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항생제 내성을 가진 유산균의 현황과 전망
Status and Prospect of Lactic Acid Bacteria with Antibiotic Resistance 원문보기

Journal of dairy science and biotechnology, v.38 no.2, 2020년, pp.70 - 88  

천정환 (건국대학교 수의과대학 KU식품안전건강연구소 및 공중보건학) ,  서건호 (건국대학교 수의과대학 KU식품안전건강연구소 및 공중보건학) ,  배동렬 (건국대학교 수의과대학 KU식품안전건강연구소 및 공중보건학) ,  정동관 (고신대학교 식품영양학과) ,  송광영 (건국대학교 수의과대학 KU식품안전건강연구소 및 공중보건학)

초록
AI-Helper 아이콘AI-Helper

대부분의 스타터 배양균은 유산균(LAB)군(group)에 속하며 미국 식품의약국(FDA)과 유럽식품안전청(EFSA)에 의해 안전하다고 인정받고 있다. 그러나, LAB는 항생제 내성(antibiotic resistance) 유전자를 위한 내적 또는 외적 저장소로 작용할 수 있다. 하지만 저항 유전자 전달이 수직이기 때문에 이 사실은 그 자체가 안전상의 문제가 아닐 수도 있다. 그럼에도 불구하고 외부 유전적 요소는 심각한 안전 문제를 나타내는 인체 장내 미생물뿐만 아니라 병원균의 저항성 수평 전달에 유리한 변화를 유도할 수 있다. 항생제 내성을 가진 유산균의 일부 속(genus)에는 발효육 및 유제품에서 분리된 Enterococcus, Lactobacillus, Lactococcus, Leuconostoc, Pediococcus, Streptococcus 등이 포함된다. 현재 WHO는 식품산업에서 사용되는 LAB는 저항이 없어야 한다고 권고하고 있다. 다행히도 한국의 식품의약품안전처가 인정한 프로바이오틱스 균주 중 Enterococcus에 해당되는 균주는 E. faecium과 E. faecalis인데, 2019년 4월 1일부터 E. faecium과 E. faecalis의 독성인자와 항생제 내성전달인자 모두 없다고 인정된 경우에면 사용이 허가된다. 따라서 LAB의 산업적 중요성을 고려할 때 앞으로 인체와 동물장관 유래의 LAB은 체계적인 탐색 및 동정, 병원성 및 항생제 내성 유전자의 확인, 식품 및 가축사료 첨가제로의 활용, 안전성 평가연구는 계속 필요하다고 사료된다.

Abstract ▼ AI-Helper 아이콘AI-Helper

Lactic acid bacteria (LAB) form an essential part of the intestinal microbiota of the human body and possess the ability to stabilize the intestinal microbiota, strengthen immunity, and promote digestion as well as intestinal synthesis of vitamins, amino acids, and proteins. Hence, LAB are currently...

주제어

#lactic acid bacteria   #antibiotic resistance   #probiotic   #mechanism of resistance   #regulation  

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