최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기The British journal of cancer, v.118 no.4, 2018년, pp.534 - 545
Cho, Hyun-Il (Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea , Seoul 06591, South Korea) , Kim, Un-Hee (Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea , Seoul 06591, South Korea) , Shin, A-Ri (Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea , Seoul 06591, South Korea) , Won, Ji-Na (Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea , Seoul 06591, South Korea) , Lee, Hyun-Joo (Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea , Seoul 06591, South Korea) , Sohn, Hyun-Jung (Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea , Seoul 06591, South Korea) , Kim, Tai-Gyu (Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic Uni)
Background:Adoptive transfer of genetically engineered T-cells to express antigen-specific T-cell receptor (TCR) is a feasible and effective therapeutic approach for numerous types of cancers, including Epstein–Barr virus (EBV)-associated malignancies. Here, we describe a TCR gene transfer re...
Anurathapan U, Chan RC, Hindi HF, Mucharla R, Bajgain P, Hayes BC, Fisher WE, Heslop HE, Rooney CM, Brenner MK, Leen AM, Vera JF ( 2014 ) Kinetics of tumor destruction by chimeric antigen receptor-modified T-cells . Mol Ther 22 (3): 623 –633. 24213558
Bendle GM, Linnemann C, Hooijkaas AI, Bies L, de Witte MA, Jorritsma A, Kaiser AD, Pouw N, Debets R, Kieback E, Uckert W, Song JY, Haanen JB, Schumacher TN ( 2010 ) Lethal graft-versus-host disease in mouse models of T-cell receptor gene therapy . Nat Med 16 (5): 565 –570, 1p following 570. 20400962
Bollard CM, Gottschalk S, Torrano V, Diouf O, Ku S, Hazrat Y, Carrum G, Ramos C, Fayad L, Shpall EJ, Pro B, Liu H, Wu MF, Lee D, Sheehan AM, Zu Y, Gee AP, Brenner MK, Heslop HE, Rooney CM ( 2014 ) Sustained complete responses in patients with lymphoma receiving autologous cytotoxic T lymphocytes targeting Epstein–Barr virus latent membrane proteins . J Clin Oncol 32 (8): 798 –808. 24344220
Brimnes MK, Gang AO, Donia M, Thor Straten P, Svane IM, Hadrup SR ( 2012 ) Generation of autologous tumor-specific T-cells for adoptive transfer based on vaccination, in vitro restimulation and CD3/CD28 dynabead-induced T-cell expansion . Cancer Immunol Immunother 61 (8): 1221 –1231. 22237888
Butler MO, Imataki O, Yamashita Y, Tanaka M, Ansen S, Berezovskaya A, Metzler G, Milstein MI, Mooney MM, Murray AP, Mano H, Nadler LM, Hirano N ( 2012 ) Ex vivo expansion of human CD8+ T-cells using autologous CD4+ T-cell help . PLoS One 7 (1): e30229 . 22279573
Caruso HG, Hurton LV, Najjar A, Rushworth D, Ang S, Olivares S, Mi T, Switzer K, Singh H, Huls H, Lee DA, Heimberger AB, Champlin RE, Cooper LJ ( 2015 ) Tuning sensitivity of CAR to EGFR density limits recognition of normal tissue while maintaining potent antitumor activity . Cancer Res 75 (17): 3505 –3518. 26330164
Chinnasamy N, Wargo JA, Yu Z, Rao M, Frankel TL, Riley JP, Hong JJ, Parkhurst MR, Feldman SA, Schrump DS, Restifo NP, Robbins PF, Rosenberg SA, Morgan RA ( 2011 ) A TCR targeting the HLA-A*0201-restricted epitope of MAGE-A3 recognizes multiple epitopes of the MAGE-A antigen superfamily in several types of cancer . J Immunol 186 (2): 685 –696. 21149604
Cho HI, Jung SH, Sohn HJ, Celis E, Kim TG ( 2015 a) An optimized peptide vaccine strategy capable of inducing multivalent CD8+ T-cell responses with potent antitumor effects . Oncoimmunology 4 (11): e1043504 . 26451316
