[논문]Hepatitis B and C in HIV-infected patients : Prevalence and prognostic value

Ockenga, Johann; Tillmann, Hans Ludger; Trautwein, Christian; Stoll, Matthias; Manns, Michael Peter; Schmidt, Reinhold Ernst

doi:10.1016/S0168-8278(97)80274-7

[해외논문] Hepatitis B and C in HIV-infected patients : Prevalence and prognostic value

Journal of hepatology : the journal of the European Association for the Study of the Liver, v.27 no.1, 1997년, pp.18 - 24

Ockenga, Johann (Department of Clinical Immunology, Hannover Medical School, Germany) , Tillmann, Hans Ludger (Department of Gastroenterology and Hepatology, Hannover Medical School, Germany) , Trautwein, Christian (Department of Gastroenterology and Hepatology, Hannover Medical School, Germany) , Stoll, Matthias (Department of Clinical Immunology, Hannover Medical School, Germany) , Manns, Michael Peter (Department of Gastroenterology and Hepatology, Hannover Medical School, Germany) , Schmidt, Reinhold Ernst (Correspondence: Prof. Dr. R. E. Schmidt, Department of Clinical Immunology, Medical School Hannover, 30623, Hannover, FRG Tel: + +49 511 532 6656. Fax: + +49 511 532 9067.)

Abstract ▼ AI-Helper

Abstract Background/Aims: There is only limited information on the prevalence and influence of coinfection with either hepatitis B or C on the clinical course in patients infected with the human immunodeficiency virus (HIV). Methods: Follow-up was available in 232 HIV-infected patients (age 37±8 years, CD4 count 167±167 μl; 46% had AIDS). Samples were investigated for markers of HBV and HCV infection (HBsAg, HBeAg, HBV-DNA, Anti-HBs, anti-HBc, anti-HCV, HCV-RNA). Results: 60/232 patients (23%) were anti-HCV positive. 78% of these sera were positive for HCV-RNA. 22/232 patients (9%) suffered from chronic HBV infection (HBsAg positive), 18/22 (82%) of these sera had detectable HBeAg and 19/22 (86%) HBV-DNA. Presence of HCV-RNA, HBeAg and amount of HBV-DNA were related to the degree of immunodeficiency. In contrast to the control group without HBV or HCV infection, patients infected with HIV and either HBV or HCV showed a direct correlation between a reduction in CD4 counts and decreased cholinesterase activity. In patients with AIDS, coinfection with HBV or HCV was associated with a reduced survival compared to controls (HBV: 212 days, 95% CI, 106–317; HCV: 267, 95% CI, 112–396; controls: 439 days, 95% CI, 364–513). Conclusions: Coinfection of HIV and HBV or HCV is frequently observed. Our results suggest that with prolonged survival of HIV-infected patients, coinfection with either HBV or HCV correlates with a reduced survival rate.

Keyword

참고문헌 (41)

Semin Liver Dis McNair 12 188 1992 10.1055/s-2007-1007390 Interactions of the human immunodeficiency virus and the hepatotropic viruses

상세보기
Hepatology Wright 20 1152 1994 10.1002/hep.1840200508 Hepatitis C in HIV-infected patients with and without AIDS: prevalence and relationship to patient survival

상세보기
J Med Virol Quaranta 33 177 1994 Prevalence of antibody to hepatitis C virus (HCV) in HIV-1-infected patients (NICE SEROCO Cohort)
J Infect Dis Dorruci 172 1503 1992 10.1093/infdis/172.6.1503 Coinfection of hepatitis C virus with human immunodeficiency virus and progression to AIDS

상세보기
Ann Intern Med Scharschmidt 117 837 1992 10.7326/0003-4819-117-10-837 Hepatitis B in patients with HIV infection: relationship to AIDS and patient survival

상세보기
J Infect Dis Hadler 163 454 1991 10.1093/infdis/163.3.454 Outcome of hepatitis B virus infection in homosexual men and its relation to prior human immunodeficiency virus infection

상세보기
Gastroenterology Degos 94 151 1988 10.1016/0016-5085(88)90623-3 Hepatitis B virus and hepatitis B-related viral infection in renal transplant recipients: a prospective study of 90 patients

상세보기
Hepatology Housset 15 578 1992 10.1002/hep.1840150404 Interactions between human immunodeficiency virus, hepatitis delta virus and hepatitis B virus infection in 260 chronic carrier of hepatitis B virus

상세보기
Proc Natl Acad Sci USA Twu 86 5168 1989 10.1073/pnas.86.13.5168 Hepatitis B virus X gene activates kappa B-like enhancer sequences in the long terminal repeat of human immunodeficiency virus 1

상세보기
Clin Infect Dis Horvath 18 339 1994 10.1093/clinids/18.3.339 Clinical aspects of the interactions between human immunodeficiency virus and the hepatotropic viruses

상세보기
Gastroenterol Clin North Am Gitnick 23 515 1994 10.1016/S0889-8553(21)00150-3 Hepatitis infection in immunocompromised patients

상세보기
Gastroenterology Martin 97 1559 1989 10.1016/0016-5085(89)90405-8 Rapidly progressive non-A, non-B hepatitis in patients with human immunodeficiency virus infection

