[논문]기능성 소화불량에 대한 사군자탕의 치료효과 - 체계적 문헌고찰과 메타분석

김경림; 제유란; 김경민

doi:10.22246/jikm.2021.42.3.259

기능성 소화불량에 대한 사군자탕의 치료효과 - 체계적 문헌고찰과 메타분석
The Effect of Sagunja Decoction on Functional Dyspepsia - A Systematic Review and Meta-Analysis 원문보기

대한한방내과학회지 = The journal of internal Korean medicine, v.42 no.3, 2021년, pp.259 - 278

김경림 (동의대학교 부속 한방병원 한방내과) , 제유란 (동의대학교 부속 한방병원 한방내과) , 김경민 (동의대학교 부속 한방병원 한방내과)

Abstract ▼ AI-Helper

Objectives: This study examines the effect of Sagunja-tang on functional dyspepsia (FD) through a systematic review and meta-analysis of a randomized controlled trial (RCT). Methods: A search for RCTs that tested the effect of Sagunja-tang on functional dyspepsia was conducted in Medline, Embase, PubMed, CENTRAL, CiNii, CNKI, NDSL, RISS, OASIS, and KISS databases on November 8, 2020, with no limit on the year of publication. A meta-analysis was performed by synthesizing the findings, including total efficiency, clinical symptom score, myosin light-chain kinase (MLCK) level (pg/mL, and gastric half-emptying time (min). RevMan 5.4.1 software was used for data analysis. The quality of the literature was evaluated using Cochrane's risk of bias (RoB) tool. Results: A total of 14 RCTs met the selection criteria. As a result of the meta-analysis, the treatment group had higher total efficacy and MLCK levels (gastric antrum, jejunum) than the control group, and the clinical symptom score and gastric half-emptying time were lower. However, due to the low quality of the included RCT and the small sample size, the results may be slightly biased.

주제어

표/그림 (14)

그림 Fig. 1. Flow chart of the selection process.
표 Table 1. Summary of 14 Randomized Controlled Trials Included in This Review
표 Table 2. Capacity of the Sagunja-tang Used in 14 Randomized Controlled Trials
표 Table 3. Frequency of Added Medicinal Herbs
표 Table 4. Capacity of Frequently Used Added Medicinal Herbs
그림 Fig. 2. Assessment of risk of bias on 14 randomized controlled trial. A : risk of bias graph, B : risk of bias table (red : serious risk, yellow : moderate risk/unclear risk, green : low risk)
그림 Fig. 3-1. Forest plot of comparison : SJ, MSJ vs WM, SJ, MSJ+WM vs WM, outcome : total effective rate. SJ : Sagunja-tang, MSJ : Modified Sagunja-tang, WM : Western medicine
그림 Fig. 3-2. Forest plot of comparison : MSJ vs WM, outcome: total effective rate; subgroup (treatment period : 4 weeks). SJ : Sagunja-tang, MSJ : Modified Sagunja-tang, WM : Western medicine
그림 Fig. 4. Forest plot of comparison : SJ vs WM, SJ+WM vs WM, outcome : total effective rate. SJ : Sagunja-tang, WM : Western medicine
그림 Fig. 5. Forest plot of comparison : MSJ vs WM, MSJ+WM vs WM, outcome: total effective rate. MSJ : Modified Sagunja-tang, WM : Western medicine
그림 Fig. 6. Forest plot of comparison : MSJ vs WM, outcome : the symptoms total scores comparison. SJ : Sagunja-tang, MSJ : Modified Sagunja-tang, WM : Western medicine
그림 Fig. 7-1. Forest plot of comparison : MSJ vs WM, outcome : MLCK levels of smooth muscle cells in gastric antrum. MSJ : Modified Sagunja-tang, WM : Western medicine, MLCK : myosin light-chain kinase
그림 Fig. 7-2. Forest plot of comparison : MSJ vs WM, outcome : MLCK levels of smooth muscle cells in jejunum. MSJ : Modified Sagunja-tang, WM : Western medicine, MLCK : myosin light-chain kinase
그림 Fig. 8. Forest plot of comparison : MSJ vs WM, outcome : gastric half emptying time. MSJ : Modified Sagunja-tang, WM : Western medicine

참고문헌 (50)

Brainward E, Fauci A, Kaiser D, Hauser S, Lingo D, Jameson J. Harrison's Principles of Internal Medicine(19th edition). Seoul: MIP; 2017, p. 372, 2736-8.
Baek SY, Ha NY, Ko SJ, Park JW, Kim JS. Development of a Phlegm Pattern Questionnaire for Functional Dyspepsia and Analysis of Its Reliability and Validity. J Int Korean Med 2020; 41(4):563-82.

원문보기 상세보기
Oh JH, Kwon JG. Functional dyspepsia. Korean J Gastroenterol 2019;73(2):77-83.