Cho SG, Kim N, Sohn HJ, Lee SK, Oh ST, Lee HJ, Cho HI, Yim HW, Jung SE, Park G, Oh JH, Choi BO, Kim SW, Kim SW, Chung NG, Lee JW, Hong YS, Kim TG ( 2015 b) Long-term outcome of extranodal NK/T-cell lymphoma patients treated with postremission therapy using EBV LMP1 and LMP2a-specific CTLs . Mol Ther 23 (8): 1401 –1409. 26017177
Cohen CJ, Zhao Y, Zheng Z, Rosenberg SA, Morgan RA ( 2006 ) Enhanced antitumor activity of murine-human hybrid T-cell receptor (TCR) in human lymphocytes is associated with improved pairing and TCR/CD3 stability . Cancer Res 66 (17): 8878 –8886. 16951205
Corse E, Gottschalk RA, Allison JP ( 2011 ) Strength of TCR-peptide/MHC interactions and in vivo T-cell responses . J Immunol 186 (9): 5039 –5045. 21505216
Davis JL, Theoret MR, Zheng Z, Lamers CH, Rosenberg SA, Morgan RA ( 2010 ) Development of human anti-murine T-cell receptor antibodies in both responding and nonresponding patients enrolled in TCR gene therapy trials . Clin Cancer Res 16 (23): 5852 –5861. 21138872
Demachi-Okamura A, Ito Y, Akatsuka Y, Tsujimura K, Morishima Y, Takahashi T, Kuzushima K ( 2006 ) Epstein–Barr virus (EBV) latent membrane protein-1-specific cytotoxic T lymphocytes targeting EBV-carrying natural killer cell malignancies . Eur J Immunol 36 (3): 593 –602. 16479544
Duraiswamy J, Sherritt M, Thomson S, Tellam J, Cooper L, Connolly G, Bharadwaj M, Khanna R ( 2003 ) Therapeutic LMP1 polyepitope vaccine for EBV-associated Hodgkin disease and nasopharyngeal carcinoma . Blood 101 (8): 3150 –3156. 12468425
Fogg M, Murphy JR, Lorch J, Posner M, Wang F ( 2013 ) Therapeutic targeting of regulatory T-cells enhances tumor-specific CD8+ T-cell responses in Epstein–Barr virus associated nasopharyngeal carcinoma . Virology 441 (2): 107 –113. 23601786
Fogg MH, Wirth LJ, Posner M, Wang F ( 2009 ) Decreased EBNA-1-specific CD8+ T-cells in patients with Epstein–Barr virus-associated nasopharyngeal carcinoma . Proc Natl Acad Sci USA 106 (9): 3318 –3323. 19211798
Frumento G, Zheng Y, Aubert G, Raeiszadeh M, Lansdorp PM, Moss P, Lee SP, Chen FE ( 2013 ) Cord blood T-cells retain early differentiation phenotype suitable for immunotherapy after TCR gene transfer to confer EBV specificity . Am J Transplant 13 (1): 45 –55. 23016879
Gandhi MK, Moll G, Smith C, Dua U, Lambley E, Ramuz O, Gill D, Marlton P, Seymour JF, Khanna R ( 2007 ) Galectin-1 mediated suppression of Epstein–Barr virus specific T-cell immunity in classic Hodgkin lymphoma . Blood 110 (4): 1326 –1329. 17438085
Goff SL, Johnson LA, Black MA, Xu H, Zheng Z, Cohen CJ, Morgan RA, Rosenberg SA, Feldman SA ( 2010 ) Enhanced receptor expression and in vitro effector function of a murine-human hybrid MART-1-reactive T-cell receptor following a rapid expansion . Cancer Immunol Immunother 59 (10): 1551 –1560. 20628878
Gottschalk S, Edwards OL, Sili U, Huls MH, Goltsova T, Davis AR, Heslop HE, Rooney CM ( 2003 ) Generating CTLs against the subdominant Epstein–Barr virus LMP1 antigen for the adoptive immunotherapy of EBV-associated malignancies . Blood 101 (5): 1905 –1912. 12411306
Gottschalk S, Heslop HE, Rooney CM ( 2005 ) Adoptive immunotherapy for EBV-associated malignancies . Leuk Lymphoma 46 (1): 1 –10. 15621775
Graham JP, Arcipowski KM, Bishop GA ( 2010 ) Differential B-lymphocyte regulation by CD40 and its viral mimic, latent membrane protein 1 . Immunol Rev 237 (1): 226 –248. 20727039
