$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

총백추출물의 어린이 키 성장에 대한 유효성 및 안전성을 평가하기 위한 무작위배정, 이중눈가림, 위약 대조 인체적용시험: 인체적용시험 프로토콜
Randomized, Double-blind, and Placebo-controlled Human Trial to Evaluate the Efficacy and Safety of Allium Fistulosum L. Root Extract on Improvement of Child Height Growth: Study Protocol 원문보기

大韓韓方小兒科學會誌 = The journal of pediatrics of Korean medicine, v.35 no.2, 2021년, pp.11 - 20  

심수보 (대전대학교 한의과대학 소아과학교실) ,  고병섭 (한국한의학연구원) ,  육진아 (한국한의학연구원) ,  이정한 ((주)원일식품) ,  이호봉 ((주)원일식품) ,  하기찬 (헬스케어크레임스엔드멘내지멘트(주)) ,  김영미 (헬스케어크레임스엔드멘내지멘트(주)) ,  이혜림 (대전대학교 한의과대학 소아과학교실)

Abstract AI-Helper 아이콘AI-Helper

Objectives The purpose of the study is to evaluate the safety of the Allium Fistulosum extract in children and its effectiveness in height growth. Methods This study is randomized, double-blind, placebo-controlled trial. The participants are children between the 3rd and 25th percentiles in height, a...

주제어

표/그림 (1)

참고문헌 (42)

  1. Choi SR, Kim YY, Jin JE, Koo JS. A study on correlation between height growth, obesity and bone maturity in childhood. J Korean Med. 2019;40(1):24-33. 

  2. Rona RJ, Chinn S. Genetic and environmental influences on growth. J Med Screen. 1995;2(3):133-9. 

  3. Rosenfeld RG, Cohen P. Disorders of growth hormone and insulinlike growth factor secretion and action. In: Sperling M, editors. Pediatric Endocrinology. 4th ed. Philadelphia: WB Saunders Co.; 2008:254-334. 

  4. Kim JE, Baek JH. Effects of herbal medicine for growth of children: a retrospective study. J Pediatr Korean Med. 2016;30(4):87-98. 

  5. Huh K, Park MJ. Questionnaire-based analysis of growth-promoting attempts among children visiting a university growth clinic. Korean J Pediatr. 2009;52(5):576-80. 

  6. Yoon HJ, Kim DG, Lee JY. A study for the parent's recognition of the oriental medical treatment and the expectation of children's growth. J Korean Orient Pediatr. 2011;25(1):119-27. 

  7. Molinari E, Sartori, A., Ceccarelli, A., Marchi, S. Psychological and emotional development, intellectual capabilities, and body image in short normal children. J Endocrinol Investigation. 2002;25:321-8. 

  8. Jung MJ, Yoon, KL., Shim, KS. The relationships among perception of physique, self-esteem, sociality, and behavioral characteristics in children. Korean J Pediatr. 2008;51:1052-7. 

  9. Han SS, Kim, KM. Influencing factors on self-esteem in adolescents. J Korean Acad of Nursing. 2006;36: 37-44. 

  10. Kim MY. Comparison of body image, self-esteem and behavior problems between children of short and normal stature. J Korean Acad Child Health Nurs. 2000;16(1): 41-8. 

  11. Koo BS. Flavor characteristics according to parts of raw materials on allium fistulosum l. seasoning oil. Korean J Food Preserv. 2005;12:465-9. 

  12. Brewster JL, Rabinowitch HD. Japanese brunching onion (allium fistulosum l.). Onions and allied crops 1990;Saito S (ed):37-72. 

  13. Chen JH, Chen HI, Wang JS, Tsai SI, Jen CJ. Effects of welsh onion extracts on human platelet function in vitro. Life Sci. 2000;6:1571-9. 

  14. Seo DC, Chung SM, Le JY, Kim YS, Chung JH. Effect of oriental onion (alium fistulosum) on platelet agregation. J Fd Hyg Safety. 1996;1:273-7. 

  15. Terao J, Hiwada M, Taguchi K, Takahara K, Mohri S. Glutathione peroxidase mimics as novel antioxidants from vegetables. BioFacter. 2005;23:1-6. 

  16. Cha HS, Seong KS, Kim SH, Seo JW, Park SJ, Kim SI, Lee KW, Yon SR, Han DU. Protective effects of welsh onion (alium fistulosum l.) on drug-induced hepatotoxicity in rats. J Korean Soc Fod Sci Nutr. 2004; 34:134-9. 

  17. Phay N, Higashiyama T, Tsuji M, Matsura H, Fukushi Y, Yokota A, Tomita F. An antifungal compound from roots of welsh onion. Phytochem. 1999;52:271-4. 

  18. Date Y, Nakanishi Y, Fukuda S, Nuijma Y, Kato, T, Umehara M, Ohno H, Kikuchi J. In vitro evaluation method for screning of candidate prebiotic foods. Fod Chem. 2014;152:251-60. 

  19. Ju YS. Ungok Herbology. Rev. ed. Jeonju: Woosuk Press. 2013:366-8. 

  20. Wang BS, Chen JH, Liang YC, Duh PD. Effects of welsh onion on oxidation of lowdensity lipoprotein and nitric oxide production in macrophage cell line raw 264.7. Food Chem. 2005;91:147-50. 

