$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

[국내논문] PD-L1 Aptamer-functionalized Liposome Containing SAHA for Anti-lung Cancer Immunotherapy 원문보기

Biomedical science letters = 대한의생명과학회지, v.30 no.2, 2024년, pp.37 - 48  

Si-Yeon Ryu (Department of Biomedical Laboratory Science, Konyang University) ,  Se-Yun Hong (Department of Biomedical Laboratory Science, Konyang University) ,  Keun-Sik Kim (Department of Biomedical Laboratory Science, Konyang University)

Abstract AI-Helper 아이콘AI-Helper

Liposomes are one of the most actively studied and promising drug delivery systems for the treatment of various diseases. In this study, an aptamer-conjugated liposome called "aptamosome" was used, in which an anti-PD-L1 aptamer targeting cancer cells was conjugated to the liposome. These aptamosome...

Keyword

참고문헌 (32)

  1. Abdel-Rahman O, Helbling D, Schmidt J, et al. Treatment-associated fatigue in cancer patients treated with immune?checkpoint inhibitors; a systematic review and meta-analysis.?Clin Oncol (R. Coll. Radiol). 2016. 28: 127. 

  2. Agnello L, Camorani S, Fedele M, Cerchia L. Aptamers and?antibodies: Rivals or allies in cancer targeted therapy? Explor?Target Antitumor Ther. 2021. 2: 107-121. 

  3. Akbarzadeh A, Rezaei-Sadabady R, Davaran S, et al. Liposome:?Classification, preparation, and applications. Nanoscale Res?Lett. 2013. 8: 102-102. 

  4. Alshaer W, Hillaireau H, Vergnaud J, et al. Aptamer-guided?siRNA-loaded nanomedicines for systemic gene silencing in?CD-44 expressing murine triple-negative breast cancer model.?J Control Release. 2018. 271: 98-106. 

  5. Bagalkot V, Farokhzad OC, Langer R, Jon S. An aptamer-doxorubicin physical conjugate as a novel targeted drug-delivery platform. Angewandte Chemie International Edition. 2006. 45: 8149-8152. 

  6. Baxi S, Yang A, Gennarelli RL, et al. Immune-related adverse?events for anti-PD-1 and anti-PD-L1 drugs: Systematic review?and meta-analysis. BMJ. 2018. 360: k793. 

  7. Chen S, Dominik PK, Stanfield J, et al. Dual checkpoint blockade?of CD47 and PD-L1 using an affinity-tuned bispecific antibody maximizes antitumor immunity. J Immunother Cancer. 2021. 9: e003464. doi: 10.1136/jitc-003464. 

  8. Conte M, De Palma R, Altucci L. HDAC inhibitors as epigenetic?regulators for cancer immunotherapy. Int J Biochem Cell Biol. 2018. 98: 65-74. 

  9. Ganson NJ, Povsic TJ, Sullenger BA, et al. Pre-existing anti-polyethylene glycol antibody linked to first-exposure allergic?reactions to pegnivacogin, a PEGylated RNA aptamer. J?Allergy Clin Immunol. 2016. 137: 1610-1613.e7. 

  10. Gao T, Mao Z, Li W, Pei R. Anti-PD-L1 DNA aptamer antagonizes?the interaction of PD-1/PD-L1 with antitumor effect. J Mater?Chem B. 2021. 9: 746-756. 

  11. Gilboa E, Berezhnoy A, Schrand B. Reducing toxicity of immune?therapy using aptamer-targeted drug delivery. Cancer Immunol?Res. 2015. 3: 1195-1200. 

  12. Granier C, De Guillebon E, Blanc C, et al. Mechanisms of action?and rationale for the use of checkpoint inhibitors in cancer.?ESMO Open. 2017. 2: e000213-000213. eCollection 2017. 

  13. Jain A, Maheshwari V, Alam K, Mehdi G, Sharma SC. Apoptosis?in premalignant and malignant squamous cell lesions of?the oral cavity: A light microscopic study. Indian J Pathol?Microbiol. 2009. 52: 164-166. 