Grupp SA, Kalos M, Barrett D, Aplenc R, Porter DL, Rheingold SR, Teachey DT, Chew A, Hauck B, Wright JF, Milone MC, Levine BL, June CH ( 2013 ) Chimeric antigen receptor-modified T-cells for acute lymphoid leukemia . N Engl J Med 368 (16): 1509 –1518. 23527958
Hammerschmidt W, Sugden B, Baichwal VR ( 1989 ) The transforming domain alone of the latent membrane protein of Epstein–Barr virus is toxic to cells when expressed at high levels . J Virol 63 (6): 2469 –2475. 2542565
Hinrichs CS, Borman ZA, Cassard L, Gattinoni L, Spolski R, Yu Z, Sanchez-Perez L, Muranski P, Kern SJ, Logun C, Palmer DC, Ji Y, Reger RN, Leonard WJ, Danner RL, Rosenberg SA, Restifo NP ( 2009 ) Adoptively transferred effector cells derived from naive rather than central memory CD8+ T-cells mediate superior antitumor immunity . Proc Natl Acad Sci USA 106 (41): 17469 –17474. 19805141
Johnson LA, Morgan RA, Dudley ME, Cassard L, Yang JC, Hughes MS, Kammula US, Royal RE, Sherry RM, Wunderlich JR, Lee CC, Restifo NP, Schwarz SL, Cogdill AP, Bishop RJ, Kim H, Brewer CC, Rudy SF, VanWaes C, Davis JL, Mathur A, Ripley RT, Nathan DA, Laurencot CM, Rosenberg SA ( 2009 ) Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen . Blood 114 (3): 535 –546. 19451549
Kanemitsu N, Isobe Y, Masuda A, Momose S, Higashi M, Tamaru J, Sugimoto K, Komatsu N ( 2012 ) Expression of Epstein-Barr virus-encoded proteins in extranodal NK/T-cell Lymphoma, nasal type (ENKL): differences in biologic and clinical behaviors of LMP1-positive and -negative ENKL . Clin Cancer Res 18 (8): 2164 –2172. 22371452
Khanna R, Burrows SR, Nicholls J, Poulsen LM ( 1998 ) Identification of cytotoxic T-cellepitopes within Epstein-Barr virus (EBV) oncogene latent membrane protein 1 (LMP1): evidence for HLA A2 supertype-restricted immune recognition of EBV-infected cells by LMP1-specific cytotoxic T lymphocytes . Eur J Immunol 28 (2): 451 –458. 9521052
Lee DW, Kochenderfer JN, Stetler-Stevenson M, Cui YK, Delbrook C, Feldman SA, Fry TJ, Orentas R, Sabatino M, Shah NN, Steinberg SM, Stroncek D, Tschernia N, Yuan C, Zhang H, Zhang L, Rosenberg SA, Wayne AS, Mackall CL ( 2015 ) T-cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial . Lancet 385 (9967): 517 –528. 25319501
Li J, Zeng XH, Mo HY, Rolen U, Gao YF, Zhang XS, Chen QY, Zhang L, Zeng MS, Li MZ, Huang WL, Wang XN, Zeng YX, Masucci MG ( 2007 ) Functional inactivation of EBV-specific T-lymphocytes in nasopharyngeal carcinoma: implications for tumor immunotherapy . PLoS One 2 (11): e1122 . 17987110
Mitsuyasu RT, Anton PA, Deeks SG, Scadden DT, Connick E, Downs MT, Bakker A, Roberts MR, June CH, Jalali S, Lin AA, Pennathur-Das R, Hege KM ( 2000 ) Prolonged survival and tissue trafficking following adoptive transfer of CD4zeta gene-modified autologous CD4(+) and CD8(+) T-cells in human immunodeficiency virus-infected subjects . Blood 96 (3): 785 –793. 10910888
Morgan RA, Chinnasamy N, Abate-Daga D, Gros A, Robbins PF, Zheng Z, Dudley ME, Feldman SA, Yang JC, Sherry RM, Phan GQ, Hughes MS, Kammula US, Miller AD, Hessman CJ, Stewart AA, Restifo NP, Quezado MM, Alimchandani M, Rosenberg AZ, Nath A, Wang T, Bielekova B, Wuest SC, Akula N, McMahon FJ, Wilde S, Mosetter B, Schendel DJ, Laurencot CM, Rosenberg SA ( 2013 ) Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy . J Immunother 36 (2): 133 –151. 23377668
