[논문]Absence of progesterone receptor membrane component 1 reduces migration and metastasis of breast cancer

Lee, Sang R.; Lee, Young Ho; Jo, Seong Lae; Heo, Jun H.; Kim, Globinna; Lee, Geun-Shik; An, Beum-Soo; Baek, In-Jeoung; Hong, Eui-Ju

doi:10.1186/s12964-021-00719-w

[해외논문] Absence of progesterone receptor membrane component 1 reduces migration and metastasis of breast cancer 원문보기

Cell communication and signaling : CCS, v.19 no.1, 2021년, pp.42 -

Lee, Sang R. (College of Veterinary Medicine, Chungnam National University, Suite 401, Veterinary Medicine Bldg., 99, Daehak-ro, Yuseong-gu, Daejeon, 34134 Republic of Korea) , Lee, Young Ho (College of Veterinary Medicine, Chungnam National University, Suite 401, Veterinary Medicine Bldg., 99, Daehak-ro, Yuseong-gu, Daejeon, 34134 Republic of Korea) , Jo, Seong Lae (College of Veterinary Medicine, Chungnam National University, Suite 401, Veterinary Medicine Bldg., 99, Daehak-ro, Yuseong-gu, Daejeon, 34134 Republic of Korea) , Heo, Jun H. (College of Veterinary Medicine, Chungnam National University, Suite 401, Veterinary Medicine Bldg., 99, Daehak-ro, Yuseong-gu, Daejeon, 34134 Republic of Korea) , Kim, Globinna (Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505 Republic of Korea) , Lee, Geun-Shik (College of Veterinary Medicine, Kangwon National University, Chuncheon, 24341 Republic of Korea) , An, Beum-Soo (Department of Biomaterials Science, Pusan National University, Miryang, 50463 Republic of) , Baek, In-Jeoung , Hong, Eui-Ju

Abstract ▼ AI-Helper

BackgroundProgesterone receptor membrane component 1 (Pgrmc1) is a non-classical progesterone receptor associated with the development of the mammary gland and xenograft-induced breast cancer. Importantly, Pgrmc1 is associated with the expression of estrogen receptor alpha and can be used for predicting the prognosis of breast cancer. Whether the genetic deletion of Pgrmc1 affects the progression of breast cancer is still unclear.MethodsWe used MMTV-PyMT transgenic mice that spontaneously develop breast tumors. In backcrossed FVB Pgrmc1 knockout (KO) mice, we monitored the development of the primary tumor and lung metastasis. In MCF-7 and MDA-MB-231 tumor cell lines, the migratory activity was evaluated after Pgrmc1 knockdown.ResultsThere was no significant difference in the development of breast cancer in terms of tumor size at 13 weeks of age between WT and Pgrmc1 KO mice. However, Pgrmc1 KO mice had a significantly longer survival duration compared with WT mice. Furthermore, Pgrmc1 KO mice exhibited a significantly lower degree of lung metastasis. Compared with those of WT mice, the tumors of Pgrmc1 KO mice had a low expression of focal adhesion kinase and epithelial–mesenchymal transition markers. PGRMC1 knockdown resulted in a significantly reduced migration rate in breast cancer cell lines.ConclusionsPgrmc1 KO mice with breast cancer had a prolonged survival, which was accompanied by a low degree of lung metastasis. PGRMC1 showed a significant role in the migration of breast cancer cells, and may serve as a potential therapeutic target in breast cancer.Video AbstractSupplementary InformationThe online version contains supplementary material available at 10.1186/s12964-021-00719-w.

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