$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Antiviral Activities of Compounds Isolated from Pinus densiflora (Pine Tree) against the Influenza A Virus 원문보기

Biomolecules, v.10 no.5, 2020년, pp.711 -   

Ha, Thi Kim Quy (Korea Bioactive Natural Material Bank, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Korea) ,  Lee, Ba Wool (htkquy@ctu.edu.vn (T.K.Q.H.)) ,  Nguyen, Ngoc Hieu (paul36@snu.ac.kr (B.W.L.)) ,  Cho, Hyo Moon (hieusnu@gmail.com (N.H.N.)) ,  Venkatesan, Thamizhiniyan (chgyand@naver.com (H.M.C.)) ,  Doan, Thi Phuong (thamtris@snu.ac.kr (T.V.)) ,  Kim, Eunhee (phuongdoan@snu.ac.kr (T.P.D.)) ,  Oh, Won Keun (Korea Bioactive Natural Material Bank, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Korea)

Abstract AI-Helper 아이콘AI-Helper

Pinus densiflora was screened in an ongoing project to discover anti-influenza candidates from natural products. An extensive phytochemical investigation provided 26 compounds, including two new megastigmane glycosides (1 and 2), 21 diterpenoids (3–23), and three flavonoids (24–26). Th...

주제어

참고문헌 (83)

  1. 1. Paget J. Spreeuwenberg P. Charu V. Taylor R.J. Iuliano A.D. Bresee J. Simonsen L. Viboud C. Global mortality associated with seasonal influenza epidemic: New burden estimates and predictors from the GLaMOR project J. Glob. Health 2019 9 020421 10.7189/jogh.09.020421 31673337 

  2. 2. Mansoor S. Maqbool I. Swine flu a seasonal pandemic, symptoms, diagnostics and prevention Rev. Med. Microbiol. 2019 30 200 204 10.1097/MRM.0000000000000183 

  3. 3. Uyeki T.M. Peiris M. Novel avian influenza A virus infections of humans Infect. Dis. Clin. North Am. 2019 33 907 932 10.1016/j.idc.2019.07.003 31668198 

  4. 4. Shie J.-J. Fang J.-M. Development of effective anti-influenza drugs: Congeners and conjugates―A review J. Biomed. Sci. 2019 84 1 20 10.1186/s12929-019-0567-0 31640786 

  5. 5. Both G.W. Sleigh M.J. Cox N.J. Kendal A.P. Antigenic drift in influenza virus H3 hemagglutinin from 1968 to 1980: Multiple evolutionary pathways and sequential amino acid changes at key antigenic sites J. Virol. 1983 48 52 60 10.1128/JVI.48.1.52-60.1983 6193288 

  6. 6. Styk B. Russ G. Pola’kova K. Antigenic glycopolypeptides HA1 and HA2 of influenza virus hemagglutinin. III. Reactivity with human convalescent sera Acta Virol. 1979 23 1 8 35954 

  7. 7. Gocnik M. Fislova T. Mucha V. Sladkova T. Russ G. Kostolansky F. Varekova E. Antibodies induced by the HA2 glycopolypeptide of influenza virus haemagglutinin improve recovery from influenza A virus infection J. Gen. Virol. 2008 89 958 967 10.1099/vir.0.83524-0 18343837 

  8. 8. Lin D. Luo Y. Yang G. Li F. Xie X. Chen D. He L. Wang J. Ye C. Lu S. Potent influenza A virus entry inhibitors targeting a conserved region of hemagglutinin Biochem. Pharmacol. 2017 144 35 51 10.1016/j.bcp.2017.07.023 28774731 

  9. 9. Shi W.-Z. Jiang L.-Z. Song G.-P. Wang S. Xiong P. Ke C.-W. Study on the antiviral activities and hemagglutinin-based molecular mechanism of novel chlorogenin 3-O-β-chacotrioside derivatives against H5N1 subtype viruses Viruses 2020 12 304 10.3390/v12030304 

  10. 10. Kosono S. Kasai A. Komaba S. Matsubara T. Sato T. Takahashi D. Toshima K. Novel hemagglutinin-binding sulfated oligofucosides and their effect on influenza virus infection Chem. Commun. 2018 54 7467 10.1039/C8CC03865A 

