다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기
Frontiers in molecular biosciences, v.8, 2021년, pp.701975 -
Rodríguez-Saavedra, Carolina , Morgado-Martínez, Luis Enrique , Burgos-Palacios, Andrés , King-Díaz, Beatriz , López-Coria, Montserrat , Sánchez-Nieto, Sobeida
AI-Helper
Moonlighting proteins are defined as proteins with two or more functions that are unrelated and independent to each other, so that inactivation of one of them should not affect the second one and vice versa. Intriguingly, all the glycolytic enzymes are described as moonlighting proteins in some orga...
Abolhassani Rad S. Clayton E. J. Cornelius E. J. Howes T. R. Kohalmi S. E. ( 2018 ). Moonlighting Proteins: Putting the Spotlight on Enzymes . Plant Signal. Behav. 13 ( 10 ), 1 ？ 6 . 10.1080/15592324.2018.1517075
Adams V. Griffin L. D. Gelb B. D. McCabe E. R. B. ( 1991 ). Protein Kinase Activity of Rat Brain Hexokinase . Biochem. Biophysical Res. Commun. 177 ( 3 ), 1101 ？ 1106 . 10.1016/0006-291x(91)90652-n
Adamus G. Brown L. Schiffman J. Iannaccone A. ( 2011 ). Diversity in Autoimmunity against Retinal, Neuronal, and Axonal Antigens in Acquired Neuro-Retinopathy . J. Ophthal Inflamm. Infect. 1 ( 3 ), 111 ？ 121 . 10.1007/s12348-011-0028-8
Adamus G. ( 2017 ). Impact of Autoantibodies against Glycolytic Enzymes on Pathogenicity of Autoimmune Retinopathy and Other Autoimmune Disorders . Front. Immunol. 8 , 505 . 10.3389/fimmu.2017.00505 28503176
Affourtit C. Alberts B. Barlow J. Carre J. E. Wynne A. G. ( 2018 ). Control of Pancreatic β-cell Bioenergetics . Biochem. Soc. Trans. 46 , 555 ？ 564 . 10.1042/BST20170505 29666215
Agarwal S. Kulshreshtha P. Bambah Mukku D. Bhatnagar R. ( 2008 ). α-Enolase Binds to Human Plasminogen on the Surface of Bacillus Anthracis . Biochim. Biophys. Acta (Bba) - Proteins Proteomics 1784 , 986 ？ 994 . 10.1016/j.bbapap.2008.03.017 18456007
Aguilera-Alvarado G. P. Guevara-Garcia A. A. Estrada-Antolin S. A. Sanchez-Nieto S. ( 2019 ). Biochemical Properties and Subcellular Localization of Six Members of the HXK Family in maize and its Metabolic Contribution to Embryo Germination . BMC Plant Biol. 19 ( 1 ), 27 . 10.1186/s12870-018-1605-x 30646852
Aguilera-Alvarado G. P. Sanchez-Nieto S. ( 2017 ). Plant Hexokinases Are Multifaceted Proteins . Plant Cel Physiol. 58 ( 7 ), 1151 ？ 1160 . 10.1093/pcp/pcx062
Ahuatzi D. Herrero P. de la Cera T. Moreno F. ( 2004 ). The Glucose-Regulated Nuclear Localization of Hexokinase 2 in Saccharomyces cerevisiae Is Mig1-dependent . J. Biol. Chem. 279 ( 14 ), 14440 ？ 14446 . 10.1074/jbc.M313431200 14715653
Ahuatzi D. Riera A. Pela´ez R. Herrero P. Moreno F. ( 2007 ). Hxk2 Regulates the Phosphorylation State of Mig1 and Therefore its Nucleocytoplasmic Distribution . J. Biol. Chem. 282 , 4485 ？ 4493 . 10.1074/jbc.M606854200 17178716
Alcantar-Aguirre F. C. Chagolla A. Tiessen A. Delano J. P. Gonzalez de la Vara L. E. ( 2013 ). ATP Produced by Oxidative Phosphorylation Is Channeled toward Hexokinase Bound to Mitochondrial Porin (VDAC) in Beetroots (Beta Vulgaris) . Planta 237 , 1571 ？ 1583 . 10.1007/s00425-013-1866-4 23503782
Alexander N. J. Proctor R. H. McCormick S. P. ( 2009 ). Genes, Gene Clusters, and Biosynthesis of Trichothecenes and Fumonisins inFusarium . Toxin Rev. 28 , 198 ？ 215 . 10.3390/toxins1101003610.1080/15569540903092142
Amela I. Cedano J. Querol E. ( 2007 ). Pathogen Proteins Eliciting Antibodies Do Not Share Epitopes with Host Proteins: A Bioinformatics Approach . PLoS One 2 ( 6 ), e512 . 10.1371/journal.pone.0000512 17551592
Anderson C. Zucker F. Steitz T. ( 1979 ). Space-filling Models of Kinase Clefts and Conformation Changes . Science 204 ( 4391 ), 375 ？ 380 . 10.1126/science.220706 220706
Arner E. S. J. Holmgren A. ( 2000 ). Physiological Functions of Thioredoxin and Thioredoxin Reductase . Eur. J. Biochem. 267 ( 20 ), 6102 ？ 6109 . 10.1046/j.1432-1327.2000.01701.x 11012661
Arora K. K. Pedersen P. L. ( 1988 ). Functional Significance of Mitochondrial Bound Hexokinase in Tumor Cell Metabolism. Evidence for Preferential Phosphorylation of Glucose by Intramitochondrially Generated ATP . J. Biol. Chem. 263 ( 33 ), 17422 ？ 17428 . 10.1016/S0021-9258(19)77853-3 3182854
Artymiuk P. J. Green J. ( 2006 ). The Double Life of Aconitase . Structure 14 ( 1 ), 2 ？ 4 . 10.1016/j.str.2005.12.001 16407059
Bahia D. ( 2017 ). A New Trick for a Conserved Enzyme: Mevalonate Kinase, a Glycosomal Enzyme, Can Be Secreted by Trypanosoma Cruzi and Modulate Cell Invasion and Signaling. Is it Another Moonlighting Enzyme? Front. Cel. Infect. Microbiol. 7 , 426 . 10.3389/fcimb.2017.00426
Baines C. P. Kaiser R. A. Purcell N. H. Blair N. S. Osinska H. Hambleton M. A. ( 2005 ). Loss of Cyclophilin D Reveals a Critical Role for Mitochondrial Permeability Transition in Cell Death . Nature 434 , 658 ？ 662 . 10.1038/nature03434 15800627
Behlke J. Heidrich K. Naumann M. Muller E.-C. Otto A. Reuter R. ( 1998 ). Hexokinase 2 fromSaccharomyces Cerevisiae: Regulation of Oligomeric Structure Byin VivoPhosphorylation at Serine-14† . Biochemistry 37 ( 34 ), 11989 ？ 11995 . 10.1021/bi980914m 9718324
Bennett W. S. Jr Steitz T. A. ( 1980 ). Structure of a Complex between Yeast Hexokinase A and Glucose . J. Mol. Biol. 140 ( 2 ), 183 ？ 209 . 10.1016/0022-2836(80)90102-3 7001031
Betz C. Hall M. N. ( 2013 ). Where Is mTOR and what Is it Doing There? J. Cel. Biol. 203 ( 4 ), 563 ？ 574 . 10.1083/jcb.201306041
Blattner J. Dorsam H. Clatyon C. E. ( 1995 ). Function of N-Terminal Import Signals in Trypanosome Microbodies . FEBS Lett. 360 ( 3 ), 310 ？ 314 . 10.1016/0014-5793(95)00128-v 7883054
Blau K. Portnoi M. Shagan M. Kaganovich A. Rom S. Kafka D. ( 2007 ). Flamingo Cadherin: A Putative Host Receptor forStreptococcus Pneumoniae . J. Infect. Dis. 195 ( 12 ), 1828 ？ 1837 . 10.1086/518038 17492599
Bolter B. Soll J. Schwenkert S. ( 2015 ). Redox Meets Protein Trafficking . Biochim. Biophys. Acta (Bba) - Bioenerg. 1847 ( 9 ), 949 ？ 956 . 10.1016/j.bbabio.2015.01.010
Boone T. J. Burnham C.-A. D. Tyrrell G. J. ( 2011 ). Binding of Group B Streptococcal Phosphoglycerate Kinase to Plasminogen and Actin . Microb. Pathogenesis 51 ( 4 ), 255 ？ 261 . 10.1016/j.micpath.2011.06.005
Bosch J. Buscaglia C. A. Krumm B. Ingason B. P. Lucas R. Roach C. ( 2007 ). Aldolase Provides an Unusual Binding Site for Thrombospondin-Related Anonymous Protein in the Invasion Machinery of the Malaria Parasite . Proc. Natl. Acad. Sci. 104 ( 17 ), 7015 ？ 7020 . 10.1073/pnas.0605301104 17426153
Boukouris A. E. Zervopoulos S. D. Michelakis E. D. ( 2016 ). Metabolic Enzymes Moonlighting in the Nucleus: Metabolic Regulation of Gene Transcription . Trends Biochem. Sci. 41 ( 8 ), 712 ？ 730 . 10.1016/j.tibs.2016.05.013 27345518
Broekemeier K. M. Dempsey M. E. Pfeiffer D. R. ( 1989 ). Cyclosporin A Is a Potent Inhibitor of the Inner Membrane Permeability Transition in Liver Mitochondria . J. Biol. Chem. 264 ( 14 ), 7826 ？ 7830 . 10.1016/S0021-9258(18)83116-7 2470734
Brown J. Miller D. M. Holloway M. T. Leve G. D. ( 1967 ). Hexokinase Isoenzymes in Liver and Adipose Tissue of Man and Dog . Science 155 ( 3759 ), 205 ？ 207 . 10.1126/science.155.3759.205 6015527
Brown R. W. B. Collingridge P. W. Gull K. Rigden D. J. Ginger M. L. ( 2014 ). Evidence for Loss of a Partial Flagellar Glycolytic Pathway during Trypanosomatid Evolution . PLoS ONE 9 ( 7 ), e103026 . 10.1371/journal.pone.0103026 25050549
Bustos D. M. Iglesias A. A. ( 2000 ). The Kinetic Properties of Liver Glucokinase and its Function in Glucose Physiology as a Model for the Comprehensive Study of Enzymes' Kinetic Parameters and Reversible Inhibitors . Biochem. Mol. Biol. Edu. 28 , 332 ？ 337 . 10.1016/S1470.8175(00)00027-810.1111/j.1539-3429.2000.tb00186.x
