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Role of reactive oxygen species in the pathophysiology of human reproduction 원문보기

Fertility and sterility, v.79 no.4, 2003년, pp.829 - 843  

Agarwal, Ashok (Center for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Urological Institute and Department of Obstetrics-Gynecology, Cleveland Clinic Foundation, Cleveland, Ohio, USA) ,  Saleh, Ramadan A. (Center for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Urological Institute and Department of Obstetrics-Gynecology, Cleveland Clinic Foundation, Cleveland, Ohio, USA) ,  Bedaiwy, Mohamed A. (Center for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Urological Institute and Department of Obstetrics-Gynecology, Cleveland Clinic Foundation, Cleveland, Ohio, USA)

Abstract AI-Helper 아이콘AI-Helper

AbstractObjectiveTo summarize the role of reactive oxygen species (ROS) in the pathophysiology of human reproduction.DesignReview of literature.SettingFertility research center and obstetrics and gynecology department in a tertiary care facility.Result(s)ROS plays an essential role in the pathogenes...

주제어

참고문헌 (123)

  1. Hum Reprod de Lamirande 10 15 1995 10.1093/humrep/10.suppl_1.15 Impact of reactive oxygen species on spermatozoa 

  2. Curr Med Chem Sikka 8 851 2001 10.2174/0929867013373039 Relative impact of oxidative stress on male reproductive function 

  3. Urology Sharma 48 835 1996 10.1016/S0090-4295(96)00313-5 Role of reactive oxygen species in male infertility 

  4. Fertil Steril Padron 67 1115 1997 10.1016/S0015-0282(97)81448-3 Seminal reactive oxygen species, sperm motility and morphology in men with spinal cord injury 

  5. Front Biosci Sikka 1 78 1996 10.2741/A146 Oxidative stress and role of antioxidants in normal and abnormal sperm function 

  6. Mol Reprod Dev Alvarez 42 334 1995 10.1002/mrd.1080420311 Differential incorporation of fatty acids into and peroxidative loss of fatty acids from phospholipids of human spermatozoa 

  7. Fertil Steril Iwasaki 57 409 1992 10.1016/S0015-0282(16)54855-9 Formation of reactive oxygen species in spermatozoa of infertile patients 

  8. Reprod Fertil Dev Aitken 6 19 1994 10.1071/RD9940019 A free radical theory of male infertility 

  9. J Reprod Fertil Aitken 115 1 1999 10.1530/jrf.0.1150001 The Amoroso lecture. The human spermatozoon-a cell in crisis? 

  10. Ann NY Acad Sci Gagnon 637 436 1991 10.1111/j.1749-6632.1991.tb27328.x Reactive oxygen species and human spermatozoa 

  11. Adv Exp Med Biol de Lamirande 366 185 1994 10.1007/978-1-4615-1833-4_14 Reactive oxygen species (ROS) and reproduction 

  12. Mol Hum Reprod Aitken 3 169 1997 10.1093/molehr/3.3.169 Molecular mechanisms regulating human sperm function 

  13. Biol Reprod Aitken 40 183 1989 10.1095/biolreprod41.1.183 Generation of reactive oxygen species, lipid peroxidation, and human sperm function 

  14. Free Radic Biol Med de Lamirande 14 255 1993 Human sperm hyperactivation and capacitation as parts of an oxidative process 

  15. J Androl Zini 16 424 1996 10.1002/j.1939-4640.1995.tb00558.x Low levels of nitric oxide promote human sperm capacitation in vitro 

  16. Biol Reprod Alvarez 29 548 1983 10.1095/biolreprod29.3.548 Taurine, hypotaurine, epinephrine and albumin inhibit lipid peroxidation in rabbit spermatozoa and protect against loss of motility 

  17. Eur J Biochem Sies 215 213 1993 10.1111/j.1432-1033.1993.tb18025.x Strategies of antioxidant defence 

  18. J Androl Armstrong 19 412 1998 10.1002/j.1939-4640.1998.tb02034.x Antioxidant potential of human serum albumin 

  19. Fertil Steril Donnelly 72 484 1999 10.1016/S0015-0282(99)00267-8 Antioxidant supplementation in vitro does not improve human sperm motility 

  20. Eur J Biochem Wefers 174 353 1988 10.1111/j.1432-1033.1988.tb14105.x The protection by ascorbate and glutathione against microsomal lipid peroxidation is dependent on vitamin E 

  21. Arch Biochem Biophys Buettner 300 535 1993 10.1006/abbi.1993.1074 The pecking order of free radicals and antioxidants, lipid peroxidation, alpha-tocopherol and ascorbate 

