[논문]4-Hydroxykobusin Inhibits the Induction of Nitric Oxide Synthase by Inhibiting NF-κB and AP-1 Activation

Pokharel, Yuba Raj; Liu, Qing-He; Oh, Jae Wook; Woo, Eun-Rhan; Kang, Keon Wook

doi:10.1248/bpb.30.1097

[해외논문] 4-Hydroxykobusin Inhibits the Induction of Nitric Oxide Synthase by Inhibiting NF-κB and AP-1 Activation 원문보기

Biological & pharmaceutical bulletin, v.30 no.6, 2007년, pp.1097 - 1101

Pokharel, Yuba Raj (BK21 Project Team, Chosun University) , Liu, Qing-He (College of Pharmacy, Chosun University) , Oh, Jae Wook (Department of Anatomy, Medical School, Chosun University) , Woo, Eun-Rhan (College of Pharmacy, Chosun University) , Kang, Keon Wook (BK21 Project Team, Chosun University)

Abstract ▼ AI-Helper

We recently isolated a novel lignan, 4-hydroxykobusin from Geranium thunbergii (Liu et al., Arch. Pharm. Res., 29, 1109—1113, 2006). Here, we studied its effect on the expression of inducible nitric oxide synthase (iNOS) gene in RAW264.7 cells. 4-Hydroxykobusin inhibited nitric oxide (NO) production in a concentration-dependent manner and blocked the lipopolysaccharide (LPS)-induced expression of inducible nitric oxide synthase (iNOS). To identify the mechanistic basis for its inhibition of iNOS induction, we examined the effect of 4-hydroxykobusin on the transactivation of iNOS gene by luciferase reporter activity using −1.59 kb flanking region. The lignan suppressed the reporter gene activity and the LPS-induced reporter activations of nuclear factor-κB (NF-κB) and activator protein-1 (AP-1) were also significantly blocked by 4-hydroxykobusin. These findings suggest that the inhibition of LPS-induced NO formation by 4-hydroxykobusin is due to its inhibition of NF-κB and AP-1 activation.

주제어

참고문헌 (39)

10.1248/yakushi1947.95.12_1462 1) Okuda T., Yoshida T., Mori K., Yakugaku Zasshi , 95, 1462—1466 (1975).

상세보기
0951-6433 Biofactors Hiramatsu N., Xiufen W., Takechi R. 22 123 2004 10.1002/biof.5520220124

상세보기
0020-5915 Int. Arch. Allerg. Appl. Immunol. Ushio Y., Okuda T., Abe H. 96 224 1991 10.1159/000235499

상세보기
0951-6433 Biofactors Xiufen W., Hiramatsu N., Matsubara 21 281 2004 10.1002/biof.552210155

상세보기
0022-3573 J. Pharm. Pharmacol. 46 1 46 1994 10.1111/j.2042-7158.1994.tb03718.x

상세보기
Z. Naturforsch. Gohar A. A., Lahloub M. E., Niwa M. 58 670 2003 10.1515/znc-2003-9-1013

상세보기
0253-6269 Arch. Pharm. Res. Liu Q. H., Jeong J. E., Choi E. J., 29 1109 2006 10.1007/BF02969300

원문보기 상세보기
0785-3890 Ann. Med. Porsti I., Paakkari I. 27 407 1995 10.3109/07853899509002594

상세보기
0090-3493 Am. J. Resp. Crit. Care Med. Kristof A. S., Goldberg P., Laubach 158 1883 1998 10.1164/ajrccm.158.6.9802100

상세보기
0003-2999 Anesth. Analg. Strunk V., Hahnenkamp K., Schneuing 92 681 2001 10.1213/00000539-200103000-00025

상세보기
Kubes, Paul, McCafferty, Donna-Marie. Nitric oxide and intestinal inflammation. The American journal of medicine, vol.109, no.2, 150-158.

상세보기
Kim, Hyun Pyo, Son, Kun Ho, Chang, Hyeun Wook, Kang, Sam Sik. Anti-inflammatory Plant Flavonoids and Cellular Action Mechanisms. Journal of pharmacological sciences, vol.96, no.3, 229-245.