Candela M. Bergmann S. Vici M. Vitali B. Turroni S. Eikmanns B. J. ( 2007 ). Binding of Human Plasminogen to Bifidobacterium . J. Bacteriol. 189 , 5929 ？ 5936 . 10.1128/JB.00159-07 17557824
Carballo E. Lai W. S. Blackshear P. J. ( 1998 ). Feedback Inhibition of Macrophage Tumor Necrosis Factor- Production by Tristetraprolin . Science 281 ( 5379 ), 1001 ？ 1005 . 10.1126/science.281.5379.1001 9703499
Cardenas M. L. Cornish-Bowden A. Ureta T. ( 1998 ). Evolution and Regulatory Role of the Hexokinases . Biochim. Biophys. Acta (Bba) - Mol. Cel Res. 1401 ( 3 ), 242 ？ 264 . 10.1016/s0167-4889(97)00150-x
Castello A. Hentze M. W. Preiss T. ( 2015 ). Metabolic Enzymes Enjoying New Partnerships as RNA-Binding Proteins . Trends Endocrinol. Metab. 26 ( 12 ), 746 ？ 757 . 10.1016/j.tem.2015.09.012 26520658
Cesari I. M. Carvalho E. Figueiredo Rodrigues M. Mendonca B. d. S. Amoedo N. D. Rumjanek F. D. ( 2014 ). Methyl Jasmonate: Putative Mechanisms of Action on Cancer Cells Cycle, Metabolism, and Apoptosis . Int. J. Cel Biol. 2014 , 1 ？ 25 . 10.1155/2014/572097
Chantranupong L. Sabatini D. M. ( 2016 ). The TORC1 Pathway to Protein Destruction . Nature 536 ( 7615 ), 155 ？ 156 . 10.1038/nature18919 27462809
Chavez-munguia B. Segovia-Gamboa N. Salazar-Villatoro L. Omana-molina M. Espinosa-Cantellano M. Martinez-palomo A. ( 2011 ). Naegleria Fowleri: Enolase Is Expressed during Cyst Differentiation . J. Eukaryot. Microbiol. 58 ( 5 ), 463 ？ 468 . 10.1111/j.1550-7408.2011.00574.x 21895838
Chen C.-Y. Gherzi R. Ong S.-E. Chan E. L. Raijmakers R. Pruijn G. J. M. ( 2001 ). AU Binding Proteins Recruit the Exosome to Degrade ARE-Containing mRNAs . Cell 107 ( 4 ), 451 ？ 464 . 10.1016/s0092-8674(01)00578-5 11719186
Chen X. Liu Z. Gu Y. Zhang Y. Liu Y. Wang L. ( 2021b ). A Hexokinase from the Oyster Crassostrea gigas Is Involved in Immune Recognition as a Pattern Recognition Receptor . Developmental Comp. Immunol. 122 , 104083 . 10.1016/j.dci.2021.104083
Chen Y. Wang Y. Yang J. Zhou W. Dai S. ( 2021a ). Exploring the Diversity of Plant Proteome . J. Integr. Plant Biol. 10.1111/jipb.13087
Cho J.-I. Ryoo N. Eom J.-S. Lee D.-W. Kim H.-B. Jeong S.-W. ( 2009 ). Role of the Rice Hexokinases OsHXK5 and OsHXK6 as Glucose Sensors . Plant Physiol. 149 ( 2 ), 745 ？ 759 . 10.1104/pp.108.131227 19010999
Cho J.-I. Ryoo N. KoLee S. S. K. Lee S.-K. Lee J. Jung K.-H. ( 2006a ). Structure, Expression, and Functional Analysis of the Hexokinase Gene Family in rice (Oryza Sativa L.) . Planta 224 ( 3 ), 598 ？ 611 . 10.1007/s00425-006-0251-y 16552590
Cho Y.-H. Yoo S.-D. Sheen J. ( 2006b ). Regulatory Functions of Nuclear Hexokinase1 Complex in Glucose Signaling . Cell 127 ( 3 ), 579 ？ 589 . 10.1016/j.cell.2006.09.028 17081979
Claeyssen E. Rivoal J. ( 2007 ). Isozymes of Plant Hexokinase: Occurrence, Properties and Functions . Phytochemistry 68 ( 6 ), 709 ？ 731 . 10.1016/j.phytochem.2006.12.001 17234224
Cohen S. Flescher E. ( 2009 ). Methyl Jasmonate: A Plant Stress Hormone as an Anti-cancer Drug . Phytochemistry 70 ( 13-14 ), 1600 ？ 1609 . 10.1016/j.phytochem.2009.06.007 19660769
Collinridge P. W. Brown R. W. B. Ginger M. L. ( 2010 ). Moonlighting Enzymes in Parasitic Protozoa . Parasitology 137 ( 9 ), 1467 ？ 1475 . 10.1017/S0031182010000259 20233494
Colowick S. P. Kalckar H. M. ( 1943 ). The Role of Myokinase in Transphosphorylations . J. Biol. Chem. 148 , 117 ？ 126 . 10.1016/S0021-9258(18)72324-7
Commichau F. M. Rothe F. M. Herzberg C. Wagner E. Hellwig D. Lehnik-Habrink M. ( 2009 ). Novel Activities of Glycolytic Enzymes in Bacillus Subtilis . Mol. Cell Proteomics 8 ( 6 ), 1350 ？ 1360 . 10.1074/mcp.M800546-MCP200 19193632
Copley S. D. ( 2014 ). An Evolutionary Perspective on Protein Moonlighting . Biochem. Soc. Trans. 42 ( 6 ), 1684 ？ 1691 . 10.1042/BST20140245 25399590
Crowe J. D. Sievwright I. K. Auld G. C. Moore N. R. Gow N. A. R. Booth N. A. ( 2003 ). Candida Albicans Binds Human Plasminogen: Identification of Eight Plasminogen-Binding Proteins . Mol. Microbiol. 47 ( 6 ), 1637 ？ 1651 . 10.1046/j.1365-2958.2003.03390.x 12622818
Culbert A. A. Tavare J. M. ( 2002 ). Multiple Signalling Pathways Mediate Insulin-Stimulated Gene Expression in 3T3-L1 Adipocytes . Biochim. Biophys. Acta (Bba) - Gene Struct. Expr. 1578 , 43 ？ 50 . 10.1016/s0167-4781(02)00481-5
Dang X. Yu P. Li Y. Yang Y. Zhang Y. Ren H. ( 2018 ). Reactive Oxygen Species Mediate Conical Cell Shaping in Arabidopsis thaliana Petals . Plos Genet. 14 ( 10 ), e1007705 . 10.1371/journal.pgen.1007705 30296269
Dastoor Z. Dreyer J. L. ( 2001 ). Potential Role of Nuclear Translocation of Glyceraldehyde-3-Phosphate Dehydrogenase in Apoptosis and Oxidative Stress . J. Cel Sci. 114 ( 9 ), 1643 ？ 1653 . 10.1242/jcs.114.9.1643
Desai K. Sullards M. C. Allegood J. Wang E. Schmelz E. M. Hartl M. ( 2002 ). Fumonisins and Fumonisin Analogs as Inhibitors of Ceramide Synthase and Inducers of Apoptosis . Biochim. Biophys. Acta (Bba) - Mol. Cel Biol. Lipids 1585 , 188 ？ 192 . 10.1016/s1388-1981(02)00340-2
Dubey A. K. Godbole A. Mathew M. K. ( 2016 ). Regulation of VDAC Trafficking Modulates Cell Death . Cel Death Discov. 2 ( 2 ), 16085 . 10.1038/cddiscovery.2016.85
Egea L. Aguilera L. Gimenez R. Sorolla M. A. Aguilar J. Badia J. ( 2007 ). Role of Secreted Glyceraldehyde-3-Phosphate Dehydrogenase in the Infection Mechanism of Enterohemorrhagic and Enteropathogenic Escherichia coli : Interaction of the Extracellular Enzyme with Human Plasminogen and Fibrinogen . Int. J. Biochem. Cel Biol. 39 ( 6 ), 1190 ？ 1203 . 10.1016/j.biocel.2007.03.008
Enzo E. Santinon G. Pocaterra A. Aragona M. Bresolin S. Forcato M. ( 2015 ). Aerobic Glycolysis Tunes YAP /TAZ Transcriptional Activity . EMBO J. 34 ( 10 ), 1349 ？ 1370 . 10.15252/embj.201490379 25796446
Feng J. Zhao S. Chen X. Wang W. Dong W. Chen J. ( 2015 ). Biochemical and Structural Study ofArabidopsishexokinase 1 . Acta Cryst. D Biol. Crystallogr. 71 ( 2 ), 367 ？ 375 . 10.1107/S1399004714026091 25664748
Fernandez R. Herrero P. Fernandez E. Fernandez T. Lopez-Boado Y. S. Moreno F. ( 1988 ). Autophosphorylation of Yeast Hexokinase PII . Microbiology 134 , 2493 ？ 2498 . 10.1099/00221287-134-9-2493
Fernandez-Garcia P. Pelaez R. Herrero P. Moreno F. ( 2012 ). Phosphorylation of Yeast Hexokinase 2 Regulates its Nucleocytoplasmic Shuttling . J. Biol. Chem. 287 ( 50 ), 42151 ？ 42164 . 10.1074/jbc.M112.401679 23066030
Fox D. Smulian A. G. ( 2001 ). Plasminogen-binding Activity of Enolase in the Opportunistic Pathogen Pneumocystis Carinii . Med. Mycol. 39 ( 6 ), 495 ？ 507 . 10.1080/mmy.39.6.495.507 11798055
Foyer C. H. Baker A. Wright M. Sparkes I. A. Mhamdi A. Schippers J. H. M. ( 2020 ). On the Move: Redox-dependent Protein Relocation in Plants . J. Exp. Bot. 71 ( 2 ), 620 ？ 631 . 10.1093/jxb/erz330 31421053
Franco-Serrano L. Cedano J. Perez-Pons J. A. Mozo-Villarias A. Pinol J. Amela I. ( 2018 ). A Hypothesis Explaining Why So many Pathogen Virulence Proteins Are Moonlighting Proteins . Pathog. Dis. 76 ( 5 ), fty046 . 10.1093/femspd/fty046
Froguel P. Zouali H. Vionnet N. Velho G. Vaxillaire M. Sun F. ( 1993 ). Familial Hyperglycemia Due to Mutations in Glucokinase -- Definition of a Subtype of Diabetes Mellitus . N. Engl. J. Med. 328 ( 10 ), 697 ？ 702 . 10.1056/NEJM199303113281005 8433729
Furman T. C. Neet K. E. ( 1983 ). Association Equilibria and Reacting Enzyme Gel Filtration of Yeast Hexokinaseltration of Yeast Hexokinase . J. Biol. Chem. 258 ( 8 ), 4930 ？ 4936 . 10.1016/s0021-9258(18)32517-1 6833283
Gancedo C. Flores C.-L. Gancedo J. M. ( 2014 ). Evolution of Moonlighting Proteins: Insight from Yeasts . Biochem. Soc. Trans. 42 ( 6 ), 1715 ？ 1719 . 10.1042/BST20140199 25399595
Gancedo C. Flores C.-L. Gancedo J. M. ( 2016 ). The Expanding Landscape of Moonlighting Proteins in Yeasts . Microbiol. Mol. Biol. Rev. 80 ( 3 ), 765 ？ 777 . 10.1128/MMBR.00012-16 27466281