  22. Ann NY Acad Sci Sies 669 7 1992 10.1111/j.1749-6632.1992.tb17085.x Antioxidant function of vitamins. Vitamins E and C, beta-carotenoids, and other carotenoids 

  23. Fertil Steril Lewis 64 868 1995 10.1016/S0015-0282(16)57870-4 Total antioxidant capacity of seminal plasma is different in fertile and infertile men 

  24. Int J Androl Zini 16 183 1993 10.1111/j.1365-2605.1993.tb01177.x Reactive oxygen species in the semen of infertile patients 

  25. Reprod Fertil Dev Aitken 7 659 1995 10.1071/RD9950659 Free radicals, lipid peroxidation, sperm function 

  26. J Exp Zool Fisher 277 390 1997 10.1002/(SICI)1097-010X(19970401)277:5<390::AID-JEZ5>3.0.CO;2-K Comparative analysis of the ability of precursor germ cells and epididymal spermatozoa to generate reactive oxygen metabolites 

  27. J Urol Hendin 161 1831 1999 10.1016/S0022-5347(05)68818-0 Varicocele is associated with elevated spermatozoal reactive oxygen species production and diminished seminal plasma antioxidant capacity 

  28. Hum Reprod Gil-Guzman 16 1922 2001 10.1093/humrep/16.9.1922 Differential production of reactive oxygen species by subsets of human spermatozoa at different stages of maturation 

  29. J Cell Physiol Aitken 151 466 1992 10.1002/jcp.1041510305 Reactive oxygen species and human spermatozoa 

  30. Arch Androl Gavella 28 135 1992 10.3109/01485019208987691 NADH-dependent oxido-reductase (diaphorase) activity and isozyme pattern of sperm in infertile men 

  31. Fertil Steril Plante 62 387 1994 10.1016/S0015-0282(16)56895-2 Reactive oxygen species released by activated neutrophils, but not by deficient spermatozoa, are sufficient to affect normal sperm motility 

  32. Int J Androl Gomez 21 81 1998 10.1046/j.1365-2605.1998.00106.x Evaluation of a spectrophotometric assay for the measurement of malondialdehyde and 4-hydroxyalkenals in human spermatozoa 

  33. Int J Androl Aitken 3 433 1990 10.1111/j.1365-2605.1990.tb01051.x Analysis of the relationship between reactive oxygen species production and leukocyte infiltration in fractions of human semen separated on Percoll gradients 

  34. Biol Reprod Huszar 56 1020 1997 10.1095/biolreprod56.4.1020 Sperm plasma membrane remodeling during spermiogenic maturation in men 

  35. Mol Reprod Dev Huszar 34 292 1993 10.1002/mrd.1080340309 Incomplete development of human spermatozoa is associated with increased creatine phosphokinase concentration and abnormal head morphology 

  36. Int J Fertil Wom Med Sidhu 43 192 1998 Relationship between creatine kinase activity and semen characteristics in sub-fertile men 

  37. Urology Hallak 58 446 2001 10.1016/S0090-4295(01)01224-9 Creatine kinase as an indicator of sperm quality and maturity in men with oligospermia 

  38. J Androl Huszar 15 71 1994 10.1002/j.1939-4640.1994.tb01687.x Correlation between the rate of lipid peroxidation and cellular maturity as measured by creatine kinase activity in human spermatozoa 

  39. Hum Reprod Ollero 16 1912 2001 10.1093/humrep/16.9.1912 Characterization of subsets of human spermatozoa at different stages of maturation 

  40. 1999 Laboratory manual for the examination of human semen and sperm-cervical mucus interaction 

  41. Urology Kruger 30 248 1987 10.1016/0090-4295(87)90246-9 New method of evaluating sperm morphology with predictive value for human in vitro fertilization 

  42. Arch Androl Agarwal 32 169 1994 10.3109/01485019408987783 Levels of reactive oxygen species before and after sperm preparation 

  43. Arch Androl Agarwal 33 157 1994 10.3109/01485019408987819 Effect of sperm washing on reactive oxygen species level in semen 

  44. Eur Urol Shekarriz 28 31 1995 10.1159/000475016 A method of human semen centrifugation to minimize the iatrogenic sperm injuries caused by reactive oxygen species 

  45. Hum Reprod Lopes 13 896 1998 10.1093/humrep/13.4.896 Reactive oxygen species 

  46. Urology Zini 56 1081 2000 10.1016/S0090-4295(00)00770-6 Influence of semen processing on human sperm DNA integrity 

  47. Hum Reprod Tomlinson 7 517 1992 10.1093/oxfordjournals.humrep.a137682 The removal of morphologically abnormal sperm forms by phagocytes 

