[논문]Passage of Interleukin-1-Beta Across the Blood-Brain Barrier Is Reduced in Aged Mice: A Possible Mechanism for Diminished Fever in Aging

McLay, Robert N.; Kastin, Abba J.; Zadina, James E.

doi:10.1159/000054275

[해외논문] Passage of Interleukin-1-Beta Across the Blood-Brain Barrier Is Reduced in Aged Mice: A Possible Mechanism for Diminished Fever in Aging

Neuroimmunomodulation, v.8 no.3, 2000년, pp.148 - 153

McLay, Robert N. (Tulane University School of Medicine and VA Medical Center, New Orleans, La., USA) , Kastin, Abba J. (Tulane University School of Medicine and VA Medical Center, New Orleans, La., USA) , Zadina, James E. (Tulane University School of Medicine and VA Medical Center, New Orleans, La., USA)

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Objective: Cytokine signaling is the key to fighting infection. Fever is elicited by the production of inflammatory cytokines, particularly interleukin-1β (IL-1β), and the subsequent action of cytokines in the hypothalamus. In old age, the ability to produce fever in response to infection or to peripheral injections of IL-1β is diminished. Intracerebroventricular injections of IL-1β can still produce a normal fever response in the aged. A logical hypothesis to explain this discrepancy is that passage of IL-1β across the blood-brain barrier (BBB) is altered. Method: We used a quantitative in vivo technique, which previously showed a saturable system transporting IL-1β across the BBB, to investigate the speed at which radiolabeled IL-1β crosses from blood to brain in mice of widely different ages. Results: We found that passage of IL-1β across the BBB was significantly decreased in old (23-month) mice as compared with young (2-month) or middle-aged (12-month) animals. Passage of IL-1β across the blood-testis barrier was not significantly different among the groups. The passage of radiolabeled albumin across the BBB was not increased in any group, ruling out any disruption of the BBB by IL-1β. Conclusion: These results provide a mechanism that could help explain why fever production is reduced in old age and suggest an important role for the BBB in regulating immune changes.Copyright © 2000 S. Karger AG, Basel

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[해외논문] Passage of Interleukin-1-Beta Across the Blood-Brain Barrier Is Reduced in Aged Mice: A Possible Mechanism for Diminished Fever in Aging

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