최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기International journal of molecular sciences, v.23 no.21, 2022년, pp.13525 -
Edirisinghe, Shan Lakmal (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea) , Nikapitiya, Chamilani (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea) , Dananjaya, S. H. S. (Zerone Bio Inc., 322-1 Sanhak Building, Dankook University, 119 Dandae-ro, Cheonan-si 31116, Korea) , Park, Jungho (Zerone Bio Inc., 322-1 Sanhak Building, Dankook University, 119 Dandae-ro, Cheonan-si 31116, Korea) , Kim, Dukgyu (Zerone Bio Inc., 322-1 Sanhak Building, Dankook University, 119 Dandae-ro, Cheonan-si 31116, Korea) , Choi, Dongrack (Zerone Bio Inc., 322-1 Sanhak Building, Dankook University, 119 Dandae-ro, Cheonan-si 31116, Korea) , De Zoysa, Mahanama (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea)
This study aimed to develop a corneal epithelial injury model in zebrafish (Danio rerio) and investigate the effectiveness of polydeoxyribonucleotide (PDRN) treatment on in vivo corneal epithelial regeneration and wound healing. Chemical injury to zebrafish cornea was produced by placing a small cot...
1. Böhnke M. Masters B.R. Confocal microscopy of the cornea Prog. Retin. Eye Res. 1999 18 553 628 10.1016/S1350-9462(98)00028-7 10438152
2. Jester J.V. Moller-Pedersen T. Huang J. Sax C.M. Kays W.T. Cavangh H.D. Petroll W.M. Piatigorsky J. The cellular basis of corneal transparency: Evidence for “corneal crystallins” J. Cell Sci. 1999 112 613 622 10.1242/jcs.112.5.613 9973596
3. Sridhar M.S. Anatomy of cornea and ocular surface Indian J. Ophthalmol. 2018 66 190 194 10.4103/ijo.IJO_646_17 29380756
4. DelMonte D.W. Kim T. Anatomy and physiology of the cornea J. Cataract. Refract. Surg. 2011 37 588 598 10.1016/j.jcrs.2010.12.037 21333881
7. Chaurasia S.S. Kaur H. de Medeiros F.W. Smith S.D. Wilson S.E. Dynamics of the expression of intermediate filaments vimentin and desmin during myofibroblast differentiation after corneal injury Exp. Eye Res. 2009 89 133 139 10.1016/j.exer.2009.02.022 19285070
8. Wilson S.E. Mohan R.R. Mohan R.R. Ambro R. Hong J. Lee J. The corneal wound healing response-cytokine mediated interaction of epithelium, stroma and, inflammatory cells Prog. Retin. Eye Res. 2001 20 625 637 11470453
9. Shoham A. Hadziahmetovic M. Dunaief J.L. Mydlarski M.B. Schipper H.M. Oxidative stress in diseases of the human cornea Free Radic. Biol. Med. 2008 45 1047 1055 10.1016/j.freeradbiomed.2008.07.021 18718524
10. Bukowiecki A. Hos D. Cursiefen C. Eming S.A. Wound-healing studies in cornea and skin: Parallels, differences and opportunities Int. J. Mol. Sci. 2017 18 1257 10.3390/ijms18061257
12. Mckenna C.C. Lwigale P.Y. Innervation of the mouse cornea during development Investig. Ophthalmol. Vis. Sci. 2011 52 30 35 10.1167/iovs.10-5902 20811061
13. Schumann S. Dietrich E. Kruse C. Grisanti S. Ranjbar M. Establishment of a robust and simple corneal organ culture model to monitor wound healing J. Clin. Med. 2021 10 3486 10.3390/jcm10163486 34441782