  48. Hum Reprod Thomas 12 2418 1997 10.1093/humrep/12.11.2418 Increased polymorphonuclear granulocytes in seminal plasma in relation to sperm morphology 

  49. Fertil Steril Wolff 63 1143 1995 10.1016/S0015-0282(16)57588-8 The biologic significance of white blood cells in semen 

  50. Fertil Steril Tomlinson 60 1069 1993 10.1016/S0015-0282(16)56412-7 Prospective study of leukocytes and leukocyte subpopulations in semen suggests that they are not a cause of male infertility 

  51. Mol Reprod Dev Aitken 39 268 1994 10.1002/mrd.1080390304 Relationship between biochemical markers for residual sperm cytoplasm, reactive oxygen species generation and the presence of leukocytes and precursor germ cells in human sperm suspension 

  52. Fertil Steril Rajasekaran 64 166 1995 10.1016/S0015-0282(16)57674-2 Oxidative stress and interleukins in seminal plasma during leukocytospermia 

  53. J Assist Reprod Genet Shekarriz 12 70 1995 10.1007/BF02211372 Positive myeloperoxidase staining (Endtz Test) as an indicator of excessive reactive oxygen species formation in semen 

  54. Urology Pasqualotto 55 881 2000 10.1016/S0090-4295(99)00613-5 Seminal oxidative stress in chronic prostatitis patients 

  55. Free Radic Biol Med Saran 26 482 1999 10.1016/S0891-5849(98)00187-7 Phagocytic killing of microorganisms by radical processes 

  56. Hum Reprod Ochsendorf 5 399 1999 Infections in the male genital tract and reactive oxygen species 

  57. J Androl Sharma 22 575 2001 10.1002/j.1939-4640.2001.tb02217.x Relationship between seminal white blood cell counts and oxidative stress in men treated at an infertility clinic 

  58. Fertil Steril Kovalski 58 809 1992 10.1016/S0015-0282(16)55332-1 Reactive oxygen species generated by human neutrophils inhibit sperm motility 

  59. 10.1016/S0015-0282(02)04237-1 Saleh RA, Agarwal A, Kandirali E, Sharma RK, Thomas AJ Jr, Nada EA, et al. Leukocytospermia is associated with increased reactive oxygen species production by human spermatozoa. Fertil Steril. 2002;78:1215-24. 

  60. J Lipid Mediat Spitteler 7 77 1993 Review 

  61. Lab Invest Jannsen 69 261 1993 Cell and tissue responses to oxidative damage 

  62. Rev Reprod de Lamirande 2 48 1997 10.1530/ror.0.0020048 Reactive oxygen species (ROS) and sperm physiology 

  63. J Androl Sikka 16 464 1995 10.1002/j.1939-4640.1995.tb00566.x Role of oxidative stress and antioxidants in male infertility 

  64. Free Radic Res Commun Halliwell 9 1 1990 10.3109/10715769009148569 How to characterize a biological antioxidant 

  65. Bioassays Aitken 16 259 1994 10.1002/bies.950160409 Reactive oxygen species generation and human spermatozoa 

  66. Hum Reprod Lenzi 9 2044 1993 10.1093/oxfordjournals.humrep.a138391 Placebo-controlled, double-blind, cross-over trial of glutathione therapy, in male infertility 

  67. J Urol Agarwal 152 107 1994 10.1016/S0022-5347(17)32829-X Relationship of sperm parameters to levels of reactive oxygen species in semen specimens 

  68. Free Radic Biol Med Armstrong 26 869 1999 10.1016/S0891-5849(98)00275-5 Characterization of reactive oxygen species induced effects on human spermatozoa movement and energy metabolism 

  69. J Androl de Lamirande 13 379 1992 10.1002/j.1939-4640.1992.tb03328.x Reactive oxygen species and human spermatozoa. II. Depletion of adenosine triphosphate (ATP) plays an important role in the inhibition of sperm motility 

  70. Mol Reprod Dev Aitken 47 468 1997 10.1002/(SICI)1098-2795(199708)47:4<468::AID-MRD14>3.0.CO;2-S Reactive oxygen species generation by human spermatozoa is induced by exogenous NADPH and inhibited by flavoprotein inhibitors diphenylene iodonium and quinacrine 

  71. J Reprod Fertil Griveau 103 17 1995 10.1530/jrf.0.1030017 Reactive oxygen species, lipid peroxidation and enzymatic defense systems in human spermatozoa 

