[논문]Hepatitis B and C in HIV-infected patients : Prevalence and prognostic value

Ockenga, Johann; Tillmann, Hans Ludger; Trautwein, Christian; Stoll, Matthias; Manns, Michael Peter; Schmidt, Reinhold Ernst

doi:10.1016/S0168-8278(97)80274-7

[해외논문] Hepatitis B and C in HIV-infected patients : Prevalence and prognostic value

Journal of hepatology : the journal of the European Association for the Study of the Liver, v.27 no.1, 1997년, pp.18 - 24

Ockenga, Johann (Department of Clinical Immunology, Hannover Medical School, Germany) , Tillmann, Hans Ludger (Department of Gastroenterology and Hepatology, Hannover Medical School, Germany) , Trautwein, Christian (Department of Gastroenterology and Hepatology, Hannover Medical School, Germany) , Stoll, Matthias (Department of Clinical Immunology, Hannover Medical School, Germany) , Manns, Michael Peter (Department of Gastroenterology and Hepatology, Hannover Medical School, Germany) , Schmidt, Reinhold Ernst (Correspondence: Prof. Dr. R. E. Schmidt, Department of Clinical Immunology, Medical School Hannover, 30623, Hannover, FRG Tel: + +49 511 532 6656. Fax: + +49 511 532 9067.)

Abstract ▼ AI-Helper

Abstract Background/Aims: There is only limited information on the prevalence and influence of coinfection with either hepatitis B or C on the clinical course in patients infected with the human immunodeficiency virus (HIV). Methods: Follow-up was available in 232 HIV-infected patients (age 37±8 years, CD4 count 167±167 μl; 46% had AIDS). Samples were investigated for markers of HBV and HCV infection (HBsAg, HBeAg, HBV-DNA, Anti-HBs, anti-HBc, anti-HCV, HCV-RNA). Results: 60/232 patients (23%) were anti-HCV positive. 78% of these sera were positive for HCV-RNA. 22/232 patients (9%) suffered from chronic HBV infection (HBsAg positive), 18/22 (82%) of these sera had detectable HBeAg and 19/22 (86%) HBV-DNA. Presence of HCV-RNA, HBeAg and amount of HBV-DNA were related to the degree of immunodeficiency. In contrast to the control group without HBV or HCV infection, patients infected with HIV and either HBV or HCV showed a direct correlation between a reduction in CD4 counts and decreased cholinesterase activity. In patients with AIDS, coinfection with HBV or HCV was associated with a reduced survival compared to controls (HBV: 212 days, 95% CI, 106–317; HCV: 267, 95% CI, 112–396; controls: 439 days, 95% CI, 364–513). Conclusions: Coinfection of HIV and HBV or HCV is frequently observed. Our results suggest that with prolonged survival of HIV-infected patients, coinfection with either HBV or HCV correlates with a reduced survival rate.

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[해외논문] Hepatitis B and C in HIV-infected patients : Prevalence and prognostic value

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