Gancedo C. Flores C.-L. ( 2008 ). Moonlighting Proteins in Yeasts . Mmbr 72 ( 1 ), 197 ？ 210 . 10.1128/MMBR.00036-07 18322039
Gao X. Wang H. Yang J. J. Liu X. Liu Z. R. ( 2012 ). Piruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase . Mol. Cell. 45 , 598 ？ 609 . 10.1016/j.molcel.2012.01.001 22306293
Godbole A. Dubey A. K. Reddy P. S. Udayakumar M. Mathew M. K. ( 2013 ). Mitochondrial VDAC and Hexokinase Together Modulate Plant Programmed Cell Death . Protoplasma 250 ( 4 ), 875 ？ 884 . 10.1007/s00709-012-0470-y 23247919
Goeb V. Thomas-L'Otellier M. Daveau R. Charlionet R. Fardellone P. Le Loet X. ( 2009 ). Candidate Autoantigens Identified by Mass Spectrometry in Early Rheumatoid Arthritis Are Chaperones and Citrullinated Glycolytic Enzymes . Arthritis Res. Ther. 11 ( 2 ), R38 . 10.1186/ar2644 19284558
Golbik R. Naumann M. Otto A. Muller E.-C. Behlke J. Reuter R. ( 2001 ). Regulation of Phosphotransferase Activity of Hexokinase 2 fromSaccharomycescerevisiaeby Modification at Serine-14† . Biochemistry 40 ( 4 ), 1083 ？ 1090 . 10.1021/bi001745k 11170432
Goldin N. Arzoine L. Heyfets A. Israelson A. Zaslavsky Z. Bravman T. ( 2008 ). Methyl Jasmonate Binds to and Detaches Mitochondria-Bound Hexokinase . Oncogene 27 , 4636 ？ 4643 . 10.1038/onc.2008.108 18408762
Goldstein J. L. Brown M. S. ( 1990 ). Regulation of the Mevalonate Pathway . Nature 343 ( 6257 ), 425 ？ 430 . 10.1038/343425a0 1967820
Gonzalez C. Ureta T. Sanchez R. Niemeyer H. ( 1964 ). Multiple Molecular Forms of ATP: Hexose 6-phosphotransferase from Rat Liver . Biochem. Biophysical Res. Commun. 16 ( 4 ), 347 ？ 352 . 10.1016/0006-291x(64)90038-5
Gonzalez-Arzola K. Velazquez-Cruz A. Guerra-Castellano A. Casado-Combreras M. Perez-Mejias G. Diaz-Quintana A. ( 2019 ). New Moonlighting Functions of Mitochondrial Cytochrome C in the Cytoplasm and Nucleus . FEBS Lett. 593 ( 22 ), 3101 ？ 3119 . 10.1002/1873-3468.13655 31663111
Grosse F. Nasheuer H.-P. Scholtissek S. Schomburg U. ( 1986 ). Lactate Dehydrogenase and Glyceraldehyde-Phosphate Dehydrogenase Are Single-Stranded DNA-Binding Proteins that Affect the DNA-Polymerase-Alpha-Primase Complex . Eur. J. Biochem. 160 ( 3 ), 459 ？ 467 . 10.1111/j.1432-1033.1986.tb10062.x 3536507
Grupe A. Hultgren B. Ryan A. Ma Y. H. Bauer M. Stewart T. A. ( 1995 ). Transgenic Knockouts Reveal a Critical Requirement for Pancreatic β Cell Glucokinase in Maintaining Glucose Homeostasis . Cell 83 ( 1 ), 69 ？ 78 . 10.1016/0092-8674(95)90235-x 7553875
Guo C. Ludvik A. E. Arlotto M. E. Hayes M. G. Armstrong L. L. Scholtens D. M. ( 2015 ). Coordinated Regulatory Variation Associated with Gestational Hyperglycaemia Regulates Expression of the Novel Hexokinase HKDC1 . Nat. Commun. 6 , 6069 . 10.1038/ncomms7069 25648650
Gupta V. Bamezai R. N. K. ( 2010 ). Human Pyruvate Kinase M2: a Multifunctional Protein . Protein Sci. 19 ( 11 ), 2031 ？ 2044 . 10.1002/pro.505 20857498
Hagemann L. Grundel A. Jacobs E. Dumke R. ( 2017 ). The Surface-Displayed Chaperones GroEL and DnaK of Mycoplasma Pneumoniae Interact with Human Plasminogen and Components of the Extracellular Matrix . FEMS J. Pathog. Dis. 75 ( 3 ). 10.1093/femspd/ftx017
Han S. Wang Y. Zheng X. Jia Q. Zhao J. Bai F. ( 2015 ). Cytoplastic Glyceraldehyde-3-Phosphate Dehydrogenases Interact with ATG3 to Negatively Regulate Autophagy and Immunity in Nicotiana Benthamiana . Plant Cell 27 ( 4 ), 1316 ？ 1331 . 10.1105/tpc.114.134692 25829441
Hapeta P. Szczepaska P. Neuveglise C. Lazar Z. ( 2021 ). A 37-amino Acid Loop in the Yarrowia Lipolytica Hexokinase Impacts its Activity and Affinity and Modulates Gene Expression . Sci. Rep. 11 ( 1 ), 6412 . 10.1038/s41598-021-85837-8 33742083
Hara M. R. Agrawal N. Kim S. F. Cascio M. B. Fujimuro M. Ozeki Y. ( 2005 ). S-nitrosylated GAPDH Initiates Apoptotic Cell Death by Nuclear Translocation Following Siah1 Binding . Nat. Cel Biol. 7 ( 7 ), 665 ？ 674 . 10.1038/ncb1268
Hashiguchi A. Komatsu S. ( 2017 ). Posttranslational Modifications and Plant-Environment Interaction . Methods Enzymol. 586 , 97 ？ 113 . 10.1016/bs.mie.2016.09.030 28137579
Hattori T. Takei N. Mizuno Y. Kato K. Kohsaka S. ( 1995 ). Neurotrophic and Neuroprotective Effects of Neuron-specific Enolase on Cultured Neurons from Embryonic Rat Brain . Neurosci. Res. 21 ( 3 ), 191 ？ 198 . 10.1016/0168-0102(94)00849-b 7753500
He C. Chen J. Wang H. Wan Y. Zhou J. Dan Z. ( 2019 ). Crystal Structures of rice Hexokinase 6 with a Series of Substrates Shed Light on its Enzymatic Mechanism . Biochem. Biophysical Res. Commun. 515 ( 4 ), 614 ？ 620 . 10.1016/j.bbrc.2019.05.139
Heidrich K. Otto A. Behlke J. Rush J. Wenzel K.-W. Kriegel T. ( 1997 ). Autophosphorylation？Inactivation Site of Hexokinase 2 inSaccharomyces Cerevisiae† . Biochemistry 36 , 1960 ？ 1964 . 10.1021/bi9623643 9047292
Henderson B. Martin A. ( 2011 ). Bacterial Virulence in the Moonlight: Multitasking Bacterial Moonlighting Proteins Are Virulence Determinants in Infectious Disease . Infect. Immun. 79 ( 9 ), 3476 ？ 3491 . 10.1128/IAI.00179-11 21646455
Hendriks W. Mulders J. W. Bibby M. A. Slingsby C. Bloemendal H. de Jong W. W. ( 1988 ). Duck Lens Epsilon-Crystallin and Lactate Dehydrogenase B4 Are Identical: a Single-Copy Gene Product with Two Distinct Functions . Proc. Natl. Acad. Sci. 85 , 7114 ？ 7118 . 10.1073/pnas.85.19.7114 3174623
Heneberg P. ( 2019 ). Redox Regulation of Hexokinases . Antioxid. Redox Signaling 30 ( 3 ), 415 ？ 442 . 10.1089/ars.2017.72510.1089/ars.2017.7255
Henry E. Fung N. Liu J. Drakakaki G. Coaker G. ( 2015 ). Beyond Glycolysis: GAPDHs Are Multi-Functional Enzymes Involved in Regulation of ROS, Autophagy, and Plant Immune Responses . Plos Genet. 11 ( 4 ), e1005199 . 10.1371/journal.pgen.1005199 25918875
Hentze M. W. Preiss T. ( 2010 ). The REM Phase of Gene Regulation . Trends Biochem. Sci. 35 ( 8 ), 423 ？ 426 . 10.1016/j.tibs.2010.05.009 20554447
Hernandez S. Ferragut G. Amela I. Perez-Pons J. Pinol J. Mozo-Villarias A. ( 2014 ). MultitaskProtDB: a Database of Multitasking Proteins . Nucl. Acids Res. 42 , D517 ？ D520 . 10.1093/nar/gkt1153 24253302
Hernandez S. Franco L. Calvo A. Ferragut G. Hermoso A. Amela I. ( 2015 ). Bioinformatics and Moonlighting Proteins . Front. Bioeng. Biotechnol. 3 ( 90 ), 1 ？ 16 . 10.3389/fbioe.2015.0009010.3389/fbioe.2015.00090 25654078
Herrero P. Fernandez R. Moreno F. ( 1989 ). The Hexokinase Isoenzyme PII of Saccharomyces cerevisiae Is a Protein Kinase . Microbiology 135 ( 5 ), 1209 ？ 1216 . 10.1099/00221287-135-5-1209
Herrero P. Martinez-Campa C. Moreno F. ( 1998 ). The Hexokinase 2 Protein Participates in Regulatory DNA-Protein Complexes Necessary for Glucose Repression of the SUC2 Gene in Saccharomyces cerevisiae . FEBS Lett. 434 ( 2 ), 71 ？ 76 . 10.1016/s0014-5793(98)00872-2 9738454
Hu D.-G. Sun C.-H. Zhang Q.-Y. An J.-P. You C.-X. Hao Y.-J. ( 2016 ). Glucose Sensor MdHXK1 Phosphorylates and Stabilizes MdbHLH3 to Promote Anthocyanin Biosynthesis in Apple . Plos Genet. 12 ( 8 ), e1006273 . 10.1371/journal.pgen.1006273 27560976
Huang W. Yu C. Hu J. Wang L. Dan Z. Zhou W. ( 2015 ). Pentatricopeptide-repeat Family Protein RF6 Functions with Hexokinase 6 to rescue rice Cytoplasmic Male Sterility . Proc. Natl. Acad. Sci. U.S.A. 112 ( 48 ), 14984 ？ 14989 . 10.1073/pnas.1511748112 26578814
Huberts D. H. E. W. van der Klei I. J. ( 2010 ). Moonlighting Proteins: An Intriguing Mode of Multitasking . Biochim. Biophys. Acta (Bba) - Mol. Cel Res. 1803 , 520 ？ 525 . 10.1016/j.bbamcr.2010.01.022
Hurmalainen V. Edelman S. Antikainen J. Baumann M. Lahteenmaki K. Korhonen T. K. ( 2007 ). Extracellular Proteins of Lactobacillus Crispatus Enhance Activation of Human Plasminogen . Microbiology (Reading) 153 ( 4 ), 1112 ？ 1122 . 10.1099/mic.0.2006/000901-0 17379720
Ikeda R. Ichikawa T. ( 2014 ). Interaction of Surface Molecules on Cryptococcus Neoformans with Plasminogen . FEMS Yeast Res. 14 ( 3 ), 445 ？ 450 . 10.1111/1567-1364.12131 24373348
