[논문]Chemerin Treatment Inhibits the Growth and Bone Invasion of Breast Cancer Cells

Kim, Hyungkeun; Lee, Joo-Hee; Lee, Sun Kyoung; Song, Na-Young; Son, Seung Hwa; Kim, Ki Rim; Chung, Won-Yoon

doi:10.3390/ijms21082871

Chemerin Treatment Inhibits the Growth and Bone Invasion of Breast Cancer Cells 원문보기

International journal of molecular sciences, v.21 no.8, 2020년, pp.2871 -

Kim, Hyungkeun (Department of Applied Life Science, The Graduate School, Yonsei University, Seoul 03722, Korea) , Lee, Joo-Hee (khg165@gmail.com (H.K.)) , Lee, Sun Kyoung (lpluto@yuhs.ac (S.K.L.)) , Song, Na-Young (nysong608@yuhs.ac (N.-Y.S.)) , Son, Seung Hwa (Department of Oral Biology and BK21 PLUS Project, Yonsei University College of Dentistry, Seoul 03722, Korea) , Kim, Ki Rim (jhlee1201@yuhs.ac (J.-H.L.)) , Chung, Won-Yoon (shson0729@yuhs.ac (S.H.S.))

Abstract ▼ AI-Helper

Chemerin is secreted as prochemerin from various cell types and then cleaved into the bioactive isoform by specific proteases. In various cancer types, chemerin exhibits pro- or antitumor effects. In the present study, chemerin treatment significantly inhibited the viability and invasion of breast cancer cells in the absence or presence of transforming growth factor (TGF)-β and insulin-like growth factor (IGF)-1. The expression levels of E-cadherin and vimentin were reduced in chemerin-treated breast cancer cells. However, chemerin treatment recovered the reduced E-cadherin expression level in breast cancer cells treated with TGF-β or IGF-1. Chemerin treatment inhibited nuclear β-catenin levels in breast cancer cells stimulated with or without TGF-β or IGF-1. In addition, chemerin treatment blocked the increase in the receptor activator of nuclear factor kappa-Β ligand (RANKL)/osteoprotegerin (OPG) ratio in osteoblastic cells exposed to metastatic breast cancer cell-derived conditioned medium. Chemerin treatment inhibited RANKL-induced osteoclast formation and bone resorption by reducing the secretion of matrix metalloproteinase (MMP)-2, MMP-9, and cathepsin K. Intraperitoneal administration of chemerin inhibited tumor growth in MCF-7 breast cancer cell-injected mice and reduced the development of osteolytic lesions resulting from intratibial inoculation of MDA-MB-231 cells. Taken together, chemerin inhibits the growth and invasion of breast cancer cells and prevents bone loss resulting from breast cancer cells by inhibiting finally osteoclast formation and activity.

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참고문헌 (41)

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Chemerin Treatment Inhibits the Growth and Bone Invasion of Breast Cancer Cells 원문보기

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Chemerin Treatment Inhibits the Growth and Bone Invasion of Breast Cancer Cells 원문보기

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