[논문]Long-acting nanoparticulate DNase-1 for effective suppression of SARS-CoV-2-mediated neutrophil activities and cytokine storm

Lee, Yun Young; Park, Hee Ho; Park, Wooram; Kim, Hyelim; Jang, Jong Geol; Hong, Kyung Soo; Lee, Jae-Young; Seo, Hee Seung; Na, Dong Hee; Kim, Tae-Hyung; Choy, Young Bin; Ahn, June Hong; Lee, Wonhwa; Park, Chun Gwon

doi:10.1016/j.biomaterials.2020.120389

[해외논문] Long-acting nanoparticulate DNase-1 for effective suppression of SARS-CoV-2-mediated neutrophil activities and cytokine storm 원문보기

Biomaterials, v.267, 2021년, pp.120389 -

Lee, Yun Young (Department of Biomedical Engineering, Seoul National University College of Medicine) , Park, Hee Ho (Department of Biotechnology and Bioengineering, Kangwon National University) , Park, Wooram (Department of Biomedical-Chemical Engineering, The Catholic University of Korea) , Kim, Hyelim (College of Pharmacy, Chungnam National University) , Jang, Jong Geol (Division of Pulmonary and Allergy, Department of Internal Medicine, College of Medicine, Yeungnam University and Regional Center for Respiratory Diseases, Yeungnam University Medical Center) , Hong, Kyung Soo (Division of Pulmonary and Allergy, Department of Internal Medicine, College of Medicine, Yeungnam University and Regional Center for Respiratory Diseases, Yeungnam University Medical Center) , Lee, Jae-Young (College of Pharmacy, Chungnam National University) , Seo, Hee Seung (Departm) , Na, Dong Hee , Kim, Tae-Hyung , Choy, Young Bin , Ahn, June Hong , Lee, Wonhwa , Park, Chun Gwon

Abstract ▼ AI-Helper

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new strain of coronavirus not previously identified in humans. Globally, the number of confirmed cases and mortality rates of coronavirus disease 2019 (COVID-19) have risen dramatically. Currently, there are no FDA-approved antiviral drugs and there is an urgency to develop treatment strategies that can effectively suppress SARS-CoV-2-mediated cytokine storms, acute respiratory distress syndrome (ARDS), and sepsis. As symptoms progress in patients with SARS-CoV-2 sepsis, elevated amounts of cell-free DNA (cfDNA) are produced, which in turn induce multiple organ failure in these patients. Furthermore, plasma levels of DNase-1 are markedly reduced in SARS-CoV-2 sepsis patients. In this study, we generated recombinant DNase-1-coated polydopamine-poly(ethylene glycol) nanoparticulates (named long-acting DNase-1), and hypothesized that exogenous administration of long-acting DNase-1 may suppress SARS-CoV-2-mediated neutrophil activities and the cytokine storm. Our findings suggest that exogenously administered long-acting nanoparticulate DNase-1 can effectively reduce cfDNA levels and neutrophil activities and may be used as a potential therapeutic intervention for life-threatening SARS-CoV-2-mediated illnesses.

Keyword

참고문헌 (49)

1 Mehta P. McAuley D.F. Brown M. Sanchez E. Tattersall R.S. Manson J.J. COVID-19: consider cytokine storm syndromes and immunosuppression Lancet 395 10229 2020 1033 1034 32192578
2 Vincent J.L. Taccone F.S. Understanding pathways to death in patients with COVID-19 Lancet Respir Med 8 5 2020 430 432 32272081

상세보기
3 Du Y.X. Chen X.P. Favipiravir: pharmacokinetics and concerns about clinical trials for 2019nCoV infection Clin. Pharmacol. Ther. 108 2 2020 242 247 32246834

상세보기
4 Li H. Zhou Y. Zhang M. Wang H. Zhao Q. Liu J. Updated approaches against SARS-CoV-2 Antimicrob. Agents Chemother. 64 6 2020 e00483-20

상세보기
5 Wang M. Cao R. Zhang L. Yang X. Liu J. Xu M. Shi Z. Hu Z. Zhong W. Xiao G. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro Cell Res. 30 3 2020 269 271 32020029
6 Zhou Y. Hou Y. Shen J. Huang Y. Martin W. Cheng F. Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2 Cell Discov. 6 2020 14 32194980
7 Phua J. Weng L. Ling L. Egi M. Lim C.M. Divatia J.V. Shrestha B.R. Arabi Y.M. Ng J. Gomersall C.D. Nishimura M. Koh Y. Du B. G. Asian Critical Care Clinical Trials, Intensive care management of coronavirus disease 2019 (COVID-19): challenges and recommendations Lancet Respir Med 8 5 2020 506 517 32272080
8 Jean S.-S. Lee P.-I. Hsueh P.-R. Treatment options for COVID-19: the reality and challenges J. Microbiol. Immunol. Infect. 53 3 2020 436 443 32307245
9 Russell C.D. Millar J.E. Baillie J.K. Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury Lancet 395 10223 2020 473 475 32043983
10 Papayannopoulos V. Neutrophil extracellular traps in immunity and disease Nat. Rev. Immunol. 18 2 2018 134 147 28990587