Ikeda Y. Yamaji R. Irie K. Kioka N. Murakami A. ( 2012 ). Glyceraldehyde-3-phosphate Dehydrogenase Regulates Cyclooxygenase-2 Expression by Targeting mRNA Stability . Arch. Biochem. Biophys. 528 ( 2 ), 141 ？ 147 . 10.1016/j.abb.2012.09.004 23000033
Imle R. Wang B.-T. Stutzenberger N. Birkenhagen J. Tandon A. Carl M. ( 2019 ). ADP-dependent Glucokinase Regulates Energy Metabolism via ER-Localized Glucose Sensing . Sci. Rep. 9 , 14248 . 10.1038/s41598-019-50566-6 31582762
Irwin D. M. Tan H. ( 2014 ). Evolution of Glucose Utilization: Glucokinase and Glucokinase Regulator Protein . Mol. Phylogenet. Evol. 70 , 195 ？ 203 . 10.1016/j.ympev.2013.09.016 24075984
Jagot-Lacoussiere L. Faye A. Bruzzoni-Giovanelli H. Villoutreix B. O. Rain J.-C. Poyet J.-L. ( 2015 ). DNA Damage-Induced Nuclear Translocation of Apaf-1 Is Mediated by Nucleoporin Nup107 . Cell Cycle 14 ( 8 ), 1242 ？ 1251 . 10.1080/15384101.2015.1014148 25695197
Jang J. C. Leon P. Zhou L. Sheen J. ( 1997 ). Hexokinase as a Sugar Sensor in Higher Plants . Plant Cell 9 , 5 ？ 19 . 10.1105/tpc.9.1.5 9014361
Jeffery C. J. ( 2020 ). Enzymes, Pseudoenzymes, and Moonlighting Proteins: Diversity of Function in Protein Superfamilies . FEBS J. 287 , 4141 ？ 4149 . 10.1111/febs.15446 32534477
Jeffery C. J. ( 2004 ). Molecular Mechanisms for Multitasking: Recent crystal Structures of Moonlighting Proteins . Curr. Opin. Struct. Biol. 14 ( 6 ), 663 ？ 668 . 10.1016/j.sbi.2004.10.001 15582389
Jeffery C. J. ( 1999 ). Moonlighting Proteins . Trends Biochem. Sci. 24 ( 1 ), 8 ？ 11 . 10.1016/s0968-0004(98)01335-8 10087914
Jeffery C. J. ( 2009 ). Moonlighting Proteins-An Update . Mol. Biosyst. 5 ( 4 ), 345 ？ 350 . 10.1039/b900658n 19396370
Jeffery C. J. ( 2016 ). Protein Species and Moonlighting Proteins: Very Small Changes in a Protein's Covalent Structure Can Change its Biochemical Function . J. Proteomics 134 , 19 ？ 24 . 10.1016/j.jprot.2015.10.003 26455812
Jiang J. Peng L. Wang K. Huang C. ( 2021 ). Moonlighting Metabolic Enzymes in Cancer: New Perspectives on the Redox Code . Antioxid. Redox Signaling 34 ( 13 ), 979 ？ 1003 . 10.1089/ars.2020.8123
Jiao L. Zhang H.-L. Li D.-D. Yang K.-L. Tang J. Li X. ( 2018 ). Regulation of Glycolytic Metabolism by Autophagy in Liver Cancer Involves Selective Autophagic Degradation of HK2 (Hexokinase 2) . Autophagy 14 ( 4 ), 671 ？ 684 . 10.1080/15548627.2017.1381804 28980855
Johnston M. ( 1999 ). Feasting, Fasting and Fermenting: Glucose Sensing in Yeast and Other Cells . Trends Genet. 15 ( 1 ), 29 ？ 33 . 10.1016/s0168-9525(98)01637-0 10087931
Joice A. C. Lyda T. L. Sayce A. C. Verplaetse E. Morris M. T. Michels P. A. M. ( 2012 ). Extra-glycosomal Localisation of Trypanosoma Brucei Hexokinase 2 . Int. J. Parasitol. 42 , 401 ？ 409 . 10.1016/j.ijpara.2012.02.008 22619756
Jones M. N. Holt R. G. ( 2007 ). Cloning and Characterization of an α-enolase of the Oral Pathogen Streptococcus Mutans that Binds Human Plasminogen . Biochem. Biophysical Res. Commun. 364 ( 4 ), 924 ？ 929 . 10.1016/j.bbrc.2007.10.098
Jong A. Y. Chen S. H. M. Stins M. F. Kim K. S. Tuan T.-L. Huang S.-H. ( 2003 ). Binding of Candida Albicans Enolase to Plasmin(ogen) Results in Enhanced Invasion of Human Brain Microvascular Endothelial Cells . J. Med. Microbiol. 52 ( 8 ), 615 ？ 622 . 10.1099/jmm.0.05060-0 12867553
Kainulainen V. Loimaranta V. Pekkala A. Edelman S. Antikainen J. Kylvaja R. ( 2012 ). Glutamine Synthetase and Glucose-6-Phosphate Isomerase Are Adhesive Moonlighting Proteins of Lactobacillus Crispatus Released by Epithelial Cathelicidin LL-37 . J. Bacteriol. 194 ( 10 ), 2509 ？ 2519 . 10.1128/JB.06704-11 22389474
Kamata K. Mitsuya M. Nishimura T. Eiki J.-i. Nagata Y. ( 2004 ). Structural Basis for Allosteric Regulation of the Monomeric Allosteric Enzyme Human Glucokinase . Structure 12 ( 3 ), 429 ？ 438 . 10.1016/j.str.2004.02.005 15016359
Kao A. W. Noda Y. Johnson J. H. Pessin J. E. Saltiel A. R. ( 1999 ). Aldolase Mediates the Association of F-Actin with the Insulin-Responsive Glucose Transporter GLUT4 . J. Biol. Chem. 274 ( 25 ), 17742 ？ 17747 . 10.1074/jbc.274.25.17742 10364216
Kaps S. Kettner K. Migotti R. Kanashova T. Krause U. Rodel G. ( 2015 ). Protein Kinase Ymr291w/Tda1 Is Essential for Glucose Signaling in Saccharomyces cerevisiae on the Level of Hexokinase Isoenzyme ScHxk2 Phosphorylation* . J. Biol. Chem. 290 ( 10 ), 6243 ？ 6255 . 10.1074/jbc.M114.595074 25593311
Katakura Y. Sano R. Hashimoto T. Ninomiya K. Shioya S. ( 2010 ). Lactic Acid Bacteria Display on the Cell Surface Cytosolic Proteins that Recognize Yeast Mannan . Appl. Microbiol. Biotechnol. 86 ( 1 ), 319 ？ 326 . 10.1007/s00253-009-2295-y 19898842
Kelley N. Jeltema D. Duan Y. He Y. ( 2019 ). The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation . Ijms 20 ( 13 ), 3328 . 10.3390/ijms20133328
Kennedy M. C. Mende-Mueller L. Blondin G. A. Beinert H. ( 1992 ). Purification and Characterization of Cytosolic Aconitase from Beef Liver and its Relationship to the Iron-Responsive Element Binding Protein . Proc. Natl. Acad. Sci. 89 ( 24 ), 11730 ？ 11734 . 10.1073/pnas.89.24.11730 1334546
Kim D. J. Vo M.-T. Choi S. H. Lee J.-H. Jeong S. Y. Hong C. H. ( 2019 ). Tristetraprolin-mediated Hexokinase 2 Expression Regulation Contributes to Glycolysis in Cancer Cells . MBoC 30 ( 5 ), 542 ？ 553 . 10.1091/mbc.E18-09-0606 30650008
Kim H.-B. Cho J.-I. Ryoo N. Shin D.-H. Park Y.-I. Hwang Y.-S. ( 2016 ). Role of rice Cytosolic Hexokinase OsHXK7 in Sugar Signaling and Metabolism . J. Integr. Plant Biol. 58 ( 2 ), 127 ？ 135 . 10.1111/jipb.12366 25951042
Kim H. Smith J. E. Ridenour J. B. Woloshuk C. P. Bluhm B. H. ( 2011 ). HXK1 Regulates Carbon Catabolism, Sporulation, Fumonisin B1 Production and Pathogenesis in Fusarium Verticillioides . Microbiol. 157 , 2658 ？ 2669 . 10.1099/mic.0.052506-0
Kim J.-w. Dang C. V. ( 2005 ). Multifaceted Roles of Glycolytic Enzymes . Trends Biochem. Sci. 30 ( 3 ), 142 ？ 150 . 10.1016/j.tibs.2005.01.005 15752986
Kim M. Lim J.-H. Ahn C. S. Park K. Kim G. T. Kim W. T. ( 2006 ). Mitochondria-Associated Hexokinases Play a Role in the Control of Programmed Cell Death in Nicotiana Benthamiana . Plant Cell 18 ( 9 ), 2341 ？ 2355 . 10.1105/tpc.106.041509 16920781
Kim S.-C. Guo L. Wang X. ( 2020 ). Nuclear Moonlighting of Cytosolic Glyceraldehyde-3-Phosphate Dehydrogenase Regulates Arabidopsis Response to Heat Stress . Nat. Commun. 11 ( 1 ), 3439 . 10.1038/s41467-020-17311-4 32651385
Kim S. G. Hoffman G. R. Poulogiannis G. Buel G. R. Jang Y. J. Lee K. W. ( 2013a ). Metabolic Stress Controls mTORC1 Lysosomal Localization and Dimerization by Regulating the TTT-Ruvbl1/2 Complex . Mol. Cel 49 , 172 ？ 185 . 10.1016/j.molcel.2012.10.003
Kim Y.-M. Heinzel N. Giese J.-O. Koeber J. Melzer M. Rutten T. ( 2013b ). A Dual Role of Tobacco Hexokinase 1 in Primary Metabolism and Sugar Sensing . Plant Cel Environ 36 ( 7 ), 1311 ？ 1327 . 10.1111/pce.12060
Kimura A. Sakurai T. Koumura A. Yamada M. Hayashi Y. Tanaka Y. ( 2010 ). High Prevalence of Autoantibodies against Phosphoglycerate Mutase 1 in Patients with Autoimmune central Nervous System Diseases . J. Neuroimmunology 219 ( 1-2 ), 105 ？ 108 . 10.1016/j.jneuroim.2009.11.014 19969379
Kinnby B. Booth N. A. Svensater G. ( 2008 ). Plasminogen Binding by Oral Streptococci from Dental Plaque and Inflammatory Lesions . Microbiology 154 ( 3 ), 924 ？ 931 . 10.1099/mic.0.2007/013235-0 18310038
Kiri A. Goldspink G. ( 2002 ). RNA-protein Interactions of the 3’ Untranslated Regions of Myosin Heavy Chain Transcripts . J. Muscle Res. Cel Motil. 23 , 119 ？ 129 . 10.1023/a:1020211729728
Kotiadis V. N. Duchen M. R. Osellame L. D. ( 2014 ). Mitochondrial Quality Control and Communications with the Nucleus Are Important in Maintaining Mitochondrial Function and Cell Health . Biochim. Biophys. Acta (Bba) - Gen. Subjects 1840 ( 4 ), 1254 ？ 1265 . 10.1016/j.bbagen.2013.10.041
