$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

염화벤잘코늄(Benzalkonium chloride) 살균제의 용도 및 건강 위험에 대한 고찰 - 가습기 살균제를 중심으로
A Review on the Health Risks Associated with the Use of Products Containing Benzalkonium Chloride (BKC), Focusing on Humidifier Disinfectant Products 원문보기

韓國環境保健學會誌 = Journal of environmental health sciences, v.47 no.6, 2021년, pp.513 - 520  

김지원 (존스 홉킨스 대학교 인류학과) ,  조경이 (서울대학교 보건대학원 환경보건학과) ,  김하나 (서울대학교 보건대학원 보건학과) ,  박동욱 (한국방송통신대학교 보건환경학과)

Abstract AI-Helper 아이콘AI-Helper

Background: Benzalkonium chloride (BKC) has been extensively used as a preservative in industrial products and in hygiene, medical, and cosmetic applications. Humidifier disinfectant (HD) products containing BKC have been used in South Korea. Objectives: This study was aimed to review types of produ...

주제어

참고문헌 (49)

  1. Park DU, Lee S, Lim HK, Kim SY, Kim J, Park J, et al. Comprehensive review on humidifier disinfectant (HD) products, focusing on the number of products and their disinfectant type. J Environ Health Sci. 2020; 46(5): 481-494. 

  2. Korea Environmental Industry & Technology Institute (KEITI). Comprehensive Supporting Portal for Humidifier Disinfectant Victims: Statistical Data. Available: https://www.healthrelief.or.kr/home/content/stats01/view.do [accessed 30 November 2021]. 

  3. Park DU, Ryu SH, Roh HS, Lee E, Cho HJ, Yoon J, et al. Association of high-level humidifier disinfectant exposure with lung injury in preschool children. Sci Total Environ. 2018; 616-617: 855-862. 

  4. Purohit A, Kopferschmitt-Kubler MC, Moreau C, Popin E, Blaumeiser M, Pauli G. Quaternary ammonium compounds and occupational asthma. Int Arch Occup Environ Health. 2000; 73(6): 423-427. 

  5. United States. Environmental Protection Agency. Reregistration Eligibility Decision for Alkyl Dimethyl Benzyl Ammonium Chloride (ADBAC). Washington, D.C.: U.S. Environmental Protection Agency; 2006. 

  6. Choi SM, Roh TH, Lim DS, Kacew S, Kim HS, Lee BM. Risk assessment of benzalkonium chloride in cosmetic products. J Toxicol Environ Health B Crit Rev. 2018; 21(1): 8-23. 

  7. European Union. Biocidal Products Regulation. Brussels: European Parliament, Council of the European Union; 2012. 

  8. European Commission. Commission Implementing Decision (EU) 2016/1950 of 4 November 2016 on the Non-Approval of Certain Biocidal Active Substances Pursuant to Regulation (EU) No 528/2012 of the European Parliament and of the Council. Available: https://eur-lex.europa.eu/legal-content/en/ALL/?uriCELEX:32016D1950 [accessed 30 September 2021]. 

  9. European Union (EU). Regulation (EU) 528/2012- Annex V: List of Preservatives Allowed in Cosmetic Products. Available: https://ec.europa.eu/growth/tools-databases/cosing/pdf/COSING_Annex%20V_v2.pdf [accessed 30 September 2021]. 

  10. European Commission. Regulation (EC) No. 1223/2009 on Cosmetic Products - Annex III. Available: https://ec.europa.eu/health/sites/default/files/endocrine_disruptors/docs/cosmetic_1223_2009_regulation_en.pdf [accessed 30 September 2021]. 

  11. Cosmetic Ingredient Review Expert Panel. Annual review of cosmetic ingredient safety assessments: 2005/2006. Int J Toxicol. 2008; 27(Suppl 1): 77-142. 

  12. US Food and Drug Administration, HHS. Safety and effectiveness of health care antiseptics; topical antimicrobial drug products for over-the-counter human use. Final rule. Fed Regist. 2017; 82(242): 60474-60503. 

  13. Japan Ministry of Health and Welfare. Standards for Cosmetics, Notification No.331. Tokyo: Ministry of Health and Welfare, Japan; 2000. 

  14. Korea Ministry of Food and Drug Safety. Regulations on Safety Standards for Cosmetics. No. 2020-12 (Amended on Feb 25, 2020). Available: https://www.mfds.go.kr/brd/m_211/view.do?seq14453 [accessed 30 September 2021]. 

