다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기
Kidney360, v.2 no.7, 2021년, pp.1124 - 1131
Xiong, Xinyu (Department of Biochemistry, Duke University, Durham, North Carolina) , Nazo, Nour (Department of Biochemistry, Duke University, Durham, North Carolina) , Revoori, Ritika (Division of Nephrology, Duke University School of Medicine, Durham, North Carolina) , Rajagopal, Sudarshan (Department of Biochemistry, Duke University, Durham, North Carolina) , Sparks, Matthew A. (Division of Nephrology, Duke University School of Medicine, Durham, North Carolina)
AI-Helper
Visual Abstract [Figure]Key PointsEndothelins activated a wide range of G proteins at the ETAREndothelin derivatives did display structure-activity relationships in their degrees of agonismβ-arrestin 1 and 2 does not augment the diurnal blood pressure, acute, or chronic pressor response to en...
Pharmacol Rev Davenport 68 357 2016 10.1124/pr.115.011833 Endothelin
Br J Pharmacol Maguire 171 5555 2014 10.1111/bph.12874 Endothelin@25: New agonists, antagonists, inhibitors and emerging research frontiers: IUPHAR Review 12
Front Cardiovasc Med Viswanathan 5 179 2018 10.3389/fcvm.2018.00179 The role of G protein-coupled receptors in the right ventricle in pulmonary hypertension
Lancet Heerspink 393 1937 2019 10.1016/S0140-6736(19)30772-X Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): A double-blind, randomised, placebo-controlled trial
Nat Rev Drug Discov Smith 17 243 2018 10.1038/nrd.2017.229 Biased signalling: From simple switches to allosteric microprocessors
J Biol Chem Ahn 279 35518 2004 10.1074/jbc.M405878200 Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor
J Biol Chem Ahn 284 8855 2009 10.1074/jbc.M808463200 Beta-arrestin-2 mediates anti-apoptotic signaling through regulation of BAD phosphorylation
J Pharmacol Exp Ther Violin 377 572 2010 10.1124/jpet.110.173005 Selectively engaging beta-arrestins at the AT1R reduces blood pressure and increases cardiac performance
Circ Heart Fail Boerrigter 5 627 2012 10.1161/CIRCHEARTFAILURE.112.969220 TRV120027, a novel β-arrestin biased ligand at the angiotensin II type I receptor, unloads the heart and maintains renal function when added to furosemide in experimental heart failure
Circ Res Conner 81 1021 1997 10.1161/01.RES.81.6.1021 Beta-arrestin 1 knockout mice appear normal but demonstrate altered cardiac responses to beta-adrenergic stimulation
Science Bohn 286 2495 1999 10.1126/science.286.5449.2495 Enhanced morphine analgesia in mice lacking beta-arrestin 2
Nat Methods Inoue 9 1021 2012 10.1038/nmeth.2172 TGFα shedding assay: An accurate and versatile method for detecting GPCR activation
Sci Signal Smith 11 eaaq1075 2018 10.1126/scisignal.aaq1075 Biased agonists of the chemokine receptor CXCR3 differentially control chemotaxis and inflammation
Mol Pharmacol Rajagopal 80 367 2011 10.1124/mol.111.072801 Quantifying ligand bias at seven-transmembrane receptors
Sci Rep Onaran 7 44247 2017 10.1038/srep44247 Systematic errors in detecting biased agonism: Analysis of current methods and development of a new model-free approach
J Am Soc Nephrol Sparks 26 2953 2015 10.1681/ASN.2014080816 Vascular type 1A angiotensin II receptors control BP by regulating renal blood flow and urinary sodium excretion
Cell Inoue 177 1933 2019 10.1016/j.cell.2019.04.044 Illuminating G-protein-coupling selectivity of GPCRs
Circ Heart Fail Boerrigter 4 770 2011 10.1161/CIRCHEARTFAILURE.111.962571 Cardiorenal actions of TRV120027, a novel ß-arrestin-biased ligand at the angiotensin II type I receptor, in healthy and heart failure canines: A novel therapeutic strategy for acute heart failure
Proc Natl Acad Sci U S A Rosanò 106 2806 2009 10.1073/pnas.0807158106 Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis
Can J Physiol Pharmacol Cianfrocca 88 796 2010 10.1139/Y10-052 Beta-arrestin-1 mediates the endothelin-1-induced activation of Akt and integrin-linked kinase
Life Sci Cianfrocca 118 179 2014 10.1016/j.lfs.2014.01.078 β-Arrestin 1 is required for endothelin-1-induced NF-κB activation in ovarian cancer cells
Oncogene Rosanò 32 5066 2013 10.1038/onc.2012.527 β-arrestin-1 is a nuclear transcriptional regulator of endothelin-1-induced β-catenin signaling
Proc Natl Acad Sci U S A Wei 100 10782 2003 10.1073/pnas.1834556100 Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2
Mol Pharmacol Holloway 61 768 2002 10.1124/mol.61.4.768 Side-chain substitutions within angiotensin II reveal different requirements for signaling, internalization, and phosphorylation of type 1A angiotensin receptors
Sci Transl Med Gesty-Palmer 1 1ra1 2009 10.1126/scitranslmed.3000071 A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation
J Biol Chem Corbisier 290 9542 2015 10.1074/jbc.M114.596098 Biased signaling at chemokine receptors
J Biol Chem Rajagopal 288 35039 2013 10.1074/jbc.M113.479113 Biased agonism as a mechanism for differential signaling by chemokine receptors
Nature Manglik 537 185 2016 10.1038/nature19112 Structure-based discovery of opioid analgesics with reduced side effects
Semin Nephrol Maguire 35 125 2015 10.1016/j.semnephrol.2015.02.002 Endothelin receptors and their antagonists
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
오픈액세스 학술지에 출판된 논문
Copyright KISTI. All Rights Reserved.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.