$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

[해외논문] Combined gene therapy with suicide gene and interleukin-12 is more efficient than therapy with one gene alone in a murine model of hepatocellular carcinoma

Journal of hepatology : the journal of the European Association for the Study of the Liver, v.32 no.2, 2000년, pp.279 - 286  

Drozdzik, Marek (Division of Hepatology and Gene Therapy, Department of Medicine, School of Medicine and Clinica Universitaria, University of Navarra, Pamplona, Spain) ,  Qian, Cheng (Cheng Qian or Prof. Jesus Prieto, Division of Hepatology and Gene Therapy, Department of Medicine, School of Medicine and Clinica Universitaria, University of Navarra, Irunlarrea s) ,  Xie, Xiaoming (Division of Hepatology and Gene Therapy, Department of Medicine, School of Medicine and Clinica Universitaria, University of Navarra, Pamplona, Spain) ,  Peng, Dacheng (Division of Hepatology and Gene Therapy, Department of Medicine, School of Medicine and Clinica Universitaria, University of Navarra, Pamplona, Spain) ,  Bilbao, Roberto (Division of Hepatology and Gene Therapy, Department of Medicine, School of Medicine and Clinica Universitaria, University of Navarra, Pamplona, Spain) ,  Mazzolini, Guillermo (Division of Hepatology and Gene Therapy, Department of Medicine, School of Medicine and Clinica Universitaria, University of Navarra, P) ,  Prieto, Jesus

Abstract AI-Helper 아이콘AI-Helper

AbstractBackground/Aims: Gene therapy has emerged as a new form of treatment for unresectable hepatocellular carcinoma (HCC). We evaluate here the effect of IL-12 and the suicide gene thymidine kinase as single agents and in combination to treat experimental liver cancer.Methods: Recombinant adenovi...

Keyword

참고문헌 (46)

  1. J Hepatol Colombo 15 225 1995 10.1016/0168-8278(92)90041-M Hepatocellular carcinoma 

  2. J Clin Oncol Venook 12 1323 1994 10.1200/JCO.1994.12.6.1323 Treatment of hepatocellular carcinoma: too many options? 

  3. Immunol Today Chouaib 18 493 1997 10.1016/S0167-5699(97)01115-8 The host-tumor immune conflict: from immunosuppression to resistance and destruction 

  4. Adv Immunol Roth 57 281 1994 10.1016/S0065-2776(08)60675-6 Immune response against tumors 

  5. Nat Med Gabrilovich 2 1096 1996 10.1038/nm1096-1096 Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells 

  6. Immunol Today Zier 17 39 1996 10.1016/0167-5699(96)80567-6 Preventing abnormalities in signal transduction of T cells in cancer: the promise of cytokine gene therapy 

  7. Immunol Today Musiani 18 32 1997 10.1016/S0167-5699(97)80012-6 Cytokine, tumor-cell death and immunogenicity: a question of choice 

  8. Immunol Today Schmidt-Wolf 16 173 1995 10.1016/0167-5699(95)80116-2 Cytokines and gene therapy 

  9. Immunol Today Colombo 15 48 1994 10.1016/0167-5699(94)90131-7 Cytokine gene transfer in tumor inhibition and tumor therapy: where are we now? 

  10. Immunol Today Lamonta 17 214 1996 10.1016/0167-5699(96)30011-X IL-12: a key cytokine in immune regulation 

  11. J Immunol Wolf 146 3074 1991 10.4049/jimmunol.146.9.3074 Cloning of cDNA for natural killer cell stimulatory factor, a heterdimeric cytokine with multiple biologic effect on T and natural killer cells 

  12. Proc Natl Acad Sci USA Seder 90 10188 1993 10.1073/pnas.90.21.10188 IL-12 acts directly on CD4+ T cells to enhance priming for IFN-γ production and diminishes IL-4 inhibition of such priming 

  13. Int Immunol Gately 6 157 1994 10.1093/intimm/6.1.157 Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocytes activity and induces production of IFN-γ in vivo 

  14. J Natl Cancer Inst Voest 87 581 1995 10.1093/jnci/87.8.581 Interleukin-12 inhibits angiogenesis in vivo 

  15. J Exp Med Brunda 178 1223 1993 10.1084/jem.178.4.1223 Antitumor and antimetastatic activity of interleukin-12 against murine tumors 

  16. J Immunol Nastala 153 1697 1994 10.4049/jimmunol.153.4.1697 Recombinant interleukin-12 administration induces tumor regression in association with interferon-γ production 

  17. Cancer Res Mu 55 4404 1995 Administration of recombinant interleukin-12 prevents outgrowth of tumor cells metastasizing spontaneously to lung and lymph nodes 

  18. J Immunol Tannenbaum 156 693 1996 10.4049/jimmunol.156.2.693 Cytokine and chemokine expression in tumors of mice receiving systemic therapy IL-12 

  19. Proc Natl Acad Sci USA Noguchi 93 11798 1996 10.1073/pnas.93.21.11798 Effect of interleukin 12 on tumor induction by 3-methylcolantrene 