  15. Korea Ministry of Food and Drug Safety. Korean Manufacturing Standard for Medicine. No.2021-68 (Partly Amended and Enforced on August 9, 2021). Available: https://www.law.go.kr/%ED%96%89%EC%A0%95%EA%B7%9C%EC%B9%99/%EC%9D%98%EC%95%BD%EC%99%B8%ED%92%88%ED%91%9C%EC%A4%80%EC%A0%9C%EC%A1%B0%EA%B8%B0%EC%A4%80/(2021-68,20210809) [accessed 30 September 2021]. 

  16. Korea Ministry of Food and Drug Safety. Prior Notice 1: Modification Order for Approving Drugs Containing Benzalkonium Chlorides. Available: https://nedrug.mfds.go.kr/CCBAR01F012/getList/getItem?infoNo20210099&infoClassCode3 [accessed 30 September 2021]. 

  17. Korea Ministry of Food and Drug Safety. Prior Notice 2: Modification Order for Approving Drugs Containing Benzalkonium Chlorides. Available: https://nedrug.mfds.go.kr/CCBAR01F012/getList/ getItem?infoNo20210133&infoClassCode3 [accessed 30 September 2021]. 

  18. Korea Ministry of Environment. Standard for Consumer Chemical Products Designated as Products Subject to Safety Confirmation and their Safety and Labeling No.2021-150 (Partly Amended and Enforced on July 30, 2021). Available: https://www.law.go.kr/admRulSc.do?menuId5&query%EC%95%88%EC%A0%84%ED%99%95%EC%9D%B8%EB%8C%80%EC%83%81%EC%83%9D%ED%99%9C%ED%99%94%ED%95%99%EC%A0%9C%ED%92%88%20%EC%A7%80%EC%A0%95%20%EB%B0%8F%20%EC%95%88%EC%A0%84%C2%B7%ED%91%9C%EC%8B%9C%EA%B8%B0%EC%A4%80#AJAX [accessed 30 September 2021]. 

  19. Lewis RJ, Sax NI. Sax's Dangerous Properties of Industrial Materials, 12th ed. Oxford: Wiley-Blackwell; 2012. 

  20. Willis CM, Stephens JM, Wilkinson JD. Experimentally-induced irritant contact dermatitis. Determination of optimum irritant concentrations. Contact Dermatitis. 1988; 18(1): 20-24. 

  21. Dao H Jr, Fricker C, Nedorost ST. Sensitization prevalence for benzalkonium chloride and benzethonium chloride. Dermatitis. 2012; 23(4): 162-166. 

  22. Fisher AA. Allergic contact dermatitis and conjunctivitis from benzalkonium chloride. Cutis. 1987; 39(5): 381-383. 

  23. Suneja T, Belsito DV. Occupational dermatoses in health care workers evaluated for suspected allergic contact dermatitis. Contact Dermatitis. 2008; 58(5): 285-290. 

  24. Stanford D, Georgouras K. Allergic contact dermatitis from benzalkonium chloride in plaster of Paris. Contact Dermatitis. 1996; 35(6): 371-372. 

  25. Isaac J, Scheinman PL. Benzalkonium chloride: an irritant and sensitizer. Dermatitis. 2017; 28(6): 346-352. 

  26. Oiso N, Fukai K, Ishii M. Irritant contact dermatitis from benzalkonium chloride in shampoo. Contact Dermatitis. 2005; 52(1): 54. 

  27. Tartari F, Vincenzi C, Di Altobrando A, Bruni F, Neri I. Allergic contact dermatitis to benzalkonium chloride with erythema multiforme-like reaction in a child. Contact Dermatitis. 2020; 82(6): 397-399. 

  28. Ling T, Highet A. Irritant reactions to an antiseptic bath emollient. J Dermatol Treat. 2000; 11(4): 263-267. 

  29. Krogsrud NE, Larsen AI. Airborne irritant contact dermatitis from benzalkonium chloride. Contact Dermatitis. 1997; 36(2): 112. 

  30. Mauleon C, Mauleon P, Chavarria E, de la Cueva P, Suarez R, Lazaro P. Airborne contact dermatitis from n-alkyl dimethylbenzylammonium chloride and n-alkyl dimethylethyl-benzylammonium chloride in a detergent. Contact Dermatitis. 2006; 55(5): 311-312. 

  31. Freeman PD, Kahook MY. Preservatives in topical ophthalmic medications: historical and clinical perspectives. Expert Rev Ophthalmol. 2009; 4(1): 59-64. 

  32. Lee J. Glaucoma and ocular surface disease. J Korean Glaucoma Soc. 2019; 8(1): 33-35. 

  33. Rasmussen CA, Kaufman PL, Kiland JA. Benzalkonium chloride and glaucoma. J Ocul Pharmacol Ther. 2014; 30(2-3): 163-169. 