  72. Hum Reprod Twigg 13 1864 1998 10.1093/humrep/13.7.1864 Oxidative damage to DNA in human spermatozoa does not preclude pronucleus formation at intracytoplasmic sperm injection 

  73. Fertil Steril Duru 74 1200 2000 10.1016/S0015-0282(00)01591-0 Effects of hydrogen peroxide on DNA and plasma membrane integrity of human spermatozoa 

  74. Reproduction Aitken 122 497 2001 10.1530/rep.0.1220497 Oxidative stress, DNA damage and the Y chromosome 

  75. Proc Natl Acad Sci USA Fraga 88 11003 1991 10.1073/pnas.88.24.11003 Ascorbic acid protects against endogenous oxidative DNA damage in human sperm 

  76. Mutat Res Fraga 351 199 1996 10.1016/0027-5107(95)00251-0 Smoking and low antioxidant levels increase oxidative damage to sperm DNA 

  77. Fertil Steril Kodama 65 519 1997 10.1016/S0015-0282(97)00236-7 Increased oxidative deoxyribonucleic acid damage in the spermatozoa of infertile male patients 

  78. Biol Reprod Sun 56 602 1997 10.1095/biolreprod56.3.602 Detection of deoxyribonucleic acid fragmentation in human sperm 

  79. Mol Hum Reprod Twigg 4 439 1998 10.1093/molehr/4.5.439 Iatrogenic DNA damage induced in human spermatozoa during sperm preparation 

  80. Curr Opin Immunol Vaux 12 719 2000 10.1016/S0952-7915(00)00168-0 Apoptosis genes and autoimmunity 

  81. Cell Vaux 96 245 1999 10.1016/S0092-8674(00)80564-4 Cell death in development 

  82. Rev Reprod Sakkas 4 31 1999 10.1530/ror.0.0040031 Origin of DNA damage in ejaculated human spermatozoa 

  83. Rev Reprod Sinha Hikim 4 38 1999 10.1530/ror.0.0040038 Hormonal and genetic control of germ cell apoptosis in the testis 

  84. Int J Androl Blanco-Rodriguez 21 236 1998 10.1046/j.1365-2605.1998.00133.x A matter of death and life 

  85. Radiat Res Hasegawa 149 263 1998 10.2307/3579959 Resistance of differentiating spermatogonia to radiation-induced apoptosis and loss in p53-deficient mice 

  86. Cancer Res Kemp 61 327 2001 p53 induction and apoptosis in response to radio- and chemotherapy in vivo is tumor-type-dependent 

  87. Endocrinology Lee 138 2081 1997 10.1210/endo.138.5.5110 The Fas system is a key regulator of germ cell apoptosis in the testis 

  88. J Clin Endocrinol Metab Sinha Hikim 83 152 1998 10.1210/jcem.83.1.4485 Spontaneous germ cell apoptosis in humans 

  89. Mol Hum Reprod Jurisicova 5 323 1999 10.1093/molehr/5.4.323 DNA damage in round spermatids of mice with a targeted disruption of the Pp1cgamma gene and in testicular biopsies of patients with non-obstructive azoospermia 

  90. Hum Reprod Gandini 15 830 2000 10.1093/humrep/15.4.830 Study of apoptotic DNA fragmentation in human spermatozoa 

  91. Cell Sentman 67 879 1991 10.1016/0092-8674(91)90361-2 Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes 

  92. Science Kane 262 1274 1993 10.1126/science.8235659 Bcl-2 inhibition of neural death 

  93. Curr Opin Immunol Krammer 6 279 1994 10.1016/0952-7915(94)90102-3 Regulation of apoptosis in the immune system 

  94. Cell Suda 75 1169 1993 10.1016/0092-8674(93)90326-L Molecular cloning and expression of Fas ligand, a novel member of the tumor necrosis factor family 

  95. Hum Reprod Sharma 14 2801 1999 10.1093/humrep/14.11.2801 The reactive oxygen species-total antioxidant capacity score is a new measure of oxidative stress to predict male infertility 

  96. J Androl Alvarez 8 336 1987 10.1002/j.1939-4640.1987.tb00973.x Spontaneous lipid peroxidation and production of hydrogen peroxide and superoxide in human spermatozoa 

  97. J Androl Kobayashi 22 568 2000 10.1002/j.1939-4640.2001.tb02216.x Quality control of reactive oxygen species measurement by luminol-dependent chemiluminescence assay 

  98. Fertil Steril Kolettis 71 249 1999 10.1016/S0015-0282(98)00467-1 The effects of seminal oxidative stress on fertility after vasectomy reversal 