  11. 11. Kadam R.U. Wilson I.A. Structural basis of influenza virus fusion inhibition by the antiviral drug Arbidol Proc. Natl. Acad. Sci. USA 2017 114 206 214 10.1073/pnas.1617020114 28003465 

  12. 12. Leneva I.A. Falynskova I.N. Makhmudova N.R. Poromov A.A. Yatsyshina S.B. Maleev V.V. Umifenovir susceptibility monitoring and characterization of influenza viruses isolated during ARBITR clinical study J. Med. Virol. 2019 91 588 597 10.1002/jmv.25358 30431664 

  13. 13. Davidson S. Treating influenza infection, from now and into the future Front. Immunol. 2018 9 10.3389/fimmu.2018.01946 30250466 

  14. 14. Barik S. New treatments for influenza BMC Med. 2012 10 104 10.1186/1741-7015-10-104 22973873 

  15. 15. Hurt A.C. Antiviral therapy for the next influenza pandemic Trop. Med. Infect. Dis. 2019 4 10.3390/tropicalmed4020067 

  16. 16. Kim N.-Y. Jang M.-K. Lee D.-G. Yu K.-H. Jang H.J. Kim M. Kim S.G. Yoo B.H. Lee S.-H. Comparison of methods for proanthocyanidin extraction from pine ( Pinus densiflora ) needles and biological activities of the extracts Nutr. Res. Pract. 2020 4 16 22 10.4162/nrp.2010.4.1.16 

  17. 17. Hur J. Dongeubogam Dongeuhak Institute, Ryo-gang Pub. Co. Seoul, Korea 1994 

  18. 18. Li S. Compendium of Materia Medica (Bencao Gangmu) Huaxia Press Beijing, China 2012 (1593 republished in 2012) 

  19. 19. The Korean Herbal Pharmacopoeia Food and Drug Administration Seoul, Korea 2020 

  20. 20. Kim Y.S. Shin D.H. Volatile components and antibacterial effects of pine needle ( Pinus densiflora S. and Z.) extracts Food Microbiol. 2005 22 37 45 10.1016/j.fm.2004.05.002 

  21. 21. Chun H.S. Kim J.-M. Choi E.H. Chang N. Neuroprotective effects of several Korean medicinal plants traditionally used for stroke remedy J. Med. Food 2008 11 246 251 10.1089/jmf.2007.542 18598165 

  22. 22. Park G. Paudyal D.P. Hwang I. Tripathi G.R. Yang Y. Cheong H. Production of fermented needle extracts from red pine and their functional characterization Biotechnol. Bioprocess Eng. 2008 13 256 261 10.1007/s12257-008-0006-7 

  23. 23. Kwak C.S. Moon S.C. Lee M.S. Antioxidant, antimutagenic, and antitumor effects of pine needles ( Pinus densiflora ) Nutr. Cancer 2006 56 162 171 10.1207/s15327914nc5602_7 17474862 

  24. 24. Arbuthnot P. Antiviral Drugs: Aspects of Clinical Use and Recent Advances InTech Rijeka, Croatia 2012 180 

  25. 25. Kim Y.J. Cho B.J. Ko M.S. Jung J.M. Kim H.R. Song H.S. Lee J.Y. Sim S.S. Kim C.J. Anti-oxidant and anti-aging activities of essential oils of Pinus densiflora needles and twigs Yakhak Hoeji 2010 54 215 225 

  26. 26. Jung M.J. Jung H.A. Kang S.S. Hwang G.S. Choi J.S. A new abietic acid-type diterpene glucoside from the needles of Pinus densiflora Arch. Pharm. Res. 2009 32 1699 1704 10.1007/s12272-009-2206-x 20162397 

  27. 27. Lee S.K. Lee H.J. Min H.Y. Park E.J. Lee K.M. Ahn Y.H. Cho Y.J. Pyee J.H. Antibacterial and antifungal activity of pinosylvin, a constituent of pine Fitoterapia 2005 76 258 260 10.1016/j.fitote.2004.12.004 15752644 