상세보기
11 Ma A. Kubes P. Platelets, neutrophils, and neutrophil extracellular traps (NETs) in sepsis J. Thromb. Haemostasis 6 3 2008 415 420 18088344
12 Lefrancais E. Mallavia B. Zhuo H. Calfee C.S. Looney M.R. Maladaptive role of neutrophil extracellular traps in pathogen-induced lung injury JCI Insight 3 3 2018 98178 29415887
13 Zhang C.Y. Dong X. Gao J. Lin W. Liu Z. Wang Z. Nanoparticle-induced neutrophil apoptosis increases survival in sepsis and alleviates neurological damage in stroke Sci. Adv. 5 11 2019 eaax7964

상세보기
14 Colon D.F. Wanderley C.W. Franchin M. Silva C.M. Hiroki C.H. Castanheira F.V. Donate P.B. Lopes A.H. Volpon L.C. Kavaguti S.K. Neutrophil extracellular traps (NETs) exacerbate severity of infant sepsis Crit. Care 23 1 2019 113 30961634
15 Albrengues J. Shields M.A. Ng D. Park C.G. Ambrico A. Poindexter M.E. Upadhyay P. Uyeminami D.L. Pommier A. Kuttner V. Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice Science 361 6409 2018 eaao4227
16 Park J. Wysocki R.W. Amoozgar Z. Maiorino L. Fein M.R. Jorns J. Schott A.F. Kinugasa-Katayama Y. Lee Y. Won N.H. Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps Sci. Transl. Med. 8 361 2016 361ra138

상세보기
17 Singer M. Deutschman C.S. Seymour C.W. Shankar-Hari M. Annane D. Bauer M. Bellomo R. Bernard G.R. Chiche J.-D. Coopersmith C.M. The third international consensus definitions for sepsis and septic shock (Sepsis-3) J. Am. Med. Assoc. 315 8 2016 801 810
18 Hazeldine J. Harris P. Chapple I.L. Grant M. Greenwood H. Livesey A. Sapey E. Lord J.M. Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals Aging Cell 13 4 2014 690 698 24779584

상세보기
19 Sapey E. Greenwood H. Walton G. Mann E. Love A. Aaronson N. Insall R.H. Stockley R.A. Lord J.M. Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence Blood 123 2 2014 239 248 24191150

상세보기
20 Xu J. Zhou P. Wang W. Sun A. Guo F. RelB, together with RelA, sustains cell survival and confers proteasome inhibitor sensitivity of chronic lymphocytic leukemia cells from bone marrow J. Mol. Med. 92 1 2014 77 92 24042463
21 Rittirsch D. Huber-Lang M.S. Flierl M.A. Ward P.A. Immunodesign of experimental sepsis by cecal ligation and puncture Nat. Protoc. 4 1 2009 31 36 19131954

상세보기
22 Wang T. Du Z. Zhu F. Cao Z. An Y. Gao Y. Jiang B. Comorbidities and multi-organ injuries in the treatment of COVID-19 Lancet 395 10228 2020 e52 32171074
23 Xu Y. Li X. Zhu B. Liang H. Fang C. Gong Y. Guo Q. Sun X. Zhao D. Shen J. Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding Nat. Med. 26 4 2020 502 505 32284613

상세보기
24 Zhang B. Zhou X. Zhu C. Feng F. Qiu Y. Feng J. Jia Q. Song Q. Zhu B. Wang J. Immune Phenotyping Based on Neutrophil-To-Lymphocyte Ratio and IgG Predicts Disease Severity and Outcome for Patients with COVID-19 2020 medRxiv
25 Jorch S.K. Kubes P. An emerging role for neutrophil extracellular traps in noninfectious disease Nat. Med. 23 3 2017 279 287 28267716

상세보기
26 Czaikoski P.G. Mota J.M.S.C. Nascimento D.C. Sonego F. Castanheira F.V.e.S. Melo P.H. Scortegagna G.T. Silva R.L. Barroso-Sousa R. Souto F.O. Neutrophil extracellular traps induce organ damage during experimental and clinical sepsis PloS One 11 2 2016 e0148142

상세보기
27 Onder G. Rezza G. Brusaferro S. Case-fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy 2020 JAMA
28 Wu Z. McGoogan J.M. Characteristics of and Important Lessons from the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases from the Chinese Center for Disease Control and Prevention 2020 JAMA
29 Prince W. Baker D. Dodge A. Ahmed A. Chestnut R. Sinicropi D. Pharmacodynamics of recombinant human DNase I in serum Clin. Exp. Immunol. 113 2 1998 289 296 9717980

상세보기
30 Liu X. Cao J. Li H. Li J. Jin Q. Ren K. Ji J. Mussel-inspired polydopamine: a biocompatible and ultrastable coating for nanoparticles in vivo ACS Nano 7 10 2013 9384 9395 24010584