  21. Lee DH, Lee SH, Song JB, Jee HJ, Cha SH, Chang GT. Effects of astragalus extract mixture ht042 on height growth in children with mild short stature: a multicenter randomized controlled trial. Phytother Res. 2018;32(1): 49-57. 

  22. Ranke MB. Towards a consensus on the definition of idiopathic short stature. 1996;45:64-6. 

  23. Woelfle J, Chia DJ, Rotwein P. Mechanisms of growth hormone (Gh) action. identification of conserved stat5 binding sites that mediate gh-induced insulin-like growth factor-I gene activation. J Biol Chem. 2003; 278(1):51261. 

  24. Kim HS. The Role of the insulin-like growth factors and insulin-like growth factor binding proteins in growth disorders. Endocrinol Metab. 2003;18(6):543-51. 

  25. Kawai M, Momoi T, Yorifuji T, Yamanaka C, Sasaki H, Furusho K. Unfavorable effects of growth hormone therapy on the final height of boy with short stature not caused by growth hormone deficiency. J Pediatr. 1997;130(2):205-9. 

  26. Yang SW. Management of children with short stature. J Korean Soc Endocrinol. 2003;18(6):561-70. 

  27. Kim HY, Park BC, Cheon JH, Choi JY, An BM, Park JH, Lee BJ, Kim KB. Randomized, double-blind, and placebo-controlled a human study for growing of stature via the analysis of effect of ferment oyster extract: study protocol. J Pediatr Korean Med. 2019;33(4):37-46. 

  28. Han JE, An TEB, Park JK, Sung HK, Yeon JH, Sung SH. Treatments of korean medicine for pediatric growth: a literature review of clinical studies. J Pediatr Korean Med. 2021;35(1):18-29. 

  29. Department of Pediatrics Nationwide Korean Medicine College. Pediatrics of Korean Medicine. 3rd edition ed. Seoul: Ui Sung Dang Publishing Co.; 2020:808-17. 

  30. Kim HJ, Lee SH, Lee SH, Lee JH, Kim HC, Chang GT, Lee DH. Longitudinal bone growth stimulating effect of allium macrostemon in adolescent female rats. Molecules. 2020;25(22):5449. 

  31. Sung YY, Kim DS, Kim SH, Kim HK. Aqueous and ethanolic extracts of welsh onion, allium fistulosum, attenuate high-fat diet-induced obesity. BMC Complement Altern Med. 2018;18(1):105. 

  32. Sung YY, Kim SH, Yoo BW, Kim HK. The nutritional composition and anti-obesity effects of an herbal mixed extract containing allium fistulosum and viola mandshurica in high-fat-diet-induced obese mice. BMC Complement Altern Med. 2015;15:370. 

  33. Choi HK, Hwang JT, Nam TG, Kim SH, Min DK, Park SW, Chung MY. Welsh onion extract inhibits pcsk9 expression contributing to the maintenance of the ldlr level under lipid depletion conditions of hepg2 cells. Food Funct. 2017;8(12):4582-91. 

  34. Ueda H, Takeuchi A, Wako T. Activation of immune responses in mice by an oral administration of bunching onion (allium fistulosum) mucus. Biosci Biotechnol Biochem. 2013;77(9):1809-13. 

  35. Lee JB, Miyake S, Umetsu R, Hayashi K, Chijimatsu T, Hayashi T. Anti-influenza a virus effects of fructan from welsh onion (allium fistulosum l.). Food Chem. 2012;134(4):2164-8. 

  36. Choi EY, Cho YO. Allium vegetable diet can reduce the exercise-induced oxidative stress but does not alter plasma cholesterol profile in rats. Ann Nutr Metab. 2006;50(2):132-8. 

  37. Choi SH, Park EJ. A clinical study of the pediatric patients who visited oriental medical hospital for growth treatment. J Pediatr Korean Med. 2018;32(4):51-62. 

  38. Cheong EJ, Chun PS. Effect of growth hormone therapy on height in children and adolescents. Yakhak Hoeji. 2016;60(4):211-21. 

  39. National institution of health. Korean genome analysis project [Internet]. Korea centers for disease control and prevention; 2019 [Updated 2020; cited 2020 Dec 20]. Available from: http://www.cdc.go.kr/menu.es?mida40504100200 

  40. World health organization. Global database on child growth and malnutrition [Internet]. World health organization; 1997 [Updated 1997; cited 2020 Dec 20]. Available from: https://www.who.int/nutgrowthdb/about/introduction/en/index4.html 

  41. Juul A, Kastrup KW, Pedersen SA, Skakkebaek NE. Growth hormone (gh) provocative retesting of 108 young adults with childhood-onset gh deficiency and the diagnostic value of insulin-like growth factor I (igf-I) and igf-binding protein-3. J Clin Endocrinol Metab. 1997; 82(4):1195-201. 

  42. Kannisto S, Korppi M, Arikoski P, Remes K, Voutilainen R. Biochemical markers of bone metabolism in relation to adrenocortical and growth suppression during the initiation phase of inhaled steroid therapy. Pediatr Res. 2002;52(2):258-62. 

저자의 다른 논문 :

관련 콘텐츠

오픈액세스(OA) 유형

GOLD

오픈액세스 학술지에 출판된 논문

이 논문과 함께 이용한 콘텐츠

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로