상세보기
J Int Korean Med. Standard Clinical Practice Guidelines of Oriental Medicine with Functional Digestion. Guideline center for Korean Medicine/The society of Internal Korean Medicine; 2017, p. 2.
The Korean society of gastrointestinal motility. Functional dyspepsia revised edition. Seoul: JIN; 2006, p. 43.
Acupuncture classroom of national oriental medical college. Acupuncture. Seoul: Jipmoon Dang; 1991, p. 1315-6.
Committee of Digestive Diesease, National Korean Medicine College. Gastroenterology. Seoul: Koonja; 2008, p. 348.
Ko WH, Ha NY, Ko SJ, Park JW, Kim JS. A Clinical Study on the Relationship between Pattern and Ryodoraku Test Identifications for Patients with Functional Dyspepsia. J Int Korean Med 2019;40(3):369-89.

원문보기 상세보기
Chen SW, Pei ZY. The third prescription of Taiping Huimin Heji Bureau. Beijing: Haenam; 2001, p. 126.
College of Oriental Medicine Professor of The Herbal Formula Science. The Herbal Formula Science. Paju: Gunja Publishing House; 2020, p. 541.
Lee SJ. Research Trends on the Effect of Sagunzatang and Samultang. Daejeon University Journal of Oriental Medicine Research Institute 2011;20(1):175-82.
Kang RY, Kim HJ, Han HJ, Park EY, Jang JA, Kim JW, et al. Two cases of the Gastric Dysmotility-like Dyspepsia in functional dyspepsia that were improved by Bojungiki-Tang. Herbal formula science 2009;17(2):203-13.
Oh JH, Kim BS, Lim HY, Kim DW, Choi BH, Hur JI, et al. Three Cases Report of Functional Dyspepsia Patients Who were Administered by LJTG(Ljintang-Gamibang). J Int Korean Med 2005;26(3):641-51.
Park SK, Kim JS, Hong JH, Hong SS, Lim JH, Han SY, et al. An Evaluation & Clinical Report on Three cases of Functional Dyspepsia. J Int Korean Med 2002;23(2):244-52.
Jeon SH, Kim JW. Effects of a Herbal Medicine, Yukgunja-Tang Extract Granule, on Functional Dyspepsia Patients by Sasang Constitution: Placebo-Controlled, Double-Blind, Randomized Trial. J Sasang Constitut Med 2018;30(2):42-54.

원문보기 상세보기
Kim SJ, Lee JH, Ko SJ, Pack JW. Clinical Case Report of Functional Dyspepsia with Gyejibanhasaenggangtang, Acupuncture, and Moxibustion. J Int Korean Med 2016;37(2) :406-11.
Lee SH, Jung M, Lim KS, Yun YG. Effect of Sagunja-tang on Immune Function of Mouse Immune Cells. J Korean Med Ophthalmol Otolaryngol Dermatol 2015;28(3):14-29.

원문보기 상세보기
Hong SS, Ryu BH, Yoon SW, Kim JS. The effect of Sagunja-tang on TNBS-induced Inflammatory Bowel Disease in Mouse. J Int Korean Med 2010;31(4):731-51.
Lee JA, Ha HK, Jung DY, Lee HY, Lee NH, Lee JK, et al. Anti-inflammatory activities of Sagunja-tang(Sijunzi-tang). The Korean J of Oriental Medical prescription 2010;18(1):87-94.
Kim SY, Park JE, Seo HJ, Lee YJ, Jang BH Son HJ, et al. NECA's Guidance for Undertaking Systematic Reviews and Meta-analyses for Intervention. Seoul: National Evidence-based Health care Collaborating Agency; 2011, p. 1-28, 64.
Wiggins JPT, Altman DG, Sterne JAC, ChapterS: assising risk of bias in included studies. In: Higgines JPT, Green S. Chochrane hand book for systematic rivies of interventions version5.1.0 [updated March 2011]. The cochrane collaboration. 2011. Available from: http://handbook.cochrane.org/
Lee JY. Meta-analysis. J Korean Endocrinology 2008;23(6):361-78.

