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[해외논문] The SARS-CoV-2 RNA interactome 원문보기

Molecular cell, v.81 no.13, 2021년, pp.2838 - 2850.e6  

Lee, Sungyul (Center for RNA Research, Institute for Basic Science) ,  Lee, Young-suk (Center for RNA Research, Institute for Basic Science) ,  Choi, Yeon (Center for RNA Research, Institute for Basic Science) ,  Son, Ahyeon (Center for RNA Research, Institute for Basic Science) ,  Park, Youngran (Center for RNA Research, Institute for Basic Science) ,  Lee, Kyung-Min (International Vaccine Institute) ,  Kim, Jeesoo (Center for RNA Research, Institute for Basic Science) ,  Kim, Jong-Seo (Center for RNA Research, Institute for Basic Science) ,  Kim, V. Narry (Center for RNA Research, Institute for Basic Science)

Abstract AI-Helper 아이콘AI-Helper

Summary SARS-CoV-2 is an RNA virus whose success as a pathogen relies on its abilities to repurpose host RNA-binding proteins (RBPs) and to evade antiviral RBPs. To uncover the SARS-CoV-2 RNA interactome, we here develop a robust ribonucleoprotein (RNP) capture protocol and identify 109 host factor...

Keyword

참고문헌 (99)

  1. Alexa A. Rahnenführer J. Lengauer T. Improved scoring of functional groups from gene expression data by decorrelating GO graph structure Bioinformatics 22 2006 1600 1607 16606683 

  2. Anderson E.C. Hunt S.L. Jackson R.J. Internal initiation of translation from the human rhinovirus-2 internal ribosome entry site requires the binding of Unr to two distinct sites on the 5′ untranslated region J. Gen. Virol. 88 2007 3043 3052 17947529 

  3. Atasheva S. Frolova E.I. Frolov I. Interferon-stimulated poly(ADP-Ribose) polymerases are potent inhibitors of cellular translation and virus replication J. Virol. 88 2014 2116 2130 24335297 

  4. Balinsky C.A. Schmeisser H. Wells A.I. Ganesan S. Jin T. Singh K. Zoon K.C. IRAV ( FLJ11286 ), an interferon-stimulated gene with antiviral activity against dengue virus, interacts with MOV10 J. Virol. 91 2017 e01606 e01616 27974568 

  5. Baltz A.G. Munschauer M. Schwanhäusser B. Vasile A. Murakawa Y. Schueler M. Youngs N. Penfold-Brown D. Drew K. Milek M. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts Mol. Cell 46 2012 674 690 22681889 

  6. Banerjee A.K. Blanco M.R. Bruce E.A. Honson D.D. Chen L.M. Chow A. Bhat P. Ollikainen N. Quinodoz S.A. Loney C. SARS-CoV-2 disrupts splicing, translation, and protein trafficking to suppress host defenses Cell 183 2020 1325 1339.e21 33080218 

  7. Blanco-Melo D. Nilsson-Payant B.E. Liu W.-C. Uhl S. Hoagland D. Møller R. Jordan T.X. Oishi K. Panis M. Sachs D. Imbalanced host response to SARS-CoV-2 drives development of COVID-19 Cell 181 2020 1036 1045.e9 32416070 

  8. Blichenberg A. Schwanke B. Rehbein M. Garner C.C. Richter D. Kindler S. Identification of a cis-acting dendritic targeting element in MAP2 mRNAs J. Neurosci. 19 1999 8818 8829 10516301 

  9. Bojkova D. Klann K. Koch B. Widera M. Krause D. Ciesek S. Cinatl J. Münch C. Proteomics of SARS-CoV-2-infected host cells reveals therapy targets Nature 583 2020 469 472 32408336 

  10. Bouhaddou M. Memon D. Meyer B. White K.M. Rezelj V.V. Correa Marrero M. Polacco B.J. Melnyk J.E. Ulferts S. Kaake R.M. The global phosphorylation landscape of SARS-CoV-2 infection Cell 182 2020 685 712.e19 32645325 

  11. Boussadia O. Niepmann M. Créancier L. Prats A.-C. Dautry F. Jacquemin-Sablon H. Unr is required in vivo for efficient initiation of translation from the internal ribosome entry sites of both rhinovirus and poliovirus J. Virol. 77 2003 3353 3359 12610110 