Kriegel T. M. Rush J. Vojtek A. B. Clifton D. Fraenkel D. G. ( 1994 ). In Vivo phosphorylation Site of Hexokinase 2 in Saccharomyces cerevisiae . Biochemistry 33 , 148 ？ 152 . 10.1021/bi00167a019 8286332
Kuettner E. B. Kettner K. Keim A. Svergun D. I. Volke D. Singer D. ( 2010 ). Crystal Structure of Hexokinase Klhxk1 of Kluyveromyces Lactis: A Molecular Basis for Understanding the Control of Yeast Hexokinase Functions via Covalent Modification and Oligomerization . J. Biol. Chem. 285 , 41019 ？ 41033 . 10.1074/jbc.M110.185850 20943665
Kundu M. ( 2014 ). Too Sweet for Autophagy: Hexokinase Inhibition of mTORC1 Activates Autophagy . Mol. Cel 53 ( 4 ), 517 ？ 518 . 10.1016/j.molcel.2014.02.009
Kuser P. R. Krauchenco S. Antunes O. A. C. Polikarpov I. ( 2000 ). The High Resolution Crystal Structure of Yeast Hexokinase PII with the Correct Primary Sequence Provides New Insights into its Mechanism of Action . J. Biol. Chem. 275 ( 27 ), 20814 ？ 20821 . 10.1074/jbc.M910412199 10749890
Larion M. Hansen A. L. Zhang F. Bruschweiler-Li L. Tugarinov V. Miller B. G. ( 2015 ). Kinetic Cooperativity in Human Pancreatic Glucokinase Originates from Millisecond Dynamics of the Small Domain . Angew. Chem. Int. Ed. 54 , 8129 ？ 8132 . 10.1002/anie.201501204
Larion M. Miller B. G. ( 2012 ). Homotropic Allosteric Regulation in Monomeric Mammalian Glucokinase . Arch. Biochem. Biophys. 519 ( 2 ), 103 ？ 111 . 10.1016/j.abb.2011.11.007 22107947
Laurian R. Dementhon K. Doumeche B. Soulard A. Noel T. Lemaire M. ( 2019 ). Hexokinase and Glucokinases Are Essential for Fitness and Virulence in the Pathogenic Yeast Candida Albicans . Front. Microbiol. 10 , 327 . 10.3389/fmicb.2019.00327 30858840
Lay A. J. Jiang X.-M. Kisker O. Flynn E. Underwood A. Condron R. ( 2000 ). Phosphoglycerate Kinase Acts in Tumour Angiogenesis as a Disulphide Reductase . Nature 408 ( 6814 ), 869 ？ 873 . 10.1038/35048596 11130727
Lee S.-K. Kim H. Cho J.-I. Nguyen C. D. Moon S. Park J. E. ( 2019 ). Deficiency of rice Hexokinase HXK5 Impairs Synthesis and Utilization of Starch in Pollen Grains and Causes Male Sterility . J. Exp. Bot. 71 ( 1 ), 116 ？ 125 . 10.1093/jxb/erz436
Li S. Swanson S. K. Gogol M. Florens L. Washburn M. P. Workman J. L. ( 2015 ). Serine and SAM Responsive Complex SESAME Regulates Histone Modification Crosstalk by Sensing Cellular Metabolism . Mol. Cel 60 ( 3 ), 408 ？ 421 . 10.1016/j.molcel.2015.09.024
Ling Q. Jarvis P. ( 2015 ). Regulation of Chloroplast Protein Import by the Ubiquitin E3 Ligase SP1 Is Important for Stress Tolerance in Plants . Curr. Biol. 25 ( 19 ), 2527 ？ 2534 . 10.1016/j.cub.2015.08.015 26387714
Lionaki E. Gkikas I. Tavernarakis N. ( 2016 ). Differential Protein Distribution between the Nucleus and Mitochondria: Implications in Aging . Front. Genet. 7 , 162 . 10.3389/fgene.2016.00162 27695477
Liu H.-E. Shi H.-H. Luo X.-J. ( 2020 ). Upregulated Long Noncoding RNA UCA1 Enhances Warburg Effect via miR-203/HK2 Axis in Esophagal Cancer . J. Oncol. 2020 , 1 ？ 11 . 10.1155/2020/8847687
Liu H. Zeng H. Yao Q. Yuan J. Zhang Y. Qiu D. ( 2012 ). Steinernema Glaseri Surface Enolase: Molecular Cloning, Biological Characterization, and Role in Host Immune Suppression . Mol. Biochem. Parasitol. 185 ( 2 ), 89 ？ 98 . 10.1016/j.molbiopara.2012.06.006 22750626
Lu G.-T. Xie J.-R. Chen L. Hu J.-R. An S.-Q. Su H.-Z. ( 2009 ). Glyceraldehyde-3-phosphate Dehydrogenase of Xanthomonas Campestris Pv. Campestris Is Required for Extracellular Polysaccharide Production and Full Virulence . Microbiology 155 ( 5 ), 1602 ？ 1612 . 10.1099/mic.0.023762-0 19372163
Lu M. Holliday L. S. Zhang L. Dunn W. A. Jr Gluck S. L. ( 2001 ). Interaction between Aldolase and Vacuolar H+-ATPase . J. Biol. Chem. 276 ( 32 ), 30407 ？ 30413 . 10.1074/jbc.M008768200 11399750
Ludvik A. E. Pusec C. M. Priyadarshini M. Angueira A. R. Guo C. Lo A. ( 2016 ). HKDC1 Is a Novel Hexokinase Involved in Whole-Body Glucose Use . Endocrinology 157 ( 9 ), 3452 ？ 3461 . 10.1210/en.2016-1288 27459389
Lykke-Andersen J. Wagner E. ( 2005 ). Recruitment and Activation of mRNA Decay Enzymes by Two ARE-Mediated Decay Activation Domains in the Proteins TTP and BRF-1 . Genes Development 19 , 351 ？ 361 . 10.1101/gad.1282305 15687258
Ma R. Wu Y. Li S. Yu X. ( 2021 ). Interplay between Glucose Metabolism and Chromatin Modifications in Cancer . Front. Cel Dev. Biol. 9 , 654337 . 10.3389/fcell.2021.654337
Maccallini P. Bonin S. Trevisan G. ( 2018 ). Autoimmunity against a Glycolytic Enzyme as a Possible Cause for Persistent Symptoms in Lyme Disease . Med. Hypotheses 110 , 1 ？ 8 . 10.1016/j.mehy.2017.10.024 29317049
Machida K. Ohta Y. Osada H. ( 2006 ). Suppression of Apoptosis by Cyclophilin D via Stabilization of Hexokinase II Mitochondrial Binding in Cancer Cells . J. Biol. Chem. 281 , 14314 ？ 14320 . 10.1074/jbc.M513297200 16551620
Madureira P. Baptista M. Vieira M. Magalhaes V. Camelo A. Oliveira L. ( 2007 ). Streptococcus agalactiaeGAPDH Is a Virulence-Associated Immunomodulatory Protein . J. Immunol. 178 ( 3 ), 1379 ？ 1387 . 10.4049/jimmunol.178.3.1379 17237385
Magrys A. Anekonda T. Ren G. Adamus G. ( 2007 ). The Role of Anti-α-enolase Autoantibodies in Pathogenicity of Autoimmune-Mediated Retinopathy . J. Clin. Immunol. 27 ( 2 ), 181 ？ 192 . 10.1007/s10875-006-9065-8 17235687
Majewski N. Nogueira V. Bhaskar P. Coy P. E. Skeen J. E. Gottlob K. ( 2004 ). Hexokinase-mitochondria Interaction Mediated by Akt Is Required to Inhibit Apoptosis in the Presence or Absence of Bax and Bak . Mol. Cel 16 ( 5 ), 819 ？ 830 . 10.1016/j.molcel.2004.11.014
Mani M. Chen C. Amblee V. Liu H. Mathur T. Zwicke G. ( 2015 ). MoonProt: a Database for Proteins that Are Known to Moonlight . Nucleic Acids Res. 43 , D277 ？ D282 . 10.1093/nar/gku954 25324305
Marcos C. M. Oliveira H. C. d. da Silva J. d. F. Assato P. c. A. Fusco-Almeida A. M. Mendes-Giannini M. J. S. ( 2014 ). The Multifaceted Roles of Metabolic Enzymes in the Paracoccidioides Species Complex . Front. Microbiol. 5 ( 719 ), 1 ？ 10 . 10.3389/fmicb.2014.00719 24478763
Mathupala S. P. Ko Y. H. Pedersen P. L. ( 2006 ). Hexokinase II: Cancer's Double-Edged Sword Acting as Both Facilitator and Gatekeeper of Malignancy when Bound to Mitochondria . Oncogene 25 ( 34 ), 4777 ？ 4786 . 10.1038/sj.onc.1209603 16892090
Matschinsky F. M. Randle P. J. ( 1993 ). Evolution of the Glucokinase Glucose Sensor Paradigm for Pancreatic Beta Cells . Diabetologia 36 ( 11 ), 1215 ？ 1217 . 10.1007/BF00401072 8270142
Matschinsky F. M. Wilson D. F. ( 2019 ). The central Role of Glucokinase in Glucose Homeostasis: a Perspective 50 Years after Demonstrating the Presence of the Enzyme in Islets of Langerhans . Front. Physiol. 10 , 148 . 10.3389/fphys.2019.00148 30949058
Matta S. K. Agarwal S. Bhatnagar R. ( 2010 ). Surface Localized and Extracellular Glyceraldehyde-3-Phosphate Dehydrogenase of Bacillus Anthracis Is a Plasminogen Binding Protein . Biochim. Biophys. Acta (Bba) - Proteins Proteomics 1804 ( 11 ), 2111 ？ 2120 . 10.1016/j.bbapap.2010.08.004 20727989
McConnell E. W. Berg P. Westlake T. J. Wilson K. M. Popescu G. V. Hicks L. M. ( 2019 ). Proteome-wide Analysis of Cysteine Reactivity during Effector-Triggered Immunity . Plant Physiol. 179 ( 4 ), 1248 ？ 1264 . 10.1104/pp.18.01194 30510037
Meyer-Siegler K. Mauro D. J. Seal G. Wurzer J. deRiel J. K. Sirover M. A. ( 1991 ). A Human Nuclear Uracil DNA Glycosylase Is the 37-kDa Subunit of Glyceraldehyde-3-Phosphate Dehydrogenase . Proc. Natl. Acad. Sci. 88 ( 19 ), 8460 ？ 8464 . 10.1073/pnas.88.19.8460 1924305
Meyerhof O. ( 1927 ). Uber die enzymatische Milchsaurebildung im Muskelextrakt. III. Mitteilung: Die Milchsaurebildung aus den garfahigen Hexosen . Biochem. Z. 183 , 176 ？ 215 .
