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[해외논문] Determination of the passive absorption through the rat intestine using chromatographic indices and molar volume

European journal of pharmaceutical sciences, v.12 no.3, 2001년, pp.223 - 229  

Genty, Muriel (Laboratoires UPSA) ,  González, Gustavo (fense, France) ,  Clere, Christian (Department of Analytical Chemistry, University of Seville, Seville E-41012, Spain) ,  Desangle-Gouty, Valérie (Laboratoires UPSA) ,  Legendre, Jean-Yves (fense, France)

Abstract AI-Helper 아이콘AI-Helper

AbstractImmobilized artificial membrane (IAM) chromatography coupled to physicochemical descriptors was evaluated to model the passive intestinal absorption of drugs through rat gut sacs. The chromatographic capacity factors (logk′IAM) of 12 structurally diverse compounds were determined on a...

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