  12. Bouvet M. Debarnot C. Imbert I. Selisko B. Snijder E.J. Canard B. Decroly E. In vitro reconstitution of SARS-coronavirus mRNA cap methylation PLoS Pathog. 6 2010 e1000863 20421945 

  13. Castello A. Fischer B. Eichelbaum K. Horos R. Beckmann B.M. Strein C. Davey N.E. Humphreys D.T. Preiss T. Steinmetz L.M. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins Cell 149 2012 1393 1406 22658674 

  14. Chapman E.G. Costantino D.A. Rabe J.L. Moon S.L. Wilusz J. Nix J.C. Kieft J.S. The structural basis of pathogenic subgenomic flavivirus RNA (sfRNA) production Science 344 2014 307 310 24744377 

  15. Choudhury N.R. Heikel G. Trubitsyna M. Kubik P. Nowak J.S. Webb S. Granneman S. Spanos C. Rappsilber J. Castello A. Michlewski G. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination BMC Biol. 15 2017 105 29117863 

  16. Cox J. Mann M. MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification Nat. Biotechnol. 26 2008 1367 1372 19029910 

  17. Cox J. Neuhauser N. Michalski A. Scheltema R.A. Olsen J.V. Mann M. Andromeda: a peptide search engine integrated into the MaxQuant environment J. Proteome Res. 10 2011 1794 1805 21254760 

  18. de Groot R.J. Baker S.C. Baric R.S. Brown C.S. Drosten C. Enjuanes L. Fouchier R.A.M. Galiano M. Gorbalenya A.E. Memish Z.A. Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group J. Virol. 87 2013 7790 7792 23678167 

  19. Egloff M.-P. Ferron F. Campanacci V. Longhi S. Rancurel C. Dutartre H. Snijder E.J. Gorbalenya A.E. Cambillau C. Canard B. The severe acute respiratory syndrome-coronavirus replicative protein nsp9 is a single-stranded RNA-binding subunit unique in the RNA virus world Proc. Natl. Acad. Sci. U S A 101 2004 3792 3796 15007178 

  20. El-Gebali S. Mistry J. Bateman A. Eddy S.R. Luciani A. Potter S.C. Qureshi M. Richardson L.J. Salazar G.A. Smart A. The Pfam protein families database in 2019 Nucleic Acids Res. 47 D1 2019 D427 D432 30357350 

  21. Engreitz J.M. Pandya-Jones A. McDonel P. Shishkin A. Sirokman K. Surka C. Kadri S. Xing J. Goren A. Lander E.S. The Xist lncRNA exploits three-dimensional genome architecture to spread across the X chromosome Science 341 2013 1237973 23828888 

  22. Fehr A.R. Athmer J. Channappanavar R. Phillips J.M. Meyerholz D.K. Perlman S. The nsp3 macrodomain promotes virulence in mice with coronavirus-induced encephalitis J. Virol. 89 2015 1523 1536 25428866 

  23. Finkel Y. Mizrahi O. Nachshon A. Weingarten-Gabbay S. Yahalom-Ronen Y. Tamir H. Achdout H. Melamed S. Weiss S. Israely T. The coding capacity of SARS-CoV-2 bioRxiv 2020 10.1101/2020.05.07.082909 

  24. Flynn R.A. Belk J.A. Qi Y. Yasumoto Y. Wei J. Alfajaro M.M. Shi Q. Mumbach M.R. Limaye A. DeWeirdt P.C. Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions Cell 2021 10.1016/j.cell.2021.03.012 Published online March 11, 2021 

  25. Fonseca B.D. Zakaria C. Jia J.-J. Graber T.E. Svitkin Y. Tahmasebi S. Healy D. Hoang H.-D. Jensen J.M. Diao I.T. La-related protein 1 (LARP1) represses terminal oligopyrimidine (TOP) mRNA translation downstream of mTOR complex 1 (mTORC1) J. Biol. Chem. 290 2015 15996 16020 25940091 

  26. Fung T.S. Liu D.X. Human coronavirus: host-pathogen interaction Annu. Rev. Microbiol. 73 2019 529 557 31226023 

  27. Gene Ontology Consortium Creating the Gene Ontology resource: design and implementation Genome Res. 11 2001 1425 1433 11483584 

  28. Gerstberger S. Hafner M. Tuschl T. A census of human RNA-binding proteins Nat. Rev. Genet. 15 2014 829 845 25365966 

  29. Go C.D. Knight J.D.R. Rajasekharan A. Rathod B. Hesketh G.G. Abe K.T. Youn J.-Y. Samavarchi-Tehrani P. Zhang H. Zhu L.Y. A proximity biotinylation map of a human cell bioRxiv 2019 10.1101/796391 

