$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

[해외논문] A novel Epstein–Barr virus-latent membrane protein-1-specific T-cell receptor for TCR gene therapy 원문보기

The British journal of cancer, v.118 no.4, 2018년, pp.534 - 545  

Cho, Hyun-Il (Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea , Seoul 06591, South Korea) ,  Kim, Un-Hee (Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea , Seoul 06591, South Korea) ,  Shin, A-Ri (Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea , Seoul 06591, South Korea) ,  Won, Ji-Na (Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea , Seoul 06591, South Korea) ,  Lee, Hyun-Joo (Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea , Seoul 06591, South Korea) ,  Sohn, Hyun-Jung (Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea , Seoul 06591, South Korea) ,  Kim, Tai-Gyu (Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic Uni)

Abstract AI-Helper 아이콘AI-Helper

Background:Adoptive transfer of genetically engineered T-cells to express antigen-specific T-cell receptor (TCR) is a feasible and effective therapeutic approach for numerous types of cancers, including Epstein–Barr virus (EBV)-associated malignancies. Here, we describe a TCR gene transfer re...

주제어

참고문헌 (57)

  1. Anurathapan U, Chan RC, Hindi HF, Mucharla R, Bajgain P, Hayes BC, Fisher WE, Heslop HE, Rooney CM, Brenner MK, Leen AM, Vera JF ( 2014 ) Kinetics of tumor destruction by chimeric antigen receptor-modified T-cells . Mol Ther 22 (3): 623 –633. 24213558 

  2. Bendle GM, Linnemann C, Hooijkaas AI, Bies L, de Witte MA, Jorritsma A, Kaiser AD, Pouw N, Debets R, Kieback E, Uckert W, Song JY, Haanen JB, Schumacher TN ( 2010 ) Lethal graft-versus-host disease in mouse models of T-cell receptor gene therapy . Nat Med 16 (5): 565 –570, 1p following 570. 20400962 

  3. Bollard CM, Gottschalk S, Torrano V, Diouf O, Ku S, Hazrat Y, Carrum G, Ramos C, Fayad L, Shpall EJ, Pro B, Liu H, Wu MF, Lee D, Sheehan AM, Zu Y, Gee AP, Brenner MK, Heslop HE, Rooney CM ( 2014 ) Sustained complete responses in patients with lymphoma receiving autologous cytotoxic T lymphocytes targeting Epstein–Barr virus latent membrane proteins . J Clin Oncol 32 (8): 798 –808. 24344220 

  4. Brimnes MK, Gang AO, Donia M, Thor Straten P, Svane IM, Hadrup SR ( 2012 ) Generation of autologous tumor-specific T-cells for adoptive transfer based on vaccination, in vitro restimulation and CD3/CD28 dynabead-induced T-cell expansion . Cancer Immunol Immunother 61 (8): 1221 –1231. 22237888 

  5. Butler MO, Imataki O, Yamashita Y, Tanaka M, Ansen S, Berezovskaya A, Metzler G, Milstein MI, Mooney MM, Murray AP, Mano H, Nadler LM, Hirano N ( 2012 ) Ex vivo expansion of human CD8+ T-cells using autologous CD4+ T-cell help . PLoS One 7 (1): e30229 . 22279573 

  6. Caruso HG, Hurton LV, Najjar A, Rushworth D, Ang S, Olivares S, Mi T, Switzer K, Singh H, Huls H, Lee DA, Heimberger AB, Champlin RE, Cooper LJ ( 2015 ) Tuning sensitivity of CAR to EGFR density limits recognition of normal tissue while maintaining potent antitumor activity . Cancer Res 75 (17): 3505 –3518. 26330164 

  7. Chinnasamy N, Wargo JA, Yu Z, Rao M, Frankel TL, Riley JP, Hong JJ, Parkhurst MR, Feldman SA, Schrump DS, Restifo NP, Robbins PF, Rosenberg SA, Morgan RA ( 2011 ) A TCR targeting the HLA-A*0201-restricted epitope of MAGE-A3 recognizes multiple epitopes of the MAGE-A antigen superfamily in several types of cancer . J Immunol 186 (2): 685 –696. 21149604 

  8. Cho HI, Jung SH, Sohn HJ, Celis E, Kim TG ( 2015 a) An optimized peptide vaccine strategy capable of inducing multivalent CD8+ T-cell responses with potent antitumor effects . Oncoimmunology 4 (11): e1043504 . 26451316 

