[논문]Preparation and Analysis of Functional Hydrogel Lenses Using Cerium Iron Hydroxide Nanoparticles

Shin, Su-Mi; Sung, A-Young

doi:10.13160/ricns.2020.13.1.13

Preparation and Analysis of Functional Hydrogel Lenses Using Cerium Iron Hydroxide Nanoparticles 원문보기

Journal of the Chosun Natural Science = 조선자연과학논문집, v.13 no.1, 2020년, pp.13 - 18

Shin, Su-Mi (Department of Optometry & Vision Science, Daegu Catholic University) , Sung, A-Young (Department of Optometry & Vision Science, Daegu Catholic University)

Abstract ▼ AI-Helper

This study used cerium iron hydroxide nanoparticle with HEMA (2-hydroxyethyl methacrylate), the cross-linker EGDMA (ethylene glycol dimethacrylate), NVP (N-vinyl-2-pyrrolidone) and the initiator AIBN (azobisisobutyronitrile) for copolymerization. Also, the physical properties of the prepared lenses were compared, and their applicability as polymers for ophthalmic materials was experimented. The results of the measurement showed that the UV blocking rate and the wettability increased with the cerium iron hydroxide nanoparticles addition ratio, and the refractive index and water content were not affected. Thus, the produced copolymer is expected to be useful as a functional contact lens material while satisfying the basic physical properties of the hydrogel contact lens.

주제어

표/그림 (8)

그림 Fig. 1. Typical DSC thermogram analysis of the contact lens samples: (a) CI-AIBN0.1 and (b) CI-AIBN0.3.
표 Table 1. Percent compositions of the CI samples (unit: wt%)
그림 Fig. 2. Spectral transmittance of the contact lens samples.
그림 Fig. 3. Produced hydrogel lens samples: (a) Ref; (b) CI05; (c) CI1; and (d) C2.
표 Table 2. Physical properties of the contact lens samples with nanoparticles
그림 Fig. 4. Wettability of samples: (a) Ref. (b) CI2.
$Fig. 5. Refractive indices and breaking strengths of the contact lens samples.$ 그림 Fig. 5. Refractive indices and breaking strengths of the contact lens samples.
그림 Fig. 6. Absorbance values of the contact lens samples after 10 days.

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제안 방법

In this study, ophthalmic contact lenses were fabricated using cerium iron hydroxide nanoparticles, employed as a sunscreen, as an additive, to evaluate the physical properties of the fabricated lenses. In addition, the physical properties of the lenses fabricated by adding 4-chlorostyrene at different ratios to add functionality to the lenses and to improve their durability were evaluated.
The use of such materials increases the water content, wettability, and oxygen transmissibility, but as the water content increases, the refractive index and the strength associated with the durability of the lens decrease^[14,15] Therefore, it is necessary to study the material so that the damage to the lens can be minimized without losing the lens’s original shape, by maintaining the hydrophilic properties and improving the durability at the same time. In this study, ophthalmic contact lenses were fabricated using cerium iron hydroxide nanoparticles, employed as a sunscreen, as an additive, to evaluate the physical properties of the fabricated lenses. In addition, the physical properties of the lenses fabricated by adding 4-chlorostyrene at different ratios to add functionality to the lenses and to improve their durability were evaluated.
This study determined the combination of 2-hydroxyethyl methacrylate (HEMA, mainly used as a hydrogel material), ethylene glycol dimethacrylate (EGDMA, a crosslinking agent), N-vinylpyrrolidone (NVP, a hydrophilic monomer), and azobisisobutyronitrile (AIBN, an initiator) as a basic combination. The nanoparticle, cerium iron hydroxide (CI), was used as an additive for the fabrication of ophthalmic polymers, and their physical properties were measured. The experiment results showed that the UV blocking rate increased with the CI addition ratio, the contact angle slightly decreased, and the physical properties like the refractive index and water content were not affected.
This study determined the combination of 2-hydroxyethyl methacrylate (HEMA, mainly used as a hydrogel material), ethylene glycol dimethacrylate (EGDMA, a crosslinking agent), N-vinylpyrrolidone (NVP, a hydrophilic monomer), and azobisisobutyronitrile (AIBN, an initiator) as a basic combination. The nanoparticle, cerium iron hydroxide (CI), was used as an additive for the fabrication of ophthalmic polymers, and their physical properties were measured.
To analyze the properties of cerium iron hydroxide nanoparticles included in the hydrogel lens, the optical and physical properties were measured according to the addition ratio based on the aforementioned results. RefN7 was renamed Ref, and CI-N7 was renamed CI05.