  14. Kennedy LB, Salama AKS. A review of cancer immunotherapy?toxicity. CA Cancer J Clin. 2020. 70: 86-104. 

  15. Kim M, Lee JS, Kim W, et al. Aptamer-conjugated nano-liposome?for immunogenic chemotherapy with reversal of immunosuppression. J Control Release. 2022. 348: 893-910. 

  16. Large DE, Abdelmessih RG, Fink EA, Auguste DT. Liposome?composition in drug delivery design, synthesis, characterization, and clinical application. Adv Drug Deliv Rev. 2021.?176: 113851. 

  17. Le VKH, Pham TPD, Truong DH. Delivery systems for vorinostat?in cancer treatment: An updated review. Journal of Drug?Delivery Science and Technology. 2021. 61: 102334. 

  18. Li T, Yao F, An Y, Li X, Duan J, Yang X. Novel complex of PD-L1 aptamer and holliday junction enhances antitumor efficacy?in vivo. Molecules. 2021. 26: 1067. doi: 10.3390/molecules26041067. 

  19. Li Z, Song W, Rubinstein M, Liu D. Recent updates in cancer?immunotherapy: A comprehensive review and perspective of?the 2018 china cancer immunotherapy workshop in beijing. J.?Hematol Oncol. 2018. 11: 142-143. 

  20. Liu B, Zhang J, Liao J, et al. Aptamer-functionalized nanoparticles?for drug delivery. J Biomed Nanotechnol. 2014. 10: 3189-3203. 

  21. Lv H, Wang T, Ma F, et al. Aptamer-functionalized targeted siRNA?delivery system for tumor immunotherapy. Biomed Mater. 2022. 17: 10.1088/1748-605X/ac5415. 

  22. Mann BS, Johnson JR, Cohen MH, Justice R, Pazdur R. FDA?approval summary: Vorinostat for treatment of advanced?primary cutaneous T-cell lymphoma. Oncologist. 2007. 12:?1247-1252. 

  23. Martins F, Sofiya L, Sykiotis GP, et al. Adverse effects of immune-checkpoint inhibitors: Epidemiology, management and surveillance. Nat Rev Clin Oncol. 2019. 16: 563-580. 

  24. Melosky B, Juergens R, McLeod D, et al. Immune checkpoint-inhibitors and chemoradiation in stage III unresectable non-small cell lung cancer. Lung Cancer. 2019. 134: 259-267. 

  25. Nayak A, Raikar A, Kotrashetti V, Nayak R, Shree S, Kambali S.?Histochemical detection and comparison of apoptotic cells in?the gingival epithelium using hematoxylin and eosin and?methyl green-pyronin: A pilot study. J Indian Soc Periodontol. 2016. 20: 294-298. 

  26. Peer D, Karp JM, Hong S, Farokhzad OC, Margalit R, Langer R.?Nanocarriers as an emerging platform for cancer therapy.?Nano-Enabled Medical Applications. 2020. 61-91. 

  27. Riley RS, June CH, Langer R, Mitchell MJ. Delivery technologies?for cancer immunotherapy. Nat Rev Drug Discov. 2019. 18:?175-196. 

  28. Sanmamed MF, Chen L. A paradigm shift in cancer immunotherapy: From enhancement to normalization. Cell. 2018.?175: 313-326. 

  29. Terranova-Barberio M, Thomas S, Ali N, et al. HDAC inhibition?potentiates immunotherapy in triple negative breast cancer.?Oncotarget. 2017. 8: 114156-114172. 

  30. West AC, Johnstone RW. New and emerging HDAC inhibitors for?cancer treatment. J Clin Invest. 2014. 124: 30-39. 

  31. Xu W, Siddiqui IA, Nihal M, et al. Aptamer-conjugated and doxorubicin-loaded unimolecular micelles for targeted therapy?of prostate cancer. Biomaterials. 2013. 34: 5244-5253. 

  32. Zheng H, Zhao W, Yan C, et al. HDAC inhibitors enhance T-cell?chemokine expression and augment response to PD-1 immunotherapy in lung adenocarcinoma. Clin Cancer Res. 2016.?22: 4119-4132. 

활용도 분석정보

상세보기
다운로드
내보내기

활용도 Top5 논문

해당 논문의 주제분야에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.

관련 콘텐츠

오픈액세스(OA) 유형

GOLD

오픈액세스 학술지에 출판된 논문

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로