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[국내논문] 허혈성 뇌졸중 모델에서 혈액-뇌 장벽에 보호효과를 나타내는 한약처방, 한약재 및 활성화합물
Protective Effects of Traditional Korean Medicine Preparations, Herbs, and Active Compounds on the Blood-brain Barrier in Ischemic Stroke Models 원문보기

생명과학회지 = Journal of life science, v.32 no.7, 2022년, pp.550 - 566  

신수빈 (부산대학교 한의학전문대학원 한의학과) ,  장석주 (부산대학교 한의학전문대학원 한의학과) ,  이나경 (부산대학교 한의학전문대학원 한의학과) ,  최병태 (부산대학교 한의학전문대학원 한의학과) ,  신화경 (부산대학교 한의학전문대학원 한의학과)

초록
AI-Helper 아이콘AI-Helper

뇌졸중은 세계적으로 사망과 장기간인 신체적, 인지적 장애의 주요 원인들 중 하나이며, 매년 약 1,500만명의 사람들에게 영향을 미친다. 뇌졸중의 병태 생리학적 과정은 다수의 사건들이 관여하는 복잡한 과정으로, 그 중 혈액-뇌 장벽(blood-brain barrier: BBB)의 붕괴는 허혈성 뇌손상의 진행에 크게 기여하는 것으로 알려져 있다. 따라서 BBB 붕괴는 뇌졸중의 특징으로 인식되므로 허혈성 뇌졸중에서 BBB 기능 장애를 보호할 수 있는 새로운 치료 전략을 개발하는 것이 뇌졸중 치료에 매우 중요하다. 전통한약은 천연물로 구성되어 있으며, 이는 뇌졸중 치료약 개발을 위한 유망한 원천이 될 수 있다. 실제로 여러 연구에서 뇌졸중에 대한 한의학의 효능이 밝혀져 허혈성 뇌졸중에 대한 한의학적 치료 가치가 부각되고 있다. 본 리뷰에서는 허혈성 뇌졸중으로 인한 BBB 붕괴에 대한 전통적인 한의학의 처방, 탕약, 약재 및 활성 성분의 개선효과에 관한 현재 정보와 기본 메커니즘을 요약 정리하였다. 이러한 연구가 한의학의 신경보호 효과에 대한 추가 조사를 촉진하고 뇌졸중 환자에 대한 한방유래의 임상시험 시행을 활성화하는데 도움이 되기를 기대한다.

Abstract ▼ AI-Helper 아이콘AI-Helper

Stroke is among the leading causes of death and long-term physical and cognitive disabilities worldwide, affecting an estimated 15 million people annually. The pathophysiological process of stroke is complicated by multiple and coordinated events. The breakdown of the blood-brain barrier (BBB) in pe...

주제어

#Blood-brain barrier   #matrix metalloproteinase   #stroke   #tight junction protein   #traditional Korean medicine  

표/그림 (9)

AI 본문요약
AI-Helper 아이콘 AI-Helper

제안 방법

  • Traditional Korean medicine has been recorded in the treatment of neurovascular disorders. This review has presented several traditional Korean medicines, including the herbal formula, decoction, herbs, and active components, which exert a neuroprotective effect on cerebral ischemia-induced BBB disruption. These traditional medicines were shown to have protective effects on the BBB in many cellular ischemia models such as OGD and hypoxia, various animal ischemia models of stroke such as MCAO and photothrombosis, and experiments in various animal species such as mice and rats.
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