[논문]Apolipoprotein E genotypes predict attendance rates at lipid clinic

doi:10.1016/S0021-9150(00)00429-9

[해외논문] Apolipoprotein E genotypes predict attendance rates at lipid clinic

Atherosclerosis, v.153 no.2, 2000년, pp.461 - 468

Frikke-Schmidt, Ruth (Department of Clinical Biochemistry, Herlev University Hospital, DK-2730 Herlev, Denmark) , Wittrup, Hans H (Department of Clinical Biochemistry, Herlev University Hospital, DK-2730 Herlev, Denmark) , Tybjærg-Hansen, Anne (Department of Clinical Biochemistry, Herlev University Hospital, DK-2730 Herlev, Denmark) , Meinertz, Hans (Department of Medicine B, Division of Cardiology, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark) , Schnohr, Peter (The Copenhagen City Heart Study, Bispebjerg University Hospital, DK-2400, Copenhagen NV, Denmark) , Nordestgaard, Børge G (The Copenhagen City Heart Study, Bispebjerg University Hospital, DK-2400, Copenhagen NV, Denmark)

Abstract ▼ AI-Helper

AbstractExcept for the rare ε22 genotype it remains largely unsettled whether apolipoprotein E genotype influences an individual's referral to lipid clinics. To test this hypothesis, we compared genotype distributions among 156 hypercholesterolemic and 83 hypertriglyceridemic patients attending a lipid clinic with that among 9241 individuals sampled from the Danish general population. The relative genotype frequencies of ε22, ε32, ε42, ε33, ε43, and ε44 were 0.005, 0.126, 0.026, 0.564, 0.251, and 0.027 in the general population, which differed from genotype frequencies in both hypercholesterolemic (χ2: P=0.01) and hypertriglyceridemic patients (χ2: P<0.001). By comparison with ε33, ε44 predicted a 2-fold increase whereas ε32 predicted a 2-fold decrease in the attendance rate at the lipid clinic for hypercholesterolemic patients (95% confidence intervals: 1.1–4.3 and 0.2–0.9). Among hypertriglyceridemic patients, ε22, ε42, ε43, and ε44 versus ε33 predicted 13-, 3-, 112-, and 3-fold attendance rates at the lipid clinic, respectively (95% confidence intervals: 4.5–39.9, 1.2–8.4, 1.0–2.8, and 1.1–7.6). These findings are in accordance with the fact that ε44 raises cholesterol levels, ε32 reduces cholesterol levels, and ε22, ε42, ε43, and ε44 raise triglyceride levels in comparison with ε33. These data suggest that hypercholesterolemic individuals carrying ε44 and hypertriglyceridemic individuals carrying ε22, ε42, ε43, or ε44 are relatively more often referred to lipid clinics than carriers of ε33.

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참고문헌 (36)

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[해외논문] Apolipoprotein E genotypes predict attendance rates at lipid clinic

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