14. Glenwood G. Barbara W. MaryJane R. Stacy P. Damian G. Corneal Wound Healing Model in New Zealand White Rabbits for Evaluating Persistent Corneal Epithelial Defects Investig. Ophthalmol. Vis. Sci. 2013 54 3903
15. Pal-Ghosh S. Pajoohesh-Ganji A. Brown M. Stepp M.A. A mouse model for the study of recurrent corneal epithelial erosions: α9β1 integrin implicated in progression of the disease Investig. Ophthalmol. Vis. Sci. 2004 45 1775 1788 10.1167/iovs.03-1194 15161840
16. Choi H. Phillips C. Oh J.Y. Stock E.M. Kim D.K. Won J.K. Fulcher S. Comprehensive Modeling of Corneal Alkali Injury in the Rat Eye Curr. Eye Res. 2017 42 1348 1357 10.1080/02713683.2017.1317817 28636415
17. Conners M.S. Urbano F. Vafeas C. Stoltz R.A. Dunn M.W. Schwartzman M.L. Alkali burn-induced time-dependent synthesis of 12-HETE enantiomers in rabbit corneal epithelium Investig. Ophthalmol. Vis. Sci. 1996 37 2504 8933767
18. Bian F. Xiao Y. Zaheer M. Volpe E.A. Pflugfelder S.C. Li D.Q. De Paiva C.S. Inhibition of NLRP3 inflammasome pathway by butyrate improves corneal wound healing in corneal alkali burn Int. J. Mol. Sci. 2017 18 562 10.3390/ijms18030562
19. Anderson C. Zhou Q. Wang S. An Alkali-burn injury model of corneal neovascularization in the mouse J. Vis. Exp. 2014 86 e51159 10.3791/51159
20. Barabino S. Dana M.R. Animal models of dry eye: A critical assessment of opportunities and limitations Investig. Ophthalmol. Vis. Sci. 2004 45 1641 1646 10.1167/iovs.03-1055 15161821
21. Evangelho K. Mastronardi C.A. De-La-Torre A. Experimental models of glaucoma: A powerful translational tool for the future development of new therapies for glaucoma in humans—A review of the literature Medicina 2019 55 280 10.3390/medicina55060280
22. Sun Z. Amsterdam A. Pazour G.J. Cole D.G. Miller M.S. Hopkins N. A genetic screen in zebrafish indentifies cilia genes as a principal cause of cystic kidney Development 2004 131 4085 4093 10.1242/dev.01240 15269167
23. Kleinjan D.A. Bancewicz R.M. Gautier P. Dahm R. Schonthaler H.B. Damante G. Seawright A. Hever A.M. Yeyati P.L. Van Heyningen V. Subfunctionalization of duplicated zebrafish pax6 genes by cis-regulatory divergence PLoS Genet. 2008 4 e29 10.1371/journal.pgen.0040029 18282108
24. Bibliowicz J. Tittle R.K. Gross J.M. Toward a better understanding of human eye disease: Insights from the zebrafish, Danio rerio Prog. Mol. Biol. Transl. Sci. 2011 100 287 330 10.1016/B978-0-12-384878-9.00007-8 21377629
25. Bohnsack B.L. Kasprick D.S. Kish P.E. Goldman D. Kahana A. A zebrafish model of Axenfeld-Rieger syndrome reveals that pitx2 regulation by Retinoic Acid is essential for ocular and craniofacial development Investig. Ophthalmol. Vis. Sci. 2012 53 7 22 10.1167/iovs.11-8494 22125274
26. Gupta V. Kawahara G. Gundry S.R. Chen A.T. Lencer W.I. Zhou Y. Zon L.I. Kunkel L.M. Beggs A.H. The zebrafish dag1 mutant: A novel genetic model for dystroglycanopathies Hum. Mol. Genet. 2011 20 1712 1725 10.1093/hmg/ddr047 21296866
27. Zhao X.C. Yee R.W. Norcom E. Burgess H. Avanesov A.S. Barrish J.P. Malicki J. The zebrafish cornea: Structure and development Investig. Ophthalmol. Vis. Sci. 2006 47 4341 4348 10.1167/iovs.05-1611 17003424