  28. 28. Sultan M.Z. Jeon Y.-M. Moon S.-S. Labdane-type diterpenes active against acne from pine cones ( Pinus densiflora ) Planta Med. 2008 74 449 452 10.1055/s-2008-1034321 18484541 

  29. 29. Tang Y. Yu B. Hu J. Wu T. Hui H. Three new homoisoflavanone glycosides from the bulbs of Ornithogalum caudatum J. Nat. Prod. 2002 65 218 220 10.1021/np010466a 11858761 

  30. 30. Hoye T.R. Jeffrey C.S. Shao F. Mosher ester analysis for the determination of absolute configuration of stereogenic (chiral) carbinol carbons Nat. Protoc. 2007 2 2451 2458 10.1038/nprot.2007.354 17947986 

  31. 31. Tanaka T. Nakashima T. Ueda T. Tomii K. Kouno I. Facile discrimination of aldose enantiomers by reversed-phase HPLC Chem. Pharm. Bull. 2007 55 899 901 10.1248/cpb.55.899 17541189 

  32. 32. Ha T.K.Q. Dao T.T. Nguyen N.H. Kim J. Kim E. Cho T.O. On W.K. Antiviral phenolics from the leaves of Cleistocalyx operculatus Fitoterapia 2016 110 135 141 10.1016/j.fitote.2016.03.006 26972228 

  33. 33. Kim S.H. Ha T.K.Q. Oh W.K. Shin J. Oh D.-C. Antiviral indolosesquiterpenoid xiamycins C-E from a halophilic actinomycete J. Nat. Prod. 2016 79 51 58 10.1021/acs.jnatprod.5b00634 26698879 

  34. 34. Cho H.M. Doan T.P. Ha T.K.Q. Kim H.W. Lee B.W. Pham H.T.T. Cho T.O. Oh W.K. Dereplication by high-performance liquid chromatography (HPLC) with quadrupole-time-of-flight mass spectroscopy (qTOF-MS) and antiviral activities of phlorotannins from Ecklonia cava Mar. Drugs 2019 17 149 10.3390/md17030149 

  35. 35. Miyamoto D. Kusagaya Y. Endo N. Sometani A. Takeo S. Suzuki T. Arima Y. Nakajima K. Suzuki Y. Thujaplicin-copper chelates inhibit replication of human influenza viruses Antivir. Res. 1998 39 89 100 10.1016/S0166-3542(98)00034-5 9806486 

  36. 36. Dao T.-T. Tung B.-T. Nguyen P.-H. Thuong P.-T. Yoo S.-S. Kim E.-H. Kim S.-K. Oh W.-K. C-methylated flavonoids from Cleistocalyx operculatus and their inhibitory effects on novel influenza A (H1N1) neuraminidase J. Nat. Prod. 2010 73 1636 1642 10.1021/np1002753 20886838 

  37. 37. Theisen L.L. Muller C.P. EPs ® 7630 (Umckaloabo ® ), an extract from Pelargonium sidoides roots, exerts anti-influenza virus activity in vitro and in vivo Antivir. Res. 2012 94 147 156 10.1016/j.antiviral.2012.03.006 22475498 

  38. 38. Cecil C.E. Davis J.M. Cech N.B. Laster S.M. Inhibition of H1N1 influenza A virus growth and induction of inflammatory mediators by the isoquinoline alkaloid berberine and extracts of goldenseal ( Hydrastis canadensis ) Int. Immunopharmacol. 2011 11 1706 1714 10.1016/j.intimp.2011.06.002 21683808 

  39. 39. Miranda K.M. Espey M.G. Wink D.A. A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite Nitric Oxide 2001 5 62 71 10.1006/niox.2000.0319 11178938 

  40. 40. Yaeghoobi M. Frimayanti N. Chee C.F. Ikram K.K. Najjar B.O. Zain S.M. Abdullah Z. Wahab H.A. Rahman N.A. QSAR, in silico docking and in vitro evaluation of chalcone derivatives as potential inhibitors for H1N1 virus neuraminidase Med. Chem. Res. 2016 25 2133 2142 10.1007/s00044-016-1636-5 