  30. Goodier J.L. Pereira G.C. Cheung L.E. Rose R.J. Kazazian H.H. Jr. The broad-spectrum antiviral protein ZAP restricts human retrotransposition PLoS Genet. 11 2015 e1005252 26001115 

  31. Gordon D.E. Jang G.M. Bouhaddou M. Xu J. Obernier K. White K.M. O’Meara M.J. Rezelj V.V. Guo J.Z. Swaney D.L. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing Nature 583 2020 459 468 32353859 

  32. Grunewald M.E. Chen Y. Kuny C. Maejima T. Lease R. Ferraris D. Aikawa M. Sullivan C.S. Perlman S. Fehr A.R. The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression PLoS Pathog. 15 2019 e1007756 31095648 

  33. Hadjadj J. Yatim N. Barnabei L. Corneau A. Boussier J. Smith N. Péré H. Charbit B. Bondet V. Chenevier-Gobeaux C. Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients Science 369 2020 718 724 32661059 

  34. Hamre D. Procknow J.J. A new virus isolated from the human respiratory tract Proc. Soc. Exp. Biol. Med. 121 1966 190 193 4285768 

  35. Hentze M.W. Castello A. Schwarzl T. Preiss T. A brave new world of RNA-binding proteins Nat. Rev. Mol. Cell Biol. 19 2018 327 341 29339797 

  36. Hong S. Freeberg M.A. Han T. Kamath A. Yao Y. Fukuda T. Suzuki T. Kim J.K. Inoki K. LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs eLife 6 2017 e25237 28650797 

  37. Husain A. Byrareddy S.N. Rapamycin as a potential repurpose drug candidate for the treatment of COVID-19 Chem. Biol. Interact. 331 2020 109282 10.1016/j.cbi.2020.109282 33031791 

  38. Jacinto E. Loewith R. Schmidt A. Lin S. Rüegg M.A. Hall A. Hall M.N. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive Nat. Cell Biol. 6 2004 1122 1128 15467718 

  39. Kamel W. Noerenberg M. Cerikan B. Chen H. Järvelin A.I. Kammoun M. Lee J. Shuai N. Garcia-Moreno M. Andrejeva A. Global analysis of protein-RNA interactions in SARS-CoV-2 infected cells reveals key regulators of infection bioRxiv 2020 10.1101/2020.11.25.398008 

  40. Karam B.S. Morris R.S. Bramante C.T. Puskarich M. Zolfaghari E.J. Lotfi-Emran S. Ingraham N.E. Charles A. Odde D.J. Tignanelli C.J. mTOR inhibition in COVID-19: A commentary and review of efficacy in RNA viruses J. Med. Virol. 93 2020 1843 1846 10.1002/jmv.26728 33314219 

  41. Kerns J.A. Emerman M. Malik H.S. Positive selection and increased antiviral activity associated with the PARP-containing isoform of human zinc-finger antiviral protein PLoS Genet. 4 2008 e21 18225958 

  42. Kerr C.H. Skinnider M.A. Andrews D.D.T. Madero A.M. Chan Q.W.T. Stacey R.G. Stoynov N. Jan E. Foster L.J. Dynamic rewiring of the human interactome by interferon signaling Genome Biol. 21 2020 140 32539747 

  43. Kim D. Lee J.-Y. Yang J.-S. Kim J.W. Kim V.N. Chang H. The architecture of SARS-CoV-2 transcriptome Cell 181 2020 914 921.e10 32330414 

  44. Kim J.-M. Chung Y.-S. Jo H.J. Lee N.-J. Kim M.S. Woo S.H. Park S. Kim J.W. Kim H.M. Han M.-G. Identification of coronavirus isolated from a patient in Korea with COVID-19 Osong Public Health Res. Perspect. 11 2020 3 7 32149036 

  45. Klann K. Bojkova D. Tascher G. Ciesek S. Münch C. Cinatl J. Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication Mol. Cell 80 2020 164 174 10.1016/j.molcel.2020.08.006 32877642 

  46. Lahr R.M. Fonseca B.D. Ciotti G.E. Al-Ashtal H.A. Jia J.-J. Niklaus M.R. Blagden S.P. Alain T. Berman A.J. La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs eLife 6 2017 e24146 28379136 

