$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Recent Progress in Immunotherapy for Gastric Cancer 원문보기

Journal of gastric cancer : jgc, v.23 no.1, 2023년, pp.207 - 223  

Jeesun Yoon (Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine) ,  Tae-Yong Kim (Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine) ,  Do-Youn Oh (Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine)

Abstract AI-Helper 아이콘AI-Helper

Gastric cancer (GC) is the fourth leading cause of cancer-related deaths worldwide. Under the standard of care, patients with advanced GC (AGC) have a median survival time of approximately 12-15 months. With the emergence of immunotherapy as a key therapeutic strategy in medical oncology, relevant c...

주제어

참고문헌 (64)

  1. 1 Sung H Ferlay J Siegel RL Laversanne M Soerjomataram I Jemal A Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries CA Cancer J Clin 2021 71 209 249 33538338 

  2. 2 Park SH Kang MJ Yun EH Jung KW Epidemiology of gastric cancer in Korea: trends in incidence and survival based on Korea Central Cancer Registry data (1999-2019) J Gastric Cancer 2022 22 160 168 35938363 

  3. 3 Cunningham D Starling N Rao S Iveson T Nicolson M Coxon F Capecitabine and oxaliplatin for advanced esophagogastric cancer N Engl J Med 2008 358 36 46 18172173 

  4. 4 Bang YJ Van Cutsem E Feyereislova A Chung HC Shen L Sawaki A Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial Lancet 2010 376 687 697 20728210 

  5. 5 Mellman I Coukos G Dranoff G Cancer immunotherapy comes of age Nature 2011 480 480 489 22193102 

  6. 6 Pardoll DM The blockade of immune checkpoints in cancer immunotherapy Nat Rev Cancer 2012 12 252 264 22437870 

  7. 7 Lawrence MS Stojanov P Polak P Kryukov GV Cibulskis K Sivachenko A Mutational heterogeneity in cancer and the search for new cancer-associated genes Nature 2013 499 214 218 23770567 

  8. 8 Kono K Nakajima S Mimura K Current status of immune checkpoint inhibitors for gastric cancer Gastric Cancer 2020 23 565 578 32468420 

  9. 9 Cancer Genome Atlas Research Network Comprehensive molecular characterization of gastric adenocarcinoma Nature 2014 513 202 209 25079317 

  10. 10 Massarelli E Papadimitrakopoulou V Welsh J Tang C Tsao AS Immunotherapy in lung cancer Transl Lung Cancer Res 2014 3 53 63 25806281 

  11. 11 Ralli M Botticelli A Visconti IC Angeletti D Fiore M Marchetti P Immunotherapy in the treatment of metastatic melanoma: current knowledge and future directions J Immunol Res 2020 2020 9235638 32671117 

  12. 12 Takei S Kawazoe A Shitara K The new era of immunotherapy in gastric cancer Cancers (Basel) 2022 14 1054 35205802 

  13. 13 Kang YK Boku N Satoh T Ryu MH Chao Y Kato K Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2): a randomised, double-blind, placebo-controlled, phase 3 trial Lancet 2017 390 2461 2471 28993052 

  14. 14 Fuchs CS Doi T Jang RW Muro K Satoh T Machado M Safety and efficacy of pembrolizumab monotherapy in patients with previously treated advanced gastric and gastroesophageal junction cancer: phase 2 clinical KEYNOTE-059 Trial JAMA Oncol 2018 4 e180013 29543932 

  15. 15 Janjigian YY Shitara K Moehler M Garrido M Salman P Shen L First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): a randomised, open-label, phase 3 trial Lancet 2021 398 27 40 34102137 

  16. 16 Shitara K Ajani JA Moehler M Garrido M Gallardo C Shen L Nivolumab plus chemotherapy or ipilimumab in gastro-oesophageal cancer Nature 2022 603 942 948 35322232 

  17. 17 Hindson J KEYNOTE-811: pembrolizumab in advanced HER2 + gastric cancer Nat Rev Gastroenterol Hepatol 2022 19 79 

  18. 18 Janjigian YY Kawazoe A Yañez P Li N Lonardi S Kolesnik O The KEYNOTE-811 trial of dual PD-1 and HER2 blockade in HER2-positive gastric cancer Nature 2021 600 727 730 34912120 

  19. 19 Vafaei S Zekiy AO Khanamir RA Zaman BA Ghayourvahdat A Azimizonuzi H Combination therapy with immune checkpoint inhibitors (ICIs); a new frontier Cancer Cell Int 2022 22 2 34980128 