상세보기
Med Clin Barc Soriano 104 641 1995 Morbidity and mortality associated with chronic viral hepatopathy in patients infected with the human immunodeficiency virus
AIDS Eskild 6 571 1992 10.1097/00002030-199206000-00008 Hepatitis B antibodies in HIV-infected homosexual men are associated with more rapid progression to AIDS

상세보기
Lancet Park 339 671 1992 10.1016/0140-6736(92)90815-K European AIDS definition

상세보기
Gastroenterology Michitaka 106 1603 1994 10.1016/0016-5085(94)90417-0 Analysis of hepatitis C virus genome in patients with autoimmune hepatitis type 2

상세보기
J Immunol Hoffmeyer 155 4016 1995 10.4049/jimmunol.155.8.4016 The low affinity Fc gamma RIIa and Fc gamma RIIIb on polymorphonuclear neutrophils are differentially regulated by CD45 phosphatase

상세보기
Am J Gastroenterol Haber 90 1250 1995 Relationship of aminotransferases to liver histological status in chronic hepatitis C

상세보기
Am J Epidemiol Diamondsstone 142 304 1995 10.1093/oxfordjournals.aje.a117636 Prognostic factors for all-cause mortality among hemophiliacs infected with human immunodeficiency virus

상세보기
J Biol Chem Tamm 271 3659 1996 10.1074/jbc.271.7.3659 The IgG binding site of human Fc-gamma RIIIB receptor involves CC and FG loops of the membrane-proximal domain

상세보기
Gut Naoumov 35 1013 1994 10.1136/gut.35.8.1013 Host immune response and variations in the virus genome: pathogenesis of liver damage caused by hepatitis B virus

상세보기
Gut Tillmann 37 568 1995 10.1136/gut.37.4.568 Clinical relevance of mutations in the precore genome of the hepatitis B virus

상세보기
J Immunol Koziel 149 3339 1996 10.4049/jimmunol.149.10.3339 Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in persons with chronic hepatitis

상세보기
Lancet J 341 1501 1993 10.1016/0140-6736(93)90635-T Significance of serum hepatitis C virus RNA levels in chronic hepatitis C

상세보기
Blood Eyster 84 1020 1994 10.1182/blood.V84.4.1020.1020 Increasing hepatitis C virus RNA levels in hemophiliacs: relationship to human immunodeficiency virus infection and liver disease

상세보기
Br J Haematol Telfer 88 397 1994 10.1111/j.1365-2141.1994.tb05038.x HCV RNA levels and HIV infection: evidence for a viral interaction in haemophilic patients

상세보기
Br J Haematol Telfer 87 555 1994 10.1111/j.1365-2141.1994.tb08312.x The progression of HCV-associated liver disease in a cohort of haemophilic patients

상세보기
N Engl J Med Stanley 334 1222 1996 10.1056/NEJM199605093341903 Effect of immunization with a common recall antigen on viral expression in patients infected with human immunodeficiency virus type 1

상세보기
N Engl J Med Chaisson 333 751 1995 10.1056/NEJM199509213331202 Race, sex, drug use, and progression of human immunodeficiency virus disease

상세보기
J Acquir Immune Defic Syndr Süttmann 8 239 1995 10.1097/00042560-199503010-00004 Incidence and prognostic value of malnutrition and wasting in human immunodeficiency virus-infected outpatients

상세보기
Gastroenterology Müller 102 2033 1992 10.1016/0016-5085(92)90329-W Mechanism of insulin resistance associated with liver cirrhosis. Impact of the aetiology of cirrhosis, the clinical and the nutritional state of the patients

상세보기
Gut Trautwein 35 1163 1994 10.1136/gut.35.9.1163 Hepatocyte and immune system: acute phase reaction as a contribution to early defence mechanisms

상세보기
Eur J Clin Pharmacol Ockenga 50 167 1996 10.1007/s002280050087 Ketotifen in HIV-infected patients: effects on body weight and release of tumor necrosis factor alpha

상세보기
Lancet Benhamou 345 396 1995 10.1016/S0140-6736(95)90388-7 Efficacy of lamivudine on replication of hepatitis B virus in HIV-infected patients

상세보기
Br Med J Lundgren 308 1068 1994 10.1136/bmj.308.6936.1068 Survival differences in European patients with AIDS, 1979-89

상세보기
JAMA Osmond 271 1083 1994 10.1001/jama.1994.03510380039034 Changes in AIDS survival time in two San Francisco cohorts of homosexual men, 1983 to 1993

상세보기
Am J Clin Pathol Maschek 101 95 1994 10.1093/ajcp/101.1.95 Mycobacterium genavense. Autopsy findings in three patients

상세보기
Scand J Infect Dis Iwarson 26 19 1994 10.3109/00365549409008585 Substantial decline of notified hepatitis B in major parts of Europe after 1985

상세보기
Ann Intern Med Sharara 125 658 1996 10.7326/0003-4819-125-8-199610150-00006 Hepatitis C

상세보기
J Infect Dis Boyer 165 723 1992 10.1093/infdis/165.4.723 Recombinant interferon-alpha for chronic hepatitis inpatients positive for antibody to human immunodeficiency virus

상세보기
Gastroenterology Wong 108 165 1995 10.1016/0016-5085(95)90021-7 Interferon alpha treatment of chronic hepatitis B: randomized trial in a predominantly homosexual male population

상세보기

활용도 분석정보

상세보기

다운로드

내보내기

활용도 Top5 논문

해당 논문의 주제분야에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증