  47. Lai M.M.C. Cavanagh D. The molecular biology of coronaviruses Maramorosch K. Murphy F.A. Shatkin A.J. Advances in Virus Research 1997 Academic Press San Diego 1 100 

  48. Lai M.M. Stohlman S.A. Comparative analysis of RNA genomes of mouse hepatitis viruses J. Virol. 38 1981 661 670 6165837 

  49. Lan T.C.T. Allan M.F. Malsick L.E. Khandwala S. Nyeo S.S.Y. Bathe M. Griffiths A. Rouskin S. Structure of the full SARS-CoV-2 RNA genome in infected cells bioRxiv 2020 10.1101/2020.06.29.178343 

  50. Langmead B. Salzberg S.L. Fast gapped-read alignment with Bowtie 2 Nat. Methods 9 2012 357 359 22388286 

  51. Lee F.C.Y. Ule J. Advances in CLIP technologies for studies of protein-RNA interactions Mol. Cell 69 2018 354 369 29395060 

  52. Lee A.S. Kranzusch P.J. Doudna J.A. Cate J.H.D. eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation Nature 536 2016 96 99 27462815 

  53. Lee K.-M. Chen C.-J. Shih S.-R. Regulation mechanisms of viral IRES-driven translation Trends Microbiol. 25 2017 546 561 28242053 

  54. Li L. Zhao H. Liu P. Li C. Quanquin N. Ji X. Sun N. Du P. Qin C.-F. Lu N. Cheng G. PARP12 suppresses Zika virus infection through PARP-dependent degradation of NS1 and NS3 viral proteins Sci. Signal. 11 2018 eaas9332 29921658 

  55. Manokaran G. Finol E. Wang C. Gunaratne J. Bahl J. Ong E.Z. Tan H.C. Sessions O.M. Ward A.M. Gubler D.J. Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness Science 350 2015 217 221 26138103 

  56. Masutani M. Sonenberg N. Yokoyama S. Imataka H. Reconstitution reveals the functional core of mammalian eIF3 EMBO J. 26 2007 3373 3383 17581632 

  57. McHugh C.A. Guttman M. RAP-MS: a method to identify proteins that interact directly with a specific RNA molecule in cells Methods Mol. Biol. 1649 2018 473 488 29130217 

  58. McHugh C.A. Chen C.-K. Chow A. Surka C.F. Tran C. McDonel P. Pandya-Jones A. Blanco M. Burghard C. Moradian A. The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3 Nature 521 2015 232 236 25915022 

  59. Miknis Z.J. Donaldson E.F. Umland T.C. Rimmer R.A. Baric R.S. Schultz L.W. Severe acute respiratory syndrome coronavirus nsp9 dimerization is essential for efficient viral growth J. Virol. 83 2009 3007 3018 19153232 

  60. Mukherjee J. Hermesh O. Eliscovich C. Nalpas N. Franz-Wachtel M. Maček B. Jansen R.-P. β-Actin mRNA interactome mapping by proximity biotinylation Proc. Natl. Acad. Sci. U S A 116 2019 12863 12872 31189591 

  61. Narayanan K. Huang C. Lokugamage K. Kamitani W. Ikegami T. Tseng C.-T.K. Makino S. Severe acute respiratory syndrome coronavirus nsp1 suppresses host gene expression, including that of type I interferon, in infected cells J. Virol. 82 2008 4471 4479 18305050 

  62. Ooi Y.S. Majzoub K. Flynn R.A. Mata M.A. Diep J. Li J.K. van Buuren N. Rumachik N. Johnson A.G. Puschnik A.S. An RNA-centric dissection of host complexes controlling flavivirus infection Nat. Microbiol. 4 2019 2369 2382 31384002 

  63. Peiris J.S.M. Lai S.T. Poon L.L.M. Guan Y. Yam L.Y.C. Lim W. Nicholls J. Yee W.K.S. Yan W.W. Cheung M.T. SARS study group Coronavirus as a possible cause of severe acute respiratory syndrome Lancet 361 2003 1319 1325 12711465 

  64. Perez-Riverol Y. Csordas A. Bai J. Bernal-Llinares M. Hewapathirana S. Kundu D.J. Inuganti A. Griss J. Mayer G. Eisenacher M. The PRIDE database and related tools and resources in 2019: improving support for quantification data Nucleic Acids Res. 47 D1 2019 D442 D450 30395289 