Meyerhof O. ( 1935 ). Uber die Wirkungsweise der Hexokinase . Naturwissenschaften 23 , 850 ？ 851 . 10.1007/bf01491989
Michels P. A. Bringaud F. Herman M. Hannaert V. ( 2006 ). Metabolic Functions of Glycosomes in Trypanosomatids . Biochim. Biophys. Acta 1763 , 1463 ？ 1477 . 10.1016/j.bbamcr.2006.08.019 17023066
Modun B. Morrissey J. Williams P. ( 2000 ). The Staphylococcal Transferrin Receptor: a Glycolytic Enzyme with Novel Functions . Trends Microbiol. 8 ( 5 ), 231 ？ 237 . 10.1016/s0966-842x(00)01728-5 10785640
Monaghan R. M. Whitmarsh A. J. ( 2015 ). Mitochondrial Proteins Moonlighting in the Nucleus . Trends Biochem. Sci. 40 ( 12 ), 728 ？ 735 . 10.1016/j.tibs.2015.10.003 26520802
Moore B. d. ( 2004 ). Bifunctional and Moonlighting Enzymes: Lighting the Way to Regulatory Control . Trends Plant Sci. 9 ( 5 ), 221 ？ 228 . 10.1016/j.tplants.2004.03.005 15130547
Moore B. Zhou L. Rolland F. Hall Q. Cheng W. H. Liu Y. X. ( 2003 ). Role of the Arabidopsis Glucose Sensor HXK1 in Nutrient, Light, and Hormonal Signaling . Science 300 ( 5617 ), 332 ？ 336 . 10.1126/science.1080585 12690200
Moreno F. Herrero P. ( 2002 ). The Hexokinase 2-dependent Glucose Signal Transduction Pathway ofSaccharomyces Cerevisiae . FEMS Microbiol. Rev. 26 , 83 ？ 90 . 10.1111/j.1574-6976.2002.tb00600.x 12007644
Mouveaux T. Oria G. Werkmeister E. Slomianny C. Fox B. A. Bzik D. J. ( 2014 ). Nuclear Glycolytic Enzyme Enolase of Toxoplasma Gondii Functions as a Transcriptional Regulator . PLoS ONE 9 ( 8 ), e105820 . 10.1371/journal.pone.0105820 25153525
Nilsson A. Olsson T. Ulfstedt M. Thelander M. Ronne H. ( 2011 ). Two Novel Types of Hexokinases in the moss Physcomitrella Patens . BMC Plant Biol. 11 ( 1 ), 32 . 10.1186/1471-2229-11-32 21320325
Nogueira S. V. Fonseca F. L. Rodrigues M. L. Mundodi V. Abi-Chacra E. A. Winters M. S. ( 2010 ). Paracoccidioides Brasiliensis Enolase Is a Surface Protein that Binds Plasminogen and Mediates Interaction of Yeast Forms with Host Cells . Iai 78 ( 9 ), 4040 ？ 4050 . 10.1128/IAI.00221-10
Nojima H. Tokunaga C. Eguchi S. Oshiro N. Hidayat S. Yoshino K.-i. ( 2003 ). The Mammalian Target of Rapamycin (mTOR) Partner, Raptor, Binds the mTOR Substrates P70 S6 Kinase and 4E-BP1 through Their TOR Signaling (TOS) Motif . J. Biol. Chem. 278 ( 18 ), 15461 ？ 15464 . 10.1074/jbc.C200665200 12604610
Olsson T. Thelander M. Ronne H. ( 2003 ). A Novel Type of Chloroplast Stromal Hexokinase Is the Major Glucose-Phosphorylating Enzyme in the moss Physcomitrella Patens . J. Biol. Chem. 278 ( 45 ), 44439 ？ 44447 . 10.1074/jbc.M306265200 12941966
Osawa H. Sutherland C. Robey R. B. Printz R. L. Granner D. K. ( 1996 ). Analysis of the Signaling Pathway Involved in the Regulation of Hexokinase II Gene Transcription by Insulin . J. Biol. Chem. 271 , 16690 ？ 16694 . 10.1074/jbc.271.28.16690 8663315
Ozcan S. Leong T. Johnston M. ( 1996 ). Rgt1p of Saccharomyces cerevisiae , a Key Regulator of Glucose-Induced Genes, Is Both an Activator and a Repressor of Transcription . Mol. Cel. Biol. 16 ( 11 ), 6419 ？ 6426 . 10.1128/mcb.16.11.6419
Palomino A. Herrero P. Moreno F. ( 2005 ). Rgt1, a Glucose Sensing Transcription Factor, Is Required for Transcriptional Repression of the HXK2 Gene in Saccharomyces cerevisiae . Biochem. J. 388 , 697 ？ 703 . 10.1042/BJ20050160 15705057
Pancholi V. Fischetti V. A. ( 1992 ). A Major Surface Protein on Group A Streptococci Is a Glyceraldehyde-3-Phosphate-Dehydrogenase with Multiple Binding Activity . J. Exp. Med. 176 ( 2 ), 415 ？ 426 . 10.1084/jem.176.2.415 1500854
Parkison C. Ashizawa K. McPhie P. Lin K. H. Cheng S. Y. ( 1991 ). The Monomer of Pyruvate Kinase, Subtype M1, Is Both a Kinase and a Cytosolic Thyroid Hormone Binding Protein . Biochem. Biophys. Res. Commun. 179 ( 1 ), 668 ？ 674 . 10.1016/0006-291x(91)91424-b 1883388
Pastorino J. G. Hoek J. B. ( 2008 ). Regulation of Hexokinase Binding to VDAC . J. Bioenerg. Biomembr. 40 ( 3 ), 171 ？ 182 . 10.1007/s10863-008-9148-8 18683036
Pastorino J. G. Shulga N. Hoek J. B. ( 2002 ). Mitochondrial Binding of Hexokinase II Inhibits Bax-Induced Cytochrome C Release and Apoptosis . J. Biol. Chem. 277 ( 9 ), 7610 ？ 7618 . 10.1074/jbc.M109950200 11751859
Pelaez R. Fernandez-Garcia P. Herrero P. Moreno F. ( 2012 ). Nuclear Import of the Yeast Hexokinase 2 Protein Requires α/β-Importin-dependent Pathway . J. Biol. Chem. 287 , 3518 ？ 3529 . 10.1074/jbc.M111.317230 22157003
Pelaez R. Herrero P. Moreno F. ( 2009 ). Nuclear export of the Yeast Hexokinase 2 Protein Requires the Xpo1 (Crm1)-dependent Pathway . J. Biol. Chem. 284 , 20548 ？ 20555 . 10.1074/jbc.M109.013730 19525230
Pereira L. A. Ba¡o S. n. N. Barbosa M. n. S. da Silva J. L. M. Felipe M. S. S. de Santana J. M. ( 2007 ). Analysis of theParacoccidioides Brasiliensistriosephosphate Isomerase Suggests the Potential for Adhesin Function . FEMS Yeast Res. 7 ( 8 ), 1381 ？ 1388 . 10.1111/j.1567-1364.2007.00292.x 17714474
Petit F. M. Serres C. Bourgeon F. Pineau C. Auer J. ( 2013 ). Identification of Sperm Head Proteins Involved in Zona Pellucida Binding . Hum. Reprod. 28 ( 4 ), 852 ？ 865 . 10.1093/humrep/des452 23355646
Petit P. Antoine M. Ferry G. Boutin J. A. Lagarde A. Gluais L. ( 2011 ). The Active Conformation of Human Glucokinase Is Not Altered by Allosteric Activators . Acta Crystallogr. D Biol. Cryst. 67 ( 11 ), 929 ？ 935 . 10.1107/S0907444911036729 22101819
Piatigorsky J. Wistow G. J. ( 1989 ). Enzyme/crystallins: Gene Sharing as an Evolutionary Strategy . Cell 57 ( 2 ), 197 ？ 199 . 10.1016/0092-8674(89)90956-2 2649248
Popanda O. Fox G. Thielmann H. W. ( 1998 ). Modulation of DNA Polymerases α, δ and ε by Lactate Dehydrogenase and 3-phosphoglycerate Kinase . Biochim. Biophys. Acta (Bba) - Gene Struct. Expr. 1397 ( 1 ), 102 ？ 117 . 10.1016/s0167-4781(97)00229-7
Prior C. Mamessier P. Fukuhara H. Chen X. J. Wesolowski-Louvel M. ( 1993 ). The Hexokinase Gene Is Required for Transcriptional Regulation of the Glucose Transporter Gene RAG1 in Kluyveromyces Lactis . Mol. Cel. Biol. 13 ( 7 ), 3882 ？ 3889 . 10.1128/mcb.13.7.3882
Ramajo-Hernandez A. Perez-Sanchez R. Ramajo-Martin V. Oleaga A. ( 2007 ). Schistosoma Bovis: Plasminogen Binding in Adults and the Identification of Plasminogen-Binding Proteins from the Worm Tegument . Exp. Parasitol. 115 ( 1 ), 83 ？ 91 . 10.1016/j.exppara.2006.07.003 16962583
Ramiah K. van Reenen C. A. Dicks L. M. T. ( 2008 ). Surface-Bound Proteins of Lactobacillus Plantarum 423 that Contribute to Adhesion of Caco-2 Cells and Their Role in Competitive Exclusion and Displacement of Clostridium sporogenes and Enterococcus faecalis . Res. Microbiol. 159 , 470 ？ 475 . 10.1016/j.resmic.2008.06.002 18619532
Randez-Gil F. Herrero P. Sanz P. Prieto J. A. Moreno F. ( 1998 ). Hexokinase PII Has a Double Cytosolic-Nuclear Localisation inSaccharomyces Cerevisiae . FEBS Lett. 425 , 475 ？ 478 . 10.1016/s0014-5793(98)00289-0 9563516
Ritterson Lew C. Tolan D. R. ( 2013 ). Aldolase Sequesters WASP and Affects WASP/Arp2/3-stimulated Actin Dynamics . J. Cel. Biochem. 114 ( 8 ), 1928 ？ 1939 . 10.1002/jcb.24538
