[논문]소아 식욕부진에 대한 이공산(異功散) 치료의 효과 : 체계적 문헌고찰 및 메타분석

이보람; 하다정; 허태영; 박상은; 이선행; 장규태

doi:10.22246/jikm.2022.43.4.542

소아 식욕부진에 대한 이공산(異功散) 치료의 효과 : 체계적 문헌고찰 및 메타분석
Effects of Yigong-san for the Treatment of Anorexia in Children: A Systematic Review and Meta-Analysis 원문보기

대한한방내과학회지 = The journal of internal Korean medicine, v.43 no.4, 2022년, pp.542 - 558

이보람 (한국한의학연구원 한의과학연구부) , 하다정 (동의대학교 한의과대학 내과학교실) , 허태영 (동의대학교 한의과대학 내과학교실) , 박상은 (동의대학교 한의과대학 내과학교실) , 이선행 (경희대학교 한의과대학 소아과학교실) , 장규태 (경희대학교 한의과대학 소아과학교실)

Abstract ▼ AI-Helper

Objectives: The purpose of this study was to assess the effect of Yigong-san on anorexia in children by conducting a systematic review and meta-analysis of randomized controlled trials (RCTs). Methods: Eleven electronic databases were searched on May 30, 2022 to collect relevant studies. All studies published up to the search date were considered. RCTs reporting the effect of Yigong-san on the treatment of anorexia in children were included. The primary outcome was an improvement in clinical anorexia symptoms after treatment. In this meta-analysis, continuous and binary outcomes were assessed, and the data were presented as the mean difference and risk ratio with their 95% confidence intervals. The risk of bias was assessed using the Cochrane Collaboration's risk of bias tool. Results: A total of nine studies were included in this systematic review. The treatment group (Yigong-san only or Yigong-san plus conventional treatment) showed a statistically significant effect compared to the control group (conventional treatment only) in total effective rate (Yigong-san only: RR 1.26, 95% CI 1.17, 1.36, I2=0%; Yigong-san plus conventional treatment: RR 1.32, 95% CI 1.18, 1.47, I2=0%), clinical symptoms, some of the anthropometric outcomes, and biological markers related to appetite and growth in children with anorexia. No serious adverse events related to Yigong-san were reported. Conclusions: Yigong-san showed statistically significant effects as a treatment for anorexia in children. However, the number of studies included in the meta-analysis was insufficient, and the herbs contained in the Yigong-san used in the included studies were not standardized. Future research should focus on the implementation of methodologically robust clinical research.

주제어

표/그림 (6)

그림 Fig. 1. PRISMA flow chart of literature selection process.
표 Table 1. Characteristics of Included Studies
표 Table 2. Preparation of Yigong-san
그림 Fig. 2. Graph and summary of risk of bias.
그림 Fig. 3. Meta-analysis results: Yigong-san versus po-med.
그림 Fig. 4. Meta-analysis results: Yigong-san+po-med versus po-med.

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