[논문]혈전 측정용 3D printed chip 설계 및 흡연의 영향 사전 연구

김해빈; 염은섭

doi:10.5407/jksv.2023.21.1.074

[국내논문] 혈전 측정용 3D printed chip 설계 및 흡연의 영향 사전 연구
Design of 3D printed chip for thrombus measurement and feasibility study for smoking effect 원문보기

한국가시화정보학회지= Journal of the Korean society of visualization, v.21 no.1, 2023년, pp.74 - 79

김해빈 (School of Mechanical Engineering, PNU) , 염은섭 (School of Mechanical Engineering, Pusan National University (PNU))

Abstract ▼ AI-Helper

Thrombogenesis, which is the process of blood clot formation, can be initiated by platelet activation. Excessive formation of blood clot in the bloodstream can lead to thrombosis. Therefore, when dealing with patients with disseminated intravascular coagulation (DIC) or children, it is necessary to use small amounts of blood. Hence, it is important to develop methods for the rapid and accurate measurement of the platelet function using a small amount of blood. In this study, 3D printing technology was utilized to facilitate the production of micro channels. The amount of platelet adhesion in smokers and non-smokers was compared by repeatedly exposing the structure of the channel to adjust the number of blood injections and facilitate thrombosis attachment to simple stenosis structures.

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표/그림 (6)

그림 Fig 1. Schematic diagram of the experimental setup. The 1mL syringe is installed with syringe pump and it is connected the chip. The chip used in the experiment contained a circular column with a diameter of 0.1 mm. (W: channel width, h: channel height, L_s: stenosis length, hs: stenosis height, d_p: pillar diameter, h_p: pillar height)
그림 Fig 2. Streamlines for velocity in chips with different circular obstacles. The diameter of obstacles is 0.05, 0.1 and 0.15 mm.
그림 Fig. 3. Contours for strain rate in chips with different circular obstacles. The diameter of obstacles is 0.05, 0.1 and 0.15 mm.
그림 Fig. 4. Relation between the circle size and shear rate of stenosis in the chip. Strain rate value extracted from the A-A' line in Fig. 3.
그림 Fig. 5. Representative images of platelet adhesion using blood samples of smokers and non-smokers according to the number of injections.
표 Table 1. Adhered areas of platelets for smokers and nonsmokers according to the number of injections.

참고문헌 (6)

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Mhairi J. Maxwell, Erik Westein, Warwick S.？Nesbitt, Simon Giuliano, Sacha M. Dopheide,？Shaun P. Jackson, "Identification of a 2-stage？platelet aggregation process mediating shear-dependent thrombus formation", Blood 109 (2)？(566~576), 2007

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Suhwan Lee, Hyeonji Hong, Eunseop Yeom,？Jae Min Song, "Measurement of RBC (red？blood cell) deformability using 3D Printed Chip？combined with Smartphone", Journal of the？Korean Society of Visualization, Vol. 18, No. 3？(103-108), 2020
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