  9. Cho SG, Kim N, Sohn HJ, Lee SK, Oh ST, Lee HJ, Cho HI, Yim HW, Jung SE, Park G, Oh JH, Choi BO, Kim SW, Kim SW, Chung NG, Lee JW, Hong YS, Kim TG ( 2015 b) Long-term outcome of extranodal NK/T-cell lymphoma patients treated with postremission therapy using EBV LMP1 and LMP2a-specific CTLs . Mol Ther 23 (8): 1401 –1409. 26017177 

  10. Cohen CJ, Zhao Y, Zheng Z, Rosenberg SA, Morgan RA ( 2006 ) Enhanced antitumor activity of murine-human hybrid T-cell receptor (TCR) in human lymphocytes is associated with improved pairing and TCR/CD3 stability . Cancer Res 66 (17): 8878 –8886. 16951205 

  11. Corse E, Gottschalk RA, Allison JP ( 2011 ) Strength of TCR-peptide/MHC interactions and in vivo T-cell responses . J Immunol 186 (9): 5039 –5045. 21505216 

  12. Davis JL, Theoret MR, Zheng Z, Lamers CH, Rosenberg SA, Morgan RA ( 2010 ) Development of human anti-murine T-cell receptor antibodies in both responding and nonresponding patients enrolled in TCR gene therapy trials . Clin Cancer Res 16 (23): 5852 –5861. 21138872 

  13. Demachi-Okamura A, Ito Y, Akatsuka Y, Tsujimura K, Morishima Y, Takahashi T, Kuzushima K ( 2006 ) Epstein–Barr virus (EBV) latent membrane protein-1-specific cytotoxic T lymphocytes targeting EBV-carrying natural killer cell malignancies . Eur J Immunol 36 (3): 593 –602. 16479544 

  14. Duraiswamy J, Sherritt M, Thomson S, Tellam J, Cooper L, Connolly G, Bharadwaj M, Khanna R ( 2003 ) Therapeutic LMP1 polyepitope vaccine for EBV-associated Hodgkin disease and nasopharyngeal carcinoma . Blood 101 (8): 3150 –3156. 12468425 

  15. Fogg M, Murphy JR, Lorch J, Posner M, Wang F ( 2013 ) Therapeutic targeting of regulatory T-cells enhances tumor-specific CD8+ T-cell responses in Epstein–Barr virus associated nasopharyngeal carcinoma . Virology 441 (2): 107 –113. 23601786 

  16. Fogg MH, Wirth LJ, Posner M, Wang F ( 2009 ) Decreased EBNA-1-specific CD8+ T-cells in patients with Epstein–Barr virus-associated nasopharyngeal carcinoma . Proc Natl Acad Sci USA 106 (9): 3318 –3323. 19211798 

  17. Frumento G, Zheng Y, Aubert G, Raeiszadeh M, Lansdorp PM, Moss P, Lee SP, Chen FE ( 2013 ) Cord blood T-cells retain early differentiation phenotype suitable for immunotherapy after TCR gene transfer to confer EBV specificity . Am J Transplant 13 (1): 45 –55. 23016879 

  18. Gandhi MK, Moll G, Smith C, Dua U, Lambley E, Ramuz O, Gill D, Marlton P, Seymour JF, Khanna R ( 2007 ) Galectin-1 mediated suppression of Epstein–Barr virus specific T-cell immunity in classic Hodgkin lymphoma . Blood 110 (4): 1326 –1329. 17438085 

  19. Goff SL, Johnson LA, Black MA, Xu H, Zheng Z, Cohen CJ, Morgan RA, Rosenberg SA, Feldman SA ( 2010 ) Enhanced receptor expression and in vitro effector function of a murine-human hybrid MART-1-reactive T-cell receptor following a rapid expansion . Cancer Immunol Immunother 59 (10): 1551 –1560. 20628878 

  20. Gottschalk S, Edwards OL, Sili U, Huls MH, Goltsova T, Davis AR, Heslop HE, Rooney CM ( 2003 ) Generating CTLs against the subdominant Epstein–Barr virus LMP1 antigen for the adoptive immunotherapy of EBV-associated malignancies . Blood 101 (5): 1905 –1912. 12411306 

  21. Gottschalk S, Heslop HE, Rooney CM ( 2005 ) Adoptive immunotherapy for EBV-associated malignancies . Leuk Lymphoma 46 (1): 1 –10. 15621775 

  22. Graham JP, Arcipowski KM, Bishop GA ( 2010 ) Differential B-lymphocyte regulation by CD40 and its viral mimic, latent membrane protein 1 . Immunol Rev 237 (1): 226 –248. 20727039 

