[논문]월경전증후군에 대한 한약 치료의 효과 : 체계적 문헌 고찰과 메타 분석

서지인; 이윤재; 고서림; 김누리; 김정훈; 손미주; 김영은; 김안나; 이은희

doi:10.15204/jkobgy.2023.36.4.096

월경전증후군에 대한 한약 치료의 효과 : 체계적 문헌 고찰과 메타 분석
Herbal Medicine for Premenstrual Syndrome: A Systematic Review and Meta-analysis 원문보기

大韓韓方婦人科學會誌 = The Journal of Korean obstetrics & gynecology, v.36 no.4, 2023년, pp.96 - 120

서지인 (우석대학교 한의과대학) , 이윤재 (우석대학교 한의과대학) , 고서림 (우석대학교 한의과대학) , 김누리 (우석대학교, 한의과대학 한방부인과학교실) , 김정훈 (우석대학교 근거중심보건의료연구협력센터) , 손미주 (한국한의학연구원 연구기획팀) , 김영은 (한국한의학연구원 한의약데이터부) , 김안나 (한국한의학연구원 한의약데이터부) , 이은희 (우석대학교, 한의과대학 한방부인과학교실)

Abstract ▼ AI-Helper

Objectives: This study reports the findings that support the efficacy of herbal medicine (HM) for premenstrual syndrome (PMS). Methods: We conducted meta-analysis of findings from randomized controlled trials (RCTs) for PMS treated with HM. The articles were published before July 2022, located using 9 databases (Pubmed, EMBASE, Cochrane Library, CINAHL, CNKI, CiNii, SCIENCE ON, KoreaMed, OASIS). Results: We observed 2,034 studies, of which 23 RCTs met our inclusion criteria. The risk of bias in the included studies was relatively unclear or high. Meta-analysis of 3 RCTs showed that HM group had a significantly higher total effective rate than the western medicine group (RR 1.20 [95% CI 1.06, 1.36, p=0.004]). Meta-analysis of 1 RCT showed that HM group had a significantly lower symptom score (MD -3.04 [95% CI -5.36, -0.72, p=0.01]), while there was no significant difference in daily record of severity of problems scale (MD -20.52 [95% CI -49.33, 8.29, p=0.16]). Conclusions: HM significantly improved PMS symptoms than general treatment and no serious adverse events were reported. However, the evidence on the effectiveness and safety of HM for PMS was not enough to provide reliable results due to the small number and low quality of included studies. We believe that rigorous RCTs will lead to more reliable evidence of the intervention.

주제어

표/그림 (15)

그림 Fig. 1. PRISMA flow chart of the trial selection process.
표 Table 1. Characteristics of included Studies
표 Table 2. Frequency of Herbal Formula
그림 Fig. 2. (A) risk of bias summary. (+) : low risk of bias, (?) : unclear risk of bias, (-) : high risk of bias. (B) risk of bias graph. Review of authors' judgments about each risk-of-bias item presented as percentages across all included studies.
그림 Fig. 3. Forest plot of comparison : herbal medicine vs western medicine (total effective rate).
그림 Fig. 4. Forest plot of comparison : herbal medicine vs progestin+vitamin B6 (total effective rate).
그림 Fig. 5. Forest plot of comparison : herbal medicine vs SSRIs+dietary supplement (total effective rate).
그림 Fig. 6. Forest plot of comparison : Soyo-san vs western medicine+dietary supplement (total effective rate).
그림 Fig. 7. Forest plot of comparison : Sihosogan-san vs western medicine+dietary supplement (total effective rate).
그림 Fig. 8. Forest plot of comparison : herbal medicine vs SSRIs+dietary supplement (symptom score_total).
그림 Fig. 9. Forest plot of comparison : herbal medicine vs vitamin B6 (total effective rate).
그림 Fig. 10. Forest plot of comparison : Soyo-san vs vitamin B6 (total effective rate).
그림 Fig. 11. Forest plot of comparison : herbal medicine+psychotherapy vs western medicine+dietary supplement+psychotherapy (total effective rate).
그림 Fig. 12. Forest plot of comparison : herbal medicine+dietary supplement vs dietary supplement (total effective rate).
그림 Fig. 13. Forest plot of comparison : herbal medicine+western medicine+dietary supplement vs western medicine+dietary supplement (total effective rate).

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