Morgan RA, Dudley ME, Wunderlich JR, Hughes MS, Yang JC, Sherry RM, Royal RE, Topalian SL, Kammula US, Restifo NP, Zheng Z, Nahvi A, de Vries CR, Rogers-Freezer LJ, Mavroukakis SA, Rosenberg SA ( 2006 ) Cancer regression in patients after transfer of genetically engineered lymphocytes . Science 314 (5796): 126 –129. 16946036
Orentas RJ, Roskopf SJ, Nolan GP, Nishimura MI ( 2001 ) Retroviral transduction of a T-cell receptor specific for an Epstein–Barr virus-encoded peptide . Clin Immunol 98 (2): 220 –228. 11161978
Parkhurst MR, Yang JC, Langan RC, Dudley ME, Nathan DA, Feldman SA, Davis JL, Morgan RA, Merino MJ, Sherry RM, Hughes MS, Kammula US, Phan GQ, Lim RM, Wank SA, Restifo NP, Robbins PF, Laurencot CM, Rosenberg SA ( 2011 ) T-cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis . Mol Ther 19 (3): 620 –626. 21157437
Porter DL, Levine BL, Kalos M, Bagg A, June CH ( 2011 ) Chimeric antigen receptor-modified T-cells in chronic lymphoid leukemia . N Engl J Med 365 (8): 725 –733. 21830940
Pratt ZL, Zhang J, Sugden B ( 2012 ) The latent membrane protein 1 (LMP1) oncogene of Epstein-Barr virus can simultaneously induce and inhibit apoptosis in B cells . J Virol 86 (8): 4380 –4393. 22318153
Rapoport AP, Stadtmauer EA, Binder-Scholl GK, Goloubeva O, Vogl DT, Lacey SF, Badros AZ, Garfall A, Weiss B, Finklestein J, Kulikovskaya I, Sinha SK, Kronsberg S, Gupta M, Bond S, Melchiori L, Brewer JE, Bennett AD, Gerry AB, Pumphrey NJ, Williams D, Tayton-Martin HK, Ribeiro L, Holdich T, Yanovich S, Hardy N, Yared J, Kerr N, Philip S, Westphal S, Siegel DL, Levine BL, Jakobsen BK, Kalos M, June CH ( 2015 ) NY-ESO-1-specific TCR-engineered T-cells mediate sustained antigen-specific antitumor effects in myeloma . Nat Med 21 (8): 914 –921. 26193344
Rasmussen AM, Borelli G, Hoel HJ, Lislerud K, Gaudernack G, Kvalheim G, Aarvak T ( 2010 ) Ex vivo expansion protocol for human tumor specific T-cells for adoptive T-celltherapy . J Immunol Methods 355 (1-2): 52 –60. 20171968
Riddell SR, Greenberg PD ( 1995 ) Principles for adoptive T-cell therapy of human viral diseases . Annu Rev Immunol 13 : 545 –586. 7612234
Robbins PF, Morgan RA, Feldman SA, Yang JC, Sherry RM, Dudley ME, Wunderlich JR, Nahvi AV, Helman LJ, Mackall CL, Kammula US, Hughes MS, Restifo NP, Raffeld M, Lee CC, Levy CL, Li YF, El-Gamil M, Schwarz SL, Laurencot C, Rosenberg SA ( 2011 ) Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1 . J Clin Oncol 29 (7): 917 –924. 21282551
Rodriguez F, Slifka MK, Harkins S, Whitton JL ( 2001 ) Two overlapping subdominant epitopes identified by DNA immunization induce protective CD8(+) T-cell populations with differing cytolytic activities . J Virol 75 (16): 7399 –7409. 11462012
Rosati SF, Parkhurst MR, Hong Y, Zheng Z, Feldman SA, Rao M, Abate-Daga D, Beard RE, Xu H, Black MA, Robbins PF, Schrump DA, Rosenberg SA, Morgan RA ( 2014 ) A novel murine T-cell receptor targeting NY-ESO-1 . J Immunother 37 (3): 135 –146. 24598449
Rosenberg SA, Restifo NP, Yang JC, Morgan RA, Dudley ME ( 2008 ) Adoptive cell transfer: a clinical path to effective cancer immunotherapy . Nat Rev Cancer 8 (4): 299 –308. 18354418
Rosenberg SA, Yang JC, Sherry RM, Kammula US, Hughes MS, Phan GQ, Citrin DE, Restifo NP, Robbins PF, Wunderlich JR, Morton KE, Laurencot CM, Steinberg SM, White DE, Dudley ME ( 2011 ) Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy . Clin Cancer Res 17 (13): 4550 –4557. 21498393