  20. Science Marshall 268 1555 1995 10.1126/science.268.5217.1555 Cancer trial of interleukin-12 halted 

  21. J Natl Cancer Inst Jenks 88 576 1996 10.1093/jnci/88.9.576 After initial setback, IL-12 regaining popularity 

  22. Hum Gene Ther Bramson 7 1995 1996 10.1089/hum.1996.7.16-1995 Direct intratumoral injection of an adenovirus expressing interleukin-12 induces regression and long-lasting immunity that is associated with highly localized expression of interleukin-12 

  23. Proc Natl Acad Sci Caruso 93 11302 1996 10.1073/pnas.93.21.11302 Adenovirus mediated interleukin-12 gene therapy for metastatic colon carcinoma 

  24. J Immunol Toda 160 4457 1998 10.4049/jimmunol.160.9.4457 In situ cancer vaccination: an IL-12 defective vector/replication-competent herpes simplex virus combination induces local and systemic antitumor activity 

  25. Proc Natl Acad Sci Rakhmilevich 93 6291 1996 10.1073/pnas.93.13.6291 Gene gun-mediated skin transfection with interleukin 12 gene results in regression of established primary and metastatic murine tumors 

  26. J Immunol Tahara 154 6466 1995 10.4049/jimmunol.154.12.6466 Effective eradication of established murine tumors with IL-12 gene therapy using a polycistronic retroviral vector 

  27. Cancer Res Meko 55 4765 1995 High cytokine production and effective antitumor activity of a recombinant vaccinia virus encoding murine interleukin 12 

  28. Cancer Res Tan 56 3399 1996 Injection of complementary DNA encoding interleukin-12 inhibits tumor establishment at distant site in a murine renal carcinoma model 

  29. Cancer Gene Ther Moolten 1 279 1994 Drug sensitivity (“suicide”) genes for selective cancer chemotherapy 

  30. Qian 537 1997 Viral Hepatitis and Liver Disease In vivo gene therapy of experimental hepatocellular carcinoma using a recombinant defective adenovirus expressing the thymidine-kinase of herpes simplex virus 

  31. Hum Gene Ther Qian 8 349 1997 10.1089/hum.1997.8.3-349 Gene transfer and therapy with adenoviral vector in rats with diethylnitrosamine-induced hepatocellular carcinoma 

  32. Cancer Gene Ther Will 2 191 1995 Gene therapy for hepatocellular carcinoma: chemosensitivity conferred by adenovirus-mediated transfer of the HSV-1 thymidine kinase gene 

  33. Cancer Res Vile 54 6228 1994 Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component 

  34. Proc Natl Acad Sci Chen 92 2577 1995 10.1073/pnas.92.7.2577 Combination gene therapy for liver metastasis of colon carcinoma 

  35. Cancer Res Chen 56 3758 1996 Combination suicide and cytokine gene therapy for hepatic metastases of colon carcinoma: sustained antitumor immunity prolongs animal survival 

  36. Hepatology Qian 22 118 1995 Induction of sensitivity to ganciclovir in human hepatocellular carcinoma cells by adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase 

  37. Cancer Gene Ther Mazzolini 6 1999 10.1038/sj.cgt.7700072 Regression of colon cancer and induction of antitumor immunity by intratumoral injection of adenovirus expressing IL-12 

  38. J Immunol Lasarte 162 5270 1999 10.4049/jimmunol.162.9.5270 Different doses of adenoviral vector expressing IL-12 enhance or depress the immune response to a coadministrated antigen: the role of nitric oxide 

  39. Proc Natl Acad Sci Noguchi 92 2219 1995 10.1073/pnas.92.6.2219 Influence of IL-12 on p53 peptide vaccination against established Meth-A sarcoma 

  40. Ann NY Acad Sci Nishimura 795 375 1996 10.1111/j.1749-6632.1996.tb52697.x The application of IL-12 to cytokine therapy for tumors 

  41. Cancer Res Vagliani 56 467 1996 Interleukin-12 potentates the curative effect of a vaccine based on interleukin-2 transduced tumor cells 

  42. Proc Natl Acad Sci Noguchi 93 11798 1996 10.1073/pnas.93.21.11798 Effect of interleukin-12 on tumor induction by 3-methylcholanthrene 

  43. Jpn J Med Sci Biol Obana 48 221 1995 10.7883/yoken1952.48.221 Induction of antitumor immunity by mouse tumor cells transfected with mouse interleukin-12 gene 

  44. Hum Gene Ther Kianmanesh 8 1807 1997 10.1089/hum.1997.8.15-1807 A“distant” bystander effect of suicide gene therapy: regression of nontransduced tumors together with a distant transduced tumor 

  45. Hum Gene Ther Arbuthnot 7 1503 1996 10.1089/hum.1996.7.13-1503 In vitro and in vivo hepatoma cell-specific expression of a gene transferred with an adenoviral vector 

  46. Semin Cancer Biol Buendia 3 309 1992 Mammalian hepatitis B viruses and primary liver cancer 

활용도 분석정보

상세보기
다운로드
내보내기

활용도 Top5 논문

해당 논문의 주제분야에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.

관련 콘텐츠

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로