  20. 20 Lwin Z Gomez-Roca C Saada-Bouzid E Yanez E Muñoz FL Im SA LEAP-005: phase II study of lenvatinib (len) plus pembrolizumab (pembro) in patients (pts) with previously treated advanced solid tumours Ann Oncol 2020 31 S1170 S1170 

  21. 21 Pavlakis N Shitara K Sjoquist K Martin AJ Jaworski A Yip S INTEGRATE IIb: a randomised phase III open label study of regorafenib plus nivolumab vs standard chemotherapy in refractory advanced gastro-oesophageal cancer (AGOC) Ann Oncol 2021 32 S1074 S1074 

  22. 22 Bang YJ Van Cutsem E Fuchs CS Ohtsu A Tabernero J Ilson DH KEYNOTE-585: phase III study of perioperative chemotherapy with or without pembrolizumab for gastric cancer Future Oncol 2019 15 943 952 30777447 

  23. 23 Smyth E Knödler M Giraut A Mauer M Nilsson M Van Grieken N VESTIGE: adjuvant immunotherapy in patients with resected esophageal, gastroesophageal junction and gastric cancer following preoperative chemotherapy with high risk for recurrence (N+ and/or R1): an open label randomized controlled phase-2-study Front Oncol 2020 9 1320 32083013 

  24. 24 Chao J Fuchs CS Shitara K Tabernero J Muro K Van Cutsem E Assessment of pembrolizumab therapy for the treatment of microsatellite instability-high gastric or gastroesophageal junction cancer among patients in the KEYNOTE-059, KEYNOTE-061, and KEYNOTE-062 clinical trials JAMA Oncol 2021 7 895 902 33792646 

  25. 25 Pietrantonio F Randon G Di Bartolomeo M Luciani A Chao J Smyth EC Predictive role of microsatellite instability for PD-1 blockade in patients with advanced gastric cancer: a meta-analysis of randomized clinical trials ESMO Open 2021 6 100036 33460964 

  26. 26 Puliga E Corso S Pietrantonio F Giordano S Microsatellite instability in Gastric Cancer: between lights and shadows Cancer Treat Rev 2021 95 102175 33721595 

  27. 27 Shitara K Özgüroğlu M Bang YJ Di Bartolomeo M Mandalà M Ryu MH Pembrolizumab versus paclitaxel for previously treated, advanced gastric or gastro-oesophageal junction cancer (KEYNOTE-061): a randomised, open-label, controlled, phase 3 trial Lancet 2018 392 123 133 29880231 

  28. 28 Bang YJ Ruiz EY Van Cutsem E Lee KW Wyrwicz L Schenker M Phase III, randomised trial of avelumab versus physician’s choice of chemotherapy as third-line treatment of patients with advanced gastric or gastro-oesophageal junction cancer: primary analysis of JAVELIN Gastric 300 Ann Oncol 2018 29 2052 2060 30052729 

  29. 29 Shitara K Van Cutsem E Bang YJ Fuchs C Wyrwicz L Lee KW Efficacy and safety of pembrolizumab or pembrolizumab plus chemotherapy vs chemotherapy alone for patients with first-line, advanced gastric cancer: the KEYNOTE-062 phase 3 randomized clinical trial JAMA Oncol 2020 6 1571 1580 32880601 

  30. 30 Kang YK Chen LT Ryu MH Oh DY Oh SC Chung HC Nivolumab plus chemotherapy versus placebo plus chemotherapy in patients with HER2-negative, untreated, unresectable advanced or recurrent gastric or gastro-oesophageal junction cancer (ATTRACTION-4): a randomised, multicentre, double-blind, placebo-controlled, phase 3 trial Lancet Oncol 2022 23 234 247 35030335 

  31. 31 Xu R Arkenau T Bang Y Denlinger C Kato K Tabernero J RATIONALE 305: tislelizumab plus chemotherapy versus placebo plus chemotherapy as first-line therapy in patients with gastric or gastroesophageal junction adenocarcinoma Ann Oncol 2020 31 S97 S98 

  32. 32 Tabernero J Bang YJ Van Cutsem E Fuchs CS Janjigian YY Bhagia P KEYNOTE-859: a Phase III study of pembrolizumab plus chemotherapy in gastric/gastroesophageal junction adenocarcinoma Future Oncol 2021 17 2847 2855 33975465 

  33. 33 Catenacci DV Rosales M Chung HC H Yoon H Shen L Moehler M MAHOGANY: margetuximab combination in HER2+ unresectable/metastatic gastric/gastroesophageal junction adenocarcinoma Future Oncol 2021 17 1155 1164 33263418 

