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Frontiers in cellular neuroscience, v.13, 2020년, pp.568 -
Shen, Yang (Medicine School, Shandong University , Jinan , China) , Ding, Mao (Medicine School, Shandong University , Jinan , China) , Xie, Zhaohong (Department of Neurology Medicine, Second Hospital of Shandong University , Jinan , China) , Liu, Xiangtian (Medicine School, Shandong University , Jinan , China) , Yang, Hui (Department of Neurology Medicine, Second Hospital of Shandong University , Jinan , China) , Jin, Suqin (Department of Neurology Medicine, Second Hospital of Shandong University , Jinan , China) , Xu, Shunliang (Department of Neurology Medicine, Second Hospital of Shandong University , Jinan , China) , Zhu, Zhengyu (Department of Neurology Medicine, Second Hospital of Shandong University , Jinan , China) , Wang, Yun (Department of Neurology Medicine, Second Hospital of Shandong University , Jinan , China) , Wang, Dewei (Department of Neurology Medicine, Second Hospital of Sh) , Xu, Linlin , Zhou, Xiaoyan , Wang, Ping , Bi, Jianzhong
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Alzheimer disease (AD) is the most common form of dementia. Amyloid β-peptide (Aβ) deposition is a major neuropathologic feature of AD. When unfolded or misfolded proteins accumulate in mitochondria, the unfolded protein responses (UPRmt) is initiated. Numerous lines of evidence show that ...
Baker B. M. Nargund A. M. Sun T. Haynes C. M. ( 2012 ). Protective coupling of mitochondrial function and protein synthesis via the eIF2α kinase GCN-2 . PLoS Genet. 8 : e1002760 . 10.1371/journal.pgen.1002760 22719267
Beck J. S. Mufson E. J. Counts S. E. ( 2016 ). Evidence for mitochondrial UPR gene activation in familial and sporadic Alzheimer’s disease . Curr. Alzheimer Res. 13 , 610 ？ 614 . 10.2174/1567205013666151221145445 26687188
Bennett C. F. Vander Wende H. Simko M. Klum S. Barfield S. Choi H. . ( 2014 ). Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans . Nat. Commun. 5 : 3483 . 10.1038/ncomms4483 24662282
Blackstone N. W. ( 2015 ). The impact of mitochondrial endosymbiosis on the evolution of calcium signaling . Cell Calcium 57 , 133 ？ 139 . 10.1016/j.ceca.2014.11.006 25481706
Borchelt D. R. Thinakaran G. Eckman C. B. Lee M. K. Davenport F. Ratovitsky T. . ( 1996 ). Familial Alzheimer’s disease-linked presenilin 1 variants elevate Aβ1？42/1？40 ratio in vitro and in vivo . Neuron 17 , 1005 ？ 1013 . 10.1016/s0896-6273(00)80230-5 8938131
Caspersen C. Wang N. Yao J. Sosunov A. Chen X. Lustbader J. W. . ( 2005 ). Mitochondrial Aβ: a potential focal point for neuronal metabolic dysfunction in Alzheimer’s disease . FASEB J. 19 , 2040 ？ 2041 . 10.1096/fj.05-3735fje 16210396
Da Costa Dias B. Jovanovic K. Gonsalves D. Weiss S. F. ( 2011 ). Structural and mechanistic commonalities of amyloid-β and the prion protein . Prion 5 , 126 ？ 137 . 10.4161/pri.5.3.17025 21862871
Durieux J. Wolff S. Dillin A. ( 2011 ). The cell-non-autonomous nature of electron transport chain-mediated longevity . Cell 144 , 79 ？ 91 . 10.1016/j.cell.2010.12.016 21215371
Epstein S. Kirkpatrick C. L. Castillon G. A. Muniz M. Riezman I. David F. P. . ( 2012 ). Activation of the unfolded protein response pathway causes ceramide accumulation in yeast and INS-1E insulinoma cells . J. Lipid Res. 53 , 412 ？ 420 . 10.1194/jlr.m022186 22210926
Geekiyanage H. Chan C. ( 2011 ). MicroRNA-137/181c regulates serine palmitoyltransferase and in turn amyloid β, novel targets in sporadic Alzheimer’s disease . J. Neurosci. 31 , 14820 ？ 14830 . 10.1523/jneurosci.3883-11.2011 21994399
Goldstein J. L. Brown M. S. ( 1990 ). Regulation of the mevalonate pathway . Nature 343 , 425 ？ 430 . 10.1038/343425a0 1967820
Han X. Holtzman D. M. Mckeel D. W. Jr. Kelley J. Morris J. C. ( 2002 ). Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer’s disease: potential role in disease pathogenesis . J. Neurochem. 82 , 809 ？ 818 . 10.1046/j.1471-4159.2002.00997.x 12358786