  65. Perlman S. Netland J. Coronaviruses post-SARS: update on replication and pathogenesis Nat. Rev. Microbiol. 7 2009 439 450 19430490 

  66. Ramanathan M. Porter D.F. Khavari P.A. Methods to study RNA-protein interactions Nat. Methods 16 2019 225 234 30804549 

  67. Riva L. Yuan S. Yin X. Martin-Sancho L. Matsunaga N. Pache L. Burgstaller-Muehlbacher S. De Jesus P.D. Teriete P. Hull M.V. Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing Nature 586 2020 113 119 32707573 

  68. Rogers G.W. Jr. Richter N.J. Lima W.F. Merrick W.C. Modulation of the helicase activity of eIF4A by eIF4B, eIF4H, and eIF4F J. Biol. Chem. 276 2001 30914 30922 11418588 

  69. Roth A. Diederichs S. Molecular biology: Rap and chirp about X inactivation Nature 521 2015 170 171 25971508 

  70. Sa Ribero M. Jouvenet N. Dreux M. Nisole S. Interplay between SARS-CoV-2 and the type I interferon response PLoS Pathog. 16 2020 e1008737 32726355 

  71. Schmidt N. Lareau C.A. Keshishian H. Ganskih S. Schneider C. Hennig T. Melanson R. Werner S. Wei Y. Zimmer M. The SARS-CoV-2 RNA-protein interactome in infected human cells Nat. Microbiol. 6 2021 339 353 33349665 

  72. Shah K. McCormack C.E. Bradbury N.A. Do you know the sex of your cells? Am. J. Physiol. Cell Physiol. 306 2014 C3 C18 24196532 

  73. Shaw A.E. Hughes J. Gu Q. Behdenna A. Singer J.B. Dennis T. Orton R.J. Varela M. Gifford R.J. Wilson S.J. Palmarini M. Fundamental properties of the mammalian innate immune system revealed by multispecies comparison of type I interferon responses PLoS Biol. 15 2017 e2004086 29253856 

  74. Shi M. Wang L. Fontana P. Vora S. Zhang Y. Fu T.-M. Lieberman J. Wu H. SARS-CoV-2 Nsp1 suppresses host but not viral translation through a bipartite mechanism bioRxiv 2020 10.1101/2020.09.18.302901 

  75. Sims A.C. Burkett S.E. Yount B. Pickles R.J. SARS-CoV replication and pathogenesis in an in vitro model of the human conducting airway epithelium Virus Res. 133 2008 33 44 17451829 

  76. Snijder E.J. Decroly E. Ziebuhr J. The nonstructural proteins directing coronavirus RNA synthesis and processing Adv. Virus Res. 96 2016 59 126 27712628 

  77. Sola I. Almazán F. Zúñiga S. Enjuanes L. Continuous and discontinuous RNA synthesis in coronaviruses Annu. Rev. Virol. 2 2015 265 288 26958916 

  78. St-Germain J.R. Astori A. Samavarchi-Tehrani P. A SARS-CoV-2 BioID-based virus-host membrane protein interactome and virus peptide compendium: new proteomics resources for COVID-19 research bioRxiv 2020 10.1101/2020.08.28.269175 

  79. Stark C. Breitkreutz B.-J. Reguly T. Boucher L. Breitkreutz A. Tyers M. BioGRID: a general repository for interaction datasets Nucleic Acids Res. 34 2006 D535 D539 16381927 

  80. Sutton G. Fry E. Carter L. Sainsbury S. Walter T. Nettleship J. Berrow N. Owens R. Gilbert R. Davidson A. The nsp9 replicase protein of SARS-coronavirus, structure and functional insights Structure 12 2004 341 353 14962394 

  81. Suzuki Y. Chin W.-X. Han Q. Ichiyama K. Lee C.H. Eyo Z.W. Ebina H. Takahashi H. Takahashi C. Tan B.H. Characterization of RyDEN (C19orf66) as an interferon-stimulated cellular inhibitor against dengue virus replication PLoS Pathog. 12 2016 e1005357 26735137 

  82. Takata M.A. Gonçalves-Carneiro D. Zang T.M. Soll S.J. York A. Blanco-Melo D. Bieniasz P.D. CG dinucleotide suppression enables antiviral defence targeting non-self RNA Nature 550 2017 124 127 28953888 

  83. Tauber D. Tauber G. Khong A. Van Treeck B. Pelletier J. Parker R. Modulation of RNA condensation by the DEAD-box protein eIF4A Cell 180 2020 411 426.e16 31928844 

