[논문]Teratogenicity of D-allulose

Sa, Soonok; Seol, Yunji; Lee, Albert W.; Heo, Yong; Kim, Hye-jung; Park, Chong Jin

doi:10.1016/j.toxrep.2022.03.028

Teratogenicity of D-allulose 원문보기

Toxicology reports, v.9, 2022년, pp.821 - 824

Sa, Soonok (Samyang Corporation, Seongnam-si, Gyeonggi-do, Republic of Korea) , Seol, Yunji (AceOne RS, Clarksville, MD, USA) , Lee, Albert W. (AceOne RS, Clarksville, MD, USA) , Heo, Yong (Daegu Catholic University, Gyeongsan-si, Gyeongsangbuk-do, Republic of Korea) , Kim, Hye-jung (Samyang Corporation, Seongnam-si, Gyeonggi-do, Republic of Korea) , Park, Chong Jin (Samyang Corporation, Seongnam-si, Gyeonggi-do, Republic of Korea)

Abstract ▼ AI-Helper

The objective of this study was to evaluate whether D-allulose has teratogenic effects on rats. A prenatal developmental toxicity test was conducted in SD rats in compliance with modified OECD guidelines test number 414, prenatal developmental toxicity study. Pregnant female rats received repeated doses of 1250, 2500, or 5000 mg/kg body weight D-allulose, or a vehicle control by gavage on GD 6–15. On GD 20, one day prior to the expected day of delivery, pregnant rats were weighed and anesthetized, and laparotomized to remove the uterine and its content were weighed. Fetuses were examined macroscopically for any soft tissue and skeletal changes. The evaluation indicators included general sign observation, body weight, food consumption, animal death, corpora lutea, numbers of embryonic or fetal deaths, and viable fetuses including live birth rate, fetal resorption rate, and stillbirth rate, as well as sex, body weights, and skeletal and soft tissue alterations of fetuses. No treatment-related abnormalities were observed in prenatal developmental toxicity and fetal malformation parameters, indicating that D-allulose had no teratogenic effects on pregnant rats and fetuses. From the findings of this prenatal developmental toxicity study, the NOAEL of D-allulose was estimated to be 5000 mg/kg/day in pregnant SD rats.Highlights•D-allulose produced by M. foliorum SYG27B-MF was not teratogenic in SD rats.•The NOAEL of D-allulose was 5000 mg/kg bw, the highest level tested, in F0 male and female SD rats.•D-allulose did not induce embryo-fetal toxicity in F1 SD rats.

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참고문헌 (23)

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Teratogenicity of D-allulose 원문보기

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