Jung, E.
(Dermapro Skin Research Center, 919-1 Bangbae Dong, Seocho Gu, 137-843 Seoul City, Republic of Korea)
,
Lee, J.
,
Baek, J.
,
Jung, K.
,
Lee, J.
,
Huh, S.
,
Kim, S.
,
Koh, J.
,
Park, D.
Type I collagen is the primary component of the skin dermis. Both the quantity and quality of extracellular collagen are primarily related to skin ageing. In this study, we investigated the possibility that Camellia japonica oil (CJ oil) may be introduced as an anit-wrinkle agent. As a first step to...
Type I collagen is the primary component of the skin dermis. Both the quantity and quality of extracellular collagen are primarily related to skin ageing. In this study, we investigated the possibility that Camellia japonica oil (CJ oil) may be introduced as an anit-wrinkle agent. As a first step to this end, human COL1A2 promoter luciferase assay was performed in human dermal fibroblast cells. CJ oil was determined to activate human COL1A2 promoter in a concentration-dependent manner. In consistency with this result, while matrix metalloproteinase (MMP)-1 activity was inhibited by CJ oil, human type I procollagen synthesis was also induced by CJ oil. These results suggest the possibility that CJ oil may be involved in the skin ageing. For the evaluation of CJ oil's safety and efficiency on human skin, human skin primary irritation test and trans-epidermal water loss (TEWL) were performed. Transepidermal water loss (TEWL) was measured before treatment then, 1h and 2h after treatment; the forearm site was selected to measure TEWL. Also, a human skin primary irritation test was performed on the normal skin (upper back) in 30 volunteers to see if a certain material included in CJ oil has irritation or sensitization potential. In these assays, CJ oil reduced trans-epidermal water loss (TEWL) and did not induce any adverse reactions. Therefore, based on these results, we suggest the possibility that CJ oil may be considered as possible wrinkle-reducing candidates for topical application.
Type I collagen is the primary component of the skin dermis. Both the quantity and quality of extracellular collagen are primarily related to skin ageing. In this study, we investigated the possibility that Camellia japonica oil (CJ oil) may be introduced as an anit-wrinkle agent. As a first step to this end, human COL1A2 promoter luciferase assay was performed in human dermal fibroblast cells. CJ oil was determined to activate human COL1A2 promoter in a concentration-dependent manner. In consistency with this result, while matrix metalloproteinase (MMP)-1 activity was inhibited by CJ oil, human type I procollagen synthesis was also induced by CJ oil. These results suggest the possibility that CJ oil may be involved in the skin ageing. For the evaluation of CJ oil's safety and efficiency on human skin, human skin primary irritation test and trans-epidermal water loss (TEWL) were performed. Transepidermal water loss (TEWL) was measured before treatment then, 1h and 2h after treatment; the forearm site was selected to measure TEWL. Also, a human skin primary irritation test was performed on the normal skin (upper back) in 30 volunteers to see if a certain material included in CJ oil has irritation or sensitization potential. In these assays, CJ oil reduced trans-epidermal water loss (TEWL) and did not induce any adverse reactions. Therefore, based on these results, we suggest the possibility that CJ oil may be considered as possible wrinkle-reducing candidates for topical application.
Chemical and Pharmaceutical Bulletin (Tokyo) Akihisa 45 1023 1997 10.1248/cpb.45.2016 Triterpene alcohols from camellia and sasanqua oils and their anti-inflammatory effects
Critical Reviews in Eukaryotic Gene Expression Borden 7 159 1997 10.1615/CritRevEukarGeneExpr.v7.i1-2.90 Transcriptional control of matrix metalloproteinases and the tissue inhibitors of matrix metalloproteinases
International Journal of Cosmetic Science Conti 17 77 1995 10.1111/j.1467-2494.1995.tb00111.x Capacitance, transepidermal water loss and causal level of sebum in healthy subjects in relation to site, sex and age
Journal of Clinical Investigation Ghadially 95 2281 1995 10.1172/JCI117919 The aged epidermal permeability barrier: Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model
Life Science Lee 79 2480 2006 10.1016/j.lfs.2006.08.008 Emodin inhibits TNF alpha-induced MMP-1 expression through suppression of activator protein-1 (AP-1)
Journal of Ethnopharmacology Lee 109 29 2007 10.1016/j.jep.2006.06.008 Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling
Planta Medica Lee 71 338 2005 10.1055/s-2005-864100 Anti-inflammatory effects of magnolol and honokiol are mediated through inhibition of the downstream pathway of MEKK-1 in NF-kappaB activation signaling
Planta Medica Lee 72 324 2006 10.1055/s-2005-916227 Asiaticoside induces human collagen I synthesis through TGFβ receptor I kinase (TβRI Kinase)-independent smad signaling
※ AI-Helper는 부적절한 답변을 할 수 있습니다.