[논문]기능성소화불량 환자에서 나타나는 정신적 증상의 한약 치료 : 체계적 문헌고찰과 메타분석

조윤재; 이하늘; 정해인; 이현진; 금창열; 한아람; 하나연; 김진성

doi:10.22246/jikm.2021.42.4.488

기능성소화불량 환자에서 나타나는 정신적 증상의 한약 치료 : 체계적 문헌고찰과 메타분석
Herbal Medicine for Functional Dyspepsia with Psychological Symptoms: A Systematic Review and Meta-Analysis 원문보기

대한한방내과학회지 = The journal of internal Korean medicine, v.42 no.4, 2021년, pp.488 - 509

조윤재 (경희대학교 대학원 임상한의학과) , 이하늘 (경희대학교 대학원 임상한의학과) , 정해인 (경희대학교 대학원 임상한의학과) , 이현진 (경희대학교 대학원 임상한의학과) , 금창열 (경희대학교 대학원 임상한의학과) , 한아람 (경희대학교 대학원 임상한의학과) , 하나연 (경희대학교한방병원 위장소화내과) , 김진성 (경희대학교 대학원 임상한의학과)

Abstract ▼ AI-Helper

Purpose: Functional dyspepsia (FD) is a chronic syndrome accompanied by repetitive digestive symptoms that appear in the upper gastrointestinal tract and are not caused by specific diseases. Psychological symptoms like anxiety, depression, insomnia, and somatization are frequently observed in FD. The purpose of this study was to review the effect of herbal medicine on the psychological symptoms that accompany FD. Methods: Database search (PubMed, EMBASE, KISS, Kmbase, KoreanMed, NDSL, OASIS, CNKI) was performed on February 24, 2021; a total of 1825 studies were searched. After the screening, 22 studies were included. Results: The studies were assessed by Cochrane RoB 2 and sorted into a table according to psychological symptoms. Meta-analysis was performed to estimate the effect of herbal medicine. Twenty of the twenty-two studies reported that herbal medicine was significantly more effective than the control group. Only three of the studies did not have a high risk of bias. Conclusion: Herbal medicine was significantly effective with or without Western medicine and had fewer adverse effects. Severe adverse effect was not reported. Psychological symptoms in FD affect onset and duration of FD, and some FD patients want to be treated for their anxiety before other symptoms. Reliable information about treatment for the psychological symptoms of FD is lacking. We reviewed the effect of herbal medicine treatment in this study, the results of which could be selected for primary or secondary treatment for FD.

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표/그림 (19)

그림 Fig. 1. Flow chart of study selection. The flow diagram indicates the retrieval process of the study. The total number of included studies is 22, but the "Anxiety" and "Depression" part have 12 duplicated studies.
그림 Fig. 2. Risk of bias graph.
그림 Fig. 3. Risk of bias summary.
그림 Fig. 4. Forest plot of TER of insomnia.
그림 Fig. 5. Forest plot of TER of anxiety.
그림 Fig. 6. Forest plot of HAMA.
그림 Fig. 7. Forest plot of HAMA with 柴胡疏肝散.
그림 Fig. 8. Forest plot of HAMA with 逍遙散.
그림 Fig. 9. Forest plot of SAS.
그림 Fig. 10. Forest plot of TER of depression.
그림 Fig. 11. Forest plot of TER of depression with 六君子湯.
그림 Fig. 12. Forest plot of TER of depression with 逍遙散.
그림 Fig. 13. Forest plot of TER of depression with 柴胡疏肝散.
그림 Fig. 14. Forest plot of HAMD.
그림 Fig. 15. Forest plot of HAMD with 柴胡疏肝散.
그림 Fig. 16. Forest plot of HAMD with 六君子湯.
그림 Fig. 17. Forest plot of HAMD with 逍遙散.
그림 Fig. 18. Forest plot of HAMD with 四逆散.
그림 Fig. 19. Forest plot of SDS.

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