer’s disease FASEB J 23 739 750 10.1096/fj.08-113795 19001528
Okoye NN Ajaghaku DL Okeke HN Ilodigwe EE Nworu CS Okoye FB 2014 beta-Amyrin and alpha-amyrin acetate isolated from the stem bark of Alstonia boonei display profound anti-inflammatory activity Pharm. Biol 52 1478 1486 10.3109/13880209.2014.898078 25026352
Park SJ Ahn YJ Oh SR Lee Y Kwon G Woo H Lee HE Jang DS Jung JW Ryu JH 2014 Amyrin attenuates scopolamine-induced cognitive impairment in mice Biol. Pharm. Bull 37 1207 1213 10.1248/bpb.b14-00113 24989012
Penn AC Zhang CL Georges F Royer L Breillat C Hosy E Petersen JD Humeau Y Choquet D 2017 Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors Nature 549 384 388 10.1038/nature23658 28902836
Reddy PH 2013 Amyloid beta-induced glycogen synthase kinase 3beta phosphorylated VDAC1 in Alzheimer’s disease: implications for synaptic dysfunction and neuronal damage Biochim. Biophys. Acta 1832 1913 1921 10.1016/j.bbadis.2013.06.012 23816568
Rodriguez JJ Jones VC Tabuchi M Allan SM Knight EM LaFerla FM Oddo S Verkhratsky A 2008 Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer’s disease PLoS ONE 3 e2935 10.1371/journal.pone.0002935 18698410
Rodriguez JJ Noristani HN Olabarria M Fletcher J Somerville TD Yeh CY Verkhratsky A 2011 Voluntary running and environmental enrichment restores impaired hippocampal neurogenesis in a triple transgenic mouse model of Alzheimer’s disease Curr. Alzheimer Res 8 707 717 10.2174/156720511797633214 21453244
Rodriguez JJ Verkhratsky A 2011 Neurogenesis in Alzheimer’s disease J. Anat 219 78 89 10.1111/j.1469-7580.2011.01343.x 21323664
Santos FA Frota JT Arruda BR de Melo TS da Silva AA Brito GA Chaves MH Rao VS 2012 Antihyperglycemic and hypolipidemic effects of alpha, beta-amyrin, a triterpenoid mixture from Protium heptaphyllum in mice Lipids Health Dis 11 98 10.1186/1476-511X-11-98 22867128
Selkoe DJ 1991 The molecular pathology of Alzheimer’s disease Neuron 6 487 498 10.1016/0896-6273(91)90052-2 1673054
Shimshek DR Bus T Schupp B Jensen V Marx V Layer LE Kohr G Sprengel R 2017 Different forms of AMPA receptor mediated LTP and their correlation to the spatial working memory formation Front. Mol. Neurosci 10 214 10.3389/fnmol.2017.00214 28725178
Stein ES Itsekson-Hayosh Z Aronovich A Reisner Y Bushi D Pick CG Tanne D Chapman J Vlachos A Maggio N 2015 Thrombin induces ischemic LTP (iLTP): implications for synaptic plasticity in the acute phase of ischemic stroke Sci. Rep 5 7912 10.1038/srep07912 25604482
Szakiel A Paczkowski C Pensec F Bertsch C 2012 Fruit cuticular waxes as a source of biologically active triterpenoids Phytochem. Rev 11 263 284 10.1007/s11101-012-9241-9 23519009
Tapia-Rojas C Aranguiz F Varela-Nallar L Inestrosa NC 2016 Voluntary running attenuates memory loss, decreases neuropathological changes and induces neurogenesis in a mouse model of Alzheimer’s disease Brain Pathol 26 62 74 10.1111/bpa.12255 25763997
Thirupathi A Silveira PC Nesi RT Pinho RA 2017 beta-Amyrin, a pentacyclic triterpene, exhibits anti-fibrotic, anti-inflammatory, and anti-apoptotic effects on dimethyl nitrosamine-induced hepatic fibrosis in male rats Hum. Exp. Toxicol 36 113 122 10.1177/0960327116638727 27009110
Tiwari SK Seth B Agarwal S Yadav A Karmakar M Gupta SK Choubey V Sharma A Chaturvedi RK 2015 Ethosuximide induces hippocampal neurogenesis and reverses cognitive deficits in an amyloid-beta toxin-induced alzheimer rat model via the phosphatidylinositol 3-kinase (PI3K)/Akt/Wnt/beta-catenin pathway J. Biol. Chem 290 28540 28558 10.1074/jbc.M115.652586 26420483
Tozzi A Sclip A Tantucci M de Iure A Ghiglieri V Costa C Di Filippo M Borsello T Calabresi P 2015 Region- and age-dependent reductions of hippocampal long-term potentiation and NMDA to AMPA ratio in a genetic model of Alzheimer’s disease Neurobiol. Aging 36 123 133 10.1016/j.neurobiolaging.2014.07.002 25104560
Viola KL Klein WL 2015 Amyloid beta oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis Acta Neuropathol 129 183 206 10.1007/s00401-015-1386-3 25604547
Walsh DM Klyubin I Fadeeva JV Cullen WK Anwyl R Wolfe MS Rowan MJ Selkoe DJ 2002 Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo Nature 416 535 539 10.1038/416535a 11932745
Yan R Fan Q Zhou J Vassar R 2016 Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer’s disease Neurosci. Biobehav. Rev 65 326 340 10.1016/j.neubiorev.2016.03.025 27044452
Yi JH Baek SJ Heo S Park HJ Kwon H Lee S Jung J Park SJ Kim BC Lee YC Ryu JH Kim DH 2018 Direct pharmacological Akt activation rescues Alzheimer’s disease like memory impairments and aberrant synaptic plasticity Neuropharmacology 128 282 292 10.1016/j.neuropharm.2017.10.028 29079294
Zhu G Li J He L Wang X Hong X 2015 MPTP-induced changes in hippocampal synaptic plasticity and memory are prevented by memantine through the BDNF-TrkB pathway Br. J. Pharmacol 172 2354 2368 10.1111/bph.13061 25560396
Ziabreva I Perry E Perry R Minger SL Ekonomou A Przyborski S Ballard C 2006 Altered neurogenesis in Alzheimer’s disease J. Psychosom. Res 61 311 316 10.1016/j.jpsychores.2006.07.017 16938507
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
오픈액세스 학술지에 출판된 논문
※ AI-Helper는 부적절한 답변을 할 수 있습니다.