Savoldo B, Rooney CM, Di Stasi A, Abken H, Hombach A, Foster AE, Zhang L, Heslop HE, Brenner MK, Dotti G ( 2007 ) Epstein Barr virus specific cytotoxic T lymphocytes expressing the anti-CD30zeta artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease . Blood 110 (7): 2620 –2630. 17507664
Schaft N, Lankiewicz B, Drexhage J, Berrevoets C, Moss DJ, Levitsky V, Bonneville M, Lee SP, McMichael AJ, Gratama JW, Bolhuis RL, Willemsen R, Debets R ( 2006 ) T-cell re-targeting to EBV antigens following TCR gene transfer: CD28-containing receptors mediate enhanced antigen-specific IFNgamma production . Int Immunol 18 (4): 591 –601. 16507598
Schneck JP ( 2000 ) Monitoring antigen-specific T-cells using MHC-Ig dimers . Immunol Invest 29 (2): 163 –169. 10854185
Shaffer DR, Savoldo B, Yi Z, Chow KK, Kakarla S, Spencer DM, Dotti G, Wu MF, Liu H, Kenney S, Gottschalk S ( 2011 ) T-cells redirected against CD70 for the immunotherapy of CD70-positive malignancies . Blood 117 (16): 4304 –4314. 21304103
Smith C, Cooper L, Burgess M, Rist M, Webb N, Lambley E, Tellam J, Marlton P, Seymour JF, Gandhi M, Khanna R ( 2006 ) Functional reversion of antigen-specific CD8+ T-cells from patients with Hodgkin lymphoma following in vitro stimulation with recombinant polyepitope . J Immunol 177 (7): 4897 –4906. 16982932
Straathof KC, Leen AM, Buza EL, Taylor G, Huls MH, Heslop HE, Rooney CM, Bollard CM ( 2005 ) Characterization of latent membrane protein 2 specificity in CTL lines from patients with EBV-positive nasopharyngeal carcinoma and lymphoma . J Immunol 175 (6): 4137 –4147. 16148164
Ueno T, Fujiwara M, Tomiyama H, Onodera M, Takiguchi M ( 2004 ) Reconstitution of anti-HIV effector functions of primary human CD8 T lymphocytes by transfer of HIV-specific alphabeta TCR genes . Eur J Immunol 34 (12): 3379 –3388. 15517606
van Loenen MM, de Boer R, Amir AL, Hagedoorn RS, Volbeda GL, Willemze R, van Rood JJ, Falkenburg JH, Heemskerk MH ( 2010 ) Mixed T-cell receptor dimers harbor potentially harmful neoreactivity . Proc Natl Acad Sci USA 107 (24): 10972 –10977. 20534461
Woll MM, Fisher CM, Ryan GB, Gurney JM, Storrer CE, Ioannides CG, Shriver CD, Moul JW, McLeod DG, Ponniah S, Peoples GE ( 2004 ) Direct measurement of peptide-specific CD8+ T-cells using HLA-A2:Ig dimer for monitoring the in vivo immune response to a HER2/neu vaccine in breast and prostate cancer patients . J Clin Immunol 24 (4): 449 –461. 15163902
Xue SA, Gao L, Ahmadi M, Ghorashian S, Barros RD, Pospori C, Holler A, Wright G, Thomas S, Topp M, Morris EC, Stauss HJ ( 2013 ) Human MHC Class I-restricted high avidity CD4+ T-cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo . Oncoimmunology 2 (1): e22590 . 23483821
Yamamoto R, Nishikori M, Kitawaki T, Sakai T, Hishizawa M, Tashima M, Kondo T, Ohmori K, Kurata M, Hayashi T, Uchiyama T ( 2008 ) PD-1-PD-1 ligand interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma . Blood 111 (6): 3220 –3224. 18203952
Zheng Y, Parsonage G, Zhuang X, Machado LR, James CH, Salman A, Searle PF, Hui EP, Chan AT, Lee SP ( 2015 ) Human leukocyte antigen (HLA) A*1101-restricted Epstein–Barr virus-specific T-cell receptor gene transfer to target nasopharyngeal carcinoma . Cancer Immunol Res 3 (10): 1138 –1147. 25711537
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
저자가 APC(Article Processing Charge)를 지불한 논문에 한하여 자유로운 이용이 가능한, hybrid 저널에 출판된 논문
※ AI-Helper는 부적절한 답변을 할 수 있습니다.