  34. 34 Tabernero J Shen L Elimova E Ku G Liu T Shitara K HERIZON-GEA-01: zanidatamab + chemo ± tislelizumab for 1L treatment of HER2-positive gastroesophageal adenocarcinoma Future Oncol 2022 18 3255 3266 36000541 

  35. 35 Catenacci DVT Kang YK Yoon HH Shim BY Kim ST Oh DY Margetuximab with retifanlimab as first-line therapy in HER2+/PD-L1+ unresectable or metastatic gastroesophageal adenocarcinoma: MAHOGANY cohort A ESMO Open 2022 7 100563 36029651 

  36. 36 Bang YJ Cho JY Kim YH Kim JW Di Bartolomeo M Ajani JA Efficacy of sequential ipilimumab monotherapy versus best supportive care for unresectable locally advanced/metastatic gastric or gastroesophageal junction cancer Clin Cancer Res 2017 23 5671 5678 28655793 

  37. 37 Moehler M Dvorkin M Boku N Özgüroğlu M Ryu MH Muntean AS Phase III trial of avelumab maintenance after first-line induction chemotherapy versus continuation of chemotherapy in patients with gastric cancers: results from JAVELIN Gastric 100 J Clin Oncol 2021 39 966 977 33197226 

  38. 38 Cohen DJ Tabernero J Van Cutsem E Janjigian YY Bang YJ Qin S A randomized phase 3 study evaluating the efficacy and safety of first-line pembrolizumab plus lenvatinib plus chemotherapy versus chemotherapy in patients with advanced/metastatic gastroesophageal adenocarcinoma: LEAP-015 J Clin Oncol 2022 40 TPS369 

  39. 39 Terashima M Kim YW Yeh TS Chung HC Chen JS Boku N ATTRACTION-05 (ONO-4538-38/BMS CA209844): a randomized, multicenter, double-blind, placebo- controlled phase 3 study of nivolumab (nivo) in combination with adjuvant chemotherapy in pStage III gastric and esophagogastric junction (G/EGJ) cancer Ann Oncol 2017 28 v266 v267 

  40. 40 Janjigian YY Van Cutsem E Muro K Wainberg Z Al-Batran SE Hyung WJ MATTERHORN: phase III study of durvalumab plus FLOT chemotherapy in resectable gastric/gastroesophageal junction cancer Future Oncol 2022 18 2465 2473 

  41. 41 Ono Pharmaceutical Co. Ltd A study to evaluate the efficacy and safety of ONO-4538 in combination with ipilimumab and chemotherapy in chemotherapy-naïve participants with HER2-negative unresectable advanced or recurrent gastric cancer (including esophagogastric junction cancer) [Internet] Bethesda (MD) US National Library of Medicine 2022 cited 2022 Sep 13 Available from: https://clinicaltrials.gov/ct2/show/NCT05144854 

  42. 42 Chen LT Satoh T Ryu MH Chao Y Kato K Chung HC A phase 3 study of nivolumab in previously treated advanced gastric or gastroesophageal junction cancer (ATTRACTION-2): 2-year update data Gastric Cancer 2020 23 510 519 31863227 

  43. 43 Boku N Satoh T Ryu MH Chao Y Kato K Chung HC Nivolumab in previously treated advanced gastric cancer (ATTRACTION-2): 3-year update and outcome of treatment beyond progression with nivolumab Gastric Cancer 2021 24 946 958 33743112 

  44. 44 Varayathu H Sarathy V Thomas BE Mufti SS Naik R Combination strategies to augment immune check point inhibitors efficacy - implications for translational research Front Oncol 2021 11 559161 34123767 

  45. 45 Salas-Benito D Pérez-Gracia JL Ponz-Sarvisé M Rodriguez-Ruiz ME Martínez-Forero I Castañón E Paradigms on immunotherapy combinations with chemotherapy Cancer Discov 2021 11 1353 1367 33712487 

  46. 46 Heinhuis KM Ros W Kok M Steeghs N Beijnen JH Schellens JH Enhancing antitumor response by combining immune checkpoint inhibitors with chemotherapy in solid tumors Ann Oncol 2019 30 219 235 30608567 

  47. 47 Kim R An M Lee H Mehta A Heo YJ Kim KM Early tumor-immune microenvironmental remodeling and response to first-line fluoropyrimidine and platinum chemotherapy in advanced gastric cancer Cancer Discov 2022 12 984 1001 34933901 