28. Ikkala K. Stratoulias V. Michon F. Unilateral Zebrafish Corneal Injury Induces Bilateral Cell Plasticity Supporting Wound Closure Sci. Rep. 2022 12 1 20 10.1038/s41598-021-04086-x 34992227
29. Oliver V.F. Van Bysterveldt K.A. Cadzow M. Steger B. Romano V. Markie D. Hewitt A.W. MacKey D.A. Willoughby C.E. Sherwin T. A COL17A1 Splice-Altering Mutation Is Prevalent in Inherited Recurrent Corneal Erosions Ophthalmology 2016 123 709 722 10.1016/j.ophtha.2015.12.008 26786512
30. Colin S.P. Colin H.B. The fish cornea: Adaptation for different aquatic environment Sensory Biology of Jawed Fishes-New Insights Kapoor B.G. Hara T.J. Science Publishers Inc. New York, NY, USA 2001 57
31. Heur M. Jiao S. Schindler S. Crump J.G. Regenerative potential of the zebrafish corneal endothelium Exp. Eye Res. 2013 106 1 4 10.1016/j.exer.2012.10.009 23108006
33. Choi J.-S. Joo C.-K. Polydeoxyribonucleotide (PDRN) inhibits corneal inflammation in experimental rat keratoconjunctivitis sicca model Investig. Ophthalmol. Vis. Sci. 2016 57 5730
34. Lazzarotto M. Tomasello E.M. Caporossi A. Clinical Evaluation of Corneal Epithelialization after Photorefractive Keratectomy in Patients Treated with Polydeoxyribonucleotide (PDRN) Eye Drops: A Randomized, Double-blind, Placebo-controlled Trial Eur. J. Ophthalmol. 2004 14 284 289 10.1177/112067210401400402 15309972
35. Squadrito F. Bitto A. Irrera N. Pizzino G. Pallio G. Minutoli L. Altavilla D. Pharmacological Activity and Clinical Use of PDRN Front. Pharmacol. 2017 8 224 10.3389/fphar.2017.00224 28491036
36. Richardson R. Tracey-White D. Webster A. Moosajee M. The zebrafish eye-a paradigm for investigating human ocular genetics Eye 2017 31 68 86 10.1038/eye.2016.198 27612182
37. Fadool J.M. Dowling J.E. Zebrafish: A model system for the study of eye genetics Prog. Retin. Eye Res. 2008 27 89 110 10.1016/j.preteyeres.2007.08.002 17962065
38. Morris A.C. The genetics of ocular disorders: Insights from the zebrafish Birth Defects Res. Part C-Embryo Today Rev. 2011 93 215 228 10.1002/bdrc.20211
39. Link B.A. Collery R.F. Zebrafish Models of Retinal Disease Annu. Rev. Vis. Sci. 2015 1 125 153 10.1146/annurev-vision-082114-035717 28532376
40. Kujawski S. Crespo C. Luz M. Yuan M. Winkler S. Knust E. Loss of Crb2b-lf leads to anterior segment defects in old zebrafish Biol. Open 2020 9 1 14 10.1242/bio.047555
41. Kwon T.R. Han S.W. Kim J.H. Lee B.C. Kim J.M. Hong J.Y. Kim B.J. Polydeoxyribonucleotides Improve Diabetic Wound Healing in Mouse Animal Model for Experimental Validation Ann. Dermatol. 2019 31 403 413 10.5021/ad.2019.31.4.403 33911618
42. Joshua E.J. Barbara E.C. Corned Staining After Instillation of Topical Anesthetic (SSII) Investig. Ophthalmol. Vis. Sci. 1988 29 1096 1099 2458327
43. Ellina A.M. Peter W.J.M. Adrian C.W. Vitaliy V.K. On the Barrier Properties of the Cornea: A Microscopy Study of the Penetration of Fluorescently Labeled Nanoparticles, Polymers, and Sodium Fluorescein Mol. Pharm. 2014 11 3556 3564 10.1021/mp500332m 25165886
