[논문]별아교세포 선택적 유전자 치료전달을 위한 PLGA 나노입자 개발

신효정; 이가영; 권기상; 권오유; 김동운

doi:10.5352/jls.2021.31.9.849

별아교세포 선택적 유전자 치료전달을 위한 PLGA 나노입자 개발
Development of PLGA Nanoparticles for Astrocyte-specific Delivery of Gene Therapy: A Review 원문보기

생명과학회지 = Journal of life science, v.31 no.9, 2021년, pp.849 - 855

신효정 (충남대학교 해부학교실) , 이가영 (충남대학교 해부학교실) , 권기상 (원광보건대학교 임상병리학과) , 권오유 (충남대학교 해부학교실) , 김동운 (충남대학교 해부학교실)

초록
AI-Helper

최근에는 나노기술이 다양한 분야에 도입되고 활용되면서 신약개발이 가속화되고 있다. 나노입자는 약물의 단일 투여로 장기간 동안 혈중 약물 농도를 유지하고, 병리학적 부위에만 선택적으로 방출되는 장점이 있어 비병리 주위에 대한 부작용을 줄일 수 있다. Poly (D,L-lactic-co-glycolic acid) (PLGA)는 가장 광범위하게 개발된 생분해성 고분자 중 하나이다. PLGA는 다양한 응용분야의 약물전달에 널리 사용된다. 또한 FAD에 의해 약물전달 시스템으로 승인되었으며, 유전자 치료제와 같은 제어방출제형에 널리 적용된다. PLGA 나노입자는 수동 및 능동 표적화 방법을 사용하여 특정 세포 유형에 고효율의 전달 시스템으로 개발되었다. 이러한 PLGA 나노입자를 이용한 약물전달체 개발 후 표적 부위에 선택적으로 약물을 전달하고 질병에 따라 장기간 유효 혈중 농도를 최적화한다. 이 리뷰논문에서 우리는 유전자 치료를 위한 PLGA 나노 물질을 기반으로 하는 성상 세포 선택적 나노입자의 개발을 조사하여 세포 특이적으로 치료결과를 향상시키는 방법에 중점을 두고자 한다.

Abstract ▼ AI-Helper

Recently, as nanotechnology has been introduced and used in various fields, the development of new drugs has been accelerating. Nanoparticles have maintained blood drug concentration for extended periods of time with a single administration of the drug. The drug can then be selectively released only at the pathological site, thereby reducing side effects to other non-pathological sites. In addition, nanoparticles can be modified for selective target sites delivery for other specific diseases, with polymers being widely used in the manufacture of these nanoparticles. Poly (D,L-lactic-co-glycolic acid ) (PLGA) is one of the most extensively developed biodegradable polymers. PLGA is widely used in drug delivery for a variety of applications. It has also been approved by the FDA as a drug delivery system and is widely applied in controlled release formulations, such as in gene therapy treatments. PLGA nanoparticles have been developed as delivery systems with high efficiency to specific cell types by using passive and active targeting methods. After the development of a drug delivery system using PLGA nanoparticles, the drug is selectively delivered to the target site, and the effective blood concentration for extended periods of time is optimized according to the disease. In this review paper, we focus on ways to improve cell-specific treatment outcomes by examining the development of astrocyte selective nanoparticles based on PLGA nanomaterials for gene therapy.

주제어

표/그림 (4)

그림 Fig. 1. Chemical structure and hydrolysis of PLGA nanoparticles.
그림 Fig. 2. Schematic diagram of the cellular uptake of PLGA nano-particles by type of cells in brain.
그림 Fig. 3. Schematic representation of PLGA nanoparticles for ac-tive targeting.
표 Table 1. Active targeting of PLGA nanoparticles to astrocytes

AI 본문요약
AI-Helper

성능/효과

Therefore, studies on the stability of these materials are also being conducted at the same time. As described in this review, control of drug delivery, targeting of nanoparticles, and development of cell-specific nanoparticles have developed at a rapid pace, but there are still only a few drugs that can be directly used in clinical practice. Design and targeting strategies for nanoparticles will need to be more diverse and depend on the differences in diseases, degree of development, and location of the lesion.
In this review, possible applications for the use of PLGA-based nanoparticles targeting astrocytes have been described. These examples illustrate the promise of using nanoparticles for novel treatments.

후속연구

The development of nanotechnology has led to remarkable developments in drug delivery and bioimaging, and as a result, diagnosis, treatment, and methods of monitoring the progress of the treatment process have been improved, and customized treatments based to the patient’s diagnosis have now become a possibility. It is not possible to accurately predict how effective medical advances will be in the future by understanding the properties of materials and applying them to medicine in the nanotechnology field; however, it is clear that nanomaterials will play a decisive role in more accurate diagnoses and quality treatments in the near future.

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저자의 다른 논문 :

표제어: PCR

동의어: Packet Collision Rate

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용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

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