[논문]GHS 유해성을 기반으로 한 유독물질 지정체계 개선방안 연구

김효동; 박교식

doi:10.15269/jksoeh.2022.32.3.209

[국내논문] GHS 유해성을 기반으로 한 유독물질 지정체계 개선방안 연구
A Study on the Improvement Plan of Toxic Substance Designation Criterion Based on GHS Hazards 원문보기

한국산업보건학회지 = Journal of Korean Society of Occupational and Environmental Hygiene, v.32 no.3, 2022년, pp.209 - 220

김효동 (숭실대학교 안전.보건융합공학과) , 박교식 (숭실대학교 안전.보건융합공학과)

Abstract ▼ AI-Helper

Objectives: This study was performed to suggest how to re-establish criterion for toxic substances under the Chemical Control Act (CCA) in South Korea by comparing the GHS (Globally Harmonized System of Classification and Labeling of Chemicals) score and toxic properties. Methods: Toxic substances were classified into seven groups (Acute toxicity (1A), Chronic toxicity (2C), Environmental hazards (3E), Acute toxicity & chronic toxicity (4AC), Chronic toxicity & environmental hazards (5CE), Acute toxicity & environmental hazards (6AE), and Acute toxicity & chronic toxicity & environmental hazards (7ACE)) according to their toxic properties. The GHS score was calculated to sum up five toxicity indicators (health acute toxicity, health repeated toxicity, carcinogenicity, health other chronic toxicity and environmental hazards). Results: The GHS score of 7ACE was higher by 7 times that of 1A. 1A is the only group which has lower than the total GHS score. The highest score was 47, for sodium chromate (CAS no. 7775-11-3), which belongs to group 7ACE. This is classified as acute toxicity, carcinogenicity, germ cell mutagenicity, reproductive toxicity, and acute and chronic environmental hazard. On the other hand, the lowest score was 2.75, which was assigned to 177 chemicals belonging to group 1A. When the health acute toxicity indicator was omitted from the toxic criterion, toxic substances could be divided into the sub-groups 'human chronic hazards group' (HCG) and 'environmental hazards group' (EG) according to their GHS score and properties. Conclusions: The proposed criterion for toxic substances is to establish sub-groups defined as HCG and EG for separate control and that the 1A group be moved to substances requiring preparation for accidents under the CCA.

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표/그림 (10)

표 Table 1. Group, toxicity indicator and scoring by GHS classification category
표 Table 2. Correlation coefficient(Pearson's r) of toxicity indicators
그림 Figure 1. Number of toxic substances in the seven groups
표 Table 3. Toxic substances not corresponding to the designated criterion
표 Table 4. Normalized and normalized modified total GHS score of Chromic anhydride
표 Table 5. H code, pictogram and total GHS score of the top five ranked toxic substances
표 Table 5. Continued
표 Table 6. Correlation coefficients(Pearson's r) among each of the seven groups
그림 Figure 2. Total and modified total GHS score (Y-axis is mean score and error bar is the 95% confidence interval.)
표 Table 7. Total and modified total GHS score by the seven groups

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상세보기
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