44. Caffery B.E. Josephson J.E. Corneal staining after sequential instillations of fluorescein over 30 days Optom. Vis. Sci. 1991 68 467 469 10.1097/00006324-199106000-00011 1716353
45. Kasus J.A. Noor M.S. Griffith G.L. Hinsley H. Mathias L. Pereira H.A. A multifunctional peptide based on the neutrophil immune defense molecule, CAP37, has antibacterial and wound-healing properties J. Leukoc. Biol. 2015 97 341 350 10.1189/jlb.3A0214-104RR 25412625
46. Okada Y. Sumioka T. Ichikawa K. Sano H. Nambu A. Kobayashi K. Uchida K. Suzuki Y. Tominaga M. Reinach P.S. Sensory nerve supports epithelial stem cell function in healing of corneal epithelium in mice: The role of trigeminal nerve transient receptor potential vanilloid 4 Lab. Investig. 2019 99 210 230 10.1038/s41374-018-0118-4 30413814
48. Puri S. Sun M. Mutoji K.N. Gesteira T.F. Coulson-Thomas V.J. Epithelial Cell Migration and Proliferation Patterns During Initial Wound Closure in Normal Mice and an Experimental Model of Limbal Stem Cell Deficiency Investig. Ophthalmol. Vis. Sci. 2020 61 1 15 10.1167/iovs.61.10.27
49. Wijnholds J. “Basal Cell Migration” in Regeneration of the Corneal Wound-Bed Stem Cell Rep. 2019 12 3 5 10.1016/j.stemcr.2018.12.009
50. Gipson I.K. Goblet cells of the conjunctiva: A review of recent findings Prog. Retin. Eye Res. 2016 54 49 63 10.1016/j.preteyeres.2016.04.005 27091323
51. Thellung S. Florio T. Maragliano A. Cattarini G. Schettini G. Polydeoxyribonucleotides enhance the proliferation of human skin fibroblasts: Involvement of A2 purinergic receptor subtypes Life Sci. 1999 64 1661 1674 10.1016/S0024-3205(99)00104-6 10328526
52. Guizzardi S. Galli C. Govoni P. Boratto R. Cattarini G. Martini D. Belletti S. Scandroglio R. Polydeoxyribonucleotide (PDRN) promotes human osteoblast proliferation: A new proposal for bone tissue repair Life Sci. 2003 73 1973 1983 10.1016/S0024-3205(03)00547-2 12899922
53. Yochai S. Jacob P. Victoria D. Joseph F.P. Abraham S. Increased Expression of Inflammatory Cytokines and Matrix Metalloproteinases in Pseudophakic Corneal Edema Investig. Ophthalmol. Vis. Sci. 2005 46 1940 1947 10.1167/iovs.04-1203 15914607
54. Julie T.D. Astrid L.G. Ulpu S.K. Gillian M. Peng T.K. Human Corneal Epithelial Cells Require MMP-1 for HGF-Mediated Migration on Collagen I Investig. Ophthalmol. Vis. Sci. 2003 44 1048 1055 10.1167/iovs.02-0442 12601028
55. Blanco-Mezquita J.T. Hutcheon A.E. Zieske J.D. Role of Thrombospondin-1 in Repair of Penetrating Corneal Wounds Investig. Ophthalmol. Vis. Sci. 2013 54 6262 6268 10.1167/iovs.13-11710 23963165
56. Mauris J. Woodward A.M. Cao Z. Panjwani N. Argüeso P. Molecular basis for MMP9 induction and disruption of epithelial cell-cell contacts by galectin-3 J. Cell Sci. 2014 127 Pt 14 3141 3148 10.1242/jcs.148510 24829150
57. Fini M.E. Cook J.R. Mohan R. Proteolytic mechanisms in corneal ulceration and repair Arch. Dermatol. Res. 1998 290 S12 S23 10.1007/PL00007449 9710379
