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NTIS 바로가기Comparative immunology, microbiology and infectious diseases, v.1 no.4, 1979년, pp.305 - 319
Precausta, P. , Kato, F. , Vellut, G.
A sheep-pox virus strain has been adapted and multiplied in primary lamb kidney cell cultures. The main characteristics of the strain have been verified in vitro after clones were isolated, and the results confirmed its identity. The safety and the potency of the strain have been investigated in she...
Une souche de virus claveleux a ete adaptee et multipliee sur culture primaire de cellules renales d'agneau. Apres clonage, les proprietes principales de cette souche sont verifiees in vitro et permettent de confirmer son identite. L'innocuite et l'activite de cette souche sont etudiees chez le mouton.Chez cette espece, l'inoculation de cette souche entraine une reaction postvaccinale materialisee par un nodule au lieu d'injection et une hyperthermie de l'ordre de 1oC. Cette souche n'entraine pas de reaction defavorable pour la gestation. L'immunite se traduit par une elevation du taux d'anticorps seriques neutralisants et une protection contre le virus pathogene. Cette immunite flechit au cours de la 2eme annee apres primovaccination et necessite une intervention de rappel annuelle. Pour obtenir une meilleure immunite chez les agneaux, la primovaccination doit etre effectuee apres le 2eme mois d'age surtout si les agneaux sont issus de meres vaccinees.Cette souche constitue le principe actif d'un vaccin presente sous forme lyophilisee, sans substance adjuvante de l'immunite.
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