  84. Tcherkezian J. Cargnello M. Romeo Y. Huttlin E.L. Lavoie G. Gygi S.P. Roux P.P. Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5’TOP mRNA translation Genes Dev. 28 2014 357 371 24532714 

  85. Terrazzano G. Rubino V. Palatucci A.T. Giovazzino A. Carriero F. Ruggiero G. An Open Question: Is It Rational to Inhibit the mTor-Dependent Pathway as COVID-19 Therapy? Front. Pharmacol. 11 2020 856 10.3389/fphar.2020.00856 32574238 

  86. Thoms M. Buschauer R. Ameismeier M. Koepke L. Denk T. Hirschenberger M. Kratzat H. Hayn M. Mackens-Kiani T. Cheng J. Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2 Science 369 2020 1249 1255 32680882 

  87. Tidu A. Janvier A. Schaeffer L. Sosnowski P. Kuhn L. Hammann P. Westhof E. Eriani G. Martin F. The viral protein NSP1 acts as a ribosome gatekeeper for shutting down host translation and fostering SARS-CoV-2 translation RNA 27 2020 253 264 33268501 

  88. Ule J. Hwang H.-W. Darnell R.B. The future of cross-linking and immunoprecipitation (CLIP) Cold Spring Harb. Perspect. Biol. 10 2018 a032243 30068528 

  89. UniProt Consortium UniProt: a worldwide hub of protein knowledge Nucleic Acids Res. 47 D1 2019 D506 D515 30395287 

  90. Van Nostrand E.L. Freese P. Pratt G.A. Wang X. Wei X. Xiao R. Blue S.M. Chen J.-Y. Cody N.A.L. Dominguez D. A large-scale binding and functional map of human RNA-binding proteins Nature 583 2020 711 719 32728246 

  91. Vijgen L. Keyaerts E. Moës E. Thoelen I. Wollants E. Lemey P. Vandamme A.-M. Van Ranst M. Complete genomic sequence of human coronavirus OC43: molecular clock analysis suggests a relatively recent zoonotic coronavirus transmission event J. Virol. 79 2005 1595 1604 15650185 

  92. Wang X. Xuan Y. Han Y. Ding X. Ye K. Yang F. Gao P. Goff S.P. Gao G. Regulation of HIV-1 Gag-Pol expression by shiftless, an inhibitor of programmed-1 ribosomal frameshifting Cell 176 2019 625 635.e14 30682371 

  93. Wei J. Alfajaro M.M. DeWeirdt P.C. Hanna R.E. Lu-Culligan W.J. Cai W.L. Strine M.S. Zhang S.-M. Graziano V.R. Schmitz C.O. Genome-wide CRISPR screens reveal host factors critical for SARS-CoV-2 infection Cell 184 2021 76 91.e13 33147444 

  94. Welsby I. Hutin D. Gueydan C. Kruys V. Rongvaux A. Leo O. PARP12, an interferon-stimulated gene involved in the control of protein translation and inflammation J. Biol. Chem. 289 2014 26642 26657 25086041 

  95. Woo P.C.Y. Lau S.K.P. Lam C.S.F. Lau C.C.Y. Tsang A.K.L. Lau J.H.N. Bai R. Teng J.L.L. Tsang C.C.C. Wang M. Discovery of seven novel Mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses as the gene source of gammacoronavirus and deltacoronavirus J. Virol. 86 2012 3995 4008 22278237 

  96. Zheng X. Wang X. Tu F. Wang Q. Fan Z. Gao G. TRIM25 is required for the antiviral activity of zinc finger antiviral protein J. Virol. 91 2017 e00088-17 28202764 

  97. Zhou P. Yang X.-L. Wang X.-G. Hu B. Zhang L. Zhang W. Si H.-R. Zhu Y. Li B. Huang C.-L. A pneumonia outbreak associated with a new coronavirus of probable bat origin Nature 579 2020 270 273 32015507 

  98. Zhu Y. Chen G. Lv F. Wang X. Ji X. Xu Y. Sun J. Wu L. Zheng Y.-T. Gao G. Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation Proc. Natl. Acad. Sci. U S A 108 2011 15834 15839 21876179 

  99. Zhu Y. Wang X. Goff S.P. Gao G. Translational repression precedes and is required for ZAP-mediated mRNA decay EMBO J. 31 2012 4236 4246 23023399 

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