Roberts D. J. Miyamoto S. ( 2015 ). Hexokinase II Integrates Energy Metabolism and Cellular protection: Akting on Mitochondria and TORCing to Autophagy . Cell Death Differ 22 , 248 ？ 257 . 10.1038/cdd.2014.173 25323588
Roberts D. J. Tan-Sah V. P. Smith J. M. Miyamoto S. ( 2013 ). Akt Phosphorylates HK-II at Thr-473 and Increases Mitochondrial HK-II Association to Protect Cardiomyocytes . J. Biol. Chem. 288 , 23798 ？ 23806 . 10.1074/jbc.M113.482026 23836898
Roberts D. J. Tan-Sah V. P. Ding E. Y. Smith J. M. Miyamoto S. ( 2014 ). Hexokinase-II Positively Regulates Glucose Starvation-Induced Autophagy through TORC1 Inhibition . Mol. Cel 53 , 521 ？ 533 . 10.1016/j.molcel.2013.12.019
Rodriguez-Enriquez S. Marin-Hernandez A. Gallardo-Perez J. C. Pacheco-Velazquez S. C. Belmont-Diaz J. A. Robledo-Cadena D. X. ( 2019 ). Transcriptional Regulation of Energy Metabolism in Cancer Cells . Cells 8 ( 10 ), 1225 . 10.3390/cells8101225
Rolland F. Winderickx J. Thevelein J. M. ( 2002 ). Glucose-sensing and -signalling Mechanisms in Yeast . FEMS Yeast Res. 2 ( 2 ), 183 ？ 201 . 10.1111/j.1567-1364.2002.tb00084.x 12702307
Ros S. Schulze A. ( 2013 ). Glycolysis Back in the Limelight: Systemic Targeting of HK2 Blocks Tumor Growth . Cancer Discov. 3 ( 10 ), 1105 ？ 1107 . 10.1158/2159-8290.CD-13-0565 24124231
Roth M. S. Westcott D. J. Iwai M. Niyogi K. K. ( 2019 ). Hexokinase Is Necessary for Glucose-Mediated Photosynthesis Repression and Lipid Accumulation in a green Alga . Commun. Biol. 2 ( 2 ), 1 ？ 10 . 10.1038/s42003-019-0577-1 30740537
Ryu J.-Y. Jeong S.-W. Kim S. Y. Ko Y. Yoon S. Choi S.-B. ( 2008 ). Cyanobacterial Glucokinase Complements the Glucose Sensing Role of Arabidopsis thaliana Hexokinase 1 . Biochem. Biophysical Res. Commun. 374 ( 3 ), 454 ？ 459 . 10.1016/j.bbrc.2008.07.041
Sahoo S. Murugavel S. Devi I. K. Vedamurthy G. V. Gupta S. C. Singh B. P. ( 2013 ). Glyceraldehyde-3-phosphate Dehydrogenase of the Parasitic nematodeHaemonchus Contortusbinds to Complement C3 and Inhibits its Activity . Parasite Immunol. 35 ( 12 ), 457 ？ 467 . 10.1111/pim.12058 23927077
Saltman P. ( 1953 ). Hexokinase in Higher Plants . J. Biol. Chem. 200 , 145 ？ 154 . 10.1016/s0021-9258(18)38447-3 13034769
Sawyer G. M. Monzingo A. F. Poteet E. C. O'Brien D. A. Robertus J. D. ( 2008 ). X-ray Analysis of Phosphoglycerate Kinase 2, a Sperm-specific Isoform from Mus musculus . Proteins 71 ( 3 ), 1134 ？ 1144 . 10.1002/prot.21801 18004764
Schalm S. S. Blenis J. ( 2002 ). Identification of a Conserved Motif Required for mTOR Signaling . Curr. Biol. 12 ( 8 ), 632 ？ 639 . 10.1016/s0960-9822(02)00762-5 11967149
Schulz G. E. Schirmer R. H. ( 1979 ). “ The Covalent Structure of Proteins ,” in Principles of Protein Structure . Editor Cantor C. H. ( Boston, MA : Springer ), 47 .
Segovia-Gamboa N. C. Chavez-Munguia B. Medina-Flores Y. Cazares-Raga F. E. Hernandez-Ramirez V. I. Martinez-Palomo A. ( 2010 ). Entamoeba Invadens, Encystation Process and Enolase . Exp. Parasitol. 125 ( 2 ), 63 ？ 69 . 10.1016/j.exppara.2009.12.019 20045689
Sha J. Erova T. E. Alyea R. A. Wang S. Olano J. P. Pancholi V. ( 2009 ). Surface-expressed Enolase Contributes to the Pathogenesis of Clinical Isolate SSU of Aeromonas Hydrophila . Jb 191 ( 9 ), 3095 ？ 3107 . 10.1128/JB.00005-09
Sharma P. Guptasarma P. ( 2017 ). Endoglucanase Activity at a Second Site inPyrococcus Furiosustriosephosphate Isomerase-Promiscuity or Compensation for a Metabolic Handicap? FEBS Open Bio 7 ( 8 ), 1126 ？ 1143 . 10.1002/2211-5463.12249
Shaw G. Kamen R. ( 1986 ). A Conserved AU Sequence from the 3′ Untranslated Region of GM-CSF mRNA Mediates Selective mRNA Degradation . Cell 46 , 659 ？ 667 . 10.1016/0092-8674(86)90341-7 3488815
Sheikh T. Gupta P. Gowda P. Patrick S. Sen E. ( 2018 ). Hexokinase 2 and Nuclear Factor Erythroid 2-related Factor 2 Transcriptionally Coactivate Xanthine Oxidoreductase Expression in Stressed Glioma Cells . J. Biol. Chem. 293 ( 13 ), 4767 ？ 4777 . 10.1074/jbc.M117.816785 29414774
Shetty S. Muniyappa H. Halady P. K. S. Idell S. ( 2004 ). Regulation of Urokinase Receptor Expression by Phosphoglycerate Kinase . Am. J. Respir. Cel Mol. Biol. 31 ( 1 ), 100 ？ 106 . 10.1165/rcmb.2003-0104OC
Shyu A.-B. Wilkinson M. F. ( 2000 ). The Double Lives of Shuttling mRNA Binding Proteins . Cell 102 , 135 ？ 138 . 10.1016/s0092-8674(00)00018-0 10943833
？imikova D. Kockocva L. Vackarova K. Te？insky M. Heneberg P. ( 2017 ). Evidence-based Tailoring of Bioinformatics Approaches to Optimize Methods that Predict the Effects of Nonsynonymous Amino Acid Substitutions in Glucokinase . Sci. Rep. 7 , 9499 . 10.1038/s41598-017-09810-0 28842611
Singh N. Bhalla N. ( 2020 ). Moonlighting Proteins . Annu. Rev. Genet. 54 , 265 ？ 285 . 10.1146/annurev-genet-030620-102906 32870732
Sriram G. Martinez J. A. McCabe E. R. B. Liao J. C. Dipple K. M. ( 2005 ). Single-gene Disorders: what Role Could Moonlighting Enzymes Play? Am. J. Hum. Genet. 76 ( 6 ), 911 ？ 924 . 10.1086/430799 15877277
Steitz T. A. Shoham M. Bennett W. S. Jr. ( 1981 ). Structural Dynamics of Yeast Hexokinase during Catalysis . Philos. Trans. R. Soc. Lond. B. Biol. Sci. 293 , 43 ？ 52 . 10.1098/rstb.1981.0058 6115422
Subramanian A. Miller D. M. ( 2000 ). Structural Analysis of α-Enolase . J. Biol. Chem. 275 ( 8 ), 5958 ？ 5965 . 10.1074/jbc.275.8.5958 10681589
Sun M.-H. Ma Q.-J. Hu D.-G. Zhu X.-P. You C.-X. Shu H.-R. ( 2018 ). The Glucose Sensor MdHXK1 Phosphorylates a Tonoplast Na+/H+ Exchanger to Improve Salt Tolerance . Plant Physiol. 176 ( 4 ), 2977 ？ 2990 . 10.1104/pp.17.01472 29440593
Sun Y.-J. Chou C.-C. Chen W.-S. Wu R.-T. Meng M. Hsiao C.-D. ( 1999 ). The crystal Structure of a Multifunctional Protein: Phosphoglucose Isomerase/autocrine Motility Factor/neuroleukin . Proc. Natl. Acad. Sci. 96 ( 10 ), 5412 ？ 5417 . 10.1073/pnas.96.10.5412 10318897
Tan V. P. Miyamoto S. ( 2016 ). Nutrient-sensing mTORC1: Integration of Metabolic and Autophagic Signals . J. Mol. Cell Cardiol. 95 , 31 ？ 41 . 10.1016/j.yjmcc.2016.01.005 26773603
Tayser K. A. Colowick S. P. ( 1961 ). Properties of Crystalline Hexokinase from Yeast IV. Multiple Forms of the Enzyme . Arch. Biochem. Biophys. 94 , 177 ？ 181 . 10.1016/0003-9861(61)90026-1 13777947
Terrier B. Degand N. Guilpain P. Servettaz A. Guillevin L. Mouthon L. ( 2007 ). Alpha-enolase: a Target of Antibodies in Infectious and Autoimmune Diseases . Autoimmun. Rev. 6 ( 3 ), 176 ？ 182 . 10.1016/j.autrev.2006.10.004 17289554
Tsai H. J. Wilson J. E. ( 1996 ). Functional Organization of Mammalian Hexokinases: Both N- and C-Terminal Halves of the Rat Type II Isozyme Possess Catalytic Sites . Arch. Biochem. Biophys. 329 , 17 ？ 23 . 10.1006/abbi.1996.0186 8619630
Tsang C. K. Liu Y. Thomas J. Zhang Y. Zheng X. F. S. ( 2014 ). Superoxide Dismutase 1 Acts as a Nuclear Transcription Factor to Regulate Oxidative Stress Resistance . Nat. Commun. 5 ( 3446 ), 1 ？ 4 . 10.1038/ncomms4446
Tsuge S. Ochiai H. Inoue Y. Oku T. Tsuno K. Kaku H. ( 2004 ). Involvement of Phosphoglucose Isomerase in Pathogenicity of Xanthomonas Oryzae Pv. Oryzae . Phytopathology 94 ( 5 ), 478 ？ 483 . 10.1094/PHYTO.2004.94.5.478 18943766