대상 데이터

For 2-hydroxyethyl methacrylate (HEMA) and azobisisobutyronitrile (AIBN), an initiator, the products of Junsei were used. For N-vinylpyrrolidone (NVP), 4-chlorostyrene, ethylene glycol dimethacrylate (EGDMA, a crosslinking agent), and cerium iron hydroxide (CI, a nanoparticle), the products of Sigma-Aldrich were used.
For 2-hydroxyethyl methacrylate (HEMA) and azobisisobutyronitrile (AIBN), an initiator, the products of Junsei were used. For N-vinylpyrrolidone (NVP), 4-chlorostyrene, ethylene glycol dimethacrylate (EGDMA, a crosslinking agent), and cerium iron hydroxide (CI, a nanoparticle), the products of Sigma-Aldrich were used.
After thermal polymerization using the respective mixed monomers, the physical properties of the fabricated contact lenses were measured. The fabricated contact lens samples were named Ref, CI05, CI1, and CI2, respectively, according to the amount of CI added. CI2 was selected and classified into CI2-S1, CI2-S3, CI2-S5, CI2-S7, and CI2-S10, according to the amount of 4-chlorostyrene added.
RefN7 was renamed Ref, and CI-N7 was renamed CI05.The samples were named Ref, CI05, CI1, and CI2 according to the amount of CI added.

이론/모형

The water content and refractive index were measured based on ISO 18369-4:2006, using the gravimetric method and an ABBE refractometer (ATAGO NAR 1T, Japan), respectively. The measurement results were similar to those of the Ref regardless of the addition of CI.
The wettability of the fabricated lenses was evaluated through the contact angle, and was measured using the sessile drop method. The contact angle was 70.

성능/효과

28% for visible ray. According to the CI addition amount, the transmittance was 9-31% for UV-B, 35-64% for UV-A, and 85- 89% for visible ray, indicating that the UV blocking rate gradually increased with the CI addition ratio. Fig.
As a result, the addition of CI did not change the physical properties of the water content and the refractive index, but slightly increased the wettability and at the same time showed excellent UV protection. CI2 was selected based on these results, and 4-Chlorostyrene that can increase durability was added at each ratio.
For the results of the measurement of the spectral transmittance to identify the optical properties, a transparent lens was fabricated for the Ref without nanoparticles, showing 59.15% transmittance for UV-B, 82.20% for UV-A, and 88.28% for visible ray. According to the CI addition amount, the transmittance was 9-31% for UV-B, 35-64% for UV-A, and 85- 89% for visible ray, indicating that the UV blocking rate gradually increased with the CI addition ratio.
In the measurement results of the absorbance after 1-, 5-, and 10-day hydration, it was found to be 0.2633-0.4483 for the Ref without nanoparticles, 0.1230-0.1723 for CI2, 0.0398-0.0705 for CI2-S1, and 0.0450-0.1096 for CI2-S10. Compared to Ref, the addition of CI (the nanoparticles) improved the polymerization stability.
The comparison of the samples showed that the pH difference was very low, and all of them showed excellent polymerization stability for hydrogen ions. In the case of the absorbance and extractables, the addition of CI showed higher polymerization stability compared to the Ref without nanoparticles, and the stability was slightly higher when 1% 4-chlorostyrene was added than when 10% was added.
The nanoparticle, cerium iron hydroxide (CI), was used as an additive for the fabrication of ophthalmic polymers, and their physical properties were measured. The experiment results showed that the UV blocking rate increased with the CI addition ratio, the contact angle slightly decreased, and the physical properties like the refractive index and water content were not affected. In addition, in the case of the polymers fabricated by adding 4-chlorostyrene to increase the durability, the refractive index and the breaking strength significantly increased as the amount of 4-chlorostyrene added increased.
According to the CI addition amount, the degree of polymerization increased, and the polymerization stability increased more when 1% 4-chlorostyrene was added rather than 10%. This study revealed that CI has an excellent UV protection effect, and that 4-chlorostyrene as an additive can be used as an ophthalmic material to increase the refractive index and strength and to improve the polymerization stability.

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원문보기 상세보기
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