Hanada K. ( 2003 ). Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism . Biochim. Biophys. Acta 1632 , 16 ？ 30 . 10.1016/s1388-1981(03)00059-3 12782147
Harkany T. Abraham I. Timmerman W. Laskay G. Toth B. Sasvari M. . ( 2000 ). β-amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in rat nucleus basalis . Eur. J. Neurosci. 12 , 2735 ？ 2745 . 10.1046/j.1460-9568.2000.00164.x 10971616
Haynes C. M. Ron D. ( 2010 ). The mitochondrial UPR―protecting organelle protein homeostasis . J. Cell Sci. 123 , 3849 ？ 3855 . 10.1242/jcs.075119 21048161
Hojjati M. R. Li Z. Zhou H. Tang S. Huan C. Ooi E. . ( 2005 ). Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient mice . J. Biol. Chem. 280 , 10284 ？ 10289 . 10.1074/jbc.m412348200 15590644
Holland W. L. Brozinick J. T. Wang L. P. Hawkins E. D. Sargent K. M. Liu Y. . ( 2007 ). Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat- and obesity-induced insulin resistance . Cell Metab. 5 , 167 ？ 179 . 10.1016/j.cmet.2007.01.002 17339025
Hornemann T. Richard S. Rutti M. F. Wei Y. Von Eckardstein A. ( 2006 ). Cloning and initial characterization of a new subunit for mammalian serine-palmitoyltransferase . J. Biol. Chem. 281 , 37275 ？ 37281 . 10.1074/jbc.m608066200 17023427
Hornemann T. Wei Y. von Eckardstein A. ( 2007 ). Is the mammalian serine palmitoyltransferase a high-molecular-mass complex? Biochem. J. 405 , 157 ？ 164 . 10.1042/bj20070025 17331073
Houtkooper R. H. Mouchiroud L. Ryu D. Moullan N. Katsyuba E. Knott G. . ( 2013 ). Mitonuclear protein imbalance as a conserved longevity mechanism . Nature 497 , 451 ？ 457 . 10.1038/nature12188 23698443
Kang J. Lemaire H. G. Unterbeck A. Salbaum J. M. Masters C. L. Grzeschik K. H. . ( 1987 ). The precursor of Alzheimer’s disease amyloid A4 protein resembles a cell-surface receptor . Nature 325 , 733 ？ 736 . 10.1038/325733a0 2881207
Katsel P. Li C. andHaroutunian V. ( 2007 ). Gene expression alterations in the sphingolipid metabolism pathways during progression of dementia and Alzheimer’s disease: a shift toward ceramide accumulation at the earliest recognizable stages of Alzheimer’s disease? Neurochem. Res. 32 , 845 ？ 856 . 10.1007/s11064-007-9297-x 17342407
Lamech L. T. Haynes C. M. ( 2015 ). The unpredictability of prolonged activation of stress response pathways . J. Cell Biol. 209 , 781 ？ 787 . 10.1083/jcb.201503107 26101215
Lanzillotta C. Tramutola A. Meier S. Schmitt F. Barone E. Perluigi M. . ( 2018 ). Early and selective activation and subsequent alterations to the unfolded protein response in down syndrome mouse models . J. Alzheimers Dis. 62 , 347 ？ 359 . 10.3233/jad-170617 29439332
Lepine S. Allegood J. C. Park M. Dent P. Milstien S. Spiegel S. ( 2011 ). Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy . Cell Death Differ. 18 , 350 ？ 361 . 10.1038/cdd.2010.104 20798685
Lin Y. F. Schulz A. M. Pellegrino M. W. Lu Y. Shaham S. Haynes C. M. ( 2016 ). Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response . Nature 533 , 416 ？ 419 . 10.1038/nature17989 27135930
Liu Y. Samuel B. S. Breen P. C. Ruvkun G. ( 2014 ). Caenorhabditis elegans pathways that surveil and defend mitochondria . Nature 508 , 406 ？ 410 . 10.1038/nature13204 24695221
Lustbader J. W. Cirilli M. Lin C. Xu H. W. Takuma K. Wang N. . ( 2004 ). ABAD directly links Aβ to mitochondrial toxicity in Alzheimer’s disease . Science 304 , 448 ？ 452 . 10.1126/science.1091230 15087549
Manczak M. Anekonda T. S. Henson E. Park B. S. Quinn J. Reddy P. H. ( 2006 ). Mitochondria are a direct site of Aβ accumulation in Alzheimer’s disease neurons: implications for free radical generation and oxidative damage in disease progression . Hum. Mol. Genet. 15 , 1437 ？ 1449 . 10.1093/hmg/ddl066 16551656
Mielke M. M. Bandaru V. V. Haughey N. J. Rabins P. V. Lyketsos C. G. Carlson M. C. ( 2010 ). Serum sphingomyelins and ceramides are early predictors of memory impairment . Neurobiol. Aging 31 , 17 ？ 24 . 10.1016/j.neurobiolaging.2008.03.011 18455839
