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Effects of simvastatin on plasma antioxidant status and vitamins in hypercholesterolemic patients

International journal of cardiology, v.118 no.2, 2007년, pp.173 - 177  

Abstract AI-Helper 아이콘AI-Helper

AbstractBackgroundStatins are known to possess antioxidant properties in addition to their cholesterol-lowering effects. However, recent studies have suggested that statins reduce the levels of antioxidant vitamins such as vitamin E and coenzyme Q10, possibly resulting in impaired left ventricular f...

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참고문헌 (25)

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  6. PNAS Folkers 87 8931 1990 10.1073/pnas.87.22.8931 Lovastatin decreases coenzyme Q levels in humans 

  7. Ann Med Vasankari 36 618 2004 10.1080/07853890410018844 Effect of 12-month statin therapy on antioxidant potential of LDL and serum antioxidant vitamin concentrations 

  8. Rice-Evans 279 1994 10.1016/0076-6879(94)34095-1 Methods in Enzymology Total antioxidant status in plasma and body fluids 

  9. Int J Vitam Nutr Res Jakob 65 31 1995 Rapid HPLC-Assay for assessment of vitamin K1, A, E and beta-carotene status in children (7-19 years) 

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  11. Ann N Y Acad Sci Horwitt 203 223 1972 10.1111/j.1749-6632.1972.tb27878.x Relationship between tocopherol and serum lipid levels for determination of nutritional adequacy 

  12. Chem Pharm Bull Suzumura 47 1010 1999 10.1248/cpb.47.1010 An in vitro study of the hydroxyl radical scavenging property of fluvastatin, an HMG-CoA reductase inhibitor 

  13. Eur J Pharmacol Yamamoto 361 143 1998 10.1016/S0014-2999(98)00692-X Fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase, scavenges free radicals and inhibits lipid peroxidation in rat liver microsomes 

  14. Biochim Biophys Acta Giroux 1165 335 1993 10.1016/0005-2760(93)90145-Y Simvastatin inhibits the oxidation of low-density lipoproteins by activated human monocyte-derived macrophages 

  15. Free Radic Biol Med Pereira 37 1440 2004 10.1016/j.freeradbiomed.2004.07.019 Antioxidant effect of simvastatin is not enhanced by its association with alpha-tocopherol in hypercholesterolemic patients 

  16. J Clin Pharmacol Ghirlanda 33 226 1993 10.1002/j.1552-4604.1993.tb03948.x Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: a double-blind, placebo-controlled study 

  17. J Clin Pathol Watts 46 1055 1993 10.1136/jcp.46.11.1055 Plasma coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin 

  18. Eur J Clin Pharmacol Laaksonen 46 313 1994 10.1007/BF00194398 Serum ubiquinone concentrations after short- and long-term treatment with HMG-CoA reductase inhibitors 

  19. JAMA Jula 287 598 2002 10.1001/jama.287.5.598 Effects of diet and simvastatin on serum lipids, insulin, and antioxidants in hypercholesterolemic men: a randomized controlled trial 

  20. Arch Neurol Rundek 61 889 2004 10.1001/archneur.61.6.889 Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke 

  21. Clin Chim Acta Human 263 67 1997 10.1016/S0009-8981(97)06557-1 The effect of Simvastatin on the plasma antioxidant concentrations in patients with hypercholesterolaemia 

  22. Am J Cardiol Salonen 76 34-39C 1995 10.1016/S0002-9149(99)80468-8 The Kupio Atherosclerosis Prevention Study (KAPS): effect of pravastatin treatment on lipids, oxidation resistance of lipoproteins, and atherosclerostic progression 

  23. Eur J Clin Invest Colquhoun 35 251 2005 10.1111/j.1365-2362.2005.01486.x Effects of simvastatin on blood lipids, vitamin E, coenzyme Q10 levels and left ventricular function in humans 

  24. Am J Cardiol Silver 94 1306 2004 10.1016/j.amjcard.2004.07.121 Effect of atorvastatin on left ventricular diastolic function and ability of coenzyme Q10 to reverse that dysfunction 

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