  23. Grupp SA, Kalos M, Barrett D, Aplenc R, Porter DL, Rheingold SR, Teachey DT, Chew A, Hauck B, Wright JF, Milone MC, Levine BL, June CH ( 2013 ) Chimeric antigen receptor-modified T-cells for acute lymphoid leukemia . N Engl J Med 368 (16): 1509 –1518. 23527958 

  24. Hammerschmidt W, Sugden B, Baichwal VR ( 1989 ) The transforming domain alone of the latent membrane protein of Epstein–Barr virus is toxic to cells when expressed at high levels . J Virol 63 (6): 2469 –2475. 2542565 

  25. Hinrichs CS, Borman ZA, Cassard L, Gattinoni L, Spolski R, Yu Z, Sanchez-Perez L, Muranski P, Kern SJ, Logun C, Palmer DC, Ji Y, Reger RN, Leonard WJ, Danner RL, Rosenberg SA, Restifo NP ( 2009 ) Adoptively transferred effector cells derived from naive rather than central memory CD8+ T-cells mediate superior antitumor immunity . Proc Natl Acad Sci USA 106 (41): 17469 –17474. 19805141 

  26. Johnson LA, Morgan RA, Dudley ME, Cassard L, Yang JC, Hughes MS, Kammula US, Royal RE, Sherry RM, Wunderlich JR, Lee CC, Restifo NP, Schwarz SL, Cogdill AP, Bishop RJ, Kim H, Brewer CC, Rudy SF, VanWaes C, Davis JL, Mathur A, Ripley RT, Nathan DA, Laurencot CM, Rosenberg SA ( 2009 ) Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen . Blood 114 (3): 535 –546. 19451549 

  27. Kanemitsu N, Isobe Y, Masuda A, Momose S, Higashi M, Tamaru J, Sugimoto K, Komatsu N ( 2012 ) Expression of Epstein-Barr virus-encoded proteins in extranodal NK/T-cell Lymphoma, nasal type (ENKL): differences in biologic and clinical behaviors of LMP1-positive and -negative ENKL . Clin Cancer Res 18 (8): 2164 –2172. 22371452 

  28. Khanna R, Burrows SR, Nicholls J, Poulsen LM ( 1998 ) Identification of cytotoxic T-cellepitopes within Epstein-Barr virus (EBV) oncogene latent membrane protein 1 (LMP1): evidence for HLA A2 supertype-restricted immune recognition of EBV-infected cells by LMP1-specific cytotoxic T lymphocytes . Eur J Immunol 28 (2): 451 –458. 9521052 

  29. Lee DW, Kochenderfer JN, Stetler-Stevenson M, Cui YK, Delbrook C, Feldman SA, Fry TJ, Orentas R, Sabatino M, Shah NN, Steinberg SM, Stroncek D, Tschernia N, Yuan C, Zhang H, Zhang L, Rosenberg SA, Wayne AS, Mackall CL ( 2015 ) T-cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial . Lancet 385 (9967): 517 –528. 25319501 

  30. Li J, Zeng XH, Mo HY, Rolen U, Gao YF, Zhang XS, Chen QY, Zhang L, Zeng MS, Li MZ, Huang WL, Wang XN, Zeng YX, Masucci MG ( 2007 ) Functional inactivation of EBV-specific T-lymphocytes in nasopharyngeal carcinoma: implications for tumor immunotherapy . PLoS One 2 (11): e1122 . 17987110 

  31. Mitsuyasu RT, Anton PA, Deeks SG, Scadden DT, Connick E, Downs MT, Bakker A, Roberts MR, June CH, Jalali S, Lin AA, Pennathur-Das R, Hege KM ( 2000 ) Prolonged survival and tissue trafficking following adoptive transfer of CD4zeta gene-modified autologous CD4(+) and CD8(+) T-cells in human immunodeficiency virus-infected subjects . Blood 96 (3): 785 –793. 10910888 

  32. Morgan RA, Chinnasamy N, Abate-Daga D, Gros A, Robbins PF, Zheng Z, Dudley ME, Feldman SA, Yang JC, Sherry RM, Phan GQ, Hughes MS, Kammula US, Miller AD, Hessman CJ, Stewart AA, Restifo NP, Quezado MM, Alimchandani M, Rosenberg AZ, Nath A, Wang T, Bielekova B, Wuest SC, Akula N, McMahon FJ, Wilde S, Mosetter B, Schendel DJ, Laurencot CM, Rosenberg SA ( 2013 ) Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy . J Immunother 36 (2): 133 –151. 23377668 

  33. Morgan RA, Dudley ME, Wunderlich JR, Hughes MS, Yang JC, Sherry RM, Royal RE, Topalian SL, Kammula US, Restifo NP, Zheng Z, Nahvi A, de Vries CR, Rogers-Freezer LJ, Mavroukakis SA, Rosenberg SA ( 2006 ) Cancer regression in patients after transfer of genetically engineered lymphocytes . Science 314 (5796): 126 –129. 16946036 