상세보기
Kanno, Syu-ichi, Shouji, Ai, Tomizawa, Ayako, Hiura, Takako, Osanai, Yuu, Ujibe, Mayuko, Obara, Yutaro, Nakahata, Norimichi, Ishikawa, Masaaki. Inhibitory effect of naringin on lipopolysaccharide (LPS)-induced endotoxin shock in mice and nitric oxide production in RAW 264.7 macrophages. Life sciences, vol.78, no.7, 673-681.

상세보기
0378-8741 J. Ethnopharmacol. Yang J. W., Pokharel Y. R., Kim M. 105 107 2006 10.1016/j.jep.2005.10.001

상세보기
Woo, E.R., Lee, J.Y., Cho, I.J., Kim, S.G., Kang, K.W.. Amentoflavone inhibits the induction of nitric oxide synthase by inhibiting NF-κB activation in macrophages. Pharmacological research : the official journal of the Italian Pharmacological Society, vol.51, no.6, 539-546.

상세보기
0028-1298 Naunyn Schmiedebergs Arch. Pharmacol. 352 4 351 1995
1089-8603 Nitric Oxide Cho M. K., Suh S. H., Kim S. G. 6 319 2002 10.1006/niox.2001.0415

상세보기
Chen, Ching‐Wen, Lee, Sho Tone, Wu, Wen Tung, Fu, Wen‐Mei, Ho, Feng‐Ming, Lin, Wan Wan. Signal transduction for inhibition of inducible nitric oxide synthase and cyclooxygenase‐2 induction by capsaicin and related analogs in macrophages. British journal of pharmacology : BJP, vol.140, no.6, 1077-1087.

상세보기
1021-7770 J. Biomed. Sci. Choi D. Y., Lee J. Y., Kim M. R., W 12 949 2005 10.1007/s11373-005-9028-8

상세보기
0171-2985 Immunobiology Muller J. M., Ziegler-Heitbrock H. 187 233 1993 10.1016/S0171-2985(11)80342-6

상세보기
Guha, Mausumee, Mackman, Nigel. LPS induction of gene expression in human monocytes. Cellular signalling, vol.13, no.2, 85-94.

상세보기
Gilmore, Thomas D. The Rel/NF-κB signal transduction pathway: introduction. Oncogene, vol.18, no.49, 6842-6844.

상세보기
Wang, Tieli, Zhang, Xia, Li, Jian Jian. The role of NF-κB in the regulation of cell stress responses. International immunopharmacology, vol.2, no.11, 1509-1520.

상세보기
Schmedtje, John F., Ji, Yan-Shan, Liu, W.-L., DuBois, Raymond N., Runge, Marschall S.. Hypoxia Induces Cyclooxygenase-2 via the NF-κB p65 Transcription Factor in Human Vascular Endothelial Cells. The Journal of biological chemistry, vol.272, no.1, 601-608.

상세보기
Newton, R., Kuitert, L.M.E., Bergmann, M., Adcock, I.M., Barnes, P.J.. Evidence for Involvement of NF-κB in the Transcriptional Control of COX-2 Gene Expression by IL-1β. Biochemical and biophysical research communications, vol.237, no.1, 28-32.

상세보기
0002-9505 Am. J. Physiol. Billack B., Heck D. E., Mariano T. 283 C1267 2002 10.1152/ajpcell.00609.2001

상세보기
Gorgoni, Barbara, Caivano, Matilde, Arizmendi, Carmen, Poli, Valeria. The Transcription Factor C/EBPβ Is Essential for Inducible Expression of the cox-2 Gene in Macrophages but Not in Fibroblasts. The Journal of biological chemistry, vol.276, no.44, 40769-40777.

상세보기
0077-8923 Ann. N.Y. Acad. Sci. SZABO C 851 422 1998 10.1111/j.1749-6632.1998.tb09019.x

상세보기
Park, So Young, Hong, Seong Su, Han, Xiang Hua, Hwang, Ji Sang, Lee, Dongho, Ro, Jai Seup, Hwang, Bang Yeon. Lignans from Arctium lappa and Their Inhibition of LPS-Induced Nitric Oxide Production. Chemical & pharmaceutical bulletin, vol.55, no.1, 150-152.

