[논문]Correlation of MTS1/p16 and nm23 mRNA expression with survival in patients with peripheral synovial sarcoma

Golouh, Rastko; Stanta, Giorgio; Brač; ko, Matej; Bonin, Serena

doi:10.1002/1096-9098(200102)76:2<83::AID-JSO1015>3.0.CO;2-R

[해외논문] Correlation of MTS1/p16 and nm23 mRNA expression with survival in patients with peripheral synovial sarcoma

Journal of surgical oncology, v.76 no.2, 2001년, pp.83 - 88

Golouh, Rastko (Institute of Oncology, Ljubljana, Slovenia) , Stanta, Giorgio (Pathology Department, University of Trieste and International Centre for Genetic Engineering and Biotechnology, Trieste, Italy) , Bračko, Matej (Institute of Oncology, Ljubljana, Slovenia) , Bonin, Serena (Pathology Department, University of Trieste and International Centre for Genetic Engineering and Biotechnology, Trieste, Italy)

Abstract ▼ AI-Helper

Background and ObjectivesTumor supressor gene MTS1/p16 (cyclin-dependent kinase-4 inhibitor) and a putative tumor metastasis supressor gene nm23 (nucleoside diphosphate A kinase) have been identified in a variety of human tumors but have not been well studied in mesenchymal neoplasms.MethodsExpression of nm23 and MTS1 mRNA was determined by quantitative analysis from paraffin-embedded tumor tissue. The series comprised 31 patients with localized primary synovial sarcoma of soft tissues who were followed for a median of 83 months.ResultsNeither MTS1 nor nm23 expression levels correlated with the patient's age or sex, tumor type, depth, size, mitotic rate, or extent of tumor necrosis. In addition, there was no correlation between MTS1 and nm23 levels. Patients' survival was not related to sex, age, tumor type, location, mitotic rate, or MTS1 mRNA level. The only factors that correlated with poor survival in multivariate analysis were the presence of extensive tumor necrosis (> 15%) and higher levels of nm23 mRNA.ConclusionsOur results suggest that increased expression level of nm23 mRNA may be implicated in the mechanism of tumor progression and is associated with poor survival in patients with synovial sarcoma. J. Surg. Oncol. 2001;76:83–88. © 2001 Wiley-Liss, Inc.

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참고문헌 (70)

Cancer Cagle 59 1810 1987 10.1002/1097-0142(19870515)59:10<1810::AID-CNCR2820591021>3.0.CO;2-R

상세보기
J Surg Oncol Golouh 45 20 1990 10.1002/jso.2930450106

상세보기
Am J Surg Pathol Oda 17 35 1993 10.1097/00000478-199301000-00004

상세보기
Gene Tulchinski 87 219 1990 10.1016/0378-1119(90)90305-B

상세보기
J Natl Cancer Inst Steeg 80 200 1988 10.1093/jnci/80.3.200

상세보기
Soft Tissue Tumors Enzinger 757 1995 : Synovial sarcoma. In (eds.). ?Soft Tissue Tumors,? 3rd ed. St. Louis: Mosby; 1995; 757-786.
BioTechniques Stanta 11 304 1991

상세보기
Methods in Molecular Biology: RNA Isolation and Characterization Protocols Stanta 86 23 1998 10.1385/0-89603-494-1:23 : RNA extraction from formalin-fixed and paraffin-embedded tissues. In (eds). ?Methods in Molecular Biology: RNA Isolation and Characterization Protocols,? vol 86, chap. 5. Totowa, NY: Human Press, 1998; 23-26.
Methods in Molecular Biology: RNA Isolation and Characterization Protocols Stanta 86 113 1998 10.1385/0-89603-494-1:113 : RNA quantitative analysis from fixed and paraffin-embedded tissues. In (eds). Methods in Molecular Biology: RNA Isolation and Characterization Protocols, vol 86, Chap. 13. Humana Press, NY: Totowa, 1998; 113-119.
BioTechniques Stanta 24 271 1998 10.2144/98242st04

상세보기
Am J Surg Pathol Soule 10 78 1986

상세보기
Radiother Oncol Mullen 33 23 1994 10.1016/0167-8140(94)90082-5

상세보기
J Clin Oncol Singer 14 1201 1996 10.1200/JCO.1996.14.4.1201

상세보기
Cancer el-Naggar 65 2295 1990 10.1002/1097-0142(19900515)65:10<2295::AID-CNCR2820651022>3.0.CO;2-7

상세보기
Cancer Oda 72 478 1993 10.1002/1097-0142(19930715)72:2<478::AID-CNCR2820720225>3.0.CO;2-P

상세보기
Chin Med J Lu 108 760 1995

상세보기
Anal Cell Pathol Lopes 16 45 1998 10.1155/1998/545906

상세보기
N Engl J Med Kawai 338 153 1998 10.1056/NEJM199801153380303

상세보기
Hum Pathol Cohen 28 893 1997 10.1016/S0046-8177(97)90003-4

상세보기
J Pathol Meye 184 14 1998 10.1002/(SICI)1096-9896(199801)184:1<14::AID-PATH957>3.0.CO;2-K