  41. 41. Gerrits S.W. Cianci C. Kim S. Pearce B.C. Deminie C. Discotto L. McAuliffe B. Minassian B.F. Shi S. Zhu S. Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers Proc. Natl. Acad. Sci. USA 2011 108 15366 15371 10.1073/pnas.1107906108 21896751 

  42. 42. Obayashi E. Yoshida H. Kawai F. Shibayama N. Kawaguchi A. Nagata K. Tame J.R.H. Park S.-Y. The structural basis for an essential subunit interaction in influenza virus RNA polymerase Nature 2008 454 1127 1131 10.1038/nature07225 18660801 

  43. 43. Vavricka C.J. Li Q. Wu Y. Qi J. Wang M. Liu Y. Gao F. Liu J. Feng E. He J. Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition PLoS Pathog. 2011 7 10.1371/journal.ppat.1002249 

  44. 44. Collins P.J. Haire L.F. Lin Y.P. Liu J. Russell R.J. Walker P.A. Skehel J.J. Martin S.R. Hay A.J. Gamblin S.J. Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants Nature 2008 453 1258 1261 10.1038/nature06956 18480754 

  45. 45. Otsuka H. Tamaki A. Platanionosides D-J: Megastigmane glycosides from the Leaves of Alangium platanifolium (SIEB. Et ZUCC.) HARMS var. platanifolium Chem. Pharm. Bull. 2002 50 390 394 10.1248/cpb.50.390 11911204 

  46. 46. Agrawal P. NMR spectroscopy in the structural elucidation of oligosaccharides and glycosides Phytochemistry 1992 31 3307 3330 10.1016/0031-9422(92)83678-R 1368855 

  47. 47. Kasai R. Suzuo M. Asakawa J. Tanaka O. Carbon-13 chemical shifts of isoprenoid-β-D-glucopyranosides and -β-D-mannopyranosides. Stereochemical influences of aglycones alcohols Tetrahedron Lett. 1977 2 175 178 10.1016/S0040-4039(01)92581-X 

  48. 48. Corral J.M.M.D. Gordaliza M. Salinero M.A. San Feliciano A. 13 C NMR data for abieta-8,11,13-triene diterpenoids Magn. Reson. Chem. 1994 32 774 781 10.1002/mrc.1260321211 

  49. 49. Kinouchi Y. Ohtsu H. Tokuda H. Nishino H. Matsunaga S. Tanaka R. Potential antitumor-promoting diterpenoids from the stem bark of Picea glehni J. Nat. Prod. 2000 63 817 820 10.1021/np0000217 10869208 

  50. 50. Wu L. Li Y.-L. Li S.-M. Yang X.-W. Xia J.-H. Zhou L. Zhang W.-D. Systematic phytochemical investigation of Abies spectabilis Chem. Pharm. Bull. 2010 58 1646 1649 10.1248/cpb.58.1646 21139272 

  51. 51. Cheung H.T.A. Miyase T. Lenguyen M.P. Smal M.A. Further acidic constituents and neutral components of Pinus massoniana Resin Tetrahedron 1973 49 7903 7915 10.1016/S0040-4020(01)88015-7 

  52. 52. Yang X.-W. Li S.-M. Feng L. Shen Y.-H. Tian J.-M. Liu X.-H. Zeng H.-W. Zhang C. Zhang W.-D. Abiesanordines A-N: Fourteen new norditerpenes from Abies georgei Tetrahedron 2008 64 4354 4362 10.1016/j.tet.2008.02.069 

  53. 53. Tanaka R. Ohtsu H. Matsunaga S. Abietane diterpene acids and other constituents from the leaves of Larix kaempferi Phytochemistry 1997 46 1051 1057 10.1016/S0031-9422(97)84396-8 

  54. 54. Georges P. Legault J. Lavoie S. Grenon C. Pichette A. Diterpenoids from the buds of Pinus banksiana Lamb Molecules 2012 17 9716 9727 10.3390/molecules17089716 22890174 