Mielke M. M. Haughey N. J. ( 2012 ). Could plasma sphingolipids be diagnostic or prognostic biomarkers for Alzheimer’s disease? Clin. Lipidol. 7 , 525 ？ 536 . 10.2217/clp.12.59 23606909
Oks O. Lewin S. Goncalves I. L. Sapir A. ( 2018 ). The UPR mt protects Caenorhabditis elegans from mitochondrial dysfunction by upregulating specific enzymes of the mevalonate pathway . Genetics 209 , 457 ？ 473 . 10.1534/genetics.118.300863 29599115
Papa L. Germain D. ( 2011 ). Estrogen receptor mediates a distinct mitochondrial unfolded protein response . J. Cell Sci. 124 , 1396 ？ 1402 . 10.1242/jcs.078220 21486948
Pellegrino M. W. Nargund A. M. Haynes C. M. ( 2013 ). Signaling the mitochondrial unfolded protein response . Biochim. Biophys. Acta 1833 , 410 ？ 416 . 10.1016/j.bbamcr.2012.02.019 22445420
Perry D. K. Carton J. Shah A. K. Meredith F. Uhlinger D. J. Hannun Y. A. ( 2000 ). Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis . J. Biol. Chem. 275 , 9078 ？ 9084 . 10.1074/jbc.275.12.9078 10722759
Pettus B. J. Chalfant C. E. Hannun Y. A. ( 2002 ). Ceramide in apoptosis: an overview and current perspectives . Biochim. Biophys. Acta 1585 , 114 ？ 125 . 10.1016/s1388-1981(02)00331-1 12531544
Pleckaityte M. ( 2010 ). [Alzheimer’s disease: a molecular mechanism, new hypotheses and therapeutic strategies] . Medicina 46 , 70 ？ 76 . 10.3390/medicina46010011 20234166
Ranji P. Rauthan M. Pitot C. Pilon M. ( 2014 ). Loss of HMG-CoA reductase in C. elegans causes defects in protein prenylation and muscle mitochondria . PLoS One 9 : e100033 . 10.1371/journal.pone.0100033 24918786
Runkel E. D. Liu S. Baumeister R. Schulze E. ( 2013 ). Surveillance-activated defenses block the ROS-induced mitochondrial unfolded protein response . PLoS Genet. 9 : e1003346 . 10.1371/journal.pgen.1003346 23516373
Sapir A. Tsur A. Koorman T. Ching K. Mishra P. Bardenheier A. . ( 2014 ). Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging . Proc. Natl. Acad. Sci. U S A 111 , E3880 ？ E3889 . 10.1073/pnas.1414748111 25187565
Scarlatti F. Sala G. Somenzi G. Signorelli P. Sacchi N. Ghidoni R. ( 2003 ). Resveratrol induces growth inhibition and apoptosis in metastatic breast cancer cells via de novo ceramide signaling . FASEB J. 17 , 2339 ？ 2341 . 10.1096/fj.03-0292fje 14563682
Selkoe D. J. ( 2001 ). Alzheimer’s disease: genes, proteins, and therapy . Physiol. Rev. 81 , 741 ？ 766 . 10.1152/physrev.2001.81.2.741 11274343
Skovronsky D. M. Lee V. M. Trojanowski J. Q. ( 2006 ). Neurodegenerative diseases: new concepts of pathogenesis and their therapeutic implications . Annu. Rev. Pathol. 1 , 151 ？ 170 . 10.1146/annurev.pathol.1.110304.100113 18039111
Sorrentino V. Romani M. Mouchiroud L. Beck J. S. Zhang H. D’Amico D. . ( 2017 ). Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity . Nature 552 , 187 ？ 193 . 10.1038/nature25143 29211722
Spassieva S. D. Mullen T. D. Townsend D. M. Obeid L. M. ( 2009 ). Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response . Biochem. J. 424 , 273 ？ 283 . 10.1042/bj20090699 19728861
Spiegel S. Merrill A. H. Jr. ( 1996 ). Sphingolipid metabolism and cell growth regulation . FASEB J. 10 , 1388 ？ 1397 . 10.1096/fasebj.10.12.8903509 8903509
Swerdlow R. H. ( 2007 ). Pathogenesis of Alzheimer’s disease . Clin. Interv. Aging 2 , 347 ？ 359 . 18044185
Tatsuta T. Langer T. ( 2008 ). Quality control of mitochondria: protection against neurodegeneration and ageing . EMBO J. 27 , 306 ？ 314 . 10.1038/sj.emboj.7601972 18216873
Wang C. Youle R. J. ( 2009 ). The role of mitochondria in apoptosis* . Annu. Rev. Genet. 43 , 95 ？ 118 . 10.1146/annurev-genet-102108-134850 19659442
Westerlund M. Behbahani H. Gellhaar S. Forsell C. Belin A. C. Anvret A. . ( 2011 ). Altered enzymatic activity and allele frequency of OMI/HTRA2 in Alzheimer’s disease . FASEB J. 25 , 1345 ？ 1352 . 10.1096/fj.10-163402 21163861
Zhao Q. Wang J. Levichkin I. V. Stasinopoulos S. Ryan M. T. Hoogenraad N. J. ( 2002 ). A mitochondrial specific stress response in mammalian cells . EMBO J. 21 , 4411 ？ 4419 . 10.1093/emboj/cdf445 12198143
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