상세보기
Int J Oncol Schneider-Stock 13 325 1998

상세보기
Clin Cancer Res Yao 4 1065 1998

상세보기
Br J Cancer Royds 75 1195 1997 10.1038/bjc.1997.204

상세보기
Melanoma Res Caligo 4 179 1994 10.1097/00008390-199406000-00006

상세보기
Br J Cancer Xerri 70 1224 1994 10.1038/bjc.1994.477

상세보기
Pathology Lee 28 220 1996 10.1080/00313029600169014

상세보기
J Natl Cancer Inst Hennessy 83 281 1991 10.1093/jnci/83.4.281

상세보기
J Natl Cancer Inst Hirayama 83 1249 1991 10.1093/jnci/83.17.1249

상세보기
Int J Cancer Tokunaga 55 66 1993 10.1002/ijc.2910550113

상세보기
J Surg Oncol Han 65 22 1997 10.1002/(SICI)1096-9098(199705)65:1<22::AID-JSO5>3.0.CO;2-Q

상세보기
Hum Pathol Bertheau 29 323 1998 10.1016/S0046-8177(98)90111-3

상세보기
Cancer Sauer 84 109 1998 10.1002/(SICI)1097-0142(19980425)84:2<109::AID-CNCR7>3.0.CO;2-K

상세보기
Cancer Yamaguchi 73 2280 1994 10.1002/1097-0142(19940501)73:9<2280::AID-CNCR2820730908>3.0.CO;2-3

상세보기
Int J Urol Kanayama 1 324 1994 10.1111/j.1442-2042.1994.tb00058.x

상세보기
Cancer Mandai 75 2523 1995 10.1002/1097-0142(19950515)75:10<2523::AID-CNCR2820751019>3.0.CO;2-L

상세보기
Gynecol Oncol Kristensen 61 378 1996 10.1006/gyno.1996.0160

상세보기
Br J Cancer Marone 74 1063 1996 10.1038/bjc.1996.490

상세보기
J Clin Oncol Scambia 14 334 1996 10.1200/JCO.1996.14.2.334

상세보기
Ann Thorac Surg Lai 62 1500 1996 10.1016/0003-4975(96)00603-0

상세보기
Lung Cancer Kawakubo 17 103 1997 10.1016/S0169-5002(97)00653-3

상세보기
J Korean Med Sci Kim 10 406 1995 10.3346/jkms.1995.10.6.406

상세보기
Surg Today Ura 26 957 1996 10.1007/BF00309953

상세보기
Cancer Kodera 73 259 1994 10.1002/1097-0142(19940115)73:2<259::AID-CNCR2820730205>3.0.CO;2-V

상세보기
J Surg Oncol Patel 65 111 1997 10.1002/(SICI)1096-9098(199706)65:2<111::AID-JSO7>3.0.CO;2-A

상세보기
Oral Oncol Ohtsuki 33 237 1997 10.1016/S0964-1955(97)00020-1

상세보기
Cancer Lee 77 2246 1996 10.1002/(SICI)1097-0142(19960601)77:11<2246::AID-CNCR10>3.0.CO;2-X

상세보기
Eur J Cancer Gunduz 33 2338 1997 10.1016/S0959-8049(97)00321-3

상세보기
Br J Cancer Easty 74 109 1996 10.1038/bjc.1996.323

상세보기
J Cutan Pathol Holmes 23 344 1996 10.1111/j.1600-0560.1996.tb01308.x

상세보기
Histopathology Saitoh 29 497 1996 10.1046/j.1365-2559.1996.d01-537.x

상세보기
Melanoma Res van den Oord 7 121 1997 10.1097/00008390-199704000-00006

상세보기
J Pathol Sawan 172 27 1994 10.1002/path.1711720107

상세보기
Cancer Russell 79 1158 1997 10.1002/(SICI)1097-0142(19970315)79:6<1158::AID-CNCR14>3.0.CO;2-Z

상세보기
Anticancer Res Theisinger 18 1185 1998
Int J Urol Kanayama 1 324 1994 10.1111/j.1442-2042.1994.tb00058.x

상세보기
Cancer Shiina 78 1762 1996 10.1002/(SICI)1097-0142(19961015)78:8<1762::AID-CNCR17>3.0.CO;2-W

상세보기
Eur J Cardiothorac Surg MacKinnon 11 838 1997 10.1016/S1010-7940(97)01162-7

상세보기
Br J Cancer Higashiyama 66 533 1992 10.1038/bjc.1992.308

상세보기
Arch Otolaryngol Head Neck Surg Takes 123 412 1997 10.1001/archotol.1997.01900040048008

상세보기
J Natl Cancer Inst Myeroff 85 147 1993 10.1093/jnci/85.2.147

상세보기
Oncol Rep Heys 5 735 1998
Int J Cancer Engel 55 375 1993 10.1002/ijc.2910550306

상세보기
Clin Exp Metastasis Nakamori 11 151 1993 10.1007/BF00114973

상세보기
J Korean Med Sci Park 10 258 1995 10.3346/jkms.1995.10.4.258

상세보기
Histopathology Nakopoulou 28 429 1996 10.1046/j.1365-2559.1996.336375.x

상세보기
Virchows Arch Holm 428 85 1996 10.1007/BF00193935

상세보기
Cancer Lett Indinnimeo 111 1 1997 10.1016/S0304-3835(96)04472-2

상세보기
World J Surg Berney 22 484 1998 10.1007/s002689900421

상세보기
Oncogene Leone 8 855 1993

상세보기
Br J Cancer Takeda 74 1620 1996 10.1038/bjc.1996.598

상세보기

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