상세보기
Jiao ZH. Therapeutic effect of Sijunzi Decoction on functional dyspepsia of spleen stomach qi deficiency type. Contemporary Medical Symposium 2018;16(21):125-6.
Zhang YY. Effect analysis of modified Sijunzi Decoction in the treatment of functional dyspepsia with spleen and stomach weakness. Cardiovascular Disease Journal of Integrated Traditional Chinese and Western Medicine 2016; 4(33):145.
Li RF. 68 cases of functional dyspepsia treated with modified Sijunzi Decoction. Guide of China Medicine 2016;14(23):187-8.
Lan HB, Yuan HP. Effect of modified Sijunzi Decoction on functional dyspepsia of spleen deficiency type. Chinese Journal of Urban and Rural Enterprise Hygiene 2016;7(7):84-5.
Zhu MT, Liu XD. Effect of modified Sijunzi Decoction on functional dyspepsia of spleen deficiency type. Contemporary Medicine Forum 2015;13(17):42-3.
Sun W. Observation on 48 cases of functional dyspepsia treated with modified Sijunzi Decoction. The Medical Journal of Industrial Enterprise 2014;27(5):1053-4.
Zhang ZY. Clinical observation of Xiaopi Sanjie method in the treatment of functional dyspepsia. Chinese Journal of Medicinal Guide 2013;15(S) :161-2.
Mu DC. Effect of Sijunzi Decoction in the treatment of functional dyspepsia. Modern Medicine Journal of China 2012;14(5):68-9.
Sun ZJ. 60 cases of dysmotility functional dyspepsia treated with modified Sijunzi Decoction. Shanxi Journal of Traditional Chinese Medicine 2009; 25(1):16.
Li YH. Clinical observation of Sijunzi Decoction in the treatment of functional dyspepsia with spleen and stomach weakness. Beijing Journal of Traditional Chinese Medicine 2008;27(10) :806-7.
Cao JG. 49 cases of functional dyspepsia of spleen deficiency and liver depression treated with modified Sijunzi Decoction. Chinese Journal of Integrated Traditional and Western Medicine on Digestion 2008;16(2):126, 128.
Jin XL. Sixty cases of functional dyspepsia treated with modified Sijunzi Decoction. Journal of Changchun University of Traditional Chinese Medicine 2007;23(6):33.
Hu JF, Tan HH, Tong CZ. Observation on Functional Dyspepsia (39 case) Treated by Modified Decoction of Four Noble Drugs. Journal of Practical Traditional Chinese Medicine 2000; 16(11):3-4.
Zhang YM, Lang DM. Treatment of 95 cases of functional dyspepsia with Sijunzi Decoction. Chinese Journal of digestion 1998;6(7):306-7.
Tack J, Talley NJ, Camilleri M, Holtmann G, Hu P, Malagelada JR, et al. Functional gastroduodenal disorders. Gastroenterology 2006; 30(5):466-79.
Park JW, Ko SJ, Han GJ, Yeo IK, Ryu BH, Kim JS. The Effects of Banha-sasim-tang on Dyspeptic Symptoms and Gastric Motility in Cases of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled, and Two-Center Trial. eCAM 2013;2013:265035.

상세보기
Heo I, Shin BC, Hwang EH, Hwang MS, Kim BJ, Kim SY, et al. Chuna Manual Therapy for Functional Dyspepsia : A Systematic Review and Meta-analysis. The Journal of Korea CHUNA Manual Medicine for Spine & Nerves 2015;10(1):1-14.
Kim BY, Seo BN, Park JE, Yang CS, Kim IT, Im JW, et al. A Systematic Review of Acupuncture-Moxibution Treatment for Functional Dyspepsia. Korean Journal of Acupuncture 2017; 34(1):8-36.

원문보기 상세보기
Kim JB, Kim JH, Son GS, Kang WC, Cho JH. Development of Instrument of Pattern Identification for Functional Dyspepsia. Korean J. Oriental Physiology & Pathology 2010;24(6) :1094-8.
Qian Shule. A Meta-analysis and experimental sequential analysis of treating functional dyspepsia with Chaihu Shugan San. Clinical Journal of Chinese Medicine 2021;(8):142-8.
Hu X, Xiao K, Dong MC, Cui RH, Gan AP, Huang H. Banxia Xiexin decoction in the treatment of functional dyspepsia: A Meta-analysis of randomized controlled trials. Chinese Journal of Integrated Traditional and Western Medicine on Digestion 2020;(12):923-31.
Cheng X, Zhang Y, Tang XY, Liu K. Meta Analysis of Treating Functional Dyspepsia with Modified Four Milled Ingredients Decoction. Henan Traditional Chinese Medicine 2020;(05) :770-5.
Talley NJ, Ford AC. Fuctional Dyspepsia. N Engl J Med 2015;373(19):1853-63.

상세보기
Jeon WH, Park JW, Kim JS, Hong JH, Hong SS. Oriental Medical Treatment Can Improve Quality of Life in Patients with Functional Dyspepsia. Korean J Orient Int Med 2001;22(3) :361-6.
Wang J. The medical prescription gathers the solution. Taipei: Dafang Publishing House; 1978, p. 22.
Kim HC. Herbal Pharmacology. Paju: Jipmoondang; 2008, p. 134-7, 222, 266-7, 270, 273-6, 286-7, 422, 429, 434.
Professors of Herbal Formula Science. Herbal Formula Science. Seoul: Daesung; 1993, p. 275-6.
Lin YQ, Luo MY, Zhang W. Effects of total ginsenoside on gastric antrum smooth muscle tissues in rats with functional dyspepsia. The Chinese Journal of Clinical Pharmacology 2020; (20):3313-6.

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