58. Ottino P. Taheri F. Bazan H.E.P. Platelet-activating factor induces the gene expression of TIMP-1, -2, and PAI-1: Imbalance between the gene expression of MMP-9 and TIMP-1 and -2 Exp. Eye Res. 2002 74 393 402 10.1006/exer.2001.1135 12014920
59. Gordon G.M. Austin J.S. Sklar A.L. Feuer W.J. Lagier A.J. Fini M.E. Comprehensive gene expression profiling and functional analysis of matrix metalloproteinases and TIMPs, and identification of ADAM-10 gene expression, in a corneal model of epithelial resurfacing J. Cell. Physiol. 2011 226 1461 1470 10.1002/jcp.22306 20625997
60. Ye H.Q. Maeda M. Yu F.S.X. Azar D.T. Differential expression of MT1-MMP (MMP-14) and collagenase III (MMP-13) genes in normal and wounded rat corneas Investig. Ophthalmol. Vis. Sci. 2000 41 2894 2899 10967042
61. Haber M. Cao Z. Panjwani N. Bedenice D. Li W.W. Provost P.J. Effects of growth factors (EGF, PDGF-BB and ββ1) on cultured equine epithelial cells and keratocytes: Implications for wound healing Vet. Ophthalmol. 2003 6 211 217 10.1046/j.1463-5224.2003.00296.x 12950652
62. Jens L.A. Thomas L. Niels E. Keratocyte migration and peptide growth factors: The effect of PDGF, bFGF, EGF, IGF-I, aFGF and TGF-ß on human keratocyte migration in a collagen gel Curr. Eye Res. 1997 16 605 613 10.1076/ceyr.16.6.605.5081 9192171
63. Koroma B.M. Yang J.M. Sundin O.H. The Pax-6 homeobox gene is expressed throughout the corneal and conjunctival epithelia Investig. Ophthalmol. Vis. Sci. 1997 38 108 120 9008636
64. Dorà N. Ou J. Kucerova R. Parisi I. West J.D. Collinson J.M. PAX6 dosage effects on corneal development, growth, and wound healing Dev. Dyn. 2008 237 1295 1306 10.1002/dvdy.21528 18386822
65. Davis J. Piatigorsky J. Overexpression of Pax6 in mouse cornea directly alters corneal epithelial cells: Changes in immune function, vascularization, and differentiation Investig. Ophthalmol. Vis. Sci. 2011 52 4158 4168 10.1167/iovs.10-6726 21447684
66. Swamynathan S.K. Katz J.P. Kaestner K.H. Ashery-Padan R. Crawford M.A. Piatigorsky J. Conditional Deletion of the Mouse Klf4 Gene Results in Corneal Epithelial Fragility, Stromal Edema, and Loss of Conjunctival Goblet Cells Mol. Cell. Biol. 2007 27 182 194 10.1128/MCB.00846-06 17060454
67. Swamynathan S.K. Ocular surface development and gene expression J. Ophthalmol. 2013 2013 103947 10.1155/2013/103947 23533700
68. Peterson C.W.M. Carter R.T. Bentley E. Murphy C.J. Chandler H.L. Heat-shock protein expression in canine corneal wound healing Vet. Ophthalmol. 2016 19 262 266 10.1111/vop.12302 26302381
69. Edirisinghe S.L. Rajapaksha D.C. Nikapitiya C. Oh C. Lee K.A. Kang D.H. De Zoysa M. Spirulina maxima derived marine pectin promotes the in vitro and in vivo regeneration and wound healing in zebrafish Fish Shellfish. Immunol. 2020 107 414 425 10.1016/j.fsi.2020.10.008 33038507
70. Livak K.J. Schmittgen T.D. Analysis of relative gene expression data using realtime quantitative PCR and the 2(-Delta Delta C(T)) method Methods 2001 25 402 408 10.1006/meth.2001.1262 11846609
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
오픈액세스 학술지에 출판된 논문
※ AI-Helper는 부적절한 답변을 할 수 있습니다.