[논문]한약을 이용한 성조숙증에 대한 비임상 연구 보고 고찰

손효은; 김영식; 김용빈; 나선태; 김홍준

doi:10.14374/hfs.2023.31.4.373

한약을 이용한 성조숙증에 대한 비임상 연구 보고 고찰
Review of non-clinical experimental studies on precocious puberty using herbal medicine 원문보기

大韓韓醫學方劑學會誌 = Herbal formula science, v.31 no.4, 2023년, pp.373 - 388

손효은 (우석대학교 한의과대학 본초학교실) , 김영식 (우석대학교 한의과대학 본초학교실) , 김용빈 (우석대학교 한의과대학 본초학교실) , 나선태 (우석대학교 한의과대학 방제학교실) , 김홍준 (우석대학교 한의과대학 방제학교실)

Abstract ▼ AI-Helper

Objectives : This study aimed to provide basic data for research by investigating non-clinical experimental studies on herbal medicines and its compounds for precocious puberty. Methods : A search was conducted for all literature until October 2023 using combinations of keywords such as precocious puberty, puberty, and chinese medicine in three databases (Pubmed, OASIS, and ScienceON). Results : 1. In animal experiments, studies were mainly conducted using a model that induced precocious puberty by subcutaneously administering danazol to SD rats on the 5th day after birth, and in cell experiments, precocious puberty was induced by treating GT1-7 cells with kisspeptin 10 or estradiol. 2. Anemarrhenae Rhizoma, Phellodendri Cortex, and Prunellae Spica were mainly used as herbal medicine to evaluate their efficacy on precocious puberty in non-clinical experiments. 3. Macroscopic observation, hematological analysis, histological analysis, and genetic analysis were performed as methods to analyze the experimental results. Conclusions : In this study, the effects of herbal medicine on precocious puberty and non-clinical research methods were confirmed. Based on the results of this study, it is expected that non-clinical effectiveness and mechanism research on materials that are clinically effective in Traditional Korean Medicine will be revitalized.

주제어

표/그림 (13)

그림 Figure 1. Flow chart of study selection process
그림 Figure 2. Number of publications per year of research
표 Table 1. Classification of Academic Journals
그림 Figure 3. Number of publications per country of research
표 Table 2. Summary of animal model in studies *F; Female, NMA; N-methyl-DL-aspartic acid, SD; Spargue-Dawley
표 Table 3. Summary of cell line in studies
표 Table 4. Summary of Intervention in study
표 Table 5. Frequency of Herbal Materials for precocious puberty
그림 Figure 4. Number of overall analysis method of animal model research *M; Macroscopy, He; Hematological analysis, Hi; Histological analysis, G; Genetic analysis
표 Table 6. Summary of Animal Experiment
그림 Figure 5. Percentage of Animal Experiment Method * VO; Vaginal opening, BW; Body weight, OW; Ovarian weight, UW; Uterus weight, BI; Body length, PW; Pituitary weight, HW; Hypothalamus weight, E2, Estrogen, LH; Luteinizing hormone, FSH; Follicle-stimulating hormone, ALP; Alkaline phosphatase, EC; Estrous cycle, H&E; Hematoxylin & Eosin staining, IHC; Immunohistochemistry, BMD; Bone densitometry, WB; Western blot
그림 Figure 6. Percentage of Cell line Experiment Method *CCK-8; cell counting kit-8, ELISA; Enzyme-linked immunosorbent assay, qPCR; quantitative polymerase chain reaction
표 Table 7. Summary of cell Experiment

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