상세보기
Cieslik, Katarzyna, Zhu, Ying, Wu, Kenneth K.. Salicylate Suppresses Macrophage Nitric-oxide Synthase-2 and Cyclo-oxygenase-2 Expression by Inhibiting CCAAT/Enhancer-binding Protein-β Binding via a Common Signaling Pathway. The Journal of biological chemistry, vol.277, no.51, 49304-49310.

상세보기
Lee, Ae Kyung, Sung, Sang Hyun, Kim, Young Choong, Kim, Sang Geon. Inhibition of lipopolysaccharide‐inducible nitric oxide synthase, TNF‐α and COX‐2 expression by sauchinone effects on I‐κBα phosphorylation, C/EBP and AP‐1 activation. British journal of pharmacology : BJP, vol.139, no.1, 11-20.

상세보기
Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide. The Journal of experimental medicine, vol.177, no.6, 1779-1784.

상세보기
Díaz-Guerra, María J.M., Velasco, Marta, Martín-Sanz, Paloma, Boscá, Lisardo. Evidence for Common Mechanisms in the Transcriptional Control of Type II Nitric Oxide Synthase in Isolated Hepatocytes. The Journal of biological chemistry, vol.271, no.47, 30114-30120.

상세보기
Hayden, Matthew S., Ghosh, Sankar. Signaling to NF-κB. Genes & development, vol.18, no.18, 2195-2224.

상세보기
Huang, Wei-Chien, Chen, Jun-Jie, Chen, Ching-Chow. c-Src-dependent Tyrosine Phosphorylation of IKKβ Is Involved in Tumor Necrosis Factor-α-induced Intercellular Adhesion Molecule-1 Expression. The Journal of biological chemistry, vol.278, no.11, 9944-9952.

상세보기
Trushin, Sergey A., Pennington, Kevin N., Carmona, Eva M., Asin, Susana, Savoy, Doris N., Billadeau, Daniel D., Paya, Carlos V.. Protein Kinase Cα (PKCα) Acts Upstream of PKCθ To Activate IκB Kinase and NF-κB in T Lymphocytes. Molecular and cellular biology, vol.23, no.19, 7068-7081.

상세보기
Cho, Min Kyung, Park, Jeong Weon, Jang, Young Pyo, Kim, Young Choong, Kim, Sang Geon. Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by dibenzylbutyrolactone lignans through inhibition of I-κBα phosphorylation and of p65 nuclear translocation in macrophages. International immunopharmacology, vol.2, no.1, 105-116.

상세보기
1567-5769 Int. Immunopharmacol. Cho M. K., Jang Y. P., Kim Y. C., K 4 1419 2004 10.1016/j.intimp.2004.06.011

상세보기
Pokharel, Yuba Raj, Liu, Qing-He, Aryal, Dipendra Kumar, Kim, Yoon Gyoon, Woo, Eun-Rhan, Kang, Keon Wook. 7,7′-Dihydroxy bursehernin inhibits the expression of inducible nitric oxide synthase through NF-κB DNA binding suppression. Nitric oxide : biology and chemistry, vol.16, no.2, 274-285.

상세보기

LOADING...

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

[해외논문] 4-Hydroxykobusin Inhibits the Induction of Nitric Oxide Synthase by Inhibiting NF-κB and AP-1 Activation 원문보기

Abstract ▼ AI-Helper

주제어

참고문헌 (39)

이 논문을 인용한 문헌

연구과제 타임라인

관련 콘텐츠

원문 보기

원문 URL 링크

오픈액세스(OA) 유형

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

연합인증

[해외논문] 4-Hydroxykobusin Inhibits the Induction of Nitric Oxide Synthase by Inhibiting NF-κB and AP-1 Activation 원문보기

Abstract ▼ AI-Helper

주제어

참고문헌 (39)

이 논문을 인용한 문헌

연구과제 타임라인

전체(0) 논문(0) 특허(0) 보고서(0)

전체(0) 논문(0) 특허(0) 보고서(0)

관련 콘텐츠

원문 보기

원문 URL 링크

오픈액세스(OA) 유형

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트