[논문]Targeted gene therapy of LS174 T human colon carcinoma by anti-TAG-72 immunoliposomes

Kim, K S; Lee, Y K; Kim, J S; Koo, K H; Hong, H J; Park, Y S

doi:10.1038/cgt.2008.11

[해외논문] Targeted gene therapy of LS174 T human colon carcinoma by anti-TAG-72 immunoliposomes 원문보기

Cancer gene therapy, v.15 no.5, 2008년, pp.331 - 340

Kim, K S (1Department of Biomedical Laboratory Science, Institute of Health Science, Yonsei University, Wonju, Republic of Korea) , Lee, Y K (1Department of Biomedical Laboratory Science, Institute of Health Science, Yonsei University, Wonju, Republic of Korea) , Kim, J S (1Department of Biomedical Laboratory Science, Institute of Health Science, Yonsei University, Wonju, Republic of Korea) , Koo, K H (1Department of Biomedical Laboratory Science, Institute of Health Science, Yonsei University, Wonju, Republic of Korea) , Hong, H J (2Therapeutic Antibody Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea) , Park, Y S (1Department of Biomedical Laboratory Science, Institute of Health Science, Yonsei University, Wonju, Republic of Korea)

Abstract ▼ AI-Helper

Anti-tumor-associated glycoprotein (TAG)-72 PEG-immunoliposomes (PILs) were prepared by conjugation of Fab′ fragments of recombinant humanized monoclonal antibody, HuCC49, to sterically stabilize unilamellar liposomes (90–110 nm in diameter) to target TAG-72-overexpressing cancer cells. The liposomes consisted of 1-palmitonyl-2-oleoyl-sn-glycerol-3-phosphocholine (POPC), 92 mol percent, O,O′-dymyrisyl-N-lysyl aspartate (DMKD cationic lipid), 4 mol percent, distearoyl-phosphatidyl-ethanolamine-polyethylene glycol 2000 (DSPE-PEG2000), 3 mol percent and DSPE-maleimide (DSPE-PEG2000-Mal), 1 mol percent. These anti-TAG-72 PILs were able to adhere to the surface of TAG-72-overexpressing LS174 T human colon cancer cells more effectively than conventional liposomes. Also, in vitro gene transfection of the LS174 T cells by the anti-TAG-72 PILs in the presence of a high concentration of fetal bovine serum (up to 60%) was greater than that by conventional cationic lipoplexes. Intravenously administered anti-TAG-72 PILs efficiently localized in the LS174 T tumor tissues, while the non-targeted conventional liposomes did not. Intravenous administration of the anti-TAG-72 PILs containing plasmids encoding antiangiogenic proteins, such as angiostatin K1/3, endostatin and saxatilin, significantly inhibited in vivo growth of LS174 T tumors and angiogenesis in the tumor tissues. These results demonstrated the potential of TAG-72-mediated targeting of immunoliposomes as a modality for systemic gene delivery to human colon cancer cells.Cancer Gene Therapy (2008) 15, 331–340; doi:10.1038/cgt.2008.11; published online 29 February 2008

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[해외논문] Targeted gene therapy of LS174 T human colon carcinoma by anti-TAG-72 immunoliposomes 원문보기

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[해외논문] Targeted gene therapy of LS174 T human colon carcinoma by anti-TAG-72 immunoliposomes 원문보기

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