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NTIS 바로가기The Annals of pharmacotherapy, v.40 no.7/8, 2006년, pp.1336 - 1343
Miller, Shannon A (University of Florida College of Pharmacy, Orlando Campus, Apopka, FL) , St. Onge, Erin L
Objective: TO review the pharmacology, pharmacokinetics, safety, and efficacy of sitagliptin, a dipeptidyl peptidase IV (DPP-IV) inhibitor in the management of type 2 diabetes mellitus. Data Sources: A MEDLINE search (1966-February 2006) was conducted for English-language articles using the terms di...
McIntosh, Christopher H.S., Demuth, Hans-Ulrich, Pospisilik, J.Andrew, Pederson, Raymond. Dipeptidyl peptidase IV inhibitors: how do they work as new antidiabetic agents?. Regulatory peptides, vol.128, no.2, 159-165.
Weber, A. E.. Dipeptidyl Peptidase IV Inhibitors for the Treatment of Diabetes. Journal of medicinal chemistry, vol.47, no.17, 4135-4141.
Incretin mimetics and DPP-IV inhibitors for the treatment of type 2 diabetes. Drug discovery today, vol.10, no.10, 703-710.
Kim, D., Wang, L., Beconi, M., Eiermann, G. J., Fisher, M. H., He, H., Hickey, G. J., Kowalchick, J. E., Leiting, B., Lyons, K., Marsilio, F., McCann, M. E., Patel, R. A., Petrov, A., Scapin, G., Patel, S. B., Roy, R. S., Wu, J. K., Wyvratt, M. J., Zhang, B. B., Zhu, L., Thornberry, N. A., Weber, A. E.. (2R)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin- 7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes. Journal of medicinal chemistry, vol.48, no.1, 141-151.
Curr Opin Investig Drugs Deacon CF 419 6 2005
Creutzfeldt, Werner. The [pre-] history of the incretin concept. Regulatory peptides, vol.128, no.2, 87-91.
Vilsbøll, Tina, Krarup, Thure, Deacon, Carolyn F., Madsbad, Sten, Holst, Jens J.. Reduced Postprandial Concentrations of Intact Biologically Active Glucagon-Like Peptide 1 in Type 2 Diabetic Patients. Diabetes, vol.50, no.3, 609-613.
Ahrén, Bo, Holst, Jens J, Mårtensson, Hans, Balkan, Börk. Improved glucose tolerance and insulin secretion by inhibition of dipeptidyl peptidase IV in mice. European journal of pharmacology, vol.404, no.1, 239-245.
Pederson, Raymond A, White, Heather A, Schlenzig, Dagmar, Pauly, Robert P, McIntosh, Christopher H S, Demuth, Hans-Ulrich. Improved Glucose Tolerance in Zucker Fatty Rats by Oral Administration of the Dipeptidyl Peptidase IV Inhibitor Isoleucine Thiazolidide. Diabetes, vol.47, no.8, 1253-1258.
Marguet, Didier, Baggio, Laurie, Kobayashi, Takashi, Bernard, Anne-Marie, Pierres, Michel, Nielsen, Per F., Ribel, Ulla, Watanabe, Takeshi, Drucker, Daniel J., Wagtmann, Nicolai. Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26. Proceedings of the National Academy of Sciences of the United States of America, vol.97, no.12, 6874-6879.
Diabetes Bergman A 2100 54 1 2005
Diabetes Herman G 497-P 54 1 2005
Diabetes Bergman A 2101-PO 54 1 2005
Mitani, Hironobu, Takimoto, Misato, Hughes, Thomas E., Kimura, Masaaki. Dipeptidyl Peptidase IV Inhibition Improves Impaired Glucose Tolerance in High-Fat Diet-Fed Rats: Study Using a Fischer 344 Rat Substrain Deficient in Its Enzyme Activity. The Japanese journal of pharmacology : official publication of the Japanese Pharmacological Society, vol.88, no.4, 442-450.
Conarello, Stacey L., Li, Zhihua, Ronan, John, Roy, Ranabir Sinha, Zhu, Lan, Jiang, Guoqiang, Liu, Franklin, Woods, John, Zycband, Emanuel, Moller, David E., Thornberry, Nancy A., Zhang, Bei B.. Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance. Proceedings of the National Academy of Sciences of the United States of America, vol.100, no.11, 6825-6830.
Diabetologia Herman GA A287 1 2004
Diabetes Herman G A134 54 1 2005
Diabetes Scott R A10 54 1 2005
Diabetes Brazg R A3 54 1 2005
Diabetes Herman G A505 54 1 2005
Mest, H.-J., Mentlein, R.. Dipeptidyl peptidase inhibitors as new drugs for the treatment of type 2 diabetes. Diabetologia, vol.48, no.4, 616-620.
Mentlein, Rolf. Dipeptidyl-peptidase IV (CD26)-role in the inactivation of regulatory peptides. Regulatory peptides, vol.85, no.1, 9-24.
Deacon, Carolyn F, Ahrén, Bo, Holst, Jens J. Inhibitors of dipeptidyl peptidase IV: a novel approach for the prevention and treatment of Type 2 diabetes?. Expert opinion on investigational drugs, vol.13, no.9, 1091-1102.
Ahrén, Bo, Gomis, Ramon, Standl, Eberhard, Mills, David, Schweizer, Anja. Twelve- and 52-Week Efficacy of the Dipeptidyl Peptidase IV Inhibitor LAF237 in Metformin-Treated Patients With Type 2 Diabetes. Diabetes care, vol.27, no.12, 2874-2880.
Pospisilik, J.A., Stafford, S.G., Demuth, H-U., Brownsey, R., Parkhouse, W., Finegood, D.T., McIntosh, C.H.S., Pederson, R.A.. Long-Term Treatment With the Dipeptidyl Peptidase IV Inhibitor P32/98 Causes Sustained Improvements in Glucose Tolerance, Insulin Sensitivity, Hyperinsulinemia, and β-Cell Glucose Responsiveness in VDF (fa/fa) Zucker Rats. Diabetes, vol.51, no.4, 943-950.
Herman, G.A., Stevens, C., Van Dyck, K., Bergman, A., Yi, B., De Smet, M., Snyder, K., Hilliard, D., Tanen, M., Tanaka, W., Wang, A.Q., Zeng, W., Musson, D., Winchell, G., Davies, M.J., Ramael, S., Gottesdiener, K.M., Wagner, J.A.. Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: Results from two randomized, double-blind, placebo-controlled studies with single oral doses. Clinical pharmacology and therapeutics, vol.78, no.6, 675-688.
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