Tunio S. A. Oldfield N. J. Ala'Aldeen D. A. Wooldridge K. G. Turner D. P. ( 2010a ). The Role of Glyceraldehyde 3-phosphate Dehydrogenase (GapA-1) in Neisseria Meningitidis Adherence to Human Cells . BMC Microbiol. 10 , 280 . 10.1186/1471-2180-10-280 21062461
Tunio S. A. Oldfield N. J. Berry A. Ala'Aldeen D. A. A. Wooldridge K. G. Turner D. P. J. ( 2010b ). The Moonlighting Protein Fructose-1, 6-bisphosphate Aldolase of Neisseria Meningitidis: Surface Localization and Role in Host Cell Adhesion . Mol. Microbiol. 76 ( 3 ), 605 ？ 615 . 10.1111/j.1365-2958.2010.07098.x 20199602
Ulfstedt M. Hu G.-Z. Eklund D. M. Ronne H. ( 2018 ). The Ability of a Charophyte Alga Hexokinase to Restore Glucose Signaling and Glucose Repression of Gene Expression in a Glucose-Insensitive Arabidopsis Hexokinase Mutant Depends on its Catalytic Activity . Front. Plant Sci. 9 ( 1887 ), 1 ？ 15 . 10.3389/fpls.2018.01887 29410674
Van Schaftingen E. ( 2013 ). “ Hexokinase/Glucokinase ,” in Encyclopedia of Biological Chemistry . 2nd edition ( Academic Press ), 543 ？ 547 . 10.1016/b978-0-12-378630-2.00073-6
Vanegas G. Quinones W. Carrasco-Lopez C. Concepcion J. L. Albericio F. Avilan L. ( 2007 ). Enolase as a Plasminogen Binding Protein in Leishmania Mexicana . Parasitol. Res. 101 ( 6 ), 1511 ？ 1516 . 10.1007/s00436-007-0668-7 17653767
Veiga-Malta I. Duarte M. Dinis M. Tavares D. Videira A. Ferreira P. ( 2004 ). Enolase from Streptococcus sobrinus is an Immunosuppresive Protein . Cell Microbiol. 6 , 79 ？ 88 . 10.1046/j.1462-5822.2003.00344.x 14678332
Vega M. Riera A. Fernandez-Cid A. Herrero P. Moreno F. ( 2016 ). Hexokinase 2 Is an Intracellular Glucose Sensor of Yeast Cells that Maintains the Structure and Activity of Mig1 Protein Repressor Complex . J. Biol. Chem. 291 ( 14 ), 7267 ？ 7285 . 10.1074/jbc.M115.711408 26865637
Velho G. Froguel P. Clement K. Pueyo M. E. Rakotoambinina B. Zouali H. ( 1992 ). Primary Pancreatic Beta-Cell Secretory Defect Caused by Mutations in Glucokinase Gene in Kindreds of Maturity Onset Diabetes of the Young . The Lancet 340 , 444 ？ 448 . 10.1016/0140-6736(92)91768-4
Veramendi J. Fernie A. R. Leisse A. Willmitzer L. Trethewey R. N. ( 2002 ). Potato Hexokinase 2 Complements Transgenic Arabidopsis Plants Deficient in Hexokinase 1 but Does Not Play a Key Role in Tuber Carbohydrate Metabolism . Plant Mol. Bio. 49 ( 5 ), 491 ？ 501 . 10.1023/a:1015528014562 12090625
Vermeulen N. Vermeire S. Arijs I. Michiels G. Ballet V. Derua R. ( 2011 ). Seroreactivity against Glycolytic Enzymes in Inflammatory Bowel Disease . Inflamm. Bowel Dis. 17 ( 2 ), 557 ？ 564 . 10.1002/ibd.21388 20629101
Von Euler H. Adler E. ( 1935 ). Uber die komponenten der dehydrasesysteme. 6. dehydrierung von hexosen unter mitwirkung von adenosintriphosphorsaure . Z. Physiol. Chem. 23 , 122 ？ 153 .
Wang F. Ogasawara M. A. Huang P. ( 2010 ). Small Mitochondria-Targeting Molecules as Anti-cancer Agents . Mol. Aspects Med. 31 ( 1 ), 75 ？ 92 . 10.1016/j.mam.2009.12.003 19995573
Wang H. Xin H. Guo J. Gao Y. Liu C. Dai D. ( 2019 ). Genome-wide Screening of Hexokinase Gene Family and Functional Elucidation of HXK2 Response to Cold Stress in Jatropha Curcas . Mol. Biol. Rep. 46 ( 2 ), 1649 ？ 1660 . 10.1007/s11033-019-04613-0 30756333
Wang L. Wang F.-S. Gershwin M. E. ( 2015 ). Human Autoimmune Diseases: a Comprehensive Update . J. Intern. Med. 278 ( 4 ), 369 ？ 395 . 10.1111/joim.12395 26212387
Wang X.-Q. Zheng L.-L. Lin H. Yu F. Sun L.-H. Li L.-M. ( 2017 ). Grape Hexokinases Are Involved in the Expression Regulation of Sucrose Synthase- and Cell wall Invertase-Encoding Genes by Glucose and ABA . Plant Mol. Biol. 94 ( 2 ), 61 ？ 78 . 10.1007/s11103-017-0593-9 28247243
Watanabe H. Takehana K. Date M. Shinozaki T. Raz A. ( 1996 ). Tumor Cell Autocrine Motility Factor Is the Neuroleukin/phosphohexose Isomerase Polypeptide . Cancer Res. 56 ( 13 ), 2960 ？ 2963 . 8674049
Wen H. Ting J. P.-Y. O'Neill L. A. J. ( 2012 ). A Role for the NLRP3 Inflammasome in Metabolic Diseases-Did Warburg Miss Inflammation? Nat. Immunol. 13 , 352 ？ 357 . 10.1038/ni.2228 22430788
Wilson J. E. ( 2003 ). Isozymes of Mammalian Hexokinase: Structure, Subcellular Localization and Metabolic Function . J. Exp. Biol. 206 ( 12 ), 2049 ？ 2057 . 10.1242/jeb.00241 12756287
Wistow G. J. Lietman T. Williams L. A. Stapel S. O. de Jong W. W. Horwitz J. ( 1988 ). Tau-crystallin/alpha-enolase: One Gene Encodes Both an Enzyme and a Lens Structural Protein . J. Cel Biol. 107 , 2729 ？ 2736 . 10.1083/jcb.107.6.2729
Wistow G. J. Piatigorsky J. ( 1988 ). Lens Crystallins: the Evolution and Expression of Proteins for a Highly Specialized Tissue . Annu. Rev. Biochem. 57 , 479 ？ 504 . 10.1146/annurev.bi.57.070188.002403 3052280
Wolf A. J. Reyes C. N. Liang W. Becker C. Shimada K. Wheeler M. L. ( 2016 ). Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan . Cell 166 , 624 ？ 636 . 10.1016/j.cell.2016.05.076 27374331
Xiang L. Le Roy K. Bolouri-Moghaddam M.-R. Vanhaecke M. Lammens W. Rolland F. ( 2011 ). Exploring the Neutral Invertase-Oxidative Stress Defence Connection in Arabidopsis thaliana . J. Exp. Bot. 62 ( 11 ), 3849 ？ 3862 . 10.1093/jxb/err069 21441406
Xu L. Carrie C. Law S. R. Murcha M. W. Whelan J. ( 2013 ). Acquisition, Conservation, and Loss of Dual-Targeted Proteins in Land Plants . Plant Physiol. 161 ( 2 ), 644 ？ 662 . 10.1104/pp.112.210997 23257241
Yego E. C. K. Mohr S. ( 2010 ). siah-1 Protein Is Necessary for High Glucose-Induced Glyceraldehyde-3-Phosphate Dehydrogenase Nuclear Accumulation and Cell Death in Muller Cells . J. Biol. Chem. 285 ( 5 ), 3181 ？ 3190 . 10.1074/jbc.M109.083907 19940145
Yuan W. Tuttle D. L. Shi Y. J. Ralph G. S. Dunn W. A. Jr ( 1997 ). Glucose-induced Microautophagy in Pichia pastoris Requires the Alpha-Subunit of Phosphofructokinase . J. Cel Sci. 110 ( 16 ), 1935 ？ 1945 . 10.1242/jcs.110.16.1935
Zhang L. Li B. Zhang Y. Jia X. Zhou M. ( 2016 ). Hexokinase Plays a Critical Role in Deoxynivalenol (DON) Production and Fungal Development inFusarium Graminearum . Mol. Plant Pathol. 17 ( 1 ), 16 ？ 28 . 10.1111/mpp.12258 25808544
Zheng L-F. Jiang S. Liu M-F. ( 2017 ). MicroRNA Regulation and Analytical Methods in Cancer Cell Metabolism . Cell. Mol. Life Sci. 74 , 2929 ？ 2941 . 10.1007/s00018-017-2508-y 28321489
Zheng L. Roeder R. G. Luo Y. ( 2003 ). S Phase Activation of the Histone H2B Promoter by OCA-S, a Coactivator Complex that Contains GAPDH as a Key Component . Cell 114 ( 2 ), 255 ？ 266 . 10.1016/s0092-8674(03)00552-x 12887926
Zhu W. Zhang Q. Li J. Wei Y. Cai C. Liu L. ( 2017 ). Glyceraldehyde-3-phosphate Dehydrogenase Acts as an Adhesin in Erysipelothrix Rhusiopathiae Adhesion to Porcine Endothelial Cells and as a Receptor in Recruitment of Host Fibronectin and Plasminogen . Vet. Res. 48 ( 1 ), 16 . 10.1186/s13567-017-0421-x 28327178
Ziveri J. Tros F. Guerrera I. C. Chhuon C. Audry M. Dupuis M. ( 2017 ). The Metabolic Enzyme Fructose-1,6-Bisphosphate Aldolase Acts as a Transcriptional Regulator in Pathogenic Francisella . Nat. Commun. 8 ( 1 ), 1 ？ 15 . 10.1038/s41467-017-00889-7 28232747
Copyright KISTI. All Rights Reserved.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.