  34. Orentas RJ, Roskopf SJ, Nolan GP, Nishimura MI ( 2001 ) Retroviral transduction of a T-cell receptor specific for an Epstein–Barr virus-encoded peptide . Clin Immunol 98 (2): 220 –228. 11161978 

  35. Parkhurst MR, Yang JC, Langan RC, Dudley ME, Nathan DA, Feldman SA, Davis JL, Morgan RA, Merino MJ, Sherry RM, Hughes MS, Kammula US, Phan GQ, Lim RM, Wank SA, Restifo NP, Robbins PF, Laurencot CM, Rosenberg SA ( 2011 ) T-cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis . Mol Ther 19 (3): 620 –626. 21157437 

  36. Porter DL, Levine BL, Kalos M, Bagg A, June CH ( 2011 ) Chimeric antigen receptor-modified T-cells in chronic lymphoid leukemia . N Engl J Med 365 (8): 725 –733. 21830940 

  37. Pratt ZL, Zhang J, Sugden B ( 2012 ) The latent membrane protein 1 (LMP1) oncogene of Epstein-Barr virus can simultaneously induce and inhibit apoptosis in B cells . J Virol 86 (8): 4380 –4393. 22318153 

  38. Rapoport AP, Stadtmauer EA, Binder-Scholl GK, Goloubeva O, Vogl DT, Lacey SF, Badros AZ, Garfall A, Weiss B, Finklestein J, Kulikovskaya I, Sinha SK, Kronsberg S, Gupta M, Bond S, Melchiori L, Brewer JE, Bennett AD, Gerry AB, Pumphrey NJ, Williams D, Tayton-Martin HK, Ribeiro L, Holdich T, Yanovich S, Hardy N, Yared J, Kerr N, Philip S, Westphal S, Siegel DL, Levine BL, Jakobsen BK, Kalos M, June CH ( 2015 ) NY-ESO-1-specific TCR-engineered T-cells mediate sustained antigen-specific antitumor effects in myeloma . Nat Med 21 (8): 914 –921. 26193344 

  39. Rasmussen AM, Borelli G, Hoel HJ, Lislerud K, Gaudernack G, Kvalheim G, Aarvak T ( 2010 ) Ex vivo expansion protocol for human tumor specific T-cells for adoptive T-celltherapy . J Immunol Methods 355 (1-2): 52 –60. 20171968 

  40. Riddell SR, Greenberg PD ( 1995 ) Principles for adoptive T-cell therapy of human viral diseases . Annu Rev Immunol 13 : 545 –586. 7612234 

  41. Robbins PF, Morgan RA, Feldman SA, Yang JC, Sherry RM, Dudley ME, Wunderlich JR, Nahvi AV, Helman LJ, Mackall CL, Kammula US, Hughes MS, Restifo NP, Raffeld M, Lee CC, Levy CL, Li YF, El-Gamil M, Schwarz SL, Laurencot C, Rosenberg SA ( 2011 ) Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1 . J Clin Oncol 29 (7): 917 –924. 21282551 

  42. Rodriguez F, Slifka MK, Harkins S, Whitton JL ( 2001 ) Two overlapping subdominant epitopes identified by DNA immunization induce protective CD8(+) T-cell populations with differing cytolytic activities . J Virol 75 (16): 7399 –7409. 11462012 

  43. Rosati SF, Parkhurst MR, Hong Y, Zheng Z, Feldman SA, Rao M, Abate-Daga D, Beard RE, Xu H, Black MA, Robbins PF, Schrump DA, Rosenberg SA, Morgan RA ( 2014 ) A novel murine T-cell receptor targeting NY-ESO-1 . J Immunother 37 (3): 135 –146. 24598449 

  44. Rosenberg SA, Restifo NP, Yang JC, Morgan RA, Dudley ME ( 2008 ) Adoptive cell transfer: a clinical path to effective cancer immunotherapy . Nat Rev Cancer 8 (4): 299 –308. 18354418 

  45. Rosenberg SA, Yang JC, Sherry RM, Kammula US, Hughes MS, Phan GQ, Citrin DE, Restifo NP, Robbins PF, Wunderlich JR, Morton KE, Laurencot CM, Steinberg SM, White DE, Dudley ME ( 2011 ) Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy . Clin Cancer Res 17 (13): 4550 –4557. 21498393 

