[논문]가금 생산에서 천연 항산화제로서 식물성 Flavonoids의적용

서문강민; 장인석

doi:10.5536/kjps.2022.49.4.211

가금 생산에서 천연 항산화제로서 식물성 Flavonoids의적용
Application of Plant Flavonoids as Natural Antioxidants in Poultry Production 원문보기

한국가금학회지 = Korean journal of poultry science, v.49 no.4, 2022년, pp.211 - 220

서문강민 (경상국립대학교 동물생명융합학부) , 장인석 (경상국립대학교 동물생명융합학부)

초록
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최근 닭은 고도화된 육종개량과 함께고밀도사육, 열스트레스, 환경 및 사료 오염 등과 같은내외적스트레스요인에 의해 체 조직에서 과도한 활성산소(ROS) 발생으로 산화적 스트레스가 매우 높다. 산화적 스트레스는 지질과 산화작용으로 DNA 손상, 세포사 등을 유발하여 닭의 건강과 복지에 심각한 문제를 유발한다. 닭은 이러한 내외적 산화적 스트레스에 따라 항산화 효소와 비효소적 항산화 물질에 의해 활성산소를 제거하는 방어 작용을 한다. 최근 영양학적 방법으로서 산화적 스트레스를 억제하는 식물성 flavonoids 사료첨가제 개발에 주목하고 있다. Favonoid를 닭에게 급여 시 소화기관 및 근육에서 지질과산화도 감소, 항산화력 및 항산화 효소 활성도가 증가하는 것으로 항산화제로서 가치가 높다. Flavonoids는 구조화합물이 활성산소와 결합하여 안정화할 수 있는 구조로서 ROS를 소거 또는 항산화 효소의 발현을 통해 ROS를 제거한다. 또한 금속 이온과 결합하 는 킬레이트화 작용, 산화효소 및 NO 생성 억제 등 다양한 항산화 작용이 있다. 그러나 문제점으로 flavonoid 화합물은 용해도가 낮아 소장 흡수세포에서 흡수율이 저하됨으로 이를 극복할 수 있는 체내 운반 기술의 개발이 필요하다. 또한 사료 섭취 시 flavonoid 농도가 가장 높은 곳이 위장관으로 이곳에서 명확한 항산화 효과를 나타내는 용량을 구명하여 첨가 수준을 결정하여야 한다. 항산화 작용기전은 스트레스에 따라 다양한 전사인자들(transcrptional factors)을 통해 스트레스 반응 유전자(vitagenes)의 발현을 유도한다. Flavonoid의 항산화 작용기전으로 Nrf-2와 Nf-kB 등과 같은 전사인사의 발현 과정과 vitagenes을 통해 효율적 항산화 효과를 나타내는 방법에 관한 연구도 중요하다. 닭에서 육종 및 사육 환경 요인에 따라 발생하는 산화 스트레스는 경제성과 더불어 동물복지 측면에서도 심각한 문제를 유발한다. Flavonoid 함유 천연 항산화제 개발과 적용은 가금 산업에서 향후 중요한 분야가 될 것으로 전망된다.

Abstract ▼ AI-Helper

Poultry are exposed to extremely high levels of oxidative stress as a consequence of the excessive production of reactive oxygen species (ROS) induced by endogenous and exogenous stressors, such as high-stocking densities, thermal stress, environmental and feed contamination, along with factors associated with intensive breeding systems. Oxidative stress promotes lipid peroxidation, DNA damage, and inflammation, which can have detrimental effects on the health of birds. During the course of evolution, birds have developed antioxidant defense mechanisms that contribute to maintaining homeostasis when exposed to endogenous and exogenous stressors. The primary antioxidant defense systems are enzymatic and non-enzymatic in nature and play roles in protecting cells from ROS attack. Recently, plant flavonoids, which have been established to reduce oxidative stress, have been attracting considerable attention as potential feed additives. Flavonoids are a group of polyphenolic compounds that can be stabilized by binding structural compounds with ROS, and can promote the elimination of ROS by inducing the expression of antioxidant enzymes. However, although flavonoids can contribute to reducing lipid peroxidation and thereby enhance the antioxidant capacity of birds, they have low solubility in the gastrointestinal tract, and consequently, it is necessary to develop a delivery technology that can facilitate the effect intestinal absorption of these compounds. Furthermore, it is important to determine the dietary levels of flavonoids by assessing the exact antioxidant effects in the gastrointestinal tract wherein the concentrations of dietary flavonoids are highest. It is also necessary to examine the expression of transcriptional factors and vitagenes associated with the efficient antioxidant effects induced by flavonoids. It is anticipated that the application of flavonoids as natural antioxidants will become a particularly important field in the poultry industry.

주제어

표/그림 (4)

표 Table 1. External and internal stress factors in poultry production farms¹
그림 Fig 1. Endogenous and feed originated antioxidants in poultry production.
그림 Fig 2. Antioxidant defense system in response to internal and external stressors in poultry (adapted from Surai et al., 2019). (ROSreactive oxygen species; OSR-oxidative stress response, HSR-heat shock response, UPR-unfolded protein response; HSF1-heat shock factor; Nrf2-transcription factor; NF-κB-transcription factor; HSP70-heat shock protein 70; SOD-superoxide dismutase; GSH-syst.-glutathione system (glutathione/ glutathione reductase/ glutathione peroxidase).
표 Table 2. The classes and subclasses of flavonoids, and plant sources rich in flavonoids¹

AI 본문요약
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문제 정의

닭 사육농가에서도 소비자들의 축산물에 대한 건강 지향적인 요구에 부응하면서 생산성에도 긍정적 영향을 미치는 식물성 항산화제(phytochemicals) 개발과 사용에 관심이 매우 높다. 따라서 본 고찰에서는 닭의 체 조직에서 발생하는 산화적 스트레스와 항산화 방어 기전에 대해 살펴보고 사료첨가제로 사용할 수 있는 식물성 항산화 물질들 중 flavonoid 계열을 중심으로 이들의 항산화 효과를 조사하였다. 본 고찰을 통해 닭 사육 농가에서 이용할 수 있는 식물성 flavonoid 항산화 사료첨가제에 관한 연구 정보를 제공함으로 친환경 닭고기 및 계란의 생산을 촉진하고자 한다.
따라서 본 고찰에서는 닭의 체 조직에서 발생하는 산화적 스트레스와 항산화 방어 기전에 대해 살펴보고 사료첨가제로 사용할 수 있는 식물성 항산화 물질들 중 flavonoid 계열을 중심으로 이들의 항산화 효과를 조사하였다. 본 고찰을 통해 닭 사육 농가에서 이용할 수 있는 식물성 flavonoid 항산화 사료첨가제에 관한 연구 정보를 제공함으로 친환경 닭고기 및 계란의 생산을 촉진하고자 한다.

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저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

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