  48. 48 BeiGene BeiGene announces positive findings from phase 3 trial of tislelizumab in combination with chemotherapy in first-line gastric or gastroesophageal junction cancer [Internet] Beijing BeiGene 2022 cited 2022 Jan 24 Available from: https://ir.beigene.com/news/beigene-announces-positive-findings-from-phase-3-trial-of-tislelizumab-in-combination-with-chemotherapy-in/b8b9f75d-c374-4593-95c0-ed8bd3e649cb/ 

  49. 49 Maadi H Soheilifar MH Choi WS Moshtaghian A Wang Z Trastuzumab mechanism of action; 20 years of research to unravel a dilemma Cancers (Basel) 2021 13 3540 34298754 

  50. 50 Murciano-Goroff YR Warner AB Wolchok JD The future of cancer immunotherapy: microenvironment-targeting combinations Cell Res 2020 30 507 519 32467593 

  51. 51 Janjigian YY Bendell J Calvo E Kim JW Ascierto PA Sharma P CheckMate-032 study: efficacy and safety of nivolumab and nivolumab plus ipilimumab in patients with metastatic esophagogastric cancer J Clin Oncol 2018 36 2836 2844 30110194 

  52. 52 Hanahan D Hallmarks of cancer: new dimensions Cancer Discov 2022 12 31 46 35022204 

  53. 53 Fukuoka S Hara H Takahashi N Kojima T Kawazoe A Asayama M Regorafenib plus nivolumab in patients with advanced gastric or colorectal cancer: an open-label, dose-escalation, and dose-expansion phase Ib trial (REGONIVO, EPOC1603) J Clin Oncol 2020 38 2053 2061 32343640 

  54. 54 Kole C Charalampakis N Tsakatikas S Kouris NI Papaxoinis G Karamouzis MV Immunotherapy for gastric cancer: a 2021 update Immunotherapy 2022 14 41 64 34784774 

  55. 55 Maio M Ascierto PA Manzyuk L Motola-Kuba D Penel N Cassier PA Pembrolizumab in microsatellite instability high or mismatch repair deficient cancers: updated analysis from the phase II KEYNOTE-158 study Ann Oncol 2022 33 929 938 35680043 

  56. 56 Lima Á Sousa H Medeiros R Nobre A Machado M PD-L1 expression in EBV associated gastric cancer: a systematic review and meta-analysis Discov Oncol 2022 13 19 35318527 

  57. 57 Xie T Liu Y Zhang Z Zhang X Gong J Qi C Positive status of Epstein-Barr virus as a biomarker for gastric cancer immunotherapy: a prospective observational study J Immunother 2020 43 139 144 32134806 

  58. 58 Bai Y Xie T Wang Z Tong S Zhao X Zhao F Efficacy and predictive biomarkers of immunotherapy in Epstein-Barr virus-associated gastric cancer J Immunother Cancer 2022 10 e004080 35241494 

  59. 59 Schoemig-Markiefka B Eschbach J Scheel AH Pamuk A Rueschoff J Zander T Optimized PD-L1 scoring of gastric cancer Gastric Cancer 2021 24 1115 1122 33954872 

  60. 60 Xie T Zhang Z Zhang X Qi C Shen L Peng Z Appropriate PD-L1 cutoff value for gastric cancer immunotherapy: a systematic review and meta-analysis Front Oncol 2021 11 646355 34540656 

  61. 61 Zhao JJ Yap DW Chan YH Tan BK Teo CB Syn NL Low programmed death-ligand 1-expressing subgroup outcomes of first-line immune checkpoint inhibitors in gastric or esophageal adenocarcinoma J Clin Oncol 2022 40 392 402 34860570 

  62. 62 Samstein RM Lee CH Shoushtari AN Hellmann MD Shen R Janjigian YY Tumor mutational load predicts survival after immunotherapy across multiple cancer types Nat Genet 2019 51 202 206 30643254 

  63. 63 Lee KW Van Cutsem E Bang YJ Fuchs CS Kudaba I Garrido M Association of tumor mutational burden with efficacy of pembrolizumab±chemotherapy as first-line therapy for gastric cancer in the phase III KEYNOTE-062 study Clin Cancer Res 2022 28 3489 3498 35657979 

  64. 64 Foote MB Maron SB Cercek A Argilés G Rousseau B Diaz LA Jr TMB cut-offs fail to predict benefit of PD-1 blockade in gastroesophageal adenocarcinoma in KEYNOTE-061 Ann Oncol 2021 32 1188 1189 34139271 

관련 콘텐츠

오픈액세스(OA) 유형

GOLD

오픈액세스 학술지에 출판된 논문

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로