  46. Savoldo B, Rooney CM, Di Stasi A, Abken H, Hombach A, Foster AE, Zhang L, Heslop HE, Brenner MK, Dotti G ( 2007 ) Epstein Barr virus specific cytotoxic T lymphocytes expressing the anti-CD30zeta artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease . Blood 110 (7): 2620 –2630. 17507664 

  47. Schaft N, Lankiewicz B, Drexhage J, Berrevoets C, Moss DJ, Levitsky V, Bonneville M, Lee SP, McMichael AJ, Gratama JW, Bolhuis RL, Willemsen R, Debets R ( 2006 ) T-cell re-targeting to EBV antigens following TCR gene transfer: CD28-containing receptors mediate enhanced antigen-specific IFNgamma production . Int Immunol 18 (4): 591 –601. 16507598 

  48. Schneck JP ( 2000 ) Monitoring antigen-specific T-cells using MHC-Ig dimers . Immunol Invest 29 (2): 163 –169. 10854185 

  49. Shaffer DR, Savoldo B, Yi Z, Chow KK, Kakarla S, Spencer DM, Dotti G, Wu MF, Liu H, Kenney S, Gottschalk S ( 2011 ) T-cells redirected against CD70 for the immunotherapy of CD70-positive malignancies . Blood 117 (16): 4304 –4314. 21304103 

  50. Smith C, Cooper L, Burgess M, Rist M, Webb N, Lambley E, Tellam J, Marlton P, Seymour JF, Gandhi M, Khanna R ( 2006 ) Functional reversion of antigen-specific CD8+ T-cells from patients with Hodgkin lymphoma following in vitro stimulation with recombinant polyepitope . J Immunol 177 (7): 4897 –4906. 16982932 

  51. Straathof KC, Leen AM, Buza EL, Taylor G, Huls MH, Heslop HE, Rooney CM, Bollard CM ( 2005 ) Characterization of latent membrane protein 2 specificity in CTL lines from patients with EBV-positive nasopharyngeal carcinoma and lymphoma . J Immunol 175 (6): 4137 –4147. 16148164 

  52. Ueno T, Fujiwara M, Tomiyama H, Onodera M, Takiguchi M ( 2004 ) Reconstitution of anti-HIV effector functions of primary human CD8 T lymphocytes by transfer of HIV-specific alphabeta TCR genes . Eur J Immunol 34 (12): 3379 –3388. 15517606 

  53. van Loenen MM, de Boer R, Amir AL, Hagedoorn RS, Volbeda GL, Willemze R, van Rood JJ, Falkenburg JH, Heemskerk MH ( 2010 ) Mixed T-cell receptor dimers harbor potentially harmful neoreactivity . Proc Natl Acad Sci USA 107 (24): 10972 –10977. 20534461 

  54. Woll MM, Fisher CM, Ryan GB, Gurney JM, Storrer CE, Ioannides CG, Shriver CD, Moul JW, McLeod DG, Ponniah S, Peoples GE ( 2004 ) Direct measurement of peptide-specific CD8+ T-cells using HLA-A2:Ig dimer for monitoring the in vivo immune response to a HER2/neu vaccine in breast and prostate cancer patients . J Clin Immunol 24 (4): 449 –461. 15163902 

  55. Xue SA, Gao L, Ahmadi M, Ghorashian S, Barros RD, Pospori C, Holler A, Wright G, Thomas S, Topp M, Morris EC, Stauss HJ ( 2013 ) Human MHC Class I-restricted high avidity CD4+ T-cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo . Oncoimmunology 2 (1): e22590 . 23483821 

  56. Yamamoto R, Nishikori M, Kitawaki T, Sakai T, Hishizawa M, Tashima M, Kondo T, Ohmori K, Kurata M, Hayashi T, Uchiyama T ( 2008 ) PD-1-PD-1 ligand interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma . Blood 111 (6): 3220 –3224. 18203952 

  57. Zheng Y, Parsonage G, Zhuang X, Machado LR, James CH, Salman A, Searle PF, Hui EP, Chan AT, Lee SP ( 2015 ) Human leukocyte antigen (HLA) A*1101-restricted Epstein–Barr virus-specific T-cell receptor gene transfer to target nasopharyngeal carcinoma . Cancer Immunol Res 3 (10): 1138 –1147. 25711537 

LOADING...

관련 콘텐츠

원문 보기

원문 URL 링크

*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.

오픈액세스(OA) 유형

GOLD(Hybrid)

저자가 APC(Article Processing Charge)를 지불한 논문에 한하여 자유로운 이용이 가능한, hybrid 저널에 출판된 논문

이 논문과 함께 이용한 콘텐츠

유발과제정보 저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로