[논문]A Study on the Tyrosinase Inhibitory and Antioxidant Effect of Microalgae Extracts

Ji, Keunho; Kim, Yeeun; Kim, Young Tae

doi:10.48022/mbl.2012.12001

A Study on the Tyrosinase Inhibitory and Antioxidant Effect of Microalgae Extracts 원문보기

Microbiology and biotechnology letters = 한국미생물·생명공학회지, v.49 no.2, 2021년, pp.167 - 173

Ji, Keunho (Basic Science Research Institute, Pukyong National University) , Kim, Yeeun (Deptartment of Microbiology, Pukyong National University) , Kim, Young Tae (Deptartment of Microbiology, Pukyong National University)

Abstract ▼ AI-Helper

Reactive oxygen species (ROS) disrupt the cellular redox balance, exert cytotoxic effects, and consequently promote the development of various diseases in humans. Previous studies have reported that antioxidants counteract the adverse effects of ROS. Several studies examine the whitening effects of various agents based on their ability to inhibit tyrosinase activity. Tyrosinase is a critical enzyme involved in the synthesis of melanin, which protects the skin against radiation. Various agents exhibiting antioxidant and tyrosinase inhibitory activities have been synthesized. However, these synthetic drugs are associated with toxicity, decreased safety, and poor skin penetration in vivo, which has limited the clinical application of synthetic drugs. This study examined the antioxidant and tyrosinase inhibitory activities of some microalgae. The methanol, dichloromethane, and ethyl acetate extracts of four microalgal species (Tetraselmis tetrathele, Dunaliella tertiolecta, Platymonas sp., and Chaetoceros simplex) were prepared. The physiological and whitening effects of microalgal extracts were investigated by measuring the antioxidant and tyrosinase inhibitory activities. The ethyl acetate extract of D. tertiolecta exhibited the highest antioxidant and tyrosinase inhibitory activities. Future studies must focus on examining the whitening effects of microalgae on cell lines to facilitate the development of microalga-based therapeutics for skin diseases, functional health foods, and whitening agents. Thus, microalgae have potential applications in the pharmaceutical, food, and cosmetic industries.

주제어

표/그림 (5)

그림 Fig. 1. The extraction process using organic solvent.
그림 Fig. 2. Total polyphenol contents of microalgal extracts.
그림 Fig. 3. DPPH radical scavenging activity of macroalgal extracts.
그림 Fig. 4. ABTS radical scavenging activity of macroalgal extracts.
그림 Fig. 5. Tyrosinase inhibition activity of algal extracts.

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