[논문]합병증을 동반하지 않은 2형 당뇨병 환자에 대한 백호가인삼탕과 혈당강하제 병행치료의 혈당 강하 효과 및 안전성 연구 : 체계적 문헌 고찰과 메타분석

신재익; 백지수; 신선미; 조충식

doi:10.22246/jikm.2021.42.4.672

합병증을 동반하지 않은 2형 당뇨병 환자에 대한 백호가인삼탕과 혈당강하제 병행치료의 혈당 강하 효과 및 안전성 연구 : 체계적 문헌 고찰과 메타분석
A Study on the Hypoglycemic Effect and Safety of Combined-Therapy of Baekhogainsam-tang and Hypoglycemic Agent for Type 2 Diabetes Mellitus Patients without Complications: A Systematic Review and Meta-Analysis 원문보기

대한한방내과학회지 = The journal of internal Korean medicine, v.42 no.4, 2021년, pp.672 - 686

신재익 (대전대학교 한의과대학 신계내과학교실) , 백지수 (대전대학교 한의과대학 신계내과학교실) , 신선미 (세명대학교 한의과대학 신계내과학교실) , 조충식 (대전대학교 한의과대학 신계내과학교실)

Abstract ▼ AI-Helper

Objectives: The purpose of this study is to assess the efficacy and safety of Baekhogainsam-tang for type 2 diabetes without complications by systemic review and meta-analysis of randomized controlled trials (RCTs). Methods: For a systematic review and meta-analysis, we set a key question in accordance with PICOT-SD. We searched the following up to March 31. 2021: PubMed, EMBASE, The Cochrane Library, CNKI, CiNii, KISS, KMBASE, OASIS, and ScienceON. A meta-analysis was conducted by synthesizing the results, including fasting plasma glucose level, postprandial 2-hour plasma glucose level, and Glycated Hemoglobin (HbA1c). Results: A total of five trials are included in this systemic review. The treatment group (Baekhogainsam-tang plus conventional treatment) showed more statistically significant effect than did the control group (conventional treatment only) in fasting plasma glucose level, postprandial 2-hour plasma glucose level, and glycated hemoglobin (HbA1c). Conclusions: Baekhogainsam-tang showed statistically significant effects in hypoglycemic effect and in improving insulin resistance. However, the number of studies included in the meta-analysis was insufficient, and the BIT used in the included studies was not standardized. This topic requires further attention and more clinical research.

주제어

표/그림 (8)

표 Table 1. Search Strategy for the PubMed
그림 Fig. 1. PRISMA flow of selection process.
표 Table 2. Summary of 5 lncluded Studies
표 Table 3. Composition of Baekhogainsam-tang used in 5 lncluded Studies
그림 Fig. 2. Graph and summary of risk of bias.
그림 Fig. 3. Result of meta-analysis for FPG (BIT+Po-med vs Po-med). BIT : Baekhogainsam-tang, FPG : fasting plasma glucose
그림 Fig. 4. Result of meta-analysis for PP2hPG (BIT +Po-med vs Po-med). BIT : Baekhogainsam-tang, PP2hPG : 2 hour postprandial glucose
그림 Fig. 5. Result of Meta-Analysis for HbA1c (BIT +Po-med vs Po-med). BIT : Baekhogainsam-tang, HbA1c : Glycated hemoglobin A1c

참고문헌 (14)

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