[논문]비알코올성 지방간을 가진 난소절제 쥐에서 염증에 대한 수영운동의 영향

정선효

doi:10.12925/jkocs.2021.38.2.356

비알코올성 지방간을 가진 난소절제 쥐에서 염증에 대한 수영운동의 영향
The effect of swimming exercise on inflammation in ovariectomized mice with non-alcoholic fatty liver 원문보기

Journal of the Korean Applied Science and Technology = 한국응용과학기술학회지, v.38 no.2, 2021년, pp.356 - 367

초록
AI-Helper

본 연구는 폐경 후 비만 여성의 동물모델을 이용하여 수영운동이 비알코올성 지방간에서 염증에 미치는 영향을 조사하였다. 실험동물은 수영운동을 하지 않은 모의수술군(S/N), 수영운동을 하지 않은 난소절제 수술군(O/N) 및 수영운동을 실시한 난소절제 수술군(O/S)으로 구분되어 8주 동안 고지방식이 사료를 섭취하면서 사육되었다. 간 조직의 지방축적, 간 무게 및 혈청 속 AST와 ALT는 S/N에 비해 O/N에서 증가하였으나, O/N에 비해 O/S에서는 감소하였다. S/N에 비해 O/N는 간 조직에서의 IκBα의 유전자 발현이 감소하였고 MCP-1, IL-6 및 TNF-α의 유전자 발현은 증가하였다. 그러나 O/N에 비해 O/S는 간 조직에서의 IκBα이 증가하였고 MCP-1, IL-6 및 TNF-α의 유전자 발현은 감소하였다. 결론적으로 본 연구는 난소절제 후 고지방식이의 섭취로 비만이 유도된 비만 쥐에서 수영운동이 비만으로 유도된 비알코올성 지방간에서 염증을 개선함으로써 건강증진에 효과적임을 제시하였다.

Abstract ▼ AI-Helper

This study investigated the effect of swimming exercise on inflammation in non-alcoholic fatty liver using animal models of postmenopausal obese women. Experimental animals were divided into a sham-operate + non-swimming trained group (S/N), an ovariectomize + non-swimming trained group (O/N) and an ovariectomize + swimming trained group (O/S), and were bred while eating a high fat diet for 8 weeks. Fat accumulation in liver tissue, liver weight, and serum AST and ALT increased in O/N compared to S/N, but decreased in O/S compared to O/N. Compared to S/N, O/N decreased the gene expression of IκBα in liver tissue and increased gene expression of MCP-1, IL-6, and TNF-α. But compared to O/N, O/S increased the gene expression of IκBα in liver tissue and decreased gene expression of MCP-1, IL-6, and TNF-α. In conclusion, this study suggested that swimming exercise was effective in improving physical health by improving inflammation in non-alcoholic fatty liver in obese mice induced obesity by high fat diet after ovariectomy.

주제어

표/그림 (6)

표 Table 1. Sequences of oligonucleotide primers and PCR conditions
그림 Fig. 1. Effects of exercise on liver weight. All values are expressed as mean ± SD. ^*Significantly different versus S/N, p<0.05. ^**Significantly different versus O/N, p<0.05. S/N; sham-operate + non-swimming trained group, O/N; ovariectomize + non-swimming trained group, O/S; ovariectomize + swimming trained group.
그림 Fig. 2. Effects of exercise on hepatic lipid accumulation. Arrows indicate the lipid droplets in hepatocytes. S/N; sham-operate + non-swimming trained group, O/N; ovariectomize + non-swimming trained group, O/S; ovariectomize + swimming trained group.
그림 Fig. 3. Effects of exercise on serum AST and ALT. All values are expressed as mean ± SD. ^*Significantly different versus S/N, p<0.05. ^**Significantly different versus O/N, p<0.05. S/N; sham-operate + non-swimming trained group, O/N; ovariectomize + non-swimming trained group, O/S; ovariectomize + swimming trained group.
그림 Fig. 4. Effects of exercise on MCP-1, IL-6, TNFα in liver. All values are expressed as mean ± SD. ^*Significantly different versus S/N, p<0.05. ^**Significantly different versus O/N, p<0.05. S/N; sham-operate + non-swimming trained group, O/N; ovariectomize + non-swimming trained group, O/S; ovariectomize + swimming trained group.
그림 Fig. 5. Effects of exercise on IκBα in liver. All values are expressed as mean ± SD. ^*Significantly different versus S/N, p<0.05. ^**Significantly different versus O/N, p<0.05. S/N; sham-operate + non-swimming trained group, O/N; ovariectomize + non-swimming trained group, O/S; ovariectomize + swimming trained group.

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저자의 다른 논문 :

표제어: PCR

동의어: Packet Collision Rate

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