  55. 55. Ohtsu H. Tanaka R. Matsunaga S. Tokuda H. Nishino H. Anti-tumor-promoting rearranged abietane diterpenes from the leaves of Larix kaempferi Planta Med. 1999 65 664 966 10.1055/s-2006-960843 10575382 

  56. 56. Landucci L.L. Zinkel D.F. The 1 H and 13 C NMR spectra of the abietadienoic resin acids Holzforschung 1991 45 341 346 10.1515/hfsg.1991.45.5.341 

  57. 57. Zhang Y.-M. Gong Q.-F. Yang J.-Q. Zeng G.-Z. Tan N.-H. Antioxidant constituents from Pinus massoniana Plant Divers. Resour. 2013 35 209 215 

  58. 58. Ohtsu H. Tanaka R. In Y. Matsunaga S. Tokuda H. Nishino H. New abietane diterpenoids from the cones of Larix kaempferi Can. J. Chem. 2000 78 31 40 10.1139/v99-218 

  59. 59. Barrero A.F. Sanchez J.F. Alvarez-Manzaneda E.J.R. Dorado M.M. Haidour A. Endoperoxide diterpenoids and other constituents from Abies marocana Phytochemistry 1991 30 593 597 10.1016/0031-9422(91)83732-Z 

  60. 60. Feng T. Cai X.-H. Tan Q.-G. Luo X.-D. Abietane diterpenoids and a lignin from Pinus yunnanensis Z. Naturforsch. 2010 2010 765 769 10.1515/znb-2010-0614 

  61. 61. Kitajima J. Noda N. Ida Y. Komori T. Kawasaki T. Studies on the constituents of the crude drug “Fritillariae Bulbus.” IV. On the diterpenoid constituents of the crude drug “Fritillariae Bulbus” Chem. Pharm. Bull. 1982 30 3922 3931 10.1248/cpb.30.3922 

  62. 62. Fukushima J. Yatagai M. Ohira T. Abietane-type and labdane-type diterpenoids from the cones of Chamaecyparis obtuse J. Wood. Sci. 2002 48 326 330 10.1007/BF00831355 

  63. 63. Du J. Wang M.-L. Chen R.-Y. Yu D.-Q. Two new bislabdane-type diterpenoids and three new diterpenoids from the roots of Cunninghamia lanceolata Planta Med. 2001 67 542 547 10.1055/s-2001-16491 11509976 

  64. 64. Bohlmann F. Czerson H. Neue labdan- und pimaren-derivate aus Palafoxia rosea Phytochemistry 1979 18 115 118 10.1016/S0031-9422(00)90926-9 

  65. 65. Bohlmann F. Adler A. King R.M. Robinson H. Ent-labdanes from Mikania alvimii Phytochemistry 1982 21 173 176 10.1016/0031-9422(82)80037-X 

  66. 66. Moon C. Kwak J.H. Kim Y.B. Jeon Y.Y. Lee H.J. A composition comprising the extract of pine tree leaf or the compounds isolated therefrom for the prevention and treatment of cancer disease by inhibiting HPV virus and the uses thereby U.S. Patent Application No. 14/366,093 5 12 2013 

  67. 67. Zhang Y.-S. Zhang Q.-Y. Wang B. Li L.-Y. Zhao Y.-Y. Chemical constituents from Ampelopsis grossedentata J. Chin. Pharm. 2006 15 211 214 

  68. 68. Yue R. Li B. Shen Y. Zeng H. Li B. Yuan H. He Y. Shan L. Zhang W. 6-C-methyl flavonoids isolated from Pinus densata inhibit the proliferation and promote the apoptosis of the HL-60 human promyelocytic leukaemia cell line Planta Med. 2013 79 1024 1030 10.1055/s-0033-1350617 23877923 

  69. 69. Abou-Zaid M. Dumas M. Chauret D. Watson A. Thompson D. C-methyl flavonols from the fungus Colletotrichum dematium f.sp. epilobii Phytochemistry 1997 45 957 961 10.1016/S0031-9422(97)00083-6 