  99. Fertil Steril Pasqualotto 73 459 2000 10.1016/S0015-0282(99)00567-1 Relationship between oxidative stress, semen characteristics, and clinical diagnosis in men undergoing fertility investigation 

  100. J Androl Pasqualotto 73 459 2001 Oxidative stress in normospermic men undergoing infertility evaluation 

  101. J Urol Daitch 165 1510 2001 10.1016/S0022-5347(05)66338-0 Varicocelectomy improves intrauterine insemination success rates among men with varicocele 

  102. Urology Agarwal 50 759 1997 10.1016/S0090-4295(97)00328-2 Prevention of testicular damage by free-radical scavengers 

  103. Fertil Steril Saleh 78 491 2002 10.1016/S0015-0282(02)03294-6 Effect of cigarette smoking on levels of seminal oxidative stress in infertile men 

  104. Fertil Steril Wang 68 826 1997 10.1016/S0015-0282(97)00343-9 Importance of reactive oxygen species in the peritoneal fluid of women with endometriosis or idiopathic infertility 

  105. Hum Reprod Bedaiwy 17 426 2002 10.1093/humrep/17.2.426 Prediction of endometriosis with serum and peritoneal fluid markers 

  106. Int J Fertil Wom Med Attaran 45 314 2000 The effect of follicular fluid reactive oxygen species on the outcome of in vitro fertilization 

  107. Hum Reprod Paszkowski 17 921 2002 10.1093/humrep/17.4.921 Smoking induces oxidative stress inside the Graafian follicle 

  108. Mol Hum Reprod Jozwik 5 409 1999 10.1093/molehr/5.5.409 Oxidative stress markers in preovulatory follicular fluid in humans 

  109. Hum Reprod Bedaiwy 17 601 2002 10.1093/humrep/17.3.601 Relationship between oxidative stress and embryotoxicity of hydrosalpingeal fluid 

  110. Hum Reprod Dozortsev 10 2960 1995 10.1093/oxfordjournals.humrep.a135829 Sperm plasma membrane damage prior to intracytoplasmic sperm injection 

  111. J Inorg Biochem Toyokuni 47 241 1992 10.1016/0162-0134(92)84069-Y Iron-mediated DNA damage 

  112. Fertil Steril Ermilov 72 154 1999 10.1016/S0015-0282(99)00204-6 Culture media and their components differ in their ability to scavenge reactive oxygen species in the plasmid relaxation assay 

  113. Mol Reprod Dev Cummins 37 345 1994 10.1002/mrd.1080370314 Molecular biology of human male infertility 

  114. Hum Reprod Goyanes 5 613 1990 10.1093/oxfordjournals.humrep.a137155 Morphometric categorization of the human oocyte and early conceptus 

  115. Br Med Bull Plachot 46 675 1990 10.1093/oxfordjournals.bmb.a072424 Oocyte maturation, fertilization and embryonic growth in vitro 

  116. Fertil Steril Erenus 56 707 1991 10.1016/S0015-0282(16)54603-2 The effect of embryo quality on subsequent pregnancy rates after in vitro fertilization 

  117. Development Nasr-Esfahani 109 501 1990 10.1242/dev.109.2.501 Hydrogen peroxide levels in mouse oocytes and early cleavage stage embryos developed in vitro or in vivo 

  118. Free Radic Biol Med Goto 15 69 1993 10.1016/0891-5849(93)90126-F Increased generation of reactive oxygen species in embryos cultured in vitro 

  119. Am J Clin Nutr Halliwell 57 715S 1993 10.1093/ajcn/57.5.715S Lipid peroxidation 

  120. FEBS Lett Halliwell 281 9 1991 10.1016/0014-5793(91)80347-6 DNA damage by oxygen-derived species. Its mechanism and measurement in mammalian systems 

  121. Cell Hockenbery 75 241 1993 10.1016/0092-8674(93)80066-N Bcl-2 functions in an antioxidant pathway to prevent apoptosis 

  122. Mol Hum Reprod Jurisicova 2 93 1996 10.1093/molehr/2.2.93 Programmed cell death and human embryo fragmentation 

  123. Bedaiwy MA, Miller K, Falcone T, Nelson D, AbdelAleem A, Mohamed M, et al. Differential growth of human embryos in vitro: role of reactive oxygen species. In: 18th Annual Meeting of the European Society of Human Reproduction and Embryology, 30 Jun-3 Jul, 2002, Vienna, Austria. Hum Reprod 2002;17:38 

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