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비타민 B 결핍에 의한 노인성 근감소증
Elderly Sarcopenia and Vitamin B Deficiency: A Relationship? 원문보기

생명과학회지 = Journal of life science, v.33 no.7, 2023년, pp.574 - 585  

권기상 (원광보건대학교 임상병리과) ,  장혜정 (부산대학교 의과대학 미생물학 및 면역학 교실) ,  유선녕 (부산대학교 의과대학 미생물학 및 면역학 교실) ,  안순철 (부산대학교 의과대학 미생물학 및 면역학 교실) ,  권오유 (충남대학교 의과대학 해부학 교실)

초록
AI-Helper 아이콘AI-Helper

노인들에서 근감소증은 의료-간호비용 증가의 주요 원인 중 하나가 되고 있다. 한국에서는 근감소증 예방 대책이 일반적으로 특정 질병이 없는 노인들을 대상으로 하지만, 요양원-요양병원에서 집단 거주하는 노인들의 근감소증 대책도 필요하다. 근감소증은 운동량 감소, 단백질 및 영양분(미네랄, 비타민 포함) 섭취 감소, 테스토스테론성장호르몬 변화, 염증 등의 원인으로 발생한다. 분자 생물학적인 정확한 병태생리 기전의 이해가 요구된다. 근감소증은 골다공증, 낙상으로 인한 골절, 치매, 당뇨병, 심혈관 질환 등의 증상을 연결될 수 있다. 비타민 B 패밀리(B1-3, B5-7, B9 및 B12) 결핍을 근감소증 유발의 연구 대상으로 선택한 이유는 다음과 같다. 이는 비타민 B가 에너지 및 단백질 대사에 직접 관여하여 정상적인 신경 기능 유지에 필수적이다. 비타민 B 결핍은 신경-근육 질환, 신경성 질환으로 나타날 수 있으며, 노인성 근감소증과 병행하는 경우가 많다. 노인들은 적정치 이하의 비타민 B 패밀리 섭취, 흡수 장애 및 무식증 문제 등을 겪을 가능성이 높다. 초고령화 사회에서 elderly가 자립적으로 일상생활을 할 수 있는 'health lifetime'을 유지하는 것은 개인의 행복추구와 사회경제적 부담을 줄일수 있는 최고의 목표이다. 본 연구는 근감소증과 관련하여 노인들의 근육량 감소 및 근육 기능 저하를 조절하는 수용성 비타민 B 패밀리의 최신 정보를 제공한다. 또한, 비타민 B 패밀리를 통한 마이오카인에 의한 근감소증의 조절 가능성도 소개한다.

Abstract AI-Helper 아이콘AI-Helper

Sarcopenia is a leading cause of increased medical and nursing care costs among the elderly. In Korea, preventive measures for sarcopenia are mostly targeted toward the general elderly population without specific diseases. However, it is also necessary to implement measures for elderly individuals l...

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AI 본문요약
AI-Helper 아이콘 AI-Helper

제안 방법

  • In the era of super old age, the study of sarcopenia is crucial for promoting healthy living among the elderly and mitigating the escalating social and economic expenses. This review aims to examine the role of sarcopenia and explore how deficiencies in the vitamin B family can interact and have additive effects. The review further highlights the importance of maintaining optimal vitamin B levels to impede the deterioration of muscle mass and function that occurs with age, as well as the role of vitamin B in supporting normal skeletal muscle physiological and metabolic processes in older adults.
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참고문헌 (146)

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