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Diabetes & metabolism, v.30 no.5, 2004년, pp.433 - 439
Bayerle-Eder, M (Department of Clinical Pharmacology, Medical University of Vienna, Austria.) , Pleiner, J (Department of Clinical Pharmacology, Medical University of Vienna, Austria.) , Mittermayer, F (Department of Clinical Pharmacology, Medical University of Vienna, Austria.) , Schaller, G (Department of Clinical Pharmacology, Medical University of Vienna, Austria.) , Roden, M (Department of Internal Medicine III, Div. of Endocrinology and Metabolism, Medical University of Vienna, Austria.) , Waldhäusl, W (Department of Internal Medicine III, Div. of Endocrinology and Metabolism, Medical University of Vienna, Austria.) , Bieglmayer, C (Clinical Institute for Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Austria.) , Wolzt, M (Department of Clinical Pharmacology, Medical University of Vienna, Austria.)
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Summary Objectives Plasma malondialdehyde (MDA), a reactive product of lipid peroxidation, may be influenced by anti-oxidant therapy. The aim of the present study was to investigate if elevated MDA as induced by increased free fatty acids (FFA) correlates with endothelial function and is af...
Résumé Effet de l'administration systématique de vitamine C sur la peroxydation lipidique induite par les acides gras libres Objectifs Le malondialdehyde plasmatique (MDA), produit réactif de la peroxydation lipidique, peut être influencé par un traitement anti-oxydant. Le but de cette étude était d'évaluer si un taux élevé de MDA tel qu'induit par l'augmentation des acides gras libres (FFA) est corrélé à la fonction endothéliale et est affecté par de fortes doses de vitamine C. Méthode Il s'agit d'une étude randomisée, contrôlée par placebo, en double insu, avec double crossover. Les concentrations plasmatiques de MDA et les réponses du flux sanguin à l'avant bras (FBF) à l'acétylcholine intraartérielle (Ach) et au glyceryl trinitrate ont été évaluées au cours d'une co-administration de vitamine C ou de placebo en présence de taux élevés de FFA plasmatiques par perfusion d'Intralipid®/héparine chez 10 sujets sains masculins. Résultats L'augmentation d'un facteur 7 des FFA plasmatiques est associée à une augmentation des concentrations plasmatiques de MDA (r = 0,7, p < 0,001) et une diminution des réponses FBF à ACh (r = -0,4, p < 0,01). La co-administration de vitamine C restaure la réactivité de FBF à Ach mais n'a pas d'effet sur les concentrations élevées de MDA. Conclusions Le traitement anti-oxydant par vitamine C améliore les altérations de la vasodilatation endothélium-dépendante induites par les lipides, mais n'agit pas sur la formation ou la clairance des MDA.
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