  70. 70. Lin S. Zhang Y. Liu M. Yang S. Gan M. Zi J. Song W. Fan X. Wang S. Liu Y. Abietane and C20-norabietane diterpenes from the stem bark of Fraxinus sieboldiana and their biological activities J. Nat. Prod. 2010 73 1914 1921 10.1021/np100583u 20961093 

  71. 71. Hirata A. Kim S.Y. Kobayakawa N. Tanaka N. Kashiwada Y. Miltiorins A-D, diterpenes from radix Salviae miltiorrhizae Fitoterapia 2015 102 49 55 10.1016/j.fitote.2015.01.013 25644525 

  72. 72. Li J.-C. Zhang Z.-J. Yang T. Jiang M.-Y. Liu D. Li H.-M. Li R.-T. Six new ent-abietane-type diterpenoids from the stem bark of Euphorbia neriifolia Phytochem. Lett. 2019 34 13 17 10.1016/j.phytol.2019.09.003 

  73. 73. Liu A.-L. Wang H.-D. Lee S.M. Wang Y.-T. Du G.-H. Structure-activity relationship of flavonoids as influenza virus neuraminidase inhibitors and their in vitro anti-viral activities Bioorg. Med. Chem. 2008 16 7141 7147 10.1016/j.bmc.2008.06.049 18640042 

  74. 74. Moscona A. Neuraminidase inhibitors of influenza N. Engl. J. Med. 2005 353 1363 1373 10.1056/NEJMra050740 16192481 

  75. 75. Han Q. Chang C. Li L. Klenk C. Cheng J. Chen Y. Xia N. Shu Y. Chen Z. Gabriel G. Sumoylation of influenza A virus nucleoprotein is essential for intracellular trafficking and virus growth J. Virol. 2014 88 9379 9390 10.1128/JVI.00509-14 24920808 

  76. 76. Liao T.-L. Wu C.-Y. Su W.-C. Jeng K.-S. Lai M.M.C. Ubiquitination and deubiquitination of NP protein regulates influenza A virus RNA replication EMBO J. 2010 29 3879 3890 10.1038/emboj.2010.250 20924359 

  77. 77. Cianci C. Gerritz S.W. Deminie C. Krystal M. Influenza nucleoprotein: Promising target for antiviral chemotherapy Antivir. Chem. Chemother. 2012 23 77 91 10.3851/IMP2235 22837443 

  78. 78. Dou D. Revol R. Ostbye H. Wang H. Daniels R. Influenza A virus cell entry, replication, virion assembly and movement Front. Immunol. 2018 9 1581 10.3389/fimmu.2018.01581 30079062 

  79. 79. Guilligay D. Tarendeau F. Resa-Infante T. Coloma R. Crepin T. Sehr P. Lewis J. Ruigrok R.W. Ortin J. Hart D.J. The structural basis for cap binding by influenza virus polymerase subunit PB2 Nat. Struct. Mol. Biol. 2008 15 500 506 10.1038/nsmb.1421 18454157 

  80. 80. Dias A. Bouvier D. Crepin T. McCarthy A.A. Hart D.J. Baudin F. Cusack S. Ruigrok R.W. The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit Nature 2009 458 914 918 10.1038/nature07745 19194459 

  81. 81. Herold S. Becker C. Ridge K.M. Budinger G.R. Influenza virus-induced lung injury: Pathogenesis and implications for treatment Eur. Respir. J. 2015 45 1463 1478 10.1183/09031936.00186214 25792631 

  82. 82. Julkunen I. Melen K. Nyqvist M. Pirhonen J. Sareneva T. Matikainen S. Inflammatory responses in influenza a virus infection Vaccine 2000 19 S32 S37 10.1016/S0264-410X(00)00275-9 11163460 

  83. 83. Peiris J.S.M. Hui K.P.Y. Yen H.-L. Host response to Influenza virus: Protection versus immunopathology Curr. Opin. Immunol. 2010 22 475 481 10.1016/j.coi.2010.06.003 20594815 

LOADING...

관련 콘텐츠

오픈액세스(OA) 유형

GOLD

오픈액세스 학술지에 출판된 논문

이 논문과 함께 이용한 콘텐츠

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로