상세보기
31 Lee H. Dellatore S.M. Miller W.M. Messersmith P.B. Mussel-inspired surface chemistry for multifunctional coatings Science 318 5849 2007 426 430 17947576

상세보기
32 Huang C. Wang Y. Li X. Ren L. Zhao J. Hu Y. Zhang L. Fan G. Xu J. Gu X. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Lancet 395 10223 2020 497 506 31986264
33 Zhou F. Yu T. Du R. Fan G. Liu Y. Liu Z. Xiang J. Wang Y. Song B. Gu X. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Lancet 395 10229 2020 1054 1062 32171076
34 Channappanavar R. Perlman S. Pathogenic Human Coronavirus Infections: Causes and Consequences of Cytokine Storm and Immunopathology, Semin Immunopathol 2017 Springer 529 539
35 Liu Q. Zhou Y.-h. Yang Z.-q. The cytokine storm of severe influenza and development of immunomodulatory therapy Cell. Mol. Immunol. 13 1 2016 3 10 26189369
36 Osuchowski M.F. Connett J. Welch K. Granger J. Remick D.G. Stratification is the key: inflammatory biomarkers accurately direct immunomodulatory therapy in experimental sepsis Crit. Care Med. 37 5 2009 1567 19325479

상세보기
37 Sercundes M.K. Ortolan L.S. Debone D. Soeiro-Pereira P.V. Gomes E. Aitken E.H. Neto A.C. Russo M. D'Imperio Lima M.R. Alvarez J.M. Targeting neutrophils to prevent malaria-associated acute lung injury/acute respiratory distress syndrome in mice PLoS Pathog. 12 12 2016 e1006054

상세보기
38 Poon W. Zhang Y.-N. Ouyang B. Kingston B.R. Wu J.L. Wilhelm S. Chan W.C. Elimination pathways of nanoparticles ACS Nano 13 5 2019 5785 5798 30990673

상세보기
39 Tsoi K.M. MacParland S.A. Ma X.-Z. Spetzler V.N. Echeverri J. Ouyang B. Fadel S.M. Sykes E.A. Goldaracena N. Kaths J.M. Mechanism of hard-nanomaterial clearance by the liver Nat. Mater. 15 11 2016 1212 1221 27525571

상세보기
40 Wilhelm S. Tavares A.J. Dai Q. Ohta S. Audet J. Dvorak H.F. Chan W.C. Analysis of nanoparticle delivery to tumours Nat. Rev. Mater. 1 5 2016 1 12
41 Timsit J.-F. Azoulay E. Schwebel C. Charles P.E. Cornet M. Souweine B. Klouche K. Jaber S. Trouillet J.-L. Bruneel F. Empirical micafungin treatment and survival without invasive fungal infection in adults with ICU-acquired sepsis, Candida colonization, and multiple organ failure: the EMPIRICUS randomized clinical trial J. Am. Med. Assoc. 316 15 2016 1555 1564
42 Strnad P. Tacke F. Koch A. Trautwein C. Liver―guardian, modifier and target of sepsis Nat. Rev. Gastroenterol. Hepatol. 14 1 2017 55 66 27924081

상세보기
43 Pedersen S.F. Ho Y.-C. SARS-CoV-2: a storm is raging J. Clin. Invest. 130 5 2020 2202 2205 32217834

상세보기
44 Cao X. COVID-19: immunopathology and its implications for therapy Nat. Rev. Immunol. 20 5 2020 269 270 32273594

상세보기
45 Paunel-Gorgulu A. Wacker M. El Aita M. Hassan S. Schlachtenberger G. Deppe A. Choi Y.-H. Kuhn E. Mehler T.O. Wahlers T. cfDNA correlates with endothelial damage after cardiac surgery with prolonged cardiopulmonary bypass and amplifies NETosis in an intracellular TLR9-independent manner Sci. Rep. 7 1 2017 1 13 28127051
46 Douda D.N. Yip L. Khan M.A. Grasemann H. Palaniyar N. Akt is essential to induce NADPH-dependent NETosis and to switch the neutrophil death to apoptosis Blood 123 4 2014 597 600 24458280

상세보기
47 Bangash M.N. Patel J. Parekh D. COVID-19 and the liver: little cause for concern Lancet Gastroenterol. Hepatol. 5 6 2020 529 530 32203680

상세보기
48 Alhazzani W. Møller M.H. Arabi Y.M. Loeb M. Gong M.N. Fan E. Oczkowski S. Levy M.M. Derde L. Dzierba A. Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19) Crit. Care Med. 46 5 2020 854 887
49 Davis M.E. Chen Z.G. Shin D.M. Nanoparticle therapeutics: an emerging treatment modality for cancer Nat. Rev. Drug Discov. 7 9 2008 771 782 18758474

LOADING...

활용도 분석정보

상세보기

다운로드

내보내기

활용도 Top5 논문

해당 논문의 주제분야에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증