[논문]자하거 약침의 신경정신과 임상 응용에 관한 체계적 문헌 고찰

신혜규; 이재혁; 강형원

doi:10.7231/jon.2022.33.2.157

자하거 약침의 신경정신과 임상 응용에 관한 체계적 문헌 고찰
A Systematic Review of Placenta Pharmacopuncture for Neuropsychiatric Diseases in Practice 원문보기

동의신경정신과학회지 = Journal of oriental neuropsychiatry, v.33 no.2, 2022년, pp.157 - 180

신혜규 (세명대학교 충주한방병원 한방신경정신과) , 이재혁 (세명대학교 충주한방병원 한방신경정신과) , 강형원 (원광대학교 한의과대학 한방신경정신과학교실)

Abstract ▼ AI-Helper

Objectives: To perform a systematic review of placenta pharmacopuncture for treating neuropsychiatric diseases, focusing on its efficacy and the safety so that evidence on its clinical use could be obtained, thus contributing to further studies. Methods: Through Korean, English, and Chinese databases (OASIS, Korean TK, KISS, RISS, ScienceON, Pubmed, Cochrane, EMBASE, CINAHL, AMED, CNKI, and Wanfang), combinations of keywords (placenta, pharmacopuncture, etc.) were used to select clinical studies published until January 2021 about placenta pharmacopuncture for neuropsychiatric diseases. Interventions included combined treatments. Study design included cases studies, series, and clinical trials. Cohort studies, literature reviews, in vitro and animal experiments were excluded. The primary outcomes involved measurements of symptoms, Visual Analogue Scale, or questionnaires. Data extracted from databases were imported to Endnote X7 to remove duplicates. The quality of the literature was assessed based on CAse REports Guidelines and Cochrane's Risk of Bias (ROB). Results: Twenty-one studies were selected, including ten case reports, three case series, two one-armed clinical trials, one non-randomized clinical trial, and five randomized clinical trials. There were six studies on sleep disorders, five studies on stroke sequela, two on mood disorders, two on enuresis, two on Guillain-Barré syndrome, two on multiple sclerosis, one on neurocognitive disorder, and one on vertigo. The most frequent combined treatment was acupuncture in both the experimental group (n=10) and the control group (n=3). Acupoints were ST36, SP6, BL23, CV4, GB20, GV20, N-HN54, and so on. All studies reported improvement of symptoms. The quality of case studies was relatively high. Assessment of ROBs resulted in low risks. Conclusions: Placenta pharmacopuncture is effective for neuropsychiatric diseases such as sleep disorders, mood disorders, enuresis, and neurocognitive disorders. Regarding insomnia, several studies have reported significant improvements with placenta pharmacopuncture. There was no adverse event associated with placenta pharmacopuncture.

주제어

표/그림 (14)

표 Table 1. Categorization of "Not NP" Diseases
그림 Fig. 1. Flowchart of study selection process. HPP: Hominis Placenta Pharmacopuncture, NP: Neuropsychiatric diseases.
표 Table 2. The Characteristics and Inclusion/Exclusion Criteria of the Selected Studies
표 Table 2. Continued 1
표 Table 2. Continued 2
표 Table 3. The Characteristics of Intervention in the Selected Studies
표 Table 3. Continued 1
표 Table 4. The Characteristics of Outcomes in the Selected Studies
표 Table 4. Continued 1
표 Table 5. Percentage of Items Reported according to CARE Guidelines
표 Table 6. Percentage of Case Reports with Reported Items of CARE Guidelines by Each Item
그림 Fig. 2. Risk of bias graph.
그림 Fig. 3. Risk of bias summary.
표 Table 7. Methodological Items for Non-Randomized Studies (MINORS)

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