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Sitagliptin: A Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

The Annals of pharmacotherapy, v.40 no.7/8, 2006년, pp.1336 - 1343  

Miller, Shannon A (University of Florida College of Pharmacy, Orlando Campus, Apopka, FL) ,  St. Onge, Erin L

Abstract AI-Helper 아이콘AI-Helper

Objective: TO review the pharmacology, pharmacokinetics, safety, and efficacy of sitagliptin, a dipeptidyl peptidase IV (DPP-IV) inhibitor in the management of type 2 diabetes mellitus. Data Sources: A MEDLINE search (1966-February 2006) was conducted for English-language articles using the terms di...

참고문헌 (27)

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  2. Weber, A. E.. Dipeptidyl Peptidase IV Inhibitors for the Treatment of Diabetes. Journal of medicinal chemistry, vol.47, no.17, 4135-4141.

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  9. Pederson, Raymond A, White, Heather A, Schlenzig, Dagmar, Pauly, Robert P, McIntosh, Christopher H S, Demuth, Hans-Ulrich. Improved Glucose Tolerance in Zucker Fatty Rats by Oral Administration of the Dipeptidyl Peptidase IV Inhibitor Isoleucine Thiazolidide. Diabetes, vol.47, no.8, 1253-1258.

  10. Marguet, Didier, Baggio, Laurie, Kobayashi, Takashi, Bernard, Anne-Marie, Pierres, Michel, Nielsen, Per F., Ribel, Ulla, Watanabe, Takeshi, Drucker, Daniel J., Wagtmann, Nicolai. Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26. Proceedings of the National Academy of Sciences of the United States of America, vol.97, no.12, 6874-6879.

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  15. Conarello, Stacey L., Li, Zhihua, Ronan, John, Roy, Ranabir Sinha, Zhu, Lan, Jiang, Guoqiang, Liu, Franklin, Woods, John, Zycband, Emanuel, Moller, David E., Thornberry, Nancy A., Zhang, Bei B.. Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance. Proceedings of the National Academy of Sciences of the United States of America, vol.100, no.11, 6825-6830.

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  25. Ahrén, Bo, Gomis, Ramon, Standl, Eberhard, Mills, David, Schweizer, Anja. Twelve- and 52-Week Efficacy of the Dipeptidyl Peptidase IV Inhibitor LAF237 in Metformin-Treated Patients With Type 2 Diabetes. Diabetes care, vol.27, no.12, 2874-2880.

  26. Pospisilik, J.A., Stafford, S.G., Demuth, H-U., Brownsey, R., Parkhouse, W., Finegood, D.T., McIntosh, C.H.S., Pederson, R.A.. Long-Term Treatment With the Dipeptidyl Peptidase IV Inhibitor P32/98 Causes Sustained Improvements in Glucose Tolerance, Insulin Sensitivity, Hyperinsulinemia, and β-Cell Glucose Responsiveness in VDF (fa/fa) Zucker Rats. Diabetes, vol.51, no.4, 943-950.

  27. Herman, G.A., Stevens, C., Van Dyck, K., Bergman, A., Yi, B., De Smet, M., Snyder, K., Hilliard, D., Tanen, M., Tanaka, W., Wang, A.Q., Zeng, W., Musson, D., Winchell, G., Davies, M.J., Ramael, S., Gottesdiener, K.M., Wagner, J.A.. Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: Results from two randomized, double-blind, placebo-controlled studies with single oral doses. Clinical pharmacology and therapeutics, vol.78, no.6, 675-688.

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