  34. Yu I. Medical treatment of glaucoma and ocular surface disease: from old to new. J Korean Glaucoma Soc. 2017; 6(1): 30-33. 

  35. Orsini D, D'Arino A, Pigliacelli F, Assorgi C, Latini A, Cristaudo A. Allergic contact dermatitis to dorzolamide and benzalkonium chloride. Postepy Dermatol Alergol. 2018; 35(5): 538-539. 

  36. Lee SJ, Kim M. Allergic contact dermatitis caused by dorzolamide eyedrops. Clin Ophthalmol. 2015; 9: 575-577. 

  37. Datta S, Baudouin C, Brignole-Baudouin F, Denoyer A, Cortopassi GA. The eye drop preservative benzalkonium chloride potently induces mitochondrial dysfunction and preferentially affects LHON mutant cells. Invest Ophthalmol Vis Sci. 2017; 58(4): 2406-2412. 

  38. Suzuki K, Teranishi S, Sagara T, Yoshino H, Nakayama M, Enoki M, et al. Safety and efficacy of benzalkonium chloride-optimized tafluprost in Japanese glaucoma patients with existing superficial punctate keratitis. J Glaucoma. 2015; 24(6): e145-e150. 

  39. Sezgin Akcay BI, Guney E, Bozkurt TK, Topal CS, Akkan JC, unlu C. Effects of polyquaternium- and benzalkonium-chloride-preserved travoprost on ocular surfaces: an impression cytology study. J Ocul Pharmacol Ther. 2014; 30(7): 548-553. 

  40. Cha SH, Lee JS, Oum BS, Kim CD. Corneal epithelial cellular dysfunction from benzalkonium chloride (BAC) in vitro. Clin Exp Ophthalmol. 2004; 32(2): 180-184. 

  41. George M, Joshi SV, Concepcion E, Lee H. Paradoxical bronchospasm from benzalkonium chloride (BAC) preservative in albuterol nebulizer solution in a patient with acute severe asthma. A case report and literature review of airway effects of BAC. Respir Med Case Rep. 2017; 21: 39-41. 

  42. Lee BH, Kim SH. Benzalkonium chloride induced bronchoconstriction in patients with stable bronchial asthma. Korean J Intern Med. 2007; 22(4): 244-248. 

  43. Graf P, Enerdal J, Hallen H. Ten days' use of oxymetazoline nasal spray with or without benzalkonium chloride in patients with vasomotor rhinitis. Arch Otolaryngol Head Neck Surg. 1999; 125(10): 1128-1132. 

  44. Lechien JR, Costa de Araujo P, De Marrez LG, Halloy JL, Khalife M, Saussez S. Contact allergy to benzalkonium chloride in patients using a steroid nasal spray: a report of 3 cases. Ear Nose Throat J. 2018; 97(1-2): E20-E22. 

  45. Vandenplas O, D'Alpaos V, Evrard G, Jamart J, Thimpont J, Huaux F, et al. Asthma related to cleaning agents: a clinical insight. BMJ Open. 2013; 3(9): e003568. 

  46. The Mount Sinai Selikoff Centers for Occupational Health. Quaternary Ammonium Compounds in Cleaning Products: Health & Safety Information for Cleaners and Supervisors. Available: https://www.mountsinai.org/files/MSHealth/Assets/HS/Patient-Care/Service-Areas/Occupational-Medicine/QACsInfoforWorkers_18.pdf [accessed 30 September 2021]. 

  47. Park DU, Kwon JH, Park JH, Oh HB. Analysis of Components of Disinfectant Contained in Humidifier Disinfectant Products. Seoul: Special Committee for Examining the Cause of Tragedy caused by Humidifier Disinfectant (SCECTHD); 2020. 

  48. KOSHA. Study on the Respiratory Toxicity of Biocide, Benzalknonium Chloride. Available: https://oshri.kosha.or.kr/oshri/publication/researchReportSearch.do?modeview&articleNo411076&article.offset130&articleLimit10 [accessed 30 September 2021]. 

  49. Johnson NF. Pulmonary toxicity of benzalkonium chloride. J Aerosol Med Pulm Drug Deliv. 2018; 31(1): 1-17. 

저자의 다른 논문 :

관련 콘텐츠

오픈액세스(OA) 유형

BRONZE

출판사/학술단체 등이 한시적으로 특별한 프로모션 또는 일정기간 경과 후 접근을 허용하여, 출판사/학술단체 등의 사이트에서 이용 가능